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Conserved domains on  [gi|1861232994|ref|WP_176072013|]
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protein-L-isoaspartate O-methyltransferase [Agrobacterium sp. CGMCC 11546]

Protein Classification

protein-L-isoaspartate O-methyltransferase family protein( domain architecture ID 11457531)

protein-L-isoaspartate O-methyltransferase family protein may catalyze the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

CATH:  3.55.20.10
EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091|GO:0036211
PubMed:  35462043|20564550|35462043|9253175
SCOP:  4000666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-215 2.73e-81

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 240.76  E-value: 2.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  13 DSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldgRPARYVMKASPLAKLLQLAAVSKDDVVLEVG 92
Cdd:COG2518     1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPI------GHGQTISQPYIVARMLEALDLKPGDRVLEIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  93 GGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLR 172
Cdd:COG2518    75 TGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLA 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1861232994 173 DGGRLVVVVGYGNAAKATVYRRDGNSTSAASFFNASVKPVPGF 215
Cdd:COG2518   155 PGGRLVAPVGEGGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-215 2.73e-81

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 240.76  E-value: 2.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  13 DSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldgRPARYVMKASPLAKLLQLAAVSKDDVVLEVG 92
Cdd:COG2518     1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPI------GHGQTISQPYIVARMLEALDLKPGDRVLEIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  93 GGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLR 172
Cdd:COG2518    75 TGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLA 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1861232994 173 DGGRLVVVVGYGNAAKATVYRRDGNSTSAASFFNASVKPVPGF 215
Cdd:COG2518   155 PGGRLVAPVGEGGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-198 2.77e-48

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 157.67  E-value: 2.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   1 MMDFETARANMVDsQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQI-CSAldgrparYVmkASPL--AKLL 77
Cdd:PRK00312    2 RLMESERFARLVL-RLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIgCGQ-------TI--SQPYmvARMT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  78 QLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFIN 157
Cdd:PRK00312   72 ELLELKPGDRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVT 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1861232994 158 GSVEEVPAALTDQLRDGGRLVVVVGYGNAAKATVYRRDGNS 198
Cdd:PRK00312  152 AAAPEIPRALLEQLKEGGILVAPVGGEEQQLLTRVRKRGGR 192
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
21-197 2.54e-41

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 139.43  E-value: 2.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  21 VTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldGRPArYVMKASPLAKLLQLAAVSKDDVVLEVGGGSGYAAA 100
Cdd:pfam01135  16 IKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSI-----GYGQ-TISAPHMHAMMLELLELKPGMRVLEIGSGSGYLTA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994 101 ILSQLA---GSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLRDGGRL 177
Cdd:pfam01135  90 CFARMVgevGRVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRL 169

                         170       180
                  ....*....|....*....|
gi 1861232994 178 VVVVGYGNAAKATVYRRDGN 197
Cdd:pfam01135 170 VIPVGPNGNQVLQQFDKRND 189
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 2-196 3.46e-40

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 136.88  E-value: 3.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   2 MDFETARANMVDSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldgRPARYVMKASPLAKLLQLAA 81
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEI------GYGQTISAPHMVAMMTELLE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  82 VSKDDVVLEVGGGSGYAAAILSQL---AGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFING 158
Cdd:TIGR00080  75 LKPGMKVLEIGTGSGYQAAVLAEIvgrDGLVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTA 154

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1861232994 159 SVEEVPAALTDQLRDGGRLVVVVGYGNAAKATVYRRDG 196
Cdd:TIGR00080 155 AGPKIPEALIDQLKEGGILVMPVGEYLQVLKRAEKRGG 192
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-181 9.15e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 9.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  88 VLEVGGGSGY-AAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKG-YAGEAPYDLIFINGS----VE 161
Cdd:cd02440     2 VLDLGCGTGAlALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPlhhlVE 81

                          90       100
                  ....*....|....*....|...
gi 1861232994 162 EVPAALT---DQLRDGGRLVVVV 181
Cdd:cd02440    82 DLARFLEearRLLKPGGVLVLTL 104
rADc smart00650
Ribosomal RNA adenine dimethylases;
73-157 1.06e-08

