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Conserved domains on  [gi|1839438786|ref|WP_169792761|]
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HAMP domain-containing sensor histidine kinase [Enterococcus canis]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-302 1.54e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 130.80  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786   3 WLWPLLAWGLVSLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQEL 82
Cdd:COG0642    14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  83 DQLKLANKQLEEQQREQTDFMELWVHQMKTPLAVLTLLAE------SDDITK--EEVLAETDRLQHGLQTALTLARLQDF 154
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEllleelDEEQREylETILRSADRLLRLINDLLDLSRLEAG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 155 AFDFLIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTILSH-ESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ- 232
Cdd:COG0642   174 KLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREg 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839438786 233 ---QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKlGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG0642   254 drvRISVEDTGPGIPPEDLERIFEPFFRTDPSRR-GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-302 1.54e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 130.80  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786   3 WLWPLLAWGLVSLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQEL 82
Cdd:COG0642    14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  83 DQLKLANKQLEEQQREQTDFMELWVHQMKTPLAVLTLLAE------SDDITK--EEVLAETDRLQHGLQTALTLARLQDF 154
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEllleelDEEQREylETILRSADRLLRLINDLLDLSRLEAG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 155 AFDFLIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTILSH-ESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ- 232
Cdd:COG0642   174 KLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREg 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839438786 233 ---QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKlGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG0642   254 drvRISVEDTGPGIPPEDLERIFEPFFRTDPSRR-GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 199-302 1.48e-32

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 116.23  E-value: 1.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 199 SDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGESTGMGLFL 274
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                          90       100
                  ....*....|....*....|....*...
gi 1839438786 275 AQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:cd16948    81 VKKLCDKLGHKIDVESEVGEGTTFTITF 108
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 213-302 4.26e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 94.25  E-value: 4.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  213 SNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGESTGMGLFLAQTIAQRLAVGITV 288
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHGGEISV 94

                           90
                   ....*....|....
gi 1839438786  289 QSKVGQGTTITLRF 302
Cdd:smart00387  95 ESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 213-302 2.56e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 81.26  E-value: 2.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQ---QIDVVDHGLGIPSSDQPRIFQRYYTGENGRklGESTGMGLFLAQTIAQRLAVGITVQ 289
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIVRKLVELLGGTITVE 92

                          90
                  ....*....|...
gi 1839438786 290 SKVGQGTTITLRF 302
Cdd:pfam02518  93 SEPGGGTTVTLTL 105
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 26-303 1.57e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 76.42  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  26 ALLGYAGLLILLLSSvYWLRRYFLERSLY-RLLAEGRGLPEARTPLGEqiLRRRQQELDQL--KLANKQLEEQqreqtdF 102
Cdd:PRK11100  189 ALLLGIALLIGAGVV-WWLNRSIRRLTRYaDAVTEGKPVPLPKLGSSE--LRELAQALESMrvKLEGKAYVEQ------Y 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 103 MELWVHQMKTPLAVLT----LLAES---DDITK--EEVLAETDRLQHGLQTALTLARLQDFAFDFLIRPLDPEALVKKAI 173
Cdd:PRK11100  260 VQTLTHELKSPLAAIRgaaeLLQEDpppEDRARftGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELV 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 174 AKQKRYFIRQGVFPKLTIlSHESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQP 249
Cdd:PRK11100  340 EAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDgeqvALSVEDQGPGIPDYALP 418

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1839438786 250 RIFQRYYT---GENGRKlgeSTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRFQ 303
Cdd:PRK11100  419 RIFERFYSlprPANGRK---STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-302 1.54e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 130.80  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786   3 WLWPLLAWGLVSLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQEL 82
Cdd:COG0642    14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  83 DQLKLANKQLEEQQREQTDFMELWVHQMKTPLAVLTLLAE------SDDITK--EEVLAETDRLQHGLQTALTLARLQDF 154
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEllleelDEEQREylETILRSADRLLRLINDLLDLSRLEAG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 155 AFDFLIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTILSH-ESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ- 232
Cdd:COG0642   174 KLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREg 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839438786 233 ---QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKlGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG0642   254 drvRISVEDTGPGIPPEDLERIFEPFFRTDPSRR-GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
84-302 3.17e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 127.33  E-value: 3.17e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  84 QLKLANKQLEEQQREQTDFMELWVHQMKTPLAV----LTLLAESDDITKEE-------VLAETDRLQHGLQTALTLARLQ 152
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSilgaAELLLDEEDLSPEErrelleiIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 153 DFAFDFLIRPLDPEALVKKAIAKQKRYFIRQGVfpKLTILSHESLLS---DEKWLLLLLDQLLSNAIKYSSAGQQVELIL 229
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGI--RLELDLPPELPLvyaDPELLEQVLANLLDNAIKYSPPGGTITISA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839438786 230 KPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGeSTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG2205   159 RREgdgvRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 199-302 1.48e-32

