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Conserved domains on  [gi|1848420297|ref|WP_172700938|]
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transposase, partial [Escherichia coli]

Protein Classification

transposase( domain architecture ID 1000886)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IS5 super family cl34540
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-66 2.47e-34

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG3039:

Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 118.05  E-value: 2.47e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:COG3039   169 KGNQWYFGYKAHIGVDADSGLIHTVVTTAANVHDVTHLDELLHGEETDVYADKGYQGAEKREELKA 234
 
Name Accession Description Interval E-value
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-66 2.47e-34

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 118.05  E-value: 2.47e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:COG3039   169 KGNQWYFGYKAHIGVDADSGLIHTVVTTAANVHDVTHLDELLHGEETDVYADKGYQGAEKREELKA 234
transpos_IS5_4 NF033581
IS5 family transposase;
1-66 5.10e-27

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 98.16  E-value: 5.10e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:NF033581  146 KGKKSRHGYKAHIGVDPKSGLVHSLVTTPANVHDSRAAKELLHGDEKTVYADKGYDGDEGYQGLRE 211
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
1-66 1.98e-15

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 66.50  E-value: 1.98e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHG----EEQFVSADAGYQGAPQREELAE 66
Cdd:pfam01609  28 DGGKRRYGYKLHIAVDTRTGLILAVVLTPGNVHDSKGLLQLLDElrrrKGRLVLADAGYGGKELLDKLEE 97
transpos_IS5_2 NF033579
IS5 family transposase;
9-66 1.82e-03

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 34.18  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848420297   9 MKAHIGVDAKSGLTHSLVTTAANEHD---LNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:NF033579  140 RKVHLAVDVKTGEILAVEVTTNKVHDakvLPDLLRQIPEDIDSVLADGAYDTKKCHEAIRE 200
 
Name Accession Description Interval E-value
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-66 2.47e-34

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 118.05  E-value: 2.47e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:COG3039   169 KGNQWYFGYKAHIGVDADSGLIHTVVTTAANVHDVTHLDELLHGEETDVYADKGYQGAEKREELKA 234
transpos_IS5_4 NF033581
IS5 family transposase;
1-66 5.10e-27

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 98.16  E-value: 5.10e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:NF033581  146 KGKKSRHGYKAHIGVDPKSGLVHSLVTTPANVHDSRAAKELLHGDEKTVYADKGYDGDEGYQGLRE 211
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
1-66 1.98e-15

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 66.50  E-value: 1.98e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848420297   1 KGNQLHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHG----EEQFVSADAGYQGAPQREELAE 66
Cdd:pfam01609  28 DGGKRRYGYKLHIAVDTRTGLILAVVLTPGNVHDSKGLLQLLDElrrrKGRLVLADAGYGGKELLDKLEE 97
transpos_IS5_2 NF033579
IS5 family transposase;
9-66 1.82e-03

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 34.18  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848420297   9 MKAHIGVDAKSGLTHSLVTTAANEHD---LNQLGNLLHGEEQFVSADAGYQGAPQREELAE 66
Cdd:NF033579  140 RKVHLAVDVKTGEILAVEVTTNKVHDakvLPDLLRQIPEDIDSVLADGAYDTKKCHEAIRE 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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