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 52.51  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLAslGYDNVAVVTGDLAKGYAGEAPYD 152
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA--AADNLTVIHGDALKFDLPKLQPY 79


                   ....*
gi 1861232994  153 LIFIN 157
Cdd:smart00650  80 KVVGN 84
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-215 2.73e-81

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 240.76  E-value: 2.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  13 DSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldgRPARYVMKASPLAKLLQLAAVSKDDVVLEVG 92
Cdd:COG2518     1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPI------GHGQTISQPYIVARMLEALDLKPGDRVLEIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  93 GGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLR 172
Cdd:COG2518    75 TGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLA 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1861232994 173 DGGRLVVVVGYGNAAKATVYRRDGNSTSAASFFNASVKPVPGF 215
Cdd:COG2518   155 PGGRLVAPVGEGGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-198 2.77e-48

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 157.67  E-value: 2.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   1 MMDFETARANMVDsQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQI-CSAldgrparYVmkASPL--AKLL 77
Cdd:PRK00312    2 RLMESERFARLVL-RLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIgCGQ-------TI--SQPYmvARMT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  78 QLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFIN 157
Cdd:PRK00312   72 ELLELKPGDRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVT 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1861232994 158 GSVEEVPAALTDQLRDGGRLVVVVGYGNAAKATVYRRDGNS 198
Cdd:PRK00312  152 AAAPEIPRALLEQLKEGGILVAPVGGEEQQLLTRVRKRGGR 192
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
21-197 2.54e-41

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 139.43  E-value: 2.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  21 VTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldGRPArYVMKASPLAKLLQLAAVSKDDVVLEVGGGSGYAAA 100
Cdd:pfam01135  16 IKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSI-----GYGQ-TISAPHMHAMMLELLELKPGMRVLEIGSGSGYLTA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994 101 ILSQLA---GSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLRDGGRL 177
Cdd:pfam01135  90 CFARMVgevGRVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRL 169

                         170       180
                  ....*....|....*....|
gi 1861232994 178 VVVVGYGNAAKATVYRRDGN 197
Cdd:pfam01135 170 VIPVGPNGNQVLQQFDKRND 189
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 2-196 3.46e-40

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 136.88  E-value: 3.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   2 MDFETARANMVDSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQIcsaldgRPARYVMKASPLAKLLQLAA 81
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEI------GYGQTISAPHMVAMMTELLE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  82 VSKDDVVLEVGGGSGYAAAILSQL---AGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFING 158
Cdd:TIGR00080  75 LKPGMKVLEIGTGSGYQAAVLAEIvgrDGLVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTA 154

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1861232994 159 SVEEVPAALTDQLRDGGRLVVVVGYGNAAKATVYRRDG 196
Cdd:TIGR00080 155 AGPKIPEALIDQLKEGGILVMPVGEYLQVLKRAEKRGG 192
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 2-182 6.01e-39

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 133.60  E-value: 6.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   2 MDFETARANMVDsQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQI-----CSALDgrparyvMKASpLAKL 76
Cdd:PRK13942    1 MPLEEKRRVIEE-LIREGYIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIgygqtISAIH-------MVAI-MCEL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  77 LQLaavSKDDVVLEVGGGSGYAAAILSQLAGS---VVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDL 153
Cdd:PRK13942   72 LDL---KEGMKVLEIGTGSGYHAAVVAEIVGKsgkVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTLGYEENAPYDR 148

                         170       180
                  ....*....|....*....|....*....
gi 1861232994 154 IFINGSVEEVPAALTDQLRDGGRLVVVVG 182
Cdd:PRK13942  149 IYVTAAGPDIPKPLIEQLKDGGIMVIPVG 177
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 8-201 3.75e-28