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 116.23  E-value: 1.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 199 SDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGESTGMGLFL 274
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                          90       100
                  ....*....|....*....|....*...
gi 1839438786 275 AQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:cd16948    81 VKKLCDKLGHKIDVESEVGEGTTFTITF 108
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
4-302 6.33e-29

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 114.26  E-value: 6.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786   4 LWPLLAWGLVSLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQELD 83
Cdd:COG5002    70 LLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  84 QLKLANKQLEEQQREQTDFMELWVHQMKTPLAVLT----LLAESDDITKEE-------VLAETDRLQHGLQTALTLARLQ 152
Cdd:COG5002   150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRgyleLLLDGAADDPEErreyleiILEEAERLSRLVNDLLDLSRLE 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 153 DFAFDFLIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTILSHESLLS-DEKWLLLLLDQLLSNAIKYSSAGQQVELILKP 231
Cdd:COG5002   230 SGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLgDPDRLEQVLTNLLDNAIKYTPEGGTITVSLRE 309

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839438786 232 Q----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGES-TGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG5002   310 EddqvRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 213-302 4.26e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 94.25  E-value: 4.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  213 SNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGESTGMGLFLAQTIAQRLAVGITV 288
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHGGEISV 94

                           90
                   ....*....|....
gi 1839438786  289 QSKVGQGTTITLRF 302
Cdd:smart00387  95 ESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 213-302 2.56e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 81.26  E-value: 2.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQ---QIDVVDHGLGIPSSDQPRIFQRYYTGENGRklGESTGMGLFLAQTIAQRLAVGITVQ 289
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIVRKLVELLGGTITVE 92

                          90
                  ....*....|...
gi 1839438786 290 SKVGQGTTITLRF 302
Cdd:pfam02518  93 SEPGGGTTVTLTL 105
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 26-303 1.57e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 76.42  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  26 ALLGYAGLLILLLSSvYWLRRYFLERSLY-RLLAEGRGLPEARTPLGEqiLRRRQQELDQL--KLANKQLEEQqreqtdF 102
Cdd:PRK11100  189 ALLLGIALLIGAGVV-WWLNRSIRRLTRYaDAVTEGKPVPLPKLGSSE--LRELAQALESMrvKLEGKAYVEQ------Y 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 103 MELWVHQMKTPLAVLT----LLAES---DDITK--EEVLAETDRLQHGLQTALTLARLQDFAFDFLIRPLDPEALVKKAI 173
Cdd:PRK11100  260 VQTLTHELKSPLAAIRgaaeLLQEDpppEDRARftGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELV 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 174 AKQKRYFIRQGVFPKLTIlSHESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQP 249
Cdd:PRK11100  340 EAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDgeqvALSVEDQGPGIPDYALP 418

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1839438786 250 RIFQRYYT---GENGRKlgeSTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRFQ 303
Cdd:PRK11100  419 RIFERFYSlprPANGRK---STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-301 6.09e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 70.23  E-value: 6.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYYTGENGR-KLGESTGMGLFLAQTIAQRLAVGIT 287
Cdd:cd16947    30 SNAIKYGSDGKFLGMTLREDEkhvyIDIWDKGKGISETEKDHVFERLYTLEDSRnSAKQGNGLGLTITKRLAESMGGSIY 109

                          90
                  ....*....|....*.
gi 1839438786 288 VQSKVGQGT--TITLR 301
Cdd:cd16947   110 VNSKPYEKTvfTVTLK 125
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 213-303 3.57e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 64.82  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQ---QVELILKPQQ-----IDVVDHGLGIPSSDQPRIFQRYYTGENG--RKLGeSTGMGLFLAQTIAQRL 282
Cdd:cd16922    10 GNAIKFTEEGEvtlRVSLEEEEEDgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSttRKYG-GTGLGLAISKKLVELM 88

