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Conserved domains on  [gi|1864836872|ref|WP_177009963|]
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MULTISPECIES: HlyD family secretion protein [unclassified Pseudomonas]

Protein Classification

HlyD family secretion protein( domain architecture ID 11446287)

HlyD family secretion protein similar to Escherichia coli protein YhiI, Acinetobacter baumannii colistin resistance protein EmrA, and Burkholderia cepacia fusaric acid resistance protein FusE

Gene Ontology:  GO:0022857|GO:0016020|GO:0055085
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK10559 super family cl32535
p-hydroxybenzoic acid efflux pump subunit AaeA;
2-301 4.68e-68

p-hydroxybenzoic acid efflux pump subunit AaeA;


The actual alignment was detected with superfamily member PRK10559:

Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 214.22  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   2 IIKHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSY 81
Cdd:PRK10559    4 LIRKISRTAITLVLVILAFIAIFRAWVFYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  82 LLAQQQRTAELAEARSVFEQRSAQLKRRNQLG-DAIAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDG 160
Cdd:PRK10559   84 QKALAEAEADVAYYQVLAQEKRREAGRRNRLGvQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 161 YVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVGAATSIKLMGFSPLLEGHVASIGRGIADGNELRSNS 240
Cdd:PRK10559  164 WVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNSSSTRDSK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864836872 241 GLPQVAPTFSWIRLAQRVPVRIELDKvPPGVELAAGMTASIEVAEEGT------APRWRLVQWLQAF 301
Cdd:PRK10559  244 GMATIDSNLEWVRLAQRVPVRIRLDN-QQGNLYPAGTTATVVITGKQDrdasqdSPFRKLAHRLREF 309
 
Name Accession Description Interval E-value
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
2-301 4.68e-68

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 214.22  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   2 IIKHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSY 81
Cdd:PRK10559    4 LIRKISRTAITLVLVILAFIAIFRAWVFYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  82 LLAQQQRTAELAEARSVFEQRSAQLKRRNQLG-DAIAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDG 160
Cdd:PRK10559   84 QKALAEAEADVAYYQVLAQEKRREAGRRNRLGvQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 161 YVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVGAATSIKLMGFSPLLEGHVASIGRGIADGNELRSNS 240
Cdd:PRK10559  164 WVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNSSSTRDSK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864836872 241 GLPQVAPTFSWIRLAQRVPVRIELDKvPPGVELAAGMTASIEVAEEGT------APRWRLVQWLQAF 301
Cdd:PRK10559  244 GMATIDSNLEWVRLAQRVPVRIRLDN-QQGNLYPAGTTATVVITGKQDrdasqdSPFRKLAHRLREF 309
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
1-