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 109.38  E-value: 3.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   8 RANMVDSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADED-LQICSALDGRPARYVMKASPLAKLLQLAAVSKDD 86
Cdd:TIGR04364   5 RAALVDELREDGVIRSPRVEAAFRTVPRHLFAPGAPLEKAYAANRaVVTKRDEDGRALSSVSAPHIQAMMLEQAGVEPGM 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  87 VVLEVGGGsGYAAAILSQL---AGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEV 163
Cdd:TIGR04364  85 RVLEIGSG-GYNAALLAELvgpSGEVTTVDIDEDVTDRARACLAAAGYPQVTVVLADAEAGVPELAPYDRIIVTVGAWDI 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1861232994 164 PAALTDQLRDGGRLVVVVGYGNAAKATVYRRDGN---STSA 201
Cdd:TIGR04364 164 PPAWLDQLAPGGRLVVPLRMRGLTRSIAFERAGDhlvSVSA 204
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 23-179 1.02e-26

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 104.54  E-value: 1.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  23 SHSVLKAFLSVPREAFVPAGVrQIAYADEDLQICSALDGRPARYVMKASPLAKLLQLAAVSKDDVVLEVGGGSGYAAAIL 102
Cdd:PRK13943   20 SDHIAKAFLEVPREEFLTKSY-PLSYVYEDIVLVSYDDGEEYSTSSQPSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVM 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994 103 SQLAGS---VVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAALTDQLRDGGRLVV 179
Cdd:PRK13943   99 SRVVGEkglVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLKEGGRVIV 178
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 7-181 1.38e-21

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 88.33  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   7 ARANMVDSQLRTTDVTSHSVLKAFLSVPREAFVPAGVRQIAYADEDLQICSALDGRPARYVmkasplAKLLQLAAVSKDD 86
Cdd:PRK13944    1 MAKRLVEELVREGIIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMV------AMMCELIEPRPGM 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  87 VVLEVGGGSGYAAAILSQ---LAGSVVSLESDEALAAQATETLASLGYDN-VAVVTGDLAKGYAGEAPYDLIFINGSVEE 162
Cdd:PRK13944   75 KILEVGTGSGYQAAVCAEaieRRGKVYTVEIVKELAIYAAQNIERLGYWGvVEVYHGDGKRGLEKHAPFDAIIVTAAAST 154

                         170
                  ....*....|....*....
gi 1861232994 163 VPAALTDQLRDGGRLVVVV 181
Cdd:PRK13944  155 IPSALVRQLKDGGVLVIPV 173
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 88-181 6.65e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.42  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  88 VLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLgydNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVP--- 164
Cdd:COG2227    28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPdpa 104

                          90       100
                  ....*....|....*....|
gi 1861232994 165 ---AALTDQLRDGGRLVVVV 181
Cdd:COG2227   105 allRELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 74-180 8.08e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.78  E-value: 8.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  74 AKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYdNVAVVTGDLAKGYAGEAPYDL 153
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1861232994 154 IFINGSVEEVP------AALTDQLRDGGRLVVV 180
Cdd:COG2226    91 VISSFVLHHLPdperalAEIARVLKPGGRLVVV 123
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 76-180 1.48e-10

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 57.89  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  76 LLQLAAVSKDDVVLEVGGGSGYAAAILSQLA---GSVVSLESDEALAAQATETLASLGY-DNVAVVTGD---LAKGYAGE 148
Cdd:COG4122     8 LYLLARLLGAKRILEIGTGTGYSTLWLARALpddGRLTTIEIDPERAAIARENFARAGLaDRIRLILGDaleVLPRLADG 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1861232994 149 aPYDLIFINGSVEEVPAALT---DQLRDGGrLVVV 180
Cdd:COG4122    88 -PFDLVFIDADKSNYPDYLElalPLLRPGG-LIVA 120
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 73-179 6.38e-10

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 57.87  E-value: 6.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  73 LAKLlqlaAVSKDDVVLEVGGGSGyAAAI---LSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGYAGEA 149
Cdd:COG2242   240 LAKL----ALRPGDVLWDIGAGSG-SVSIeaaRLAPGGRVYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALADLP 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1861232994 150 PYDLIFINGSVEEVPA---ALTDQLRDGGRLVV 179
Cdd:COG2242   315 DPDAVFIGGSGGNLPEileACWARLRPGGRLVA 347
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
88-181 9.82e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 9.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  88 VLEVGGGSGYAAAILSQL--AGSVVSLESDEALAAQATETLAslgydNVAVVTGDLAkGYAGEAPYDLIFINGS---VEE 162
Cdd:COG4106     5 VLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLP-----NVRFVVADLR-DLDPPEPFDLVVSNAAlhwLPD 78