                          90       100
                  ....*....|....*....|.
gi 1839438786 283 AVGITVQSKVGQGTTITLRFQ 303
Cdd:cd16922    89 GGDISVESEPGQGSTFTFTLP 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 4-302 2.51e-12

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 66.75  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786   4 LWPLLAWGLVSLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQELD 83
Cdd:COG4191    38 LLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDIT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  84 QLKLANKQLEEQQRE--QTDFMELwV--------HQMKTPLAVLTLLAE------SDDITKEEVLAETDRLQHGLQTA-- 145
Cdd:COG4191   118 ELERAEEELRELQEQlvQSEKLAA-LgelaagiaHEINNPLAAILGNAEllrrrlEDEPDPEELREALERILEGAERAae 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 146 -----LTLARLQDFAFdfliRPLDPEALVKKAIA------KQKRYFIRQGVFPKL-TILSHES--------LLSdekwll 205
Cdd:COG4191   197 ivrslRAFSRRDEEER----EPVDLNELIDEALEllrprlKARGIEVELDLPPDLpPVLGDPGqleqvllnLLI------ 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 206 llldqllsNA-------------IKYSSAGQQVElilkpqqIDVVDHGLGIPSSDQPRIFQRYYTgenGRKLGESTGMGL 272
Cdd:COG4191   267 --------NAidameegeggritISTRREGDYVV-------ISVRDNGPGIPPEVLERIFEPFFT---TKPVGKGTGLGL 328

                         330       340       350
                  ....*....|....*....|....*....|
gi 1839438786 273 FLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG4191   329 SISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-302 1.46e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 60.50  E-value: 1.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 214 NAIKYSSAGQQVELILKPQ---QIDVVDHGLGIPSSDQPRIFQRYY--TGENgrklGESTGMGLFLAQTIAQRLAVGITV 288
Cdd:cd16940    24 NAVRYSPQGSRVEIKLSADdgaVIRVEDNGPGIDEEELEALFERFYrsDGQN----YGGSGLGLSIVKRIVELHGGQIFL 99

                          90
                  ....*....|....
gi 1839438786 289 QSKVGQGTTITLRF 302
Cdd:cd16940   100 GNAQGGGLEAWVRL 113
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 108-302 1.98e-11

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 64.21  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 108 HQMKTPLAVLTLLAES-DDITKEEVLAETDRLQHGLQTALT-LARLQDFAFDFL---------IRPLDPEALVKKAIAKQ 176
Cdd:COG5000   210 HEIKNPLTPIQLSAERlRRKLADKLEEDREDLERALDTIIRqVDRLKRIVDEFLdfarlpepqLEPVDLNELLREVLALY 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 177 KRYFIRQGVfpKLTILSHESLLS---DE-----------KwllllldqllsNAIKYSSAGQQVELILKPQ----QIDVVD 238
Cdd:COG5000   290 EPALKEKDI--RLELDLDPDLPEvlaDRdqleqvlinllK-----------NAIEAIEEGGEIEVSTRREdgrvRIEVSD 356

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839438786 239 HGLGIPSSDQPRIFQRYYTG-ENGrklgesTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG5000   357 NGPGIPEEVLERIFEPFFTTkPKG------TGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
233-302 2.51e-11

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 63.71  E-value: 2.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 233 QIDVVDHGLGIPSSDQPRIFQRYYTG-ENGrklgesTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG3852   288 RIEVIDNGPGIPEEILDRIFEPFFTTkEKG------TGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 14-302 2.66e-11

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 64.04  E-value: 2.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  14 SLIVWLDGYQQVALLGYAGLLILLLSSVYWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQELDQLKLANKQLE 93
Cdd:COG4251   197 LLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELE 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  94 EQQREQTDFMELWVHQMKTPL----AVLTLLAES-DDITKEEVLAETDRLQHGLQTA-------LTLARLQDFAFDFliR 161
Cdd:COG4251   277 RSNEELEQFAYVASHDLREPLrkisGFSQLLEEDyGDKLDEEGREYLERIRDAAERMqaliddlLAYSRVGRQELEF--E 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 162 PLDPEALVKKAIA------KQKRYFIRQGVFPKLT--------ILSHesLLSdekwllllldqllsNAIKYSSAGQ--QV 225
Cdd:COG4251   355 PVDLNELLEEVLEdlepriEERGAEIEVGPLPTVRgdptllrqVFQN--LIS--------------NAIKYSRPGEppRI 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 226 ELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGeNGRKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLR 301
Cdd:COG4251   419 EIGAEREggewVFSVRDNGIGIDPEYAEKIFEIFQRL-HSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFT 497


