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Conserved domains on  [gi|1839789386|ref|WP_169851778|]
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MULTISPECIES: MDR family MFS transporter [Pseudomonas]

Protein Classification

MDR family MFS transporter( domain architecture ID 13025406)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  27052334|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-484 7.28e-108

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 325.68  E-value: 7.28e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 164 LLMIAGLlyglekkaahwellkstdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpn 243
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 244 PLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLC 323
Cdd:cd17503   168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 324 AVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIALLA 403
Cdd:cd17503   248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 404 TLLDARTKTYFDYLREAIVPTNpqvaermatltqtfgnetaalaklseiaHQQAQIMAYNDAFHFVGLALAVSMLAIFLT 483
Cdd:cd17503   328 TLLTNRTQFHHSRLSELLAQQV----------------------------QKQALIIAFNDAFLVSAILLLVGLLLALFL 379


                  .
gi 1839789386 484 K 484
Cdd:cd17503   380 R 380
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-484 7.28e-108

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 325.68  E-value: 7.28e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 164 LLMIAGLlyglekkaahwellkstdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpn 243
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 244 PLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLC 323
Cdd:cd17503   168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 324 AVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIALLA 403
Cdd:cd17503   248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 404 TLLDARTKTYFDYLREAIVPTNpqvaermatltqtfgnetaalaklseiaHQQAQIMAYNDAFHFVGLALAVSMLAIFLT 483
Cdd:cd17503   328 TLLTNRTQFHHSRLSELLAQQV----------------------------QKQALIIAFNDAFLVSAILLLVGLLLALFL 379


                  .
gi 1839789386 484 K 484
Cdd:cd17503   380 R 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 3-483 5.64e-106

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 324.72  E-value: 5.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   3 SVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCS 82
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  83 MAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GL--LMIAGLLYGLEKKAAHwellKSTDYMGILTLAVGLGCLQVFLEEGHRKDWLESSLIVSLGSIALLSLITFVIVQLS 240
Cdd:TIGR00711 166 GIivVVVAFFILPRDKPAAS----ENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 241 KPNPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPK 320
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 321 WLCAVGFGLFGFASFS-SGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGI 399
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWrAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 400 ALLATLLDARTKTYFDYLREAIVPTNPQVAERMATLTQTFGNETAALAKLSEIAHQQAQIMAYNDAFHFVGLALAVSMLA 479
Cdd:TIGR00711 402 ALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLIL 481


                  ....
gi 1839789386 480 IFLT 483
Cdd:TIGR00711 482 IWFL 485
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-397 6.08e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 119.69  E-value: 6.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   1 MMSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLM 80
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  81 CSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINV 160
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 161 PPGLLMIAGLLYGLEKkaahwellkstdymgiltlavglgclqvflEEGHRKDWLESSLivslgsiallslitfvivqls 240
Cdd:COG2814   172 VLALLALLLLLRLLPE------------------------------SRPAARARLRGSL--------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 241 kpnplinLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPK 320
Cdd:COG2814   201 -------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839789386 321 WLCAVGFGLFGFASFssgVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAI 397
Cdd:COG2814   274 RLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
4-398 9.65e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.11  E-value: 9.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLK-DIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCS 82
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  83 MAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GLLMIAGLLYGLEKKAAHWELLKSTDYMGILTLavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskp 242
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 243 nplinLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYlAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWL 322
Cdd:pfam07690 194 -----WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839789386 323 CAVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIG 398
Cdd:pfam07690 268 LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK10504 PRK10504
putative transporter; Provisional
 4-281 8.93e-19

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 88.64  E-value: 8.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:PRK10504   15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAfTLTLIKL-PEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:PRK10504   95 SGTLNELLLARVLQGVGGAMMVPVG-RLTVMKIvPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GllmIAGLLYGLEKKAAHWELLKSTDYMGILTLAVGLGCLQVFLeEGHRKDWLESSLIVSLGSIALLSLITFVIVQLSKP 242
Cdd:PRK10504  174 G---IIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNN 249

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1839789386 243 NPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYL 281
Cdd:PRK10504  250 RALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFL 288
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-484 7.28e-108