                          90       100
                  ....*....|....*....|..
gi 1861232994 163 VPAALT---DQLRDGGRLVVVV 181
Cdd:COG4106    79 HAALLArlaAALAPGGVLAVQV 100
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-181 9.15e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 9.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  88 VLEVGGGSGY-AAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKG-YAGEAPYDLIFINGS----VE 161
Cdd:cd02440     2 VLDLGCGTGAlALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPlhhlVE 81

                          90       100
                  ....*....|....*....|...
gi 1861232994 162 EVPAALT---DQLRDGGRLVVVV 181
Cdd:cd02440    82 DLARFLEearRLLKPGGVLVLTL 104
rADc smart00650
Ribosomal RNA adenine dimethylases;
73-157 1.06e-08

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 52.51  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994   73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLAslGYDNVAVVTGDLAKGYAGEAPYD 152
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA--AADNLTVIHGDALKFDLPKLQPY 79


                   ....*
gi 1861232994  153 LIFIN 157
Cdd:smart00650  80 KVVGN 84
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 50-182 1.17e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 52.24  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  50 DEDLQICSALDGRPARYvMKASPLAKL---LQLAAVSKDDVVLEVGGGSGYAAAILSQLAG-SVVSLESDEALAAQATET 125
Cdd:COG2230    15 DPTMTYSCAYFEDPDDT-LEEAQEAKLdliLRKLGLKPGMRVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARER 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1861232994 126 LASLGY-DNVAVVTGDLAKgYAGEAPYDLIFINGSVEEVP--------AALTDQLRDGGRLVVVVG 182
Cdd:COG2230    94 AAEAGLaDRVEVRLADYRD-LPADGQFDAIVSIGMFEHVGpenypayfAKVARLLKPGGRLLLHTP 158
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
80-140 2.58e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 52.35  E-value: 2.58e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1861232994  80 AAVSKDDVVLEVGGGSGyaaaILSQLA-----GSVVSLESDEALAAQATETLASLGY-DNVAVVTGD 140
Cdd:COG4076    31 RVVKPGDVVLDIGTGSG----LLSMLAaragaKKVYAVEVNPDIAAVARRIIAANGLsDRITVINAD 93
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 77-181 3.49e-08

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 52.08  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  77 LQLAAVSKDDVVLEVGGGSGY-AAAILSQLA--GSVVSLESDEALAAQATETLASLG-YDNVAVVTGDLAKGYaGEAPYD 152
Cdd:COG2519    84 IARLDIFPGARVLEAGTGSGAlTLALARAVGpeGKVYSYERREDFAEIARKNLERFGlPDNVELKLGDIREGI-DEGDVD 162

                          90       100       110
                  ....*....|....*....|....*....|
gi 1861232994 153 LIFIN-GSVEEVPAALTDQLRDGGRLVVVV 181
Cdd:COG2519   163 AVFLDmPDPWEALEAVAKALKPGGVLVAYV 192
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 64-180 3.62e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  64 ARYVMKASP--LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGS-VVSLESDEALAAQATETLASLGYDNVAVVTGD 140
Cdd:COG0500     4 SYYSDELLPglAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGrVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1861232994 141 LAK-GYAGEAPYDLIFINGSVEEVP--------AALTDQLRDGGRLVVV 180
Cdd:COG0500    84 LAElDPLPAESFDLVVAFGVLHHLPpeereallRELARALKPGGVLLLS 132
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 73-140 5.98e-08

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 51.66  E-value: 5.98e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1861232994  73 LAKLLQLAAVSKDDVVLEVGGGSGyaaAI---LSQLAGSVVSLESDEALAAQATETLAslGYDNVAVVTGD 140
Cdd:COG0030    26 IRRIVDAAGITPGDTVLEIGPGLG---ALtraLLERAARVTAVEIDRRLAAILRETFA--AYPNLTVIEGD 91
PRK14968 PRK14968
putative methyltransferase; Provisional
 76-157 1.13e-07

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 50.28  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  76 LLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDN--VAVVTGDLAKGYAGEApYDL 153
Cdd:PRK14968   15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFEPFRGDK-FDV 93