                  .
gi 1839438786 302 F 302
Cdd:COG4251   498 L 498
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-300 5.72e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 55.51  E-value: 5.72e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839438786 232 QQIDVVDHGLGIPSSDQPRIFQRYYTGengRKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITL 300
Cdd:cd16943    36 VLIEVEDTGSGIDPEILGRIFDPFFTT---KPVGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTI 101
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-299 2.38e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 53.87  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQ--QVELILKP----QQIDVVDHGLGIPSSDQPR---IFQRYYtgenGRKLGESTGMGLFLAQTIAQRLA 283
Cdd:cd16921    10 GNAIKFRRPRRppRIEVGAEDvgeeWTFYVRDNGIGIDPEYAEKvfgIFQRLH----SREEYEGTGVGLAIVRKIIERHG 85

                          90
                  ....*....|....*.
gi 1839438786 284 VGITVQSKVGQGTTIT 299
Cdd:cd16921    86 GRIWLESEPGEGTTFY 101
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 75-302 4.45e-09

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 56.78  E-value: 4.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  75 LRRRQQELDQLKlankQLEEQQREQTdfmelwvHQMKTPLAVLTLLAESDDItkEEVLAETDRLQHGLQTALT--LARLQ 152
Cdd:COG3290   176 LERLEEELEGVK----ELAEALRAQR-------HDFRNHLHTISGLLQLGEY--DEALEYIDEISEELQELIDslLSRIG 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 153 DFAFDFLIrpldpeaLVKKAIAKQKR---YFIRQGVFPKLTILSHE--SLLS---DekwllllldqllsNAIKYSSAGQ- 223
Cdd:COG3290   243 NPVLAALL-------LGKAARARERGidlTIDIDSDLPDLPLSDTDlvTILGnllD-------------NAIEAVEKLPe 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 224 ---QVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYYTGengrKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGT 296
Cdd:COG3290   303 eerRVELSIRDDGdelvIEVEDSGPGIPEELLEKIFERGFST----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGT 378


                  ....*.
gi 1839438786 297 TITLRF 302
Cdd:COG3290   379 VFTVRL 384
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 233-302 9.00e-09

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 56.14  E-value: 9.00e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 233 QIDVVDHGLGIPSSDQPRIFQRYY-TGENGrklgesTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:COG5809   414 VISVTDEGCGIPEERLKKLGEPFYtTKEKG------TGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 213-300 2.49e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 54.95  E-value: 2.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYY--TGENGRKLGESTGMGLFLAQTIAQRLAVGI 286
Cdd:PRK11091  408 SNAVKFTQQGGVTVRVRYEEGdmltFEVEDSGIGIPEDELDKIFAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGGDI 487

                          90
                  ....*....|....
gi 1839438786 287 TVQSKVGQGTTITL 300
Cdd:PRK11091  488 TVTSEEGKGSCFTL 501
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-302 4.24e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 47.58  E-value: 4.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVEL----ILKPQQIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGES-TGMGLFLAQTIAQRLAVGIT 287
Cdd:cd16952    10 SNAVKYTPPSDTITVrwsqEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVMSRHDARLL 89

                          90
                  ....*....|....*
gi 1839438786 288 VQSKVGQGTTITLRF 302
Cdd:cd16952    90 IASELGKGSRFTCLF 104
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-293 8.13e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 46.68  E-value: 8.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 214 NAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYT---GENGRKlgeSTGMGLFLAQTIAQRLAVGI 286
Cdd:cd16945    15 NAIDFSPEGGLIALQLEADtegiELLVFDEGSGIPDYALNRVFERFYSlprPHSGQK---STGLGLAFVQEVAQLHGGRI 91