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 325.68  E-value: 7.28e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 164 LLMIAGLlyglekkaahwellkstdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpn 243
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 244 PLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLC 323
Cdd:cd17503   168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 324 AVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIALLA 403
Cdd:cd17503   248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 404 TLLDARTKTYFDYLREAIVPTNpqvaermatltqtfgnetaalaklseiaHQQAQIMAYNDAFHFVGLALAVSMLAIFLT 483
Cdd:cd17503   328 TLLTNRTQFHHSRLSELLAQQV----------------------------QKQALIIAFNDAFLVSAILLLVGLLLALFL 379


                  .
gi 1839789386 484 K 484
Cdd:cd17503   380 R 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 3-483 5.64e-106

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 324.72  E-value: 5.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   3 SVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCS 82
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  83 MAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GL--LMIAGLLYGLEKKAAHwellKSTDYMGILTLAVGLGCLQVFLEEGHRKDWLESSLIVSLGSIALLSLITFVIVQLS 240
Cdd:TIGR00711 166 GIivVVVAFFILPRDKPAAS----ENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 241 KPNPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPK 320
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 321 WLCAVGFGLFGFASFS-SGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGI 399
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWrAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 400 ALLATLLDARTKTYFDYLREAIVPTNPQVAERMATLTQTFGNETAALAKLSEIAHQQAQIMAYNDAFHFVGLALAVSMLA 479
Cdd:TIGR00711 402 ALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLIL 481


                  ....
gi 1839789386 480 IFLT 483
Cdd:TIGR00711 482 IWFL 485
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 4-429 2.73e-44

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 159.65  E-value: 2.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 164 Llmiagllyglekkaahwellkstdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpn 243
Cdd:cd17321   161 L------------------------------------------------------------------------------- 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 244 plinLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLC 323
Cdd:cd17321   162 ----VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 324 AVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIALLA 403
Cdd:cd17321   238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317

                         410       420
                  ....*....|....*....|....*.
gi 1839789386 404 TLLDARTKTYFDYLREAIVPTNPQVA 429
Cdd:cd17321   318 ALLTAGLSANLGDSGVAALLSAAAAA 343
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 4-401 3.63e-30

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 120.36  E-value: 3.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSAtLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17502     1 LMLALFLAALDQTIVATALPTIVAEFGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17502    80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 164 LLMIAGLlyglekkaahwellkstdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpn 243
Cdd:cd17502   160 GLALALL------------------------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 244 plinlgilanRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLM-KYVSPKWL 322
Cdd:cd17502   167 ----------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIsKTGRYKPL 236

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839789386 323 CAVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIAL 401
Cdd:cd17502   237 IVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-397 6.08e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 119.69  E-value: 6.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   1 MMSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLM 80
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  81 CSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINV 160
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 161 PPGLLMIAGLLYGLEKkaahwellkstdymgiltlavglgclqvflEEGHRKDWLESSLivslgsiallslitfvivqls 240
Cdd:COG2814   172 VLALLALLLLLRLLPE------------------------------SRPAARARLRGSL--------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 241 kpnplinLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPK 320
Cdd:COG2814   201 -------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839789386 321 WLCAVGFGLFGFASFssgVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAI 397
Cdd:COG2814   274 RLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 21-408 1.41e-27

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 113.44  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  21 SLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFt 100
Cdd:cd17504    18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 101 GGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPGLLmiagllyglekkaah 180
Cdd:cd17504    97 GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--------------- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 181 wellkstdymgiLTLAVglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskpnPLINLGILANRNFGLSS 260
Cdd:cd17504   162 ------------LAALV----------------------------------------------PLIDLRLLRRRNVLLAN 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 261 ISSLGMGVGLYGSIYLLPLYLAQIQNY----NALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCAVGFGLFGFASFS 336
Cdd:cd17504   184 ITALLAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLL 263

