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Conserved domains on  [gi|1835901665|ref|WP_168972994|]
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ribose-phosphate diphosphokinase [Bifidobacterium boum]

Protein Classification

ribose-phosphate pyrophosphokinase( domain architecture ID 11479877)

ribose-phosphate pyrophosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
24-327 0e+00

ribose-phosphate diphosphokinase;


:

Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 624.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  24 LAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFMGY 103
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 104 SRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPMENATVVSPDAGRI 183
Cdd:PRK03092   81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDLDNVTVVSPDAGRV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 184 KVSEQWAAKLGGLPLAFIHKTRDITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGL 263
Cdd:PRK03092  161 RVAEQWADRLGGAPLAFIHKTRDPTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835901665 264 LSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLNGLP 327
Cdd:PRK03092  241 LSGPAAERLKNCGAREVVVTDTLPIPEEKRFDKLTVLSIAPLLARAIREVFEDGSVTSLFDGLA 304
 
Name Accession Description Interval E-value
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
24-327 0e+00

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 624.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  24 LAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFMGY 103
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 104 SRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPMENATVVSPDAGRI 183
Cdd:PRK03092   81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDLDNVTVVSPDAGRV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 184 KVSEQWAAKLGGLPLAFIHKTRDITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGL 263
Cdd:PRK03092  161 RVAEQWADRLGGAPLAFIHKTRDPTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835901665 264 LSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLNGLP 327
Cdd:PRK03092  241 LSGPAAERLKNCGAREVVVTDTLPIPEEKRFDKLTVLSIAPLLARAIREVFEDGSVTSLFDGLA 304
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 10-324 2.37e-172

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 480.71  E-value: 2.37e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  10 DKRLAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRA 89
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  90 SAKSITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRnSMP 169
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIK-SKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 170 MENATVVSPDAGRIKVSEQWAAKLgGLPLAFIHKTRDitRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRD 249
Cdd:COG0462   160 LEDLVVVSPDVGGVKRARAFAKRL-GAPLAIIDKRRP--GANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKE 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835901665 250 AGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLN 324
Cdd:COG0462   237 AGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 15-323 4.67e-128

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 368.53  E-value: 4.67e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  15 VVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHT-EPINKWLMEQLIMVDALKRASAKS 93
Cdd:TIGR01251   3 IFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIQQSTsAPVNDNLMELLIMIDALKRASAKS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  94 ITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPmENA 173
Cdd:TIGR01251  83 ITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKIL-DNP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 174 TVVSPDAGRIKVSEQWAAKLgGLPLAFIHKTRdITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAK 253
Cdd:TIGR01251 162 VVVSPDAGGVERAKKVADAL-GCPLAIIDKRR-ISATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAK 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 254 SVTLVATHGLLSGPAIDRLKDCGAREIVLMDTvpVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLL 323
Cdd:TIGR01251 240 RVIAAATHGVFSGPAIERIANAGVEEVIVTNT--IPHEKHKPKVSVISVAPLIAEAIRRIHNNESVSSLF 307
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 13-129 3.34e-61

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 191.09  E-value: 3.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  13 LAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAK 92
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1835901665  93 SITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAG 129
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 156-274 4.32e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 87.45  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 156 AMPVLLDYVRNSMPmENATVVSPDAGRIKVSEQWAAKLGgLPLAFIHKTRDITRPNHAVAHG----IIGEVEGRDCIVVD 231
Cdd:cd06223     1 AGRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-LPLAFIRKERKGPGRTPSEPYGlelpLGGDVKGKRVLLVD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1835901665 232 DMIDTAGTICEAVRTLRDAGAKSVTLVATHGLLSGPAIDRLKD 274
Cdd:cd06223    79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASP 121
 
Name Accession Description Interval E-value
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
24-327 0e+00

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 624.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  24 LAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFMGY 103
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 104 SRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPMENATVVSPDAGRI 183
Cdd:PRK03092   81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDLDNVTVVSPDAGRV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 184 KVSEQWAAKLGGLPLAFIHKTRDITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGL 263
Cdd:PRK03092  161 RVAEQWADRLGGAPLAFIHKTRDPTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835901665 264 LSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLNGLP 327
Cdd:PRK03092  241 LSGPAAERLKNCGAREVVVTDTLPIPEEKRFDKLTVLSIAPLLARAIREVFEDGSVTSLFDGLA 304
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 10-324 2.37e-172

