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Conserved domains on  [gi|1859351062|ref|WP_175083129|]
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MULTISPECIES: DUF938 domain-containing protein [Pseudoalteromonas]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 3-195 8.07e-77

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam06080:

Pssm-ID: 473071  Cd Length: 201  Bit Score: 228.88  E-value: 8.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062   3 KPFSQACENNKLPILNVLAEFFSDVT-DVLEVGSGTGQHSVHFATHLAHLQWHCSDREVNHP-GILQWHQEAALTNLHAP 80
Cdd:pfam06080   1 KPFAPAAERNREPILSVLQSYFAKTTeRVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRgSIAAWADQQGLRNLRPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  81 LTLDLN-DPWPVE-----TVNAIFTANTMHIISWPLVERFFQGVAKHLAPKGKLCIYGPFKYQGKFTSASNAEFDAFLKQ 154
Cdd:pfam06080  81 LHLDVTrPPWPVEapapaSYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLRQ 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1859351062 155 QDAHSAIRDFEAICQLAEQAGLTLVEDVQMPANNQLLLFKR 195
Cdd:pfam06080 161 RDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 3-195 8.07e-77

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 228.88  E-value: 8.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062   3 KPFSQACENNKLPILNVLAEFFSDVT-DVLEVGSGTGQHSVHFATHLAHLQWHCSDREVNHP-GILQWHQEAALTNLHAP 80
Cdd:pfam06080   1 KPFAPAAERNREPILSVLQSYFAKTTeRVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRgSIAAWADQQGLRNLRPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  81 LTLDLN-DPWPVE-----TVNAIFTANTMHIISWPLVERFFQGVAKHLAPKGKLCIYGPFKYQGKFTSASNAEFDAFLKQ 154
Cdd:pfam06080  81 LHLDVTrPPWPVEapapaSYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLRQ 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1859351062 155 QDAHSAIRDFEAICQLAEQAGLTLVEDVQMPANNQLLLFKR 195
Cdd:pfam06080 161 RDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 30-133 2.85e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.70  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  30 VLEVGSGTGQHSVHFATHLaHLQWHCSDR-EVNHPGILQWHQEAALTNLHAPLTLDLNDPWPVETVNAIFTANTMHIISW 108
Cdd:COG2230    55 VLDIGCGWGGLALYLARRY-GVRVTGVTLsPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSIGMFEHVGP 133

                          90       100
                  ....*....|....*....|....*
gi 1859351062 109 PLVERFFQGVAKHLAPKGKLCIYGP 133
Cdd:COG2230   134 ENYPAYFAKVARLLKPGGRLLLHTP 158
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 29-130 1.34e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.72  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  29 DVLEVGSGTGQHSVHFATHLAHLQWHCsdrEVNhPGILQWHQEAALTNLHAPLTL---DLND--PWPVETVNAIFTANTM 103
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGV---DIS-PVALELARKAAAALLADNVEVlkgDAEElpPEADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*..
gi 1859351062 104 HiISWPLVERFFQGVAKHLAPKGKLCI 130
Cdd:cd02440    77 H-HLVEDLARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 3-195 8.07e-77

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 228.88  E-value: 8.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062   3 KPFSQACENNKLPILNVLAEFFSDVT-DVLEVGSGTGQHSVHFATHLAHLQWHCSDREVNHP-GILQWHQEAALTNLHAP 80
Cdd:pfam06080   1 KPFAPAAERNREPILSVLQSYFAKTTeRVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRgSIAAWADQQGLRNLRPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  81 LTLDLN-DPWPVE-----TVNAIFTANTMHIISWPLVERFFQGVAKHLAPKGKLCIYGPFKYQGKFTSASNAEFDAFLKQ 154
Cdd:pfam06080  81 LHLDVTrPPWPVEapapaSYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLRQ 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1859351062 155 QDAHSAIRDFEAICQLAEQAGLTLVEDVQMPANNQLLLFKR 195
Cdd:pfam06080 161 RDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 30-126 2.27e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.87  E-value: 2.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  30 VLEVGSGTGQHSVHFATHLAHlQWHCSDREVNHPGILQWHQEAALTNLHApLTLDLND-PWPVETVNAIFTANTMHIISW 108
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGA-RVTGVDLSPEMLERARERAAEAGLNVEF-VQGDAEDlPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
gi 1859351062 109 PLVERFFQGVAKHLAPKG 126
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 30-133 2.85e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.70  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  30 VLEVGSGTGQHSVHFATHLaHLQWHCSDR-EVNHPGILQWHQEAALTNLHAPLTLDLNDPWPVETVNAIFTANTMHIISW 108
Cdd:COG2230    55 VLDIGCGWGGLALYLARRY-GVRVTGVTLsPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSIGMFEHVGP 133

                          90       100
                  ....*....|....*....|....*
gi 1859351062 109 PLVERFFQGVAKHLAPKGKLCIYGP 133
Cdd:COG2230   134 ENYPAYFAKVARLLKPGGRLLLHTP 158
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
30-130 1.25e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.20  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  30 VLEVGSGTGQHSVHFATHLAHLQWHCSDrevNHPGILQWHQeAALTNLHApLTLDLNDPWPVETVNAIFTANTMHiisW- 108
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVD---LSPEMLARAR-ARLPNVRF-VVADLRDLDPPEPFDLVVSNAALH---Wl 76