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1839789386 337 SGVLNPDFAgsQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIALLATLLDA 408
Cdd:cd17504   264 LALLHSSLW--ALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTT 333
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-279 7.80e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 101.43  E-value: 7.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   1 MMSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLM 80
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  81 CSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINV 160
Cdd:COG0477    96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 161 PPGLLMIAGLLYGLEKKAAHWELLKSTDYMGILTLAVGLGCLQVFLEEGHRKDWLESSLIVSLGSIALLSLITFVIVQLS 240
Cdd:COG0477   176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1839789386 241 KPNPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPL 279
Cdd:COG0477   256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_1 pfam07690
Major Facilitator Superfamily;
4-398 9.65e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.11  E-value: 9.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLK-DIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCS 82
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  83 MAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GLLMIAGLLYGLEKKAAHWELLKSTDYMGILTLavglgclqvfleeghrkdwlesslivslgsiallslitfvivqlskp 242
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 243 nplinLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYlAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWL 322
Cdd:pfam07690 194 -----WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839789386 323 CAVGFGLFGFASFSSGVLNPDFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIG 398
Cdd:pfam07690 268 LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 6-487 2.66e-22

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 100.01  E-value: 2.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATL---EEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCS 82
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLgpsSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  83 MAWSLESMIVFRALQGFTGGALIPLAFTLTLIkLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENW--GWEYIFYINV 160
Cdd:cd06179    81 TAKSVNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 161 PPGLLMIAGLL-------YGLEKKAAHWELLKSTDYMGILTLAVGLGCLQVFLEEGHRKDWLESSLIVSLGSIALLSLIT 233
Cdd:cd06179   160 IFNALALILLFffyhpppRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 234 FVIVQL--SKPNPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLF-LIPLV 310
Cdd:cd06179   240 FGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFgAILAG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 311 PKLMKYVSPKWLCAVGFGLFGFASFSSGVLNPDfAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNIL 390
Cdd:cd06179   320 LLLTKIKHIKWQLVAGFVLFTAFLALLALITPD-NKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSA 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 391 RNLGGAIGIALLATLLDARTKTYF-DYLREAIVPTNPQVAERMATLTQTFGNETAALAKLSEI------AHQQAQIMAYN 463
Cdd:cd06179   399 RALGGAVGTAIFTSILSNRLSKNLpARVAPAALEAGLPASSLPALLGALASGNIAALTAVPGInpeiiaAATAALKQAYA 478

                         490       500
                  ....*....|....*....|....*
gi 1839789386 464 DAFHFVGLA-LAVSMLAIFLTKALP 487
Cdd:cd06179   479 DSFRYVWYAaIPFGVVAIIAALFLR 503
PRK10504 PRK10504
putative transporter; Provisional
 4-281 8.93e-19

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 88.64  E-value: 8.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:PRK10504   15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAfTLTLIKL-PEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPP 162
Cdd:PRK10504   95 SGTLNELLLARVLQGVGGAMMVPVG-RLTVMKIvPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 163 GllmIAGLLYGLEKKAAHWELLKSTDYMGILTLAVGLGCLQVFLeEGHRKDWLESSLIVSLGSIALLSLITFVIVQLSKP 242
Cdd:PRK10504  174 G---IIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNN 249

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1839789386 243 NPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYL 281
Cdd:PRK10504  250 RALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFL 288
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-398 5.76e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 85.32  E-value: 5.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAW 85
Cdd:cd17325     3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  86 SLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYInvppgll 165
Cdd:cd17325    83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 166 miagllyglekkaahwellkstdyMGILTLAVGLGCLqVFLEEGHRKDWLESSLIVSLGSIALLslitfvivqlskpnpl 245
Cdd:cd17325   156 ------------------------CAALALLALVLAL-LLLPEPRPPPNKRAVSAARLRSGLRL---------------- 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 246 inlgILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCAV 325
Cdd:cd17325   195 ----LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839789386 326 GFGLFGFASFSSGvLNPDFAGSQFnqIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIG 398
Cdd:cd17325   271 GLLLSAVALLLLP-LATSFWLLLL--LLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-168 2.62e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 80.30  E-value: 2.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:COG2271    15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:COG2271    95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174


                  ....*
gi 1839789386 164 LLMIA 168
Cdd:COG2271   175 LLLAL 179
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 8-172 2.92e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 77.23  E-value: 2.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   8 AFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSL 87
Cdd:cd17474     8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  88 ESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTEnWGWEYIFYInvpPGLLMI 167
Cdd:cd17474    88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFL---LAALIP 163