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 480.71  E-value: 2.37e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  10 DKRLAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRA 89
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  90 SAKSITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRnSMP 169
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIK-SKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 170 MENATVVSPDAGRIKVSEQWAAKLgGLPLAFIHKTRDitRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRD 249
Cdd:COG0462   160 LEDLVVVSPDVGGVKRARAFAKRL-GAPLAIIDKRRP--GANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKE 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835901665 250 AGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLN 324
Cdd:COG0462   237 AGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
13-322 9.19e-129

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 370.22  E-value: 9.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  13 LAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAK 92
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  93 SITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRnSMPMEN 172
Cdd:PRK01259   81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIK-QKNLEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 173 ATVVSPDAGRIKVSEQWAAKLgGLPLAFIHKTRdiTRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGA 252
Cdd:PRK01259  160 LVVVSPDVGGVVRARALAKRL-DADLAIIDKRR--PRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835901665 253 KSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQ-SKRLPNMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK01259  237 KSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEeAKKCDKIRVLSVAPLLAEAIRRISNEESVSSL 307
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 15-323 4.67e-128

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 368.53  E-value: 4.67e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  15 VVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHT-EPINKWLMEQLIMVDALKRASAKS 93
Cdd:TIGR01251   3 IFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIQQSTsAPVNDNLMELLIMIDALKRASAKS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  94 ITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPmENA 173
Cdd:TIGR01251  83 ITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKIL-DNP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 174 TVVSPDAGRIKVSEQWAAKLgGLPLAFIHKTRdITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAK 253
Cdd:TIGR01251 162 VVVSPDAGGVERAKKVADAL-GCPLAIIDKRR-ISATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAK 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 254 SVTLVATHGLLSGPAIDRLKDCGAREIVLMDTvpVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLL 323
Cdd:TIGR01251 240 RVIAAATHGVFSGPAIERIANAGVEEVIVTNT--IPHEKHKPKVSVISVAPLIAEAIRRIHNNESVSSLF 307
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 22-324 1.03e-104

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 308.93  E-value: 1.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  22 PQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFM 101
Cdd:PLN02369    1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 102 GYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSM-PMENATVVSPDA 180
Cdd:PLN02369   81 GYARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTiSSPDLVVVSPDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 181 GRIKVSEQWAAKLGGLPLAFIHKTRdiTRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVAT 260
Cdd:PLN02369  161 GGVARARAFAKKLSDAPLAIVDKRR--QGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACAT 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835901665 261 HGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTLLN 324
Cdd:PLN02369  239 HAVFSPPAIERLSSGLFQEVIVTNTIPVSEKNYFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 10-322 4.45e-103

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 305.90  E-value: 4.45e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  10 DKRLAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRA 89
Cdd:PRK02812   19 NNRLRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  90 SAKSITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRnSMP 169
Cdd:PRK02812   99 SARQITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLA-SKN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 170 MENATVVSPDAGRIKVSEQWAAKLGGLPLAFIHKTRdiTRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRD 249
Cdd:PRK02812  178 LEDIVVVSPDVGGVARARAFAKKLNDAPLAIIDKRR--QAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRK 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835901665 250 AGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK02812  256 EGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEERRFPQLKVLSVANMLGEAIWRIHEESSVSSM 328
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
23-322 9.90e-99

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 294.39  E-value: 9.90e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  23 QLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFMG 102
Cdd:PRK02269   16 ELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAESINVVMPYYG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 103 YSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDY-VRNSMPMENATVVSPDAG 181
Cdd:PRK02269   96 YARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYfDRRGLVGDDVVVVSPDHG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 182 RIKVSEQWAAKLGGlPLAFIHKTRDITRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATH 261
Cdd:PRK02269  176 GVTRARKLAQFLKT-PIAIIDKRRSVDKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTH 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835901665 262 GLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK02269  255 PVLSGPALDNIQKSAIEKLVVLDTIYLPEERLIDKIEQISIADLLGEAIIRIHEKRPLSPL 315
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
8-322 9.64e-87

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 263.71  E-value: 9.64e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665   8 KPDKRLAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALK 87
Cdd:PRK04923    2 QDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  88 RASAKSITVVAPFMGYSRQDKK-HQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRN 166
Cdd:PRK04923   82 RASAASVTAVIPYFGYSRQDRRmRSSRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 167 SMPMENATVVSPDAGRIKVSEQWAAKLGGLPLAFIHKTRdiTRPNHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRT 246
Cdd:PRK04923  162 AYGTDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRR--PRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1835901665 247 LRDAGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKRL-PNMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK04923  240 LKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARAcAKIRQLSVAELLAETIRRIAFGESVSSL 316
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 6-324 1.42e-83

