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Conserved domains on  [gi|1850757147|ref|WP_173407771|]
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MULTISPECIES: AraC family transcriptional regulator [Bacillus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 16-89 4.81e-30

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 107.86  E-value: 4.81e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1850757147  16 QIEAYRFHGIMQK-FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNI 89
Cdd:cd07001     1 DYEAYHFKGIMQKsFPNHFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQISGRRLDYERINI 75
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-266 7.79e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 100.62  E-value: 7.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 166 KVRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQ 244
Cdd:COG4977   211 RLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEiAAACGFGSA 290

                          90       100
                  ....*....|....*....|..
gi 1850757147 245 SHLSHFFSEFIGLTPGQYQQIF 266
Cdd:COG4977   291 SHFRRAFRRRFGVSPSAYRRRF 312
 
Name Accession Description Interval E-value
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 16-89 4.81e-30

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 107.86  E-value: 4.81e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1850757147  16 QIEAYRFHGIMQK-FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNI 89
Cdd:cd07001     1 DYEAYHFKGIMQKsFPNHFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQISGRRLDYERINI 75
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-266 7.79e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 100.62  E-value: 7.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 166 KVRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQ 244
Cdd:COG4977   211 RLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEiAAACGFGSA 290

                          90       100
                  ....*....|....*....|..
gi 1850757147 245 SHLSHFFSEFIGLTPGQYQQIF 266
Cdd:COG4977   291 SHFRRAFRRRFGVSPSAYRRRF 312
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
181-262 3.51e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 87.61  E-value: 3.51e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  181 NISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLTP 259
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVtEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 1850757147  260 GQY 262
Cdd:smart00342  81 SEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
20-264 6.68e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 91.77  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  20 YRFHGIMQKFPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNIEAGVLEKVFQ 99
Cdd:COG2207     7 LLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 100 HKPHFKAPVFSQSELTKPLYDLHQMITEEAPALNKQETFYFFMKQLIEAYADTSEEKASATRANEQKVRDVQQYIETHLT 179
Cdd:COG2207    87 ALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 180 ENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLT 258
Cdd:COG2207   167 LLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSIsEIAYELGFSSQSHFSRAFKKRFGVT 246


                  ....*.
gi 1850757147 259 PGQYQQ 264
Cdd:COG2207   247 PSEYRK 252
HTH_18 pfam12833
Helix-turn-helix domain;
187-264 9.13e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.40  E-value: 9.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 187 LGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQ--GVKPVDAAASAGFSDQSHLSHFFSEFIGLTPGQYQQ 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-131 3.58e-17

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 75.93  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  17 IEAYRFHGIMQKFPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNIEAGVLEK 96
Cdd:pfam02311   4 LEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPELLER 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1850757147  97 VF---QHKPHFKAPVFSQSELTKPLYDLHQMITEEAPA 131
Cdd:pfam02311  84 ILadiSILAGGPLPLLRDPELAALLRALFRLLEEAGRS 121
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-266 8.14e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 69.99  E-value: 8.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 172 QYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQSHLSHF 250
Cdd:PRK09393  225 DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQiAERAGFGSEESLRHH 304

                          90
                  ....*....|....*.
gi 1850757147 251 FSEFIGLTPGQYQQIF 266
Cdd:PRK09393  305 FRRRAATSPAAYRKRF 320
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
40-262 1.90e-11

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 63.07  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  40 GFIEDGQRRLVCqnqeyiiEKGDILLFNPYDNH------ACEQIDHRTLDYR-------CLN---IEAGVLEKVF---QH 100
Cdd:PRK10572   60 GVIFNGGRAFVC-------RPGDLLLFPPGEIHhygrhpDSDEWYHQWVYFRpraywadWLNwpsIFAGVGRLRIpdeAL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 101 KPHFKApVFSQSELTkplydlHQ--MITEEAPALNKQEtfyffmKQLIEAYadtSEEKASATRANEQKVRDVQQYIETHL 178
Cdd:PRK10572  133 QPEFSD-LFGQIEQA------GQseGRYSELLAMNLLE------RLLLRCM---EAIPESLHPPMDPRVREACQYISDHL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 179 TENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQSHLSHFFSEFIGL 257
Cdd:PRK10572  197 ASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATiGRNVGYDDQLYFSRVFKKCTGA 276


                  ....*
gi 1850757147 258 TPGQY 262
Cdd:PRK10572  277 SPSEF 281
 
Name Accession Description Interval E-value
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 16-89 4.81e-30

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 107.86  E-value: 4.81e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1850757147  16 QIEAYRFHGIMQK-FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNI 89
Cdd:cd07001     1 DYEAYHFKGIMQKsFPNHFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQISGRRLDYERINI 75
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-266 7.79e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 100.62  E-value: 7.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 166 KVRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQ 244
Cdd:COG4977   211 RLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEiAAACGFGSA 290