                  ....*
gi 1839789386 168 AGLLY 172
Cdd:cd17474   164 VAFLA 168
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-180 1.47e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.89  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   1 MMSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLM 80
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  81 CSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINV 160
Cdd:cd17324    81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180
                  ....*....|....*....|
gi 1839789386 161 PPGLLMIAGLLYGLEKKAAH 180
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPK 180
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-407 1.07e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 69.53  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   1 MMSVMLGAFMAvLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLM 80
Cdd:cd17320     2 LLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  81 CSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYInv 160
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 161 ppgllmiagllyglekkaahwellkstdyMGILTLAVGLGCLqVFLEEGHRKDWLESSLIVSLGSIALLslitfvivqls 240
Cdd:cd17320   159 -----------------------------LALLGLLLLLLVL-LFLPETLPEEKRKPLLSSLLRAYKRV----------- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 241 kpnplinlgiLANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGeviMWMGVPQLFLIP---LVPKLMKYV 317
Cdd:cd17320   198 ----------LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG---LLFALNAIALILgslLNGRLVRRF 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 318 SPKWLCAVGFGLFGFASFSSGVLNPDFAGSQFNQI--QIIRALGQPLIMVTISLIATAyILPQDAGSASSLFNILRNLGG 395
Cdd:cd17320   265 GPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVapLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIG 343

                         410
                  ....*....|..
gi 1839789386 396 AIGIALLATLLD 407
Cdd:cd17320   344 ALAGALVGLLPN 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 4-417 1.21e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.38  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTEN--WGWEYIFYINVP 161
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 162 PGLLMIAGLLYGLEKKaaHWELLKSTdymgiltlavglgclqvfleeghrkdwlesslivslgsiallslitfvIVQLSK 241
Cdd:cd06174   161 LALLAAILLLLVVPDP--PESARAKN------------------------------------------------EEASSK 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 242 PNPLINLGILANRNFGLSSISSLGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSP-K 320
Cdd:cd06174   191 SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrK 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 321 WLCAVGFGLFGFASFSSGVLnpdFAGSQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIA 400
Cdd:cd06174   271 PLLLIGLLLMALGLALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347

                         410
                  ....*....|....*..
gi 1839789386 401 LLATLLDARTKTYFDYL 417
Cdd:cd06174   348 LAGFLLAATFGLTGAFL 364
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 4-166 3.67e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 67.60  E-value: 3.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17319     8 LFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPG 163
Cdd:cd17319    88 ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG 167


                  ...
gi 1839789386 164 LLM 166
Cdd:cd17319   168 LLL 170
2_A_01_02 TIGR00880
Multidrug resistance protein;
41-159 1.25e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 62.28  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  41 TSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHH 120
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1839789386 121 RAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYIN 159
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFL 123
PRK14995 PRK14995
SmvA family efflux MFS transporter;
28-487 7.81e-11

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 63.98  E-value: 7.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  28 ALSATLEEGSWISTSY-LVAEIIMIPLTAwLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIP 106
Cdd:PRK14995   35 TLGASGNELLWIIDIYsLVMAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 107 LafTLTLIK---LPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPGLLMIAGLLYGLEKKAAHWEL 183
Cdd:PRK14995  114 A--TLAGIRatfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQ 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 184 LKSTDYMGILTLAVglgCLQVFLEEGHRKDWLESSLIVSLGSIALLSLITFVIVQLSKPNPLINLGILANRNFGLSSISS 263
Cdd:PRK14995  192 PLNLGHALMLIVAI---LLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 264 LGMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCAVGFGLFGFASFssGVLNPD 343
Cdd:PRK14995  269 MTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFY--GLAMTD 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 344 FAGSQFNQIQIIRALGqplIMVTISLIA-TAYIL----PQDAGSASSLFNILRNLGGAIGIALLATLLDartktyFDYLR 418
Cdd:PRK14995  347 FSTQQWQAWGLMALLG---FSAASALLAsTSAIMaaapPEKAAAAGAIETMAYELGAGLGIAIFGLLLS------RSYSA 417

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839789386 419 EAIVPT--NPQVAERMATLTqtfgNETAALAKLSEIAHQQAQIMAYNDAF---HFVGLALAVSM---LAIFLTKALP 487
Cdd:PRK14995  418 SIRLPAglPAQLIEKASSSI----GEAVQLANSLPPTLGQALLDAAKQAFiwsHSVVLSSAGSMlllLAVGVWFSLA 490
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 39-158 4.08e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.37  E-value: 4.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  39 ISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPE 118
Cdd:cd17489    36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1839789386 119 HHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYI 158
Cdd:cd17489   116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 74-160 4.73e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 57.97  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  74 FLIASLMCSMAWSLESMIVFRALQGFTGGALIPL-AFTLTLIkLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGW 152
Cdd:cd17323    74 FVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIgAGTIADL-FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152


