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Conserved domains on  [gi|1846395953|ref|WP_171907813|]
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MULTISPECIES: Rv2175c family DNA-binding protein [Curtobacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rv2175c_C super family cl39709
Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown ...
 66-117 4.56e-20

Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.


The actual alignment was detected with superfamily member pfam18367:

Pssm-ID: 436442  Cd Length: 56  Bit Score: 76.88  E-value: 4.56e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1846395953  66 LRGTLIVLGDNGFTDDEAVRWMLTVDDAMGTTPIAALRAGRKAEVRRIAQSL 117
Cdd:pfam18367   4 LPGTLTVLRDGGYDDEEILRWLFTEDESLPGRPIDALRAGRGREVKRRAQAL 55
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 15-59 1.90e-04

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


:

Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 36.67  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1846395953  15 WLTVPELVDMFSTSPGRIHRLFEQKTLLAARVGGVLRVPVEFLED 59
Cdd:pfam12728   1 LLTVEEAAELLGVSRRTVYRLIRSGELPAAKIGRRWRIRKSDLEE 45
 
Name Accession Description Interval E-value
Rv2175c_C pfam18367
Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown ...
 66-117 4.56e-20

Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.


Pssm-ID: 436442  Cd Length: 56  Bit Score: 76.88  E-value: 4.56e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1846395953  66 LRGTLIVLGDNGFTDDEAVRWMLTVDDAMGTTPIAALRAGRKAEVRRIAQSL 117
Cdd:pfam18367   4 LPGTLTVLRDGGYDDEEILRWLFTEDESLPGRPIDALRAGRGREVKRRAQAL 55
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 15-59 1.90e-04

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 36.67  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1846395953  15 WLTVPELVDMFSTSPGRIHRLFEQKTLLAARVGGVLRVPVEFLED 59
Cdd:pfam12728   1 LLTVEEAAELLGVSRRTVYRLIRSGELPAAKIGRRWRIRKSDLEE 45
 
Name Accession Description Interval E-value
Rv2175c_C pfam18367
Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown ...
 66-117 4.56e-20

Rv2175c C-terminal domain of unknown function; This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.


Pssm-ID: 436442  Cd Length: 56  Bit Score: 76.88  E-value: 4.56e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1846395953  66 LRGTLIVLGDNGFTDDEAVRWMLTVDDAMGTTPIAALRAGRKAEVRRIAQSL 117
Cdd:pfam18367   4 LPGTLTVLRDGGYDDEEILRWLFTEDESLPGRPIDALRAGRGREVKRRAQAL 55
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 15-59 1.90e-04

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 36.67  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1846395953  15 WLTVPELVDMFSTSPGRIHRLFEQKTLLAARVGGVLRVPVEFLED 59
Cdd:pfam12728   1 LLTVEEAAELLGVSRRTVYRLIRSGELPAAKIGRRWRIRKSDLEE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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