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Conserved domains on  [gi|1859351064|ref|WP_175083131|]
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MULTISPECIES: carboxylesterase [Pseudoalteromonas]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
116-339 2.90e-36

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 133.91  E-value: 2.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 116 PFELKqaNSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDADDWQKASVYAIERTLKDFDQ 195
Cdd:COG1647     8 PFFLE--GGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 196 VILGGYSTGAALVIDYLTQGPvdnKITAAMLFSPASEPHNKNGWLAKWV----DAIPFVNWIDKDADLDFAKYESFPFSA 271
Cdd:COG1647    86 VIVIGLSMGGLLALLLAARYP---DVAGLVLLSPALKIDDPSAPLLPLLkylaRSLRGIGSDIEDPEVAEYAYDRTPLRA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859351064 272 AsASHEAMSRISLDELRHRQLPnVAIFstFSDVDTTIDNQATFKILTKLHDPKTrknnqldRLVYYGD 339
Cdd:COG1647   163 L-AELQRLIREVRRDLPKITAP-TLII--QSRKDEVVPPESARYIYERLGSPDK-------ELVWLED 219
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
116-339 2.90e-36

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 133.91  E-value: 2.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 116 PFELKqaNSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDADDWQKASVYAIERTLKDFDQ 195
Cdd:COG1647     8 PFFLE--GGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 196 VILGGYSTGAALVIDYLTQGPvdnKITAAMLFSPASEPHNKNGWLAKWV----DAIPFVNWIDKDADLDFAKYESFPFSA 271
Cdd:COG1647    86 VIVIGLSMGGLLALLLAARYP---DVAGLVLLSPALKIDDPSAPLLPLLkylaRSLRGIGSDIEDPEVAEYAYDRTPLRA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859351064 272 AsASHEAMSRISLDELRHRQLPnVAIFstFSDVDTTIDNQATFKILTKLHDPKTrknnqldRLVYYGD 339
Cdd:COG1647   163 L-AELQRLIREVRRDLPKITAP-TLII--QSRKDEVVPPESARYIYERLGSPDK-------ELVWLED 219
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 122-244 6.84e-10

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 59.15  E-value: 6.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 122 ANSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDA-DDWQKASVYAIERTLKDF--DQVIL 198
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSfDDYVDDLDTFVDKIREEHpgLPLFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1859351064 199 GGYSTGAALVIDYLTQGPvdNKITAAMLFSPASEPHNKNG-WLAKWV 244
Cdd:pfam12146  81 LGHSMGGLIAALYALRYP--DKVDGLILSAPALKIKPYLApPILKLL 125
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
116-339 2.90e-36

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 133.91  E-value: 2.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 116 PFELKqaNSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDADDWQKASVYAIERTLKDFDQ 195
Cdd:COG1647     8 PFFLE--GGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 196 VILGGYSTGAALVIDYLTQGPvdnKITAAMLFSPASEPHNKNGWLAKWV----DAIPFVNWIDKDADLDFAKYESFPFSA 271
Cdd:COG1647    86 VIVIGLSMGGLLALLLAARYP---DVAGLVLLSPALKIDDPSAPLLPLLkylaRSLRGIGSDIEDPEVAEYAYDRTPLRA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859351064 272 AsASHEAMSRISLDELRHRQLPnVAIFstFSDVDTTIDNQATFKILTKLHDPKTrknnqldRLVYYGD 339
Cdd:COG1647   163 L-AELQRLIREVRRDLPKITAP-TLII--QSRKDEVVPPESARYIYERLGSPDK-------ELVWLED 219
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
121-255 5.59e-18

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 82.36  E-value: 5.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 121 QANSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDI-DADDWQKASVYAIERTLKDFDQ-VIL 198
Cdd:COG2267    24 AGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVdSFDDYVDDLRAALDALRARPGLpVVL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1859351064 199 GGYSTGAALVIDYLTQGPvdNKITAAMLFSPASEPHNKNGWLAKWVDAIPFVNWIDK 255
Cdd:COG2267   104 LGHSMGGLIALLYAARYP--DRVAGLVLLAPAYRADPLLGPSARWLRALRLAEALAR 158
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 122-244 6.84e-10

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 59.15  E-value: 6.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 122 ANSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDA-DDWQKASVYAIERTLKDF--DQVIL 198
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSfDDYVDDLDTFVDKIREEHpgLPLFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1859351064 199 GGYSTGAALVIDYLTQGPvdNKITAAMLFSPASEPHNKNG-WLAKWV 244
Cdd:pfam12146  81 LGHSMGGLIAALYALRYP--DKVDGLILSAPALKIKPYLApPILKLL 125
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 123-232 2.43e-08

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 54.24  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 123 NSRKAVLLIHGLTDSPFTYHDLAQvYYQQGYTVRTILLPGHG--TAPAALRDID--ADDwqkasVYAIERTLkDFDQVIL 198
Cdd:COG0596    21 PDGPPVVLLHGLPGSSYEWRPLIP-ALAAGYRVIAPDLRGHGrsDKPAGGYTLDdlADD-----LAALLDAL-GLERVVL 93