                  ....*..
gi 1839438786 287 TVQSKVG 293
Cdd:cd16945    92 TLRNRPD 98
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-281 1.01e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 46.55  E-value: 1.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839438786 214 NAIKYS------SAGQQVELIlkpqQIDVVDHGLGIPSSDQPRIFQRYY-TGENGRKLGESTGMGLFLAQTIAQR 281
Cdd:cd16949    11 NALRYSpskillDISQDGDQW----TITITDDGPGVPEDQLEQIFLPFYrVDSARDRESGGTGLGLAIAERAIEQ 81
PRK15347 PRK15347
two component system sensor kinase;
21-300 1.34e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 49.64  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  21 GYQQVALLGYAGL------------------LILLLSSVYWLRRYFLERSLYRLLA--EGRGLPEARTPLGEQilrrRQQ 80
Cdd:PRK15347  275 GWQQVTLYPRRNLanealkpalqqlpfalliLVLLTSVLFLLLRRYLAKPLWRFVDiiNKTGPAALEPRLPEN----RLD 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  81 ELDQLKLANKQLEEQQREQTDFMELWV-----------------------------HQMKTPL----AVLTLLAESDDIT 127
Cdd:PRK15347  351 ELGSIAKAYNQLLDTLNEQYDTLENKVaertqalaeakqraeqankrksehlttisHEIRTPLngvlGALELLQNTPLTA 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 128 KEEVLAETdrlqhGLQTALTLARLQDFAFDF----------------LIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTi 191
Cdd:PRK15347  431 EQMDLADT-----ARQCTLSLLAIINNLLDFsriesgqmtlsleetaLLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVP- 504

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 192 lshESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELILKPQQ---IDVVDHGLGIPSSDQPRIFQRYY-TGENGrklgES 267
Cdd:PRK15347  505 ---LYLHLDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQqlcFTVEDTGCGIDIQQQQQIFTPFYqADTHS----QG 577

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1839438786 268 TGMGLFLAQTIAQRLAVGITVQSKVGQGTTITL 300
Cdd:PRK15347  578 TGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-301 1.39e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.13  E-value: 1.39e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYT--GENGRklgestGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLR 301
Cdd:cd16915    39 IEVRDTGPGIAPELRDKVFERGVStkGQGER------GIGLALVRQSVERLGGSITVESEPGGGTTFSIR 102
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
215-303 1.58e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 49.20  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 215 AIKYSSAGQQVelilkpqqIDVVDHGLGIPSSDQPRIFQRYYTgenGRKLGesTGMGLFLAQTIAQRLAVGITVQSKVGQ 294
Cdd:PRK11360  525 RTWQYSDGQVA--------VSIEDNGCGIDPELLKKIFDPFFT---TKAKG--TGLGLALSQRIINAHGGDIEVESEPGV 591


                  ....*....
gi 1839438786 295 GTTITLRFQ 303
Cdd:PRK11360  592 GTTFTLYLP 600
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 234-302 3.00e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 45.45  E-value: 3.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYTGengRKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:cd16919    50 LEVSDTGSGMPAEVLRRAFEPFFTT---KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-302 3.10e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 45.15  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 214 NAIKYSSAGQ--QVELILKPQ--QIDVVDHGLGIPSSDQPRIFQRYYTGENGR-KLGESTGMGLFLAQTIAQRLAVGITV 288
Cdd:cd16946    15 NSLRYTDTGGklRIRAAQTPQevRLDVEDSAPGVSDDQLARLFERFYRVESSRnRASGGSGLGLAICHNIALAHGGTISA 94

                          90
                  ....*....|....*
gi 1839438786 289 Q-SKVGqGTTITLRF 302
Cdd:cd16946    95 EhSPLG-GLRLVLTL 108
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-302 4.62e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 44.76  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGESTGMGLFLAQTIAQRLAVGITV 288
Cdd:cd16975    14 SNACQYAPEGGTVSISIYDEEeylyFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKHGGSLII 93

                          90
                  ....*....|....
gi 1839438786 289 QSKVGQGTTITLRF 302
Cdd:cd16975    94 ENSQKGGAEVTVKI 107
PRK10337 PRK10337
sensor protein QseC; Provisional
 33-283 4.78e-06