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 259.80  E-value: 1.42e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665   6 EGKP-DKRLA---VVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLI 81
Cdd:PTZ00145  109 EKRPfEKKMEnaiLFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  82 MVDALKRASAKSITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNG--PVDHLTAMPV 159
Cdd:PTZ00145  189 MISTCRRASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGPrvPVDNLEAQLI 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 160 LLDYVRNSmPMENATVVSPDAGRIKVSEQWAAKL-----GGLPLAFIHKTRdiTRPNHAVAHGIIGEVEGRDCIVVDDMI 234
Cdd:PTZ00145  269 GLDYFTKK-DLYKPVIVSPDAGGVYRARKFQDGLnhrgiSDCGIAMLIKQR--TKPNEIEKMDLVGNVYDSDVIIVDDMI 345

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 235 DTAGTICEAVRTLRDAGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPV-PQSKRLPNMTVLSVAPLLAAGIRSV 313
Cdd:PTZ00145  346 DTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSnKNIDSCKKITKLSVSVLVADAIRRI 425

                         330
                  ....*....|.
gi 1835901665 314 FESGSVTTLLN 324
Cdd:PTZ00145  426 HQKESLNDLFN 436
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 38-322 1.22e-82

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 253.69  E-value: 1.22e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  38 ETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAKSITVVAPFMGYSRQDKKHQGREPIT 117
Cdd:PRK00553   35 EIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSITAILPYYGYARQDRKTAGREPIT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 118 ARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMPMENATVVSPDAGRIKVSEQWAAKLgGLP 197
Cdd:PRK00553  115 SKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLGKKDLVVVSPDYGGVKRARLIAESL-ELP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 198 LAFIHKtrdiTRPNHAVAHGI--IGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGLLSGPAIDRLKDC 275
Cdd:PRK00553  194 LAIIDK----RRPKHNVAESInvLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEA 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835901665 276 GAREIV----LMDTVPVPQSKRLPNMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK00553  270 FKKKLIdklfVSNSIPQTKFEKKPQFKVVDLAHLYEEVLLCYANGGSISAI 320
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 6-322 6.36e-76

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 236.17  E-value: 6.36e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665   6 EGKPDKRLAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDA 85
Cdd:PRK02458    3 ERYADKQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  86 LKRASAKSITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGADRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVR 165
Cdd:PRK02458   83 CKRASANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYC 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 166 N-SMPMENATVVSPDAGRIKVSEQWAAKLGGlPLAFIHKTRDITRPNHAVahgIIGEVEGRDCIVVDDMIDTAGTICEAV 244
Cdd:PRK02458  163 KkGLSGSDVVVVSPKNSGIKRARSLAEYLDA-PIAIIDYAQDDSEREEGY---IIGDVAGKKAILIDDILNTGKTFAEAA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835901665 245 RTLRDAGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQskRLP-NMTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:PRK02458  239 KIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKE--RVPkNVTYLSASELIADAIIRIHERKPLSPL 315
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 15-311 3.29e-70

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 220.17  E-value: 3.29e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  15 VVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQShTEPINKWLMEQLIMVDALKRASAKSI 94
Cdd:PRK00934    2 IIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIIST-TYPQDENLVELLLLIDALRDEGAKSI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  95 TVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAGaDRIMTVDLHASQEQGFFNGPVDHLTAMPVLLDYVRNSMpmENAT 174
Cdd:PRK00934   81 TLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL--DDPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 175 VVSPDAGRIKVSEQWAAKLGgLPLAFIHKTR------DITRPNHavahgiigEVEGRDCIVVDDMIDTAGTICEAVRTLR 248
Cdd:PRK00934  158 VLAPDKGALELAKEAAEILG-CEYDYLEKTRisptevEIAPKNL--------DVKGKDVLIVDDIISTGGTMATAIKILK 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835901665 249 DAGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKrlpnmtvLSVAPLLAAGIR 311
Cdd:PRK00934  229 EQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESEVSK-------ISVAPLIADLLK 284
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 13-129 3.34e-61