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1859351064 199 GGYSTGAALVIDYLTQGPvdNKITAAMLFSPASE 232
Cdd:COG0596    94 VGHSMGGMVALELAARHP--ERVAGLVLVDEVLA 125
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 128-293 2.11e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 51.32  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 128 VLLIHGLTDSPFTYHDLAQvyyqQGYTVRTILLPGHGTAPAALRDI-DADDWQkasvyAIERTLKDFDQVILGGYSTGAA 206
Cdd:pfam12697   1 VVLVHGAGLSAAPLAALLA----AGVAVLAPDLPGHGSSSPPPLDLaDLADLA-----ALLDELGAARPVVLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 207 LVIDYLTQGPVDnKITAAMLFSPASEPHNKNGWLAKWVDAIPFVNWIDKD-------ADLDFAKYESFPFSAASASHEAM 279
Cdd:pfam12697  72 VALAAAAAALVV-GVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAEslargflDDLPADAEWAAALARLAALLAAL 150

                         170
                  ....*....|....
gi 1859351064 280 SRISLDELRHRQLP 293
Cdd:pfam12697 151 ALLPLAAWRDLPVP 164
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
111-257 6.81e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.02  E-value: 6.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 111 ADLISPfelKQANSRKAVLLIHGL-TDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDADDWQKASVYAIERT 189
Cdd:COG1506    12 GWLYLP---ADGKKYPVVVYVHGGpGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859351064 190 LKDFDQVILGGYSTGAALVIDYLTQGPvdNKITAAMLFSPASEPHNKNGWLAKWVDAIPFVNWIDKDA 257
Cdd:COG1506    89 YVDPDRIGIYGHSYGGYMALLAAARHP--DRFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDPEA 154
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 126-343 4.00e-06

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 47.88  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 126 KAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTILLPGHGTAPAALRDIDADDW-QKASVYAIERTLKDfDQVILGGYSTG 204
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDdLAEDLEYILEALGL-EKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 205 AALVIDYLTQGPvdNKITAAMLFSPASEPHnkngwlaKWVDAIPFVNWIDkDADLDFAKYESFPFSAASASHEAMSRISL 284
Cdd:pfam00561  80 GLIALAYAAKYP--DRVKALVLLGALDPPH-------ELDEADRFILALF-PGFFDGFVADFAPNPLGRLVAKLLALLLL 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859351064 285 DELRHRQLPNVAIfSTFSDVDTTIDNQATFKILTKLHDPKTRKNNQLDR-----LVYYGDDNNI 343
Cdd:pfam00561 150 RLRLLKALPLLNK-RFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRldeptLIIWGDQDPL 212
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 122-214 1.62e-04

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 40.97  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 122 ANSRKAVLLIHGLTDSPFTYHDLAQVYYQQGYTVRTI-LLPGHGTAPAALRDIDAddwqkasvyAIERTLKD--FDQVIL 198
Cdd:COG1075     2 AATRYPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALnYPSTNGSIEDSAEQLAA---------FVDAVLAAtgAEKVDL 72

                          90
                  ....*....|....*.
gi 1859351064 199 GGYSTGaALVIDYLTQ 214
Cdd:COG1075    73 VGHSMG-GLVARYYLK 87
YpfH COG0400
Predicted esterase [General function prediction only];
122-230 8.17e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 40.66  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 122 ANSRKAVLLIHGLTDSPftyHDLAQVyyqqgytVRTILLPG------HGTAP------------AALRDIDADDWQKASV 183
Cdd:COG0400     2 GPAAPLVVLLHGYGGDE---EDLLPL-------APELALPGaavlapRAPVPegpggrawfdlsFLEGREDEEGLAAAAE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1859351064 184 Y---AIERTLK----DFDQVILGGYSTGAALVIDYLTQGPvdNKITAAMLFSPA 230
Cdd:COG0400    72 AlaaFIDELEArygiDPERIVLAGFSQGAAMALSLALRRP--ELLAGVVALSGY 123
DUF1749 pfam08538
Protein of unknown function (DUF1749); This is a plant and fungal family of unknown function. ...
 116-232 1.26e-03

Protein of unknown function (DUF1749); This is a plant and fungal family of unknown function. This family contains many hypothetical proteins.


Pssm-ID: 369936  Cd Length: 299  Bit Score: 40.49  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 116 PFELKQANSRKAVLLIHGLTDS----PFTYhDLAQVYYQQGYTVRTILLP----GHGTAPAalrDIDADDWQKASVYAie 187
Cdd:pfam08538  21 EYETSGGLKTNALLFIGGLGDGlgtvPYVQ-PLANALDESGWSVVQPQTSssygGWGTGSL---KRDDEEISALVEYL-- 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1859351064 188 RTLKDFD----QVILGGYSTGAALVIDYLTQG-PVD-NKITAAMLFSPASE 232
Cdd:pfam08538  95 KTTKSGTfgmrKVVLMGHSTGSQDVMYYLTSSnEMGrPKVDGGILQAPVSD 145
YpfH COG0400
Predicted esterase [General function prediction only];
110-175 6.32e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.96  E-value: 6.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859351064 110 VADLISPFELKQANSRKAVLLIHGLTDSPFTY---HDLAQVYYQQGYTVRTILLP-GHGTAPAALRDIDA 175
Cdd:COG0400   124 LPGEEALPAPEAALAGTPVFLAHGTQDPVIPVeraREAAEALEAAGADVTYREYPgGHEISPEELADARA 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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