                          90       100
                  ....*....|....*....|..
gi 1859351062 109 PLVERFFQGVAKHLAPKGKLCI 130
Cdd:COG4106    77 PDHAALLARLAAALAPGGVLAV 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 29-193 1.05e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 44.14  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  29 DVLEVGSGTGQHSVHFATHLAHlQWHCSDrevNHPGILQWHQEAALTNLHAPLTL---DLNDPWPVET--VNAIFTANTM 103
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARFGG-RVIGID---LSPEAIALARARAAKAGLGNVEFlvaDLAELDPLPAesFDLVVAFGVL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062 104 HIISWPLVERFFQGVAKHLAPKGKLCIYGPFKYQGKFTSASNAEFDAFLKQQDAHS--AIRDFEAICQLAEQAGLTLVED 181
Cdd:COG0500   105 HHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLrlLALELYLRALLAAAATEDLRSD 184

                         170
                  ....*....|..
gi 1859351062 182 VQMPANNQLLLF 193
Cdd:COG0500   185 ALLESANALEYL 196
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 16-180 8.94e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.26  E-value: 8.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  16 ILNVLAEFFSDVTDVLEVGSGTGqhsvHFATHLAHLQWHCSDREVNHPGILQWHQEAALTNLHAPLTLDLNDPWPVetvn 95
Cdd:pfam13489  12 LLLRLLPKLPSPGRVLDFGCGTG----IFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDV---- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  96 AIFTANTMHIISWPlveRFFQGVAKHLAPKGKLCIYGPFKYQGKFTSASNAEFDAFlkqQDAHSAIRDFEAICQLAEQAG 175
Cdd:pfam13489  84 IVAREVLEHVPDPP---ALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRP---RNGHISLFSARSLKRLLEEAG 157


                  ....*
gi 1859351062 176 LTLVE 180
Cdd:pfam13489 158 FEVVS 162
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 29-130 1.34e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.72  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  29 DVLEVGSGTGQHSVHFATHLAHLQWHCsdrEVNhPGILQWHQEAALTNLHAPLTL---DLND--PWPVETVNAIFTANTM 103
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGV---DIS-PVALELARKAAAALLADNVEVlkgDAEElpPEADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*..
gi 1859351062 104 HiISWPLVERFFQGVAKHLAPKGKLCI 130
Cdd:cd02440    77 H-HLVEDLARFLEEARRLLKPGGVLVL 102
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-154 1.35e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.36  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  30 VLEVGSGTGQHSVHFATHLAHLqwHCSDRevnHPGILQW-HQEAALTNLHAPLTL-DLND-PWPVETVNAIFTANTMHii 106
Cdd:COG2226    26 VLDLGCGTGRLALALAERGARV--TGVDI---SPEMLELaRERAAEAGLNVEFVVgDAEDlPFPDGSFDLVISSFVLH-- 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1859351062 107 SWPLVERFFQGVAKHLAPKGKLCIYGpfkyqgkFTSASNAEFDAFLKQ 154
Cdd:COG2226    99 HLPDPERALAEIARVLKPGGRLVVVD-------FSPPDLAELEELLAE 139
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 16-130 2.45e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  16 ILNVLAEFFSDVTDVLEVGSGTGQHSVHFATHLAHLqwHCSDRevnHPGILQWHQEAALTNLHAPLTLDLND-PWPVETV 94
Cdd:COG2227    14 LAALLARLLPAGGRVLDVGCGTGRLALALARRGADV--TGVDI---SPEALEIARERAAELNVDFVQGDLEDlPLEDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1859351062  95 NAIFTANTMHIIswPLVERFFQGVAKHLAPKGKLCI 130
Cdd:COG2227    89 DLVICSEVLEHL--PDPAALLRELARLLKPGGLLLL 122
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 31-130 3.91e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.33  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  31 LEVGSGTGQHSVHFATHLAHLqwHCSDRevnHPGILQWHQEAALTNLHAPLTLDLND-PWPVETVNAIFTANTMHiiSWP 109
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARV--TGVDI---SPEMLELAREKAPREGLTFVVGDAEDlPFPDNSFDLVLSSEVLH--HVE 73

                          90       100
                  ....*....|....*....|.
gi 1859351062 110 LVERFFQGVAKHLAPKGKLCI 130
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 31-128 4.96e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.04  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  31 LEVGSGTGQHSVHFATHLAHLQWHCSDREVNHPGILQWHQEAALTNLHAPLTLDLNDP--WPVETVNAIFTANTMHiiSW 108
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLgeLDPGSFDVVVASNVLH--HL 78

                          90       100
                  ....*....|....*....|
gi 1859351062 109 PLVERFFQGVAKHLAPKGKL 128
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
29-130 8.14e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 35.74  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351062  29 DVLEVGSGTGQHSVHFATHLAHLqwHCSDREvnhPGILQwhqEAALTNLHAPLTL-DLND-PWPVETVNAIFTANTMHII 106
Cdd:COG4976    49 RVLDLGCGTGLLGEALRPRGYRL--TGVDLS---EEMLA---KAREKGVYDRLLVaDLADlAEPDGRFDLIVAADVLTYL 120

                          90       100
                  ....*....|....*....|....
gi 1859351062 107 swPLVERFFQGVAKHLAPKGKLCI 130
Cdd:COG4976   121 --GDLAAVFAGVARALKPGGLFIF 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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