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 191.09  E-value: 3.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  13 LAVVTGRAYPQLAQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPINKWLMEQLIMVDALKRASAK 92
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1835901665  93 SITVVAPFMGYSRQDKKHQGREPITARLMFDLFRTAG 129
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
25-315 1.34e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 162.41  E-value: 1.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  25 AQETAEYLGTHLLETTAYDFANGEMYIRFTEPVRGADVFVIQSHTEPiNKWLMEQLIMVDALKRASAKSITVVAPFMGYS 104
Cdd:PRK07199   15 AGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRVGLVAPYLAYM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 105 RQDKKHQGREPITARLMFDLFrTAGADRIMTVDLH---ASQEQGFFNGPVDHLTAMPVLLDYVRNSMPmeNATVVSPDAG 181
Cdd:PRK07199   94 RQDIAFHPGEAISQRHFARLL-SGSFDRLVTVDPHlhrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVP--RPLLIGPDEE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 182 rikvSEQW---AAKLGGLPLAFIHKTR------DITRPNhavahgiIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGA 252
Cdd:PRK07199  171 ----SEQWvaaVAERAGAPHAVLRKTRhgdrdvEISLPD-------AAPWAGRTPVLVDDIVSTGRTLIEAARQLRAAGA 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835901665 253 KSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVPQSKrlpnmtvLSVAPLLAAGIRSVFE 315
Cdd:PRK07199  240 ASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSNA-------ISLAPLLAEALRREFD 295
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 5-263 2.58e-33

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 126.61  E-value: 2.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665   5 LEGKPDKRLAVVTGRAYPQLAQETAEYLG---THLLETTAYDFANGEMYIRFTEPVRGADVFVIQ--------------- 66
Cdd:PRK06827   20 LADKVDEHLVRIRERKENENIESLAFKGYsreSYLIPAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtynmfgek 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  67 SHTEPiNKWLMEQLIMVDALkRASAKSITVVAPFMGYSRQDKKHqGREPITARLMFDLFRTAGADRIMTVDLHASQEQ-- 144
Cdd:PRK06827  100 NHMSP-DDHFQDLKRTIDAI-RGKARRITVIMPFLYESRQHKRK-GRESLDCALALQELEELGVDNIITFDAHDPRIEna 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 145 ----GFFNGPVDHLTAMPVLLDYVRNSMPMENATVVSPDAGRIKVSEQWAAKLGgLPLAFIHKTRDITR----PNHAVAH 216
Cdd:PRK06827  177 iplmGFENLYPSYQIIKALLKNEKDLEIDKDHLMVISPDTGAMDRAKYYASVLG-VDLGLFYKRRDYSRvvngRNPIVAH 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835901665 217 GIIGE-VEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGL 263
Cdd:PRK06827  256 EFLGRdVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGF 303
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 156-274 4.32e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 87.45  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 156 AMPVLLDYVRNSMPmENATVVSPDAGRIKVSEQWAAKLGgLPLAFIHKTRDITRPNHAVAHG----IIGEVEGRDCIVVD 231
Cdd:cd06223     1 AGRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-LPLAFIRKERKGPGRTPSEPYGlelpLGGDVKGKRVLLVD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1835901665 232 DMIDTAGTICEAVRTLRDAGAKSVTLVATHGLLSGPAIDRLKD 274
Cdd:cd06223    79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASP 121
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 218-322 1.31e-15

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 73.70  E-value: 1.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 218 IIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVATHGLLSGPAIDRLKDCGAREIVLMDTVPVP-QSKRLPN 296
Cdd:pfam14572  77 VVGDVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEiQKMQCHK 156

                          90       100
                  ....*....|....*....|....*.
gi 1835901665 297 MTVLSVAPLLAAGIRSVFESGSVTTL 322
Cdd:pfam14572 157 IKTIDISQLIAEAIRRIHNGESMSYL 182
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 23-262 8.43e-14

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 71.26  E-value: 8.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665  23 QLAQETAEYLGT-HLLETTAYDFANG--EMYIRFTEPVRGADVFVIQSHTEPinKWLMEQLIMVDALKRASAKSITVVAP 99
Cdd:PLN02297   27 ELARKIAAESDAiELGSINWRKFPDGfpNLFINNAHGIRGQHVAFLASFSSP--AVIFEQLSVIYALPKLFVASFTLVLP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 100 FM--GYS-RQDKKHQGREPIT-ARLMFDL-FRTAGADRIMTVDLHASQEQGFFNGPVDHL--TAMPVLLDYVRNSMPMEN 172
Cdd:PLN02297  105 FFptGTSeRVEREGDVATAFTlARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCfeSGIPLLKKRLQQLPDSDN 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 173 ATVVSPDAGRIKvseQWAAKLGGLPLAFIHKTRD----ITRPNHavahgiiGEVEGRDCIVVDDMIDTAGTICEAVRTLR 248
Cdd:PLN02297  185 IVIAFPDDGAWK---RFHKQFEHFPMVVCTKVREgdkrIVRIKE-------GNPAGRHVVIVDDLVQSGGTLIECQKVLA 254