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 47.72  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  33 LLILLLssvyWLRRYFLeRSLYRLLAEGRGL-PEARTPLGEQilrRRQQELDQLKLANKQL-----EEQQREQTdFMELW 106
Cdd:PRK10337  174 MLIILM----VLLGREL-APLKKLALALRMRdPDSETPLNAT---GVPSEVRPLVEALNQLfarthAMMVRERR-FTSDA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 107 VHQMKTPLAVLTL------LAESDDITKEEVLAE----TDRLQHGLQTALTLARLQDFAFDFLIRPLDPEALVKKAIAKQ 176
Cdd:PRK10337  245 AHELRSPLAALKVqtevaqLSDDDPQARKKALLQlhagIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDI 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 177 KRYFIRQGVFPKLTILSHES-------LLSdekwllLLLDQLLSNAIKYSSAGQQVELILKPQQIDVVDHGLGIPSSDQP 249
Cdd:PRK10337  325 YHTAQQAGIDVRLTLNAHPVirtgqplLLS------LLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALA 398

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1839438786 250 RIFQRYYtgengRKLG-ESTGMGLFLaqTIAQRLA 283
Cdd:PRK10337  399 RIGERFY-----RPPGqEATGSGLGL--SIVRRIA 426
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-295 8.11e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 43.98  E-value: 8.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 214 NAIKYSSAGQQVELILKPQQ--IDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGeSTGMGLFLAQTIAQRLAVGITVQSK 291
Cdd:cd16950    11 NALRYGGGWVEVSSDGEGNRtrIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS-GTGLGLAIVQRISDAHGGSLTLANR 89


                  ....
gi 1839438786 292 VGQG 295
Cdd:cd16950    90 AGGG 93
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 213-303 9.96e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 47.15  E-value: 9.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKY-------------SSAGQQVELilkpqQIDVVDHGLGIPSSDQPRIFQ----------RYYTGengrklgesTG 269
Cdd:PRK11107  418 GNAIKFtesgnidilvelrALSNTKVQL-----EVQIRDTGIGISERQQSQLFQafrqadasisRRHGG---------TG 483

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1839438786 270 MGLFLAQTIAQRLAVGITVQSKVGQGTT--ITLRFQ 303
Cdd:PRK11107  484 LGLVITQKLVNEMGGDISFHSQPNRGSTfwFHLPLD 519
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
233-297 1.00e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 46.98  E-value: 1.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839438786 233 QIDVVDHGLGIPSSDQPRIFQRYYTGENGrklgeSTGMGLFLAQTIAQRLAVGITVQSKVGQGTT 297
Cdd:PRK13837  609 LLRVSDTGAGIDEAVLPHIFEPFFTTRAG-----GTGLGLATVHGIVSAHAGYIDVQSTVGRGTR 668
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-279 1.08e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 43.54  E-value: 1.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1839438786 231 PQQIDVVDHGLGIPSSDQPRIFQRYYTG-ENGrklgesTGMGLFLAQTIA 279
Cdd:cd16918    43 ALRVSVIDNGPGIPPDLQDTIFYPMVSGrENG------TGLGLAIAQNIV 86
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 234-301 1.09e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 46.83  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQR-YYTGENGRklgestGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLR 301
Cdd:PRK11086  470 CEVSDDGPGIAPDEIDAIFDKgYSTKGSNR------GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQ 532
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
234-300 1.27e-05

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 46.32  E-value: 1.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYTGENgrklgESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITL 300
Cdd:PRK10364  383 ISVTDSGKGIAADQLEAIFTPYFTTKA-----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 234-303 1.40e-05

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 46.26  E-value: 1.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYT-GENGrklgesTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRFQ 303
Cdd:COG5805   430 IRVIDEGIGIPEERLKKLGEPFFTtKEKG------TGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
213-303 2.19e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 43.36  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQ-----QVELILKPQQ--IDVVDHGLGIPSSDQPRifqryytGENGRKLGestGMGLFLAQTIAQRLavg 285
Cdd:COG2172    44 TNAVRHAYGGDpdgpvEVELELDPDGleIEVRDEGPGFDPEDLPD-------PYSTLAEG---GRGLFLIRRLMDEV--- 110

                          90
                  ....*....|....*...
gi 1839438786 286 iTVQSKVGqGTTITLRFQ 303
Cdd:COG2172   111 -EYESDPG-GTTVRLVKR 126
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 213-301 6.64e-05