                          90       100
                  ....*....|....*....|..
gi 1850757147 245 SHLSHFFSEFIGLTPGQYQQIF 266
Cdd:COG4977   291 SHFRRAFRRRFGVSPSAYRRRF 312
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
181-262 3.51e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 87.61  E-value: 3.51e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  181 NISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLTP 259
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVtEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 1850757147  260 GQY 262
Cdd:smart00342  81 SEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
20-264 6.68e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 91.77  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  20 YRFHGIMQKFPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNIEAGVLEKVFQ 99
Cdd:COG2207     7 LLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 100 HKPHFKAPVFSQSELTKPLYDLHQMITEEAPALNKQETFYFFMKQLIEAYADTSEEKASATRANEQKVRDVQQYIETHLT 179
Cdd:COG2207    87 ALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 180 ENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLT 258
Cdd:COG2207   167 LLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSIsEIAYELGFSSQSHFSRAFKKRFGVT 246


                  ....*.
gi 1850757147 259 PGQYQQ 264
Cdd:COG2207   247 PSEYRK 252
HTH_18 pfam12833
Helix-turn-helix domain;
187-264 9.13e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.40  E-value: 9.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 187 LGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQ--GVKPVDAAASAGFSDQSHLSHFFSEFIGLTPGQYQQ 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 155-264 4.28e-18

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 82.79  E-value: 4.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 155 EKASATRANEQKVRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVD 234
Cdd:COG2169    74 DLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTD 153

                          90       100       110
                  ....*....|....*....|....*....|
gi 1850757147 235 AAASAGFSDQSHLSHFFSEFIGLTPGQYQQ 264
Cdd:COG2169   154 AAYAAGFGSLSRFYEAFKKLLGMTPSAYRR 183
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-131 3.58e-17

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 75.93  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  17 IEAYRFHGIMQKFPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNIEAGVLEK 96
Cdd:pfam02311   4 LEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPELLER 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1850757147  97 VF---QHKPHFKAPVFSQSELTKPLYDLHQMITEEAPA 131
Cdd:pfam02311  84 ILadiSILAGGPLPLLRDPELAALLRALFRLLEEAGRS 121
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-266 8.14e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 69.99  E-value: 8.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 172 QYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQSHLSHF 250
Cdd:PRK09393  225 DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQiAERAGFGSEESLRHH 304

                          90
                  ....*....|....*.
gi 1850757147 251 FSEFIGLTPGQYQQIF 266
Cdd:PRK09393  305 FRRRAATSPAAYRKRF 320
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
40-262 1.90e-11

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 63.07  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  40 GFIEDGQRRLVCqnqeyiiEKGDILLFNPYDNH------ACEQIDHRTLDYR-------CLN---IEAGVLEKVF---QH 100
Cdd:PRK10572   60 GVIFNGGRAFVC-------RPGDLLLFPPGEIHhygrhpDSDEWYHQWVYFRpraywadWLNwpsIFAGVGRLRIpdeAL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 101 KPHFKApVFSQSELTkplydlHQ--MITEEAPALNKQEtfyffmKQLIEAYadtSEEKASATRANEQKVRDVQQYIETHL 178
Cdd:PRK10572  133 QPEFSD-LFGQIEQA------GQseGRYSELLAMNLLE------RLLLRCM---EAIPESLHPPMDPRVREACQYISDHL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 179 TENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDA-AASAGFSDQSHLSHFFSEFIGL 257
Cdd:PRK10572  197 ASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATiGRNVGYDDQLYFSRVFKKCTGA 276


                  ....*
gi 1850757147 258 TPGQY 262
Cdd:PRK10572  277 SPSEF 281
PRK10371 PRK10371
transcriptional regulator MelR;
111-265 5.09e-09

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 55.98  E-value: 5.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 111 QSELTKPLYDLHQMITEEAPALNKQetfyfFMKQLIEAYADTSEEKASATRANEQKVRDVQQ---YIETHLTENISLEDL 187
Cdd:PRK10371  139 QQELNSPNEQIRQLAIDEIGLMLKR-----FSLSGWEPILVNKTSRTHKNSVSRHAQFYVSQmlgFIAENYDQALTINDV 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1850757147 188 GELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLTPGQYQQI 265
Cdd:PRK10371  214 AEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSIlDIALTAGFRSSSRFYSTFGKYVGMSPQQYRKL 292
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
182-264 8.35e-09

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 55.57  E-value: 8.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 182 ISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPVDAAASAGFSDQSHLSHFFSEFIGLTPGQ 261
Cdd:PRK15435  100 VTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQ 179


                  ...
gi 1850757147 262 YQQ 264
Cdd:PRK15435  180 FRH 182
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
29-259 8.25e-08

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 51.99  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  29 FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTL---------DYRCLN----------- 88
Cdd:PRK13503   28 FPEHHHDFHEIVIVEHGTGIHVFNGQPYTLSGGTVCFVRDHDRHLYEHTDNLCLtnvlyrspdAFRFLAglnqllpqeqd 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  89 --------IEAGVLEKVFQhkphfkapVFSQSELTKPLYDLHQMITEEApalnkqetfyFFMKQLIEAYADTSEEKASAt 160
Cdd:PRK13503  108 gqypshwrVNQSVLQQVRQ--------LVAQMEQQEESNDLEAIASREI----------LFMQLLVLLRKSSLQENGEN- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 161 raNEQKVRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASA 239
Cdd:PRK13503  169 --SDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVtDIAYRC 246