                         250
                  ....*....|....
gi 1835901665 249 DAGAKSVTLVATHG 262
Cdd:PLN02297  255 AHGAAKVSAYVTHG 268
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 164-291 2.89e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 57.76  E-value: 2.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 164 VRNSMPMENATVVSPDAGRIKVSEQWAAKLGgLPLAFIHKTRDITRPN-HAVAHGIIGEVEGRDCIVVDDMIDTAGTICE 242
Cdd:pfam00156  22 INEDYGGKPDVVVGILRGGLPFAGILARRLD-VPLAFVRKVSYNPDTSeVMKTSSALPDLKGKTVLIVDDILDTGGTLLK 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1835901665 243 AVRTLRDAGAKSVTLVAthgLLSGPAIDRLKDCGAREIVLMDTVPVPQS 291
Cdd:pfam00156 101 VLELLKNVGPKEVKIAV---LIDKPAGTEPKDKYDKRVDDWIVFVVGFG 146
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 221-259 2.92e-06

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 46.94  E-value: 2.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1835901665 221 EVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVA 259
Cdd:COG0634    88 DIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIAT 126
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 220-255 5.23e-06

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 46.40  E-value: 5.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1835901665 220 GEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSV 255
Cdd:PRK02277  136 ASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPV 171
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 222-274 9.08e-06

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 45.85  E-value: 9.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1835901665 222 VEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVAthgLLSGP-AIDRLKD 274
Cdd:PRK00129  122 IDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLC---LVAAPeGIKALEE 172
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 188-279 4.72e-04

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 40.52  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 188 QWAAKLGGLPLAFIHKtrditrpnHAVAHG----IIGEV-EGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVAthg 262
Cdd:COG0461    79 AAVARALGLPAIFVRK--------EAKDHGtggqIEGGLlPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAV--- 147

                          90
                  ....*....|....*..
gi 1835901665 263 llsgpAIDRLKdcGARE 279
Cdd:COG0461   148 -----IVDREE--GAAE 157
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 222-273 4.83e-04

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 40.41  E-value: 4.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835901665 222 VEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKSVTLVAthgLLSGPAIDRLK 273
Cdd:PLN02238   95 VKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCA---LLDKRARRKVK 143
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 188-259 8.99e-04

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 39.81  E-value: 8.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 188 QWAAKLGGLPLAF--IHKTRDiTRP-------------NHAVAHGIIGEVEGRDCIVVDDMIDTAGTICEAVRTLRDAGA 252
Cdd:COG1040   105 RALARALGIPVLPdlLRRVRA-TPSqaglsraerrrnlRGAFAVRPPARLAGKHVLLVDDVLTTGATLAEAARALKAAGA 183


                  ....*..
gi 1835901665 253 KSVTLVA 259
Cdd:COG1040   184 ARVDVLV 190
PLN02440 PLN02440
amidophosphoribosyltransferase
 178-257 3.37e-03

amidophosphoribosyltransferase


Pssm-ID: 215241 [Multi-domain]  Cd Length: 479  Bit Score: 38.89  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 178 PDAGRIKvSEQWAAKLGgLPL------------AFI---HKTRD--ITRPNHAVAhgiiGEVEGRDCIVVDDMIDTAGTI 240
Cdd:PLN02440  283 PDSGRVA-ALGYAAKLG-VPFqqglirshyvgrTFIepsQKIRDfsVKLKLNPVR----SVLEGKRVVVVDDSIVRGTTS 356

                          90
                  ....*....|....*..
gi 1835901665 241 CEAVRTLRDAGAKSVTL 257
Cdd:PLN02440  357 SKIVRMLREAGAKEVHM 373
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 195-280 6.42e-03

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 37.44  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835901665 195 GLPLAFIHKTrditrpnhAVAHG----IIG-EVEGRDCIVVDDMIDTAGTICEAVRTLRDAGAKsVTLVAThgllsgpAI 269
Cdd:PRK00455   87 DLPAIFVRKE--------AKDHGeggqIEGrRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAE-VVGVAV-------IV 150

                          90
                  ....*....|.
gi 1835901665 270 DRlkDCGAREI 280
Cdd:PRK00455  151 DR--QSAAQEV 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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