                  ....*...
gi 1839789386 153 EYIFYINV 160
Cdd:cd17323   153 RWIFWFLA 160
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-180 5.46e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 5.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  25 IQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGAL 104
Cdd:COG2223    31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839789386 105 IPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPGLLMIAGLLYGLEKKAAH 180
Cdd:COG2223   111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAG 186
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
72-171 1.20e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 53.77  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  72 VGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWG 151
Cdd:PRK11102   64 LVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS 143

                          90       100
                  ....*....|....*....|
gi 1839789386 152 WEYIFYInvppglLMIAGLL 171
Cdd:PRK11102  144 WHAIFWV------LALAAIL 157
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 6-158 1.40e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 53.51  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAW 85
Cdd:TIGR00895  24 LIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839789386  86 SLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYI 158
Cdd:TIGR00895 104 NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
32-171 6.97e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 6.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  32 TLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARR--LAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAF 109
Cdd:COG2271   214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1839789386 110 TLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPGLLMIAGLL 171
Cdd:COG2271   294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 4-189 7.24e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 48.15  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   4 VMLG--AFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMC 81
Cdd:TIGR00710   8 LLLGclSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  82 SMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYInvp 161
Cdd:TIGR00710  88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF--- 164

                         170       180
                  ....*....|....*....|....*...
gi 1839789386 162 pglLMIAGLLYglekKAAHWELLKSTDY 189
Cdd:TIGR00710 165 ---LSLAGILL----SALIFFILPETLP 185
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 48-158 7.69e-06

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 48.00  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  48 IIMIPLtAWLVQLLSARRLAVWvsvGFLIASLMCSM-----AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRA 122
Cdd:cd17318    71 LTQIPG-GYLAEKYGAKRVLGY---SILITALLTLLtplaaRGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERS 146

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1839789386 123 KgMAMFAMT-ATFAPSIGPTIGGWLTENWGWEYIFYI 158
Cdd:cd17318   147 R-LTSIAYSgSQFGTVIAMPLSGFLCESLGWPSIFYI 182
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 37-394 2.30e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  37 SWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKL 116
Cdd:cd17473    38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 117 PEHHRAKGMAMFAMTATFAPSIGPTIGGWLTEnWGWEYIFYINVPPGLLMIAGLLYGLEKKAAhwellkstdymgiltla 196
Cdd:cd17473   118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARK----------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 197 vglgclqvflEEGHRKDWLESSLIVSLGSIALLSLITFVIVqlskpnplinlgilanrnfglssisslgmgVGLYGSIYL 276
Cdd:cd17473   180 ----------SKSAASPGAATAAALPWKRVLPIYFLAFLAM------------------------------LLFYVIPIQ 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 277 LPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCAVGFGLFGFA----SFSSGVLnPDFAGSQFNQI 352
Cdd:cd17473   220 LPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGflllALASGLW-VVLLGAILAGL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1839789386 353 qiiralGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLG 394
Cdd:cd17473   299 ------GFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 53-174 2.58e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.45  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  53 LTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTA 132
Cdd:cd06173   263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1839789386 133 TFAPSIGPTIGGWLTENWGWEYIFYINvppGLLMIAGLLYGL 174
Cdd:cd06173   343 SGAMPLGALLAGLLADALGLSAVFLLA---GALLLLAALLLL 381
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
29-179 6.67e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 6.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  29 LSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLA 108
Cdd:COG0738   241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1839789386 109 FTLTLIKLPEHHrAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVPPGLLMIAGLLYGLEKKAA 179
Cdd:COG0738   321 FSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 64-167 8.71e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 8.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  64 RRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAK----GMAMFAMTATFAPSIG 139
Cdd:cd17316    66 KKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFalglLQSGWALGALLAALVA 145