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 41.32  E-value: 6.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQQVELILKPQ-----QIDVVDHGLGIPSSDQPRIFQRYYTG--ENGRKLGeSTGMGLFLAQTIAQRLAVG 285
Cdd:cd16925    14 SNAFKFTPDGGRIRCILEKFrlnrfLLTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHG-GTGLGLSIVKEFVELHGGT 92

                          90
                  ....*....|....*.
gi 1839438786 286 ITVQSKVGQGTTITLR 301
Cdd:cd16925    93 VTVSDAPGGGALFQVE 108
PRK09303 PRK09303
histidine kinase;
42-295 1.09e-04

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 43.40  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  42 YWLRRYFLERSLYRLLAEGRGLPEARTPLGEQILRRRQQELDQLKLANKQLEEQQREQTDFMELWVHQMKTPL-----AV 116
Cdd:PRK09303   94 NWWPRWQQEGATYSGLGENLQPSEIDSGRYSQELLQLSDELFVLRQENETLLEQLKFKDRVLAMLAHDLRTPLtaaslAL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 117 LTLLAESDDITKEEVLAETDRLQHGLQTA-----------LTLARLQDFAFDFLIRPLDPEALVKKAIAK-QKRYFIRQg 184
Cdd:PRK09303  174 ETLELGQIDEDTELKPALIEQLQDQARRQleeierlitdlLEVGRTRWEALRFNPQKLDLGSLCQEVILElEKRWLAKS- 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 185 vfpkLTILSH-----ESLLSDEKWLLLLLDQLLSNAIKYSSAGQQVELIL-----KPQQIDVVDHGLGIPSSDQPRIFQ- 253
Cdd:PRK09303  253 ----LEIQTDipsdlPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMlhrttQKVQVSICDTGPGIPEEEQERIFEd 328

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1839438786 254 RYYTGENGRKlgESTGMGLFLAQTIAQRLAVGITVQSKVGQG 295
Cdd:PRK09303  329 RVRLPRDEGT--EGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
213-300 1.63e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 43.18  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  213 SNAIKYSSAGQqVELILKPQQID---------VVDHGLGIPSSDQPRIFQRYYTGENGRKlGESTGMGLFLAQTIAQRLA 283
Cdd:PRK09959   838 SNALKFTTEGA-VKITTSLGHIDdnhavikmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQ-QTGSGLGLMICKELIKNMQ 915

                           90
                   ....*....|....*..
gi 1839438786  284 VGITVQSKVGQGTTITL 300
Cdd:PRK09959   916 GDLSLESHPGIGTTFTI 932
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 213-302 1.69e-04

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 40.43  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 213 SNAIKYSSAGQ-QVELILKPQQ----IDVVDHGLGIPSSDQprifqryytgenGRKLGESTGMGLFLAQTIAQRLAVGIT 287
Cdd:cd16934    35 RNLLKHAGGGQvLLEVVAEGGRvaleILAVDQGPGIADVDE------------ALRDGFSTGGGLGLGLGGVRRLADEFD 102

                          90
                  ....*....|....*
gi 1839438786 288 VQSKVGQGTTITLRF 302
Cdd:cd16934   103 LHSAPGRGTVVVARK 117
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
213-278 1.95e-04

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 42.84  E-value: 1.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 213 SNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGR-KLGESTGMGLFLAQTI 278
Cdd:PRK09835  385 SNALRYTPAGEAITVRCQEVdhqvQLVVENPGTPIAPEHLPRLFDRFYRVDPSRqRKGEGSGIGLAIVKSI 455
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-299 2.02e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.07  E-value: 2.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839438786 233 QIDVVDHGLGIPSSDQPRIFQRYYTGENgrklgESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTIT 299
Cdd:cd16920    39 TISVKDTGPGIAEEVAGQLFDPFYTTKS-----EGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQ 100
PRK13557 PRK13557
histidine kinase; Provisional
 234-302 3.55e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 41.97  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYT--GEngrklGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:PRK13557  327 IAVTDTGSGMPPEILARVMDPFFTtkEE-----GKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-279 3.65e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 39.29  E-value: 3.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 213 SNAIKYSSAGQQVELILKPQ----QIDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGEStGMGLFLAQTIA 279
Cdd:cd16923    10 SNAIKYSPENTRIYITSFLTddvvNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGA-GLGLSIAKAII 79
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
233-302 4.56e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 41.54  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839438786 233 QIDVVDHGLGIPSSDQPRIFQRYYTGENGRklgestGMGLflaQTIAQRL------AVGITVQSKVGQGTTITLRF 302
Cdd:COG2972   374 VITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGL---RNVRERLklyygeEYGLEIESEPGEGTTVTIRI 440
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 234-301 8.73e-04