                         250       260
                  ....*....|....*....|
gi 1850757147 240 GFSDQSHLSHFFSEFIGLTP 259
Cdd:PRK13503  247 GFGDSNHFSTLFRREFSWSP 266
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 163-264 3.32e-07

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 50.41  E-value: 3.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 163 NEQKVRDVQQYIETHLT-ENISLEDLGELVSMNKYSLLRAFTKfRGITPYRYLQTVRVNFAKELL---AQGVKPVDAAAS 238
Cdd:PRK09685  195 RERQFQKVVALIDQSIQeEILRPEWIAGELGISVRSLYRLFAE-QGLVVAQYIRNRRLDRCADDLrpaADDEKITSIAYK 273

                          90       100
                  ....*....|....*....|....*.
gi 1850757147 239 AGFSDQSHLSHFFSEFIGLTPGQYQQ 264
Cdd:PRK09685  274 WGFSDSSHFSTAFKQRFGVSPGEYRR 299
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
174-271 1.30e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 45.67  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 174 IETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELL-AQGVKPVDAAASAGFSDQSHLSHFFS 252
Cdd:PRK13501  185 LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLrGSEHRISDIAARCGFEDSNYFSAVFT 264

                          90
                  ....*....|....*....
gi 1850757147 253 EFIGLTPGQYQQIFVKQVT 271
Cdd:PRK13501  265 REAGMTPRDYRQRFIRSPV 283
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
29-265 3.36e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 44.32  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  29 FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTLDYRCLNIEAGVLEKVFQH-------- 100
Cdd:PRK13500   61 FAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLDWQGaipgfsas 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 101 --KPHFKAPVFSQSELTKPLYDLHQMITEEAPALNKQ-ETFYFFMKQLIEAYADTSEEKASATraNEQKVRDVQQYIETH 177
Cdd:PRK13500  141 agQPHWRLGSVGMAQARQVIGQLEHESSQHVPFANEMaELLFGQLVMLLNRHRYTSDSLPPTS--SETLLDKLITRLAAS 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 178 LTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIG 256
Cdd:PRK13500  219 LKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLIsDISTECGFEDSNYFSVVFTRETG 298


                  ....*....
gi 1850757147 257 LTPGQYQQI 265
Cdd:PRK13500  299 MTPSQWRHL 307
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
29-270 1.19e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 42.73  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  29 FPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACEQIDHRTL-------DYRCLNIEAGVLEKVF--- 98
Cdd:PRK13502   31 FAEHTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLqniiycpERLKLNVNWQAMIPGFqga 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147  99 QHKPHFKAPVFSQSELTKPLYDL-HQMITEEAPALNKQETFYFFMKQLIEAYADTSEEKASATRanEQKVRDVQQYIETH 177
Cdd:PRK13502  111 QWHPHWRLGSMGMNQARQVINQLeHESNGRDPLANEMAELLFGQLVMTLKRHRYATDDLPATSR--ETLLDKLITALANS 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 178 LTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIG 256
Cdd:PRK13502  189 LECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMIsEISMQCGFEDSNYFSVVFTRETG 268

                         250
                  ....*....|....
gi 1850757147 257 LTPGQYQQIFVKQV 270
Cdd:PRK13502  269 MTPSQWRHLSNQSD 282
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
6-75 8.51e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.91  E-value: 8.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1850757147   6 ERTVHFDQDLQIEAYRFH---GimQKFPNHFHTYYVIGFIEDGQRRLVCQNQEYIIEKGDILLFNPYDNHACE 75
Cdd:COG1917    12 SVRVLADGEDELEVVRVTfepG--ARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFR 82
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
167-263 1.39e-03

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 37.77  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 167 VRDVQQYIETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQS 245
Cdd:PRK11511   11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPIlYLAERYGFESQQ 90

                          90
                  ....*....|....*...
gi 1850757147 246 HLSHFFSEFIGLTPGQYQ 263
Cdd:PRK11511   91 TLTRTFKNYFDVPPHKYR 108
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 183-266 4.02e-03

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 37.81  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850757147 183 SLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQTVRVNFAKELLAQGVKPV-DAAASAGFSDQSHLSHFFSEFIGLTPGQ 261
Cdd:PRK10296  190 ALENMVRLSGKSQEYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVtDIAFEAGYSSPSLFIKTFKKLTSFTPGS 269


                  ....*
gi 1850757147 262 YQQIF 266
Cdd:PRK10296  270 YRKKL 274
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 174-215 9.32e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 33.28  E-value: 9.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1850757147 174 IETHLTENISLEDLGELVSMNKYSLLRAFTKFRGITPYRYLQ 215
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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