Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477  12 LGKGQEAEVY--SYDQKRVLKLYKPTAYSKLEILKQfYESMN--SSDANFELPKIHEIIKEKDVV---LTIEKRIEGRNI 84
Cdd:COG3173    28 LSGGWSNLTYrlDTGDRLVLRRPPRGLASAHDVRRE-ARVLRalAPRLGVPVPRPLALGEDGEVIgapFYVMEWVEGETL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477  85 QKDLSNYDEQELDLFFENYLSTILSIQRIELEKQfkgikLLSDYD----EISSKDWNDFLKQSLLRKNTEVDhyLRRDVL 160
Cdd:COG3173   107 EDALPDLSPAERRALARALGEFLAALHAVDPAAA-----GLADGRpeglERQLARWRAQLRRALARTDDLPA--LRERLA 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1863079477 161 DYevkLKRLMDAfsvgyEGEYALVHGDYYPSNLLVN-ADGQINGVIDFGLMTLyGDPLFDVALSWILFDLYDELGE 235
Cdd:COG3173   180 AW---LAANLPE-----WGPPVLVHGDLRPGNLLVDpDDGRLTAVIDWELATL-GDPAADLAYLLLYWRLPDDLLG 246

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477  12 LGKGQEAEVY--SYDQKRVLKLYKPTAYSKLEILKQfYESMN--SSDANFELPKIHEIIKEKDVV---LTIEKRIEGRNI 84
Cdd:COG3173    28 LSGGWSNLTYrlDTGDRLVLRRPPRGLASAHDVRRE-ARVLRalAPRLGVPVPRPLALGEDGEVIgapFYVMEWVEGETL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477  85 QKDLSNYDEQELDLFFENYLSTILSIQRIELEKQfkgikLLSDYD----EISSKDWNDFLKQSLLRKNTEVDhyLRRDVL 160
Cdd:COG3173   107 EDALPDLSPAERRALARALGEFLAALHAVDPAAA-----GLADGRpeglERQLARWRAQLRRALARTDDLPA--LRERLA 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1863079477 161 DYevkLKRLMDAfsvgyEGEYALVHGDYYPSNLLVN-ADGQINGVIDFGLMTLyGDPLFDVALSWILFDLYDELGE 235
Cdd:COG3173   180 AW---LAANLPE-----WGPPVLVHGDLRPGNLLVDpDDGRLTAVIDWELATL-GDPAADLAYLLLYWRLPDDLLG 246

N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins; This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1863079477 178 EGEYALVHGDYYPSNLLVNADGQINGVIDFGLMTLyGDPLFDVAlsWILF 227
Cdd:cd05154   174 DGRPVLVHGDFRLGNLLFDPDGRVTAVLDWELATL-GDPLEDLA--WLLA 220

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1863079477 181 YALVHGDYYPSNLLVNADGQINGVIDFGLMTlYGDPLFDVA 221
Cdd:cd05120   111 SVLTHGDLHPGNILVKPDGKLSGIIDWEFAG-YGPPAFDYA 150

Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1863079477 183 LVHGDYYPSNLLVNaDGQINGVIDFGLMTlYGDPLFDVA---LSWI 225
Cdd:cd05153   181 VIHADLFRDNVLFD-GDRLSGIIDFYDAC-YDPLLYDLAialNDWC 224

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477  40 LEILKQFYESMNSSDANFELPKIHEIIKEkdVVLTIEK----RIEGRNIQKdlsnydeqeldlFFENY------------ 103
Cdd:cd05121    74 LRILRRLARLLERLSPLLRRLDLVAIVDE--FARSLLEeldfRREARNAER------------FRKNLkdspdvyvpkvy 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863079477 104 --LST--ILSIQRIElekqfkGIKLlSDYDEISSKDWNdflkqsllrkntevdhylRRDVLdyevklKRLMDAFsvgYEG 179
Cdd:cd05121   140 peLSTrrVLVMEYID------GVKL-TDLEALRAAGID------------------RKELA------RRLVDAY---LKQ 185

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1863079477 180 --EYALVHGDYYPSNLLVNADGQInGVIDFGLM 210
Cdd:cd05121   186 ifEDGFFHADPHPGNILVLPDGRI-ALLDFGMV 217

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1863079477 163 EVK--LKRLMDAfsVGYEGEYALVHGDYYPSNLLVNADGQINgVIDFGLMTLYGDPL 217
Cdd:cd07843   107 EVKclMLQLLSG--VAHLHDNWILHRDLKTSNLLLNNRGILK-ICDFGLAREYGSPL 160