                  ....
gi 1861232994 154 IFIN 157
Cdd:PRK14968   94 ILFN 97
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 79-180 2.39e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 49.76  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  79 LAA---VSKDDVVLEVGGGSGYAAAILSQ--LAGSVVSLESDEALAAQATETLASLGYDN-VAVVTGDL--AKGYAGEAP 150
Cdd:COG4123    29 LAAfapVKKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLkeFAAELPPGS 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1861232994 151 YDLIFIN-------------------------GSVEEVPAALTDQLRDGGRLVVV 180
Cdd:COG4123   109 FDLVVSNppyfkagsgrkspdearaiarhedaLTLEDLIRAAARLLKPGGRFALI 163
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-175 4.68e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.40  E-value: 4.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  88 VLEVGGGSGYAAAILSQLAG-SVVSLESDEALAAQATETLASLGYdNVAVVTGDLAKGYAGEAPYDLIFINGSVEEVPAA 166
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 1861232994 167 LTDQ--------LRDGG 175
Cdd:pfam13649  80 DLEAalreiarvLKPGG 96
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 73-169 4.69e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 49.40  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGYDNVAVVTGDLAK---GYAGEA 149
Cdd:COG2265   222 YAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEvlpELLWGG 301

                          90       100
                  ....*....|....*....|....
gi 1861232994 150 PYDLIFIN----GSVEEVPAALTD 169
Cdd:COG2265   302 RPDVVVLDppraGAGPEVLEALAA 325
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
73-140 6.86e-07

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 48.74  E-value: 6.86e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1861232994  73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASlgYDNVAVVTGD 140
Cdd:PRK14896   18 VDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIA--AGNVEIIEGD 83
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
47-186 8.99e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 47.30  E-value: 8.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  47 AYADE-DLQICSALDGR-PARYVmkasplAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQAte 124
Cdd:COG4976    13 QYADSyDAALVEDLGYEaPALLA------EELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKA-- 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1861232994 125 tLASLGYDNVAVvtGDLAKGYAGEAPYDLIFINGS------VEEVPAALTDQLRDGGRLVVVVGYGNA 186
Cdd:COG4976    85 -REKGVYDRLLV--ADLADLAEPDGRFDLIVAADVltylgdLAAVFAGVARALKPGGLFIFSVEDADG 149
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 83-179 1.14e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  83 SKDDVVLEVGGGSGYAAAILSQLAGS---VVSLESDEALAAQATETLASLGYDNVAVVTGD---LAKGYAGEaPYDLIFI 156
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDieeLPELLEDD-KFDVVIS 80

                          90       100
                  ....*....|....*....|....*....
gi 1861232994 157 NGSVEEVPA------ALTDQLRDGGRLVV 179
Cdd:pfam13847  81 NCVLNHIPDpdkvlqEILRVLKPGGRLII 109
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
73-157 3.39e-06

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 46.59  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLasLGYDNVAVVTGDlakGYAGEAPYD 152
Cdd:pfam00398  19 INEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKL--SLDENLTVIHQD---FLKFEFPSL 93


                  ....*
gi 1861232994 153 LIFIN 157
Cdd:pfam00398  94 VTHIH 98
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 76-181 1.35e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 44.03  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  76 LLQLAAVSKDDVVLEVGGGSGY-AAAILSQLAGSVVSL--ESDEALAAqATETLASLGYDNVAVVTGDLAKGYAGEaPYD 152
Cdd:COG2813    41 LLEHLPEPLGGRVLDLGCGYGViGLALAKRNPEARVTLvdVNARAVEL-ARANAAANGLENVEVLWSDGLSGVPDG-SFD 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1861232994 153 LIFIN-----GSVEEVPAALT------DQLRDGGRLVVVV 181
Cdd:COG2813   119 LILSNppfhaGRAVDKEVAHAliadaaRHLRPGGELWLVA 158
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 87-179 1.92e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.53  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  87 VVLEVGGGSGyaaAI----LSQLAGSVVSLESDEALAAQATETLASLGY-DNVAVVTGD---LAKGYAGEaPYDLIFI-- 156
Cdd:COG0742    44 RVLDLFAGSG---ALgleaLSRGAASVVFVEKDRKAAAVIRKNLEKLGLeDRARVIRGDalrFLKRLAGE-PFDLVFLdp 119

