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Conserved domains on  [gi|1842105570|ref|WP_171020681|]
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helix-turn-helix transcriptional regulator [Anaerofustis stercorihominis]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10054599)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.26e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1842105570   9 KLKELRRKNKLTIEKvkylLEKRdINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:cd00093     3 RLKELRKEKGLTQEE----LAEK-LGVSRSTISRIENGKRNPSLETLEKLAKALGVS 54
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.26e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1842105570   9 KLKELRRKNKLTIEKvkylLEKRdINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:cd00093     3 RLKELRKEKGLTQEE----LAEK-LGVSRSTISRIENGKRNPSLETLEKLAKALGVS 54
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
3-65 2.14e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 39.98  E-value: 2.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1842105570   3 KKGISLKLKELRRKNKLTIEKVKyllekRDINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:COG1396     5 KKALGERLRELRKARGLTQEELA-----ERLGVSRSTISRIERGRRNPSLETLLKLAKALGVS 62
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
9-64 1.55e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.73  E-value: 1.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1842105570    9 KLKELRRKNKLTIEKvkylLEKRdINVAIKTIYGWESGQRLPTPDIFLNLCDIYNV 64
Cdd:smart00530   1 RLKELREEKGLTQEE----LAEK-LGVSRSTLSRIENGKRKPSLETLKKLAKALGV 51
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 10-65 9.84e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.82  E-value: 9.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1842105570  10 LKELRRKNKLTIEKVKyllekRDINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:pfam01381   1 LKELREELGLSQEELA-----EKLGVSRSTISKIENGKREPSLETLKKLAEALGVS 51
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.26e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1842105570   9 KLKELRRKNKLTIEKvkylLEKRdINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:cd00093     3 RLKELRKEKGLTQEE----LAEK-LGVSRSTISRIENGKRNPSLETLEKLAKALGVS 54
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
3-65 2.14e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 39.98  E-value: 2.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1842105570   3 KKGISLKLKELRRKNKLTIEKVKyllekRDINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:COG1396     5 KKALGERLRELRKARGLTQEELA-----ERLGVSRSTISRIERGRRNPSLETLLKLAKALGVS 62
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-72 4.27e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 38.68  E-value: 4.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1842105570   1 MSKKgISLKLKELRRKNKLTIEKVKyllekRDINVAIKTIYGWESGQRLPTPDIFLNLCDIYNV--NDILEEFE 72
Cdd:COG1476     1 MKKK-LGNRLKELRKERGLTQEELA-----ELLGVSRQTISAIENGKYNPSLELALKIARALGVslEELFSLEE 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
9-64 1.55e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.73  E-value: 1.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1842105570    9 KLKELRRKNKLTIEKvkylLEKRdINVAIKTIYGWESGQRLPTPDIFLNLCDIYNV 64
Cdd:smart00530   1 RLKELREEKGLTQEE----LAEK-LGVSRSTLSRIENGKRKPSLETLKKLAKALGV 51
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 10-65 9.84e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.82  E-value: 9.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1842105570  10 LKELRRKNKLTIEKVKyllekRDINVAIKTIYGWESGQRLPTPDIFLNLCDIYNVN 65
Cdd:pfam01381   1 LKELREELGLSQEELA-----EKLGVSRSTISKIENGKREPSLETLKKLAEALGVS 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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