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Conserved domains on  [gi|1833099878|ref|WP_168653578|]
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MULTISPECIES: TMEM165/GDT1 family protein [Dolichospermum]

Protein Classification

TMEM165/GDT1 family protein( domain architecture ID 11450136)

TMEM165/GDT1 family protein similar to mammalian Golgi-localized transmembrane protein 165 (TMEM165) and its yeast ortholog, Gcr1 dependent translation factor 1 (Gdt1p), which are involved in calcium and pH homeostasis and might function as Ca(2+)/H(+) antiporters

Gene Ontology:  GO:0046873|GO:0030001|GO:0016020
PubMed:  23569283|24955841|32743000

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
38-125 7.78e-29

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


:

Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 103.36  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833099878  38 VFGTTFITIFLAEIGDKTQLSTLLMSAESHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLISVM 117
Cdd:COG2119   104 PFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLGTTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLV 183


                  ....*...
gi 1833099878 118 LVWDVIQG 125
Cdd:COG2119   184 TLLEALGG 191
 
Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
38-125 7.78e-29

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 103.36  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833099878  38 VFGTTFITIFLAEIGDKTQLSTLLMSAESHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLISVM 117
Cdd:COG2119   104 PFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLGTTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLV 183


                  ....*...
gi 1833099878 118 LVWDVIQG 125
Cdd:COG2119   184 TLLEALGG 191
UPF0016 pfam01169
Uncharacterized protein family UPF0016; This family contains integral membrane proteins of ...
 41-114 4.73e-23

Uncharacterized protein family UPF0016; This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions. It has been suggested that these proteins are calcium transporters.


Pssm-ID: 460096  Cd Length: 75  Bit Score: 85.16  E-value: 4.73e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1833099878  41 TTFITIFLAEIGDKTQLSTLLMSAeSHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLI 114
Cdd:pfam01169   2 TSFLLIFLAELGDKTQLATIALAA-RYRRLAVFLGATLALALATVLAVLLGSWLARRLPERLVHLVAAALFLVF 74
 
Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
38-125 7.78e-29

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 103.36  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833099878  38 VFGTTFITIFLAEIGDKTQLSTLLMSAESHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLISVM 117
Cdd:COG2119   104 PFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLGTTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLV 183


                  ....*...
gi 1833099878 118 LVWDVIQG 125
Cdd:COG2119   184 TLLEALGG 191
UPF0016 pfam01169
Uncharacterized protein family UPF0016; This family contains integral membrane proteins of ...
 41-114 4.73e-23

Uncharacterized protein family UPF0016; This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions. It has been suggested that these proteins are calcium transporters.


Pssm-ID: 460096  Cd Length: 75  Bit Score: 85.16  E-value: 4.73e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1833099878  41 TTFITIFLAEIGDKTQLSTLLMSAeSHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLI 114
Cdd:pfam01169   2 TSFLLIFLAELGDKTQLATIALAA-RYRRLAVFLGATLALALATVLAVLLGSWLARRLPERLVHLVAAALFLVF 74
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
38-118 3.21e-16

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 70.62  E-value: 3.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833099878  38 VFGTTFITIFLAEIGDKTQLSTLLMSAEsHAPWVVFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLISVM 117
Cdd:COG2119     4 AFLTSFGLVALAELGDKTQLLALALATR-YRPWPVLAGILAATLLNHALAVALGSWLASLLPPDYLRWVAALLFLAFGLW 82


                  .
gi 1833099878 118 L 118
Cdd:COG2119    83 L 83
TauE COG0730
Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport ...
 72-123 4.12e-04

Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport and metabolism];


Pssm-ID: 440494  Cd Length: 250  Bit Score: 38.25  E-value: 4.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1833099878  72 VFLGSAVALITTSLLGVLLGGWISTKLSPQTVEKSAGVMLLLISVMLVWDVI 123
Cdd:COG0730   198 VDWPLALLLALGSLLGAYLGARLARRLPPKLLRRLFAVVLLLVGLKLLLKAL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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