                          90       100
                  ....*....|....*....|....*...
gi 1861232994 157 ---NGSVEEVPAALTDQ--LRDGGRLVV 179
Cdd:COG0742   120 pyaKGLLEKALELLAENglLAPGGLIVV 147
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 89-177 1.51e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 39.66  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  89 LEVGGGSGYAAAILSQLA--GSVVSLESDEALAAQATETLASLGYDNVAVVTGD-LAKGYAGEAPYDLIFINGSVEEVP- 164
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpgLEYTGLDISPAALEAARERLAALGLLNAVRVELFqLDLGELDPGSFDVVVASNVLHHLAd 80

                          90
                  ....*....|....*...
gi 1861232994 165 -----AALTDQLRDGGRL 177
Cdd:pfam08242  81 pravlRNIRRLLKPGGVL 98
PRK08317 PRK08317
hypothetical protein; Provisional
 74-180 2.30e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 41.08  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  74 AKLLQLAAVSKDDVVLEVGGGSGYAAAILSQL---AGSVVSLESDEALAAQATETLASLGyDNVAVVTGDLAKGYAGEAP 150
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLG-PNVEFVRGDADGLPFPDGS 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1861232994 151 YDLIFINGS---VEEVPAALTDQ---LRDGGRLVVV 180
Cdd:PRK08317   88 FDAVRSDRVlqhLEDPARALAEIarvLRPGGRVVVL 123
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 73-140 3.08e-04

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 40.76  E-value: 3.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1861232994  73 LAKLLQLAAVSKDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLG-YDNVAVVTGD 140
Cdd:PTZ00338   25 LDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFQNSPlASKLEVIEGD 93
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 84-157 5.13e-04

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 39.45  E-value: 5.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1861232994  84 KDDVVLEVGGGSGYAAAILSQLAGSVVSLESDEAlAAQATETLASLGYDNVAVVTGDLAKGYAGEapYDLIFIN 157
Cdd:TIGR00537  19 KPDDVLEIGAGTGLVAIRLKGKGKCILTTDINPF-AVKELRENAKLNNVGLDVVMTDLFKGVRGK--FDVILFN 89
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 89-179 8.37e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.26  E-value: 8.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  89 LEVGGGSGYAAAILSQLAGSVVSLESDEALAAQATETLASLGydnVAVVTGDLAK-GYAGEApYDLIFINGS---VEEVP 164
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREG---LTFVVGDAEDlPFPDNS-FDLVLSSEVlhhVEDPE 76

                          90
                  ....*....|....*...
gi 1861232994 165 AALTD---QLRDGGRLVV 179
Cdd:pfam08241  77 RALREiarVLKPGGILII 94
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 89-181 9.03e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 37.67  E-value: 9.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  89 LEVGGGSGYAAAILSQLA-----GSVVSLESDEAlAAQATETLASLGY-DNVAVVTGDLAKGYAG--EAPYDLIFINGS- 159
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALrdnglGRLTAVDPDPG-AEEAGALLRKAGLdDRVRLIVGDSREALPSlaDGPIDLLFIDGDh 79

                          90       100
                  ....*....|....*....|....*..
gi 1861232994 160 -----VEEVPAALtDQLRDGGrlVVVV 181
Cdd:pfam13578  80 tyeavLNDLELWL-PRLAPGG--VILF 103
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 76-180 2.82e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 37.18  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861232994  76 LLQLAAVSKDDVVLEVGGGSGYAAAILSQLAG--SVVSLESDEALAAQATETLASLGYDNVAVVTGDLAKGyAGEAPYDL 153
Cdd:pfam05175  23 LLEHLPKDLSGKVLDLGCGAGVLGAALAKESPdaELTMVDINARALESARENLAANGLENGEVVASDVYSG-VEDGKFDL 101

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1861232994 154 I-----FINGSVEEVPAALT------DQLRDGGRLVVV 180
Cdd:pfam05175 102 IisnppFHAGLATTYNVAQRfiadakRHLRPGGELWIV 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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