                          90       100
                  ....*....|....*....|....*...
gi 1839789386 140 PTIGGWLTENWGWEYIFYINVPPGLLMI 167
Cdd:cd17316   146 SLLIPLLSGDWGWRILFLIGALPALLAL 173
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 2-159 1.68e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.79  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   2 MSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMC 81
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  82 SMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRaKGMAM--FAMTATFAPSIGPTIGGWLTENWGWEYIFYIN 159
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPR-KNIVFslFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 64-168 1.90e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 43.73  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  64 RRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIG 143
Cdd:cd17365    64 KRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLA 143

                          90       100
                  ....*....|....*....|....*.
gi 1839789386 144 GWLTENWGWEYIFYIN-VPPGLLMIA 168
Cdd:cd17365   144 AALIPAFGWRSVFLLGgVPPLILLPL 169
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 48-171 2.05e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.72  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  48 IIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAM 127
Cdd:cd17325   249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1839789386 128 FAMTATFAPSIGPTIGGWLTENWGWEYIFYINvppGLLMIAGLL 171
Cdd:cd17325   329 FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA---AALLLLAAV 369
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-172 2.30e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  32 TLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVS-VGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFT 110
Cdd:cd06174   237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGlLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1839789386 111 LTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLT-ENWGWEYIFYINVppGLLMIAGLLY 172
Cdd:cd06174   317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLA--VLLLLAAILL 377
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 6-335 6.09e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.29  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAW 85
Cdd:cd17371     6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  86 SLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKG----MAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINVP 161
Cdd:cd17371    86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKAlgyvQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 162 PGL--LMIAGLLYGLEKKAAHWELLKSTDYmgiltlavglgclQVFLEEGHRKDWLESSLIVSLGSIALL----SLITFV 235
Cdd:cd17371   166 PALlvLFIRRFVKEPPQWQAARAARRHFAD-------------RPSLRELFSPPLLRTTLLASLLATGALggyyGITTWL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 236 IVQLSKPnplinLGILANRNFGLSSISSLGMGVGlygsiYLLPLYLA-QIQNYNALQIGEVIMWMGVPQLFLIPLVPKLM 314
Cdd:cd17371   233 PSYLTGE-----RGLSFEGSAGYLVVTILGGFLG-----YLAGGFLAdRIGRRNNFALFALGSAISILLYFFLPLSPTLI 302

                         330       340
                  ....*....|....*....|.
gi 1839789386 315 KYVSPkwlcAVGFGLFGFASF 335
Cdd:cd17371   303 LILGF----PLGFFASGPFSG 319
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 45-174 1.58e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  45 VAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLtLIKLPEHHRAKG 124
Cdd:cd17324   245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLA 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1839789386 125 MAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINvppGLLMIAGLLYGL 174
Cdd:cd17324   324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG---AALLLLALLLAL 370
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 29-174 1.95e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 40.28  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  29 LSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLavWVSVGFLIASLMCSMAWSLESMIVFRALQ---GFTGGALI 105
Cdd:cd17490   225 LGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERN--TIIIGFLLLGAYCFLIPFAPNLTLLYLLQalnGFGTGILF 302

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839789386 106 PLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYINvppGLLMIAGLLYGL 174
Cdd:cd17490   303 PLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVI---GVIALLAAILSL 368
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 29-158 2.12e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.25  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  29 LSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGAlIPLA 108
Cdd:cd17330    29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVA 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1839789386 109 FTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFYI 158
Cdd:cd17330   108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
43-157 2.75e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.00  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  43 YLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRA 122
Cdd:PRK10473   47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1839789386 123 KGMAMFAMTATFAPSIGPTIGGWLTENWGWEYIFY 157
Cdd:PRK10473  127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
71-158 3.02e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 39.90  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  71 SVGFLIASLMCSMAWSLESMIVFRALQGFTGGaLIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENW 150
Cdd:PRK09874   91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169


                  ....*...
gi 1839789386 151 GWEYIFYI 158
Cdd:PRK09874  170 GLRPVFFI 177
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
32-168 3.27e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.86  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  32 TLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFTGGALIPLAFTL 111
Cdd:COG2807   248 SAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTL 327

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1839789386 112 TLIKLPEHHR-AKGMAMFAMTATFAPSIGPTIGGWLTENWG-WEYIFYINVPPGLLMIA 168
Cdd:COG2807   328 IGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLV 386
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 71-158 3.66e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  71 SVGFLIASLMCSM-----AWSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAmfamTATFAPSIGPTIGGW 145
Cdd:cd17380    68 LLAVALWSLATLLtpllaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVS----IVTAGSYLGTLLGGL 143