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 38.67  E-value: 8.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1839438786 234 IDVVDHGLGIPSSDQPRifQRYYTGengRKLGESTGMGLflaqTIAQRLAVGITVQSKVGQGTTITLR 301
Cdd:cd16942    76 LTVRDEGVGIPDIEEAR--QPLFTT---KPELERSGMGF----TIMENFMDEVIVESEVNKGTTVYLK 134
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-302 1.70e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 37.55  E-value: 1.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 234 IDVVDHGLGIPSSDQPRIFQRYYTGE-NGRKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITLRF 302
Cdd:cd16953    36 ISVEDEGPGIPQEKLESIFDRFYTERpANEAFGQHSGLGLSISRQIIEAHGGISVAENHNQPGQVIGARF 105
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 236-300 3.02e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 36.67  E-value: 3.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839438786 236 VVDHGLGIPSSDQPRIFQRYYTgenGRKLGESTGMGLFLAQTIAQRLAVGITVQSKVGQGTTITL 300
Cdd:cd16976    39 VRDNGPGIAEEHLSRVFDPFFT---TKPVGKGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTF 100
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
77-275 6.68e-03

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 38.08  E-value: 6.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786  77 RRQQELDQL-----KLANKqLEEQQREQTDFMELWVHQMKTPLAVL--TLLAESDDITKEevlaeTDRLQHGLQTAL-TL 148
Cdd:PRK10549  214 TSRDELGRLaqdfnQLAST-LEKNEQMRRDFMADISHELRTPLAVLrgELEAIQDGVRKF-----TPESVASLQAEVgTL 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 149 ARLQD----------FAFDFLIRPLDPEALVKKAIAKQKRYFIRQGVFPKLTILSHESLLSDEKWLLLLLDQLLSNAIKY 218
Cdd:PRK10549  288 TKLVDdlhqlslsdeGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRY 367

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839438786 219 SSAGQQVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYYTGENGRKLGeSTGMGLFLA 275
Cdd:PRK10549  368 TDSGGSLHISAEQRDktlrLTFADSAPGVSDEQLQKLFERFYRTEGSRNRA-SGGSGLGLA 427
PRK10604 PRK10604
sensor protein RstB; Provisional
 108-301 8.57e-03

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 37.66  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 108 HQMKTPLAVLTL-LAESDDITKEEVLA---ETDRLQHGLQTALTLARLQDFAFDFLIRPLDPEALVKKAIAKQKryFIRQ 183
Cdd:PRK10604  221 HELRTPLVRLRYrLEMSDNLSAAESQAlnrDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQ--AVTP 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 184 GVFPKLTILSHESLL-SDEKWLLLLLDQLLSNAIKYssAGQQVELILKPQQ----IDVVDHGLGIPSSDQPRIFQRYYTG 258
Cdd:PRK10604  299 EKTVRLDTPHQGDYGaLDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGnqacLIVEDDGPGIPPEERERVFEPFVRL 376

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1839438786 259 ENGRklGEST---GMGLFLAQTIAQRLAVGITVQSKVGQGTTITLR 301
Cdd:PRK10604  377 DPSR--DRATggcGLGLAIVHSIALAMGGSVNCDESELGGARFSFS 420
PRK10490 PRK10490
sensor protein KdpD; Provisional
 214-275 8.76e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 37.71  E-value: 8.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839438786 214 NAIKYssAGQQVELILKPQ------QIDVVDHGLGIPSSDQPRIFQRYYTGENgrklgEST--GMGLFLA 275
Cdd:PRK10490  789 NAVKY--AGAQAEIGIDAHvegerlQLDVWDNGPGIPPGQEQLIFDKFARGNK-----ESAipGVGLGLA 851
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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