autotransporter adhesin family protein similar to autotransporter adhesin Ag43 which is a phase-variable, bipartite, outer membrane protein that controls colony form variation and autoaggregation
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
1-387
0e+00
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).
The actual alignment was detected with superfamily member NF033177:
Pssm-ID: 467980 [Multi-domain] Cd Length: 948 Bit Score: 565.40 E-value: 0e+00
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
1-387
0e+00
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).
Pssm-ID: 467980 [Multi-domain] Cd Length: 948 Bit Score: 565.40 E-value: 0e+00
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on ...
330-386
4.37e-14
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain.
Pssm-ID: 406554 [Multi-domain] Cd Length: 57 Bit Score: 66.20 E-value: 4.37e-14
autotransporter passenger strand-loop-strand repeat; This model describes two tandem copies of ...
339-375
4.84e-03
autotransporter passenger strand-loop-strand repeat; This model describes two tandem copies of a strand-loop-strand repeat that occurs often in type V secretion system (T5SS). These repeats usually occur in the passenger domain of the classical monomeric autotransporter. Proteins with this repeat often are encoded next to a member of family TIGR04414, the Aah/TibC family O-heptosyltransferase, and may be glycosylated in regions with this repeat.
Pssm-ID: 275208 [Multi-domain] Cd Length: 38 Bit Score: 34.36 E-value: 4.84e-03
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
1-387
0e+00
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).
Pssm-ID: 467980 [Multi-domain] Cd Length: 948 Bit Score: 565.40 E-value: 0e+00
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on ...
330-386
4.37e-14
Adhesin of bacterial autotransporter system, probable stalk; The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain.
Pssm-ID: 406554 [Multi-domain] Cd Length: 57 Bit Score: 66.20 E-value: 4.37e-14
Extended Signal Peptide of Type V secretion system; This conserved domain is called ESPR for ...
6-53
5.49e-11
Extended Signal Peptide of Type V secretion system; This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm, substantially impairing its translocation across the outer membrane.
Pssm-ID: 463773 [Multi-domain] Cd Length: 50 Bit Score: 57.16 E-value: 5.49e-11
autotransporter passenger strand-loop-strand repeat; This model describes two tandem copies of ...
339-375
4.84e-03
autotransporter passenger strand-loop-strand repeat; This model describes two tandem copies of a strand-loop-strand repeat that occurs often in type V secretion system (T5SS). These repeats usually occur in the passenger domain of the classical monomeric autotransporter. Proteins with this repeat often are encoded next to a member of family TIGR04414, the Aah/TibC family O-heptosyltransferase, and may be glycosylated in regions with this repeat.
Pssm-ID: 275208 [Multi-domain] Cd Length: 38 Bit Score: 34.36 E-value: 4.84e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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