                          90
                  ....*....|....*..
gi 1839789386 146 LT----ENWGWEYIFYI 158
Cdd:cd17380   144 IGplllEYYGWPSVFYF 160
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 6-205 3.80e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATL--EEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSM 83
Cdd:cd17315     4 LGGLLFGYDLGVINGALLYIAKDLGFGLstSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  84 AWSLESMIVFRALQGFTGG---ALIPLAFTLTlikLPEHHRAKGMAMFAMTATF----APSIGPTIGgwLTENWGWEYIF 156
Cdd:cd17315    84 APNVWVLIVGRFLLGLGVGlasVLVPLYISEI---APAKIRGALGTLNQLMITFgillAYLLGLALS--LSPPGWWRLMF 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1839789386 157 YINVPPGLLMIAGLLYGLEKKAahwellkstdymgiLTLAVGLGCLQVF 205
Cdd:cd17315   159 ALAAVPALLQLLLMFFLPESRA--------------LLVGVGLQLLQQL 193
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 6-171 3.81e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386   6 LGAFMAVLDIQITNSSLKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARR-LAVWVSVGFLIASLMCSMA 84
Cdd:cd17365   178 VTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRvLALFFALGAVSLALLGVSP 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  85 WSLESMIVFRALQGFTGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWL-TENWGWEYIFYINVPPG 163
Cdd:cd17365   258 ASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLlAAGLGPESVFLALAIPA 337


                  ....*...
gi 1839789386 164 LLMIAGLL 171
Cdd:cd17365   338 ALGALAVL 345
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 71-171 4.22e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  71 SVGFLIASLMCSMAWSLESMIVFRALQGFTGGaLIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENW 150
Cdd:cd17391    73 SLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF 151

                          90       100
                  ....*....|....*....|.
gi 1839789386 151 GWEYIFYINvpPGLLMIAGLL 171
Cdd:cd17391   152 GIRNVFFIT--GGLLFLAFLL 170
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 74-174 6.49e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  74 FLIASLMCSMAWSLESMIVFRALQGftGGALIPLAFTLTLIKLPEHHRAKGMAM----FAMTATFAPSIGPTIGGWLTEN 149
Cdd:cd17472    72 FIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALigasIGIAFAISMVLGPLLAAHLGVS 149

                          90       100
                  ....*....|....*....|....*
gi 1839789386 150 WgweyIFYINvppGLLMIAGLLYGL 174
Cdd:cd17472   150 G----LFLIT---AILSLVSLLILL 167
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
191-408 7.11e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 7.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 191 GILTLAVGLGCLQVFLEEGHRKDWLESSLIVSLGSIALLSLITF-----VIVQLSKPNPLINLG-ILANRNFGLSSISSL 264
Cdd:COG2211   159 GGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFgtkerPVPEEEKVSLKESLKaLLKNRPFLLLLLAYL 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 265 GMGVGLYGSIYLLPLYLAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCAVGFGLFGFASFSSGVLNPDf 344
Cdd:COG2211   239 LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG- 317

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1839789386 345 AGSQFNQIQIIRALGQPLIMVTISLIaTAYILPQD--------AGSASSLFNILRNLGGAIGIALLATLLDA 408
Cdd:COG2211   318 NLWLLLVLAALAGIGLGAILVLPWAM-LADVVDYDewktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLAL 388
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 21-158 8.02e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 38.57  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  21 SLKDIQGALSATLEeGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVF-RALQGF 99
Cdd:TIGR00894  65 NIKNPNFKWSGALQ-GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFcRVIQGL 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386 100 TGGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENW-GWEYIFYI 158
Cdd:TIGR00894 144 AQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYV 203
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
22-152 8.03e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.70  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839789386  22 LKDIQGALSATLEEGSWISTSYLVAEIIMIPLTAWLVQLLSARRLAVWVSVGFLIASLMCSMAWSLESMIVFRALQGFtG 101
Cdd:COG2807    41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-G 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1839789386 102 GALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTIGGWLTENWGW 152
Cdd:COG2807   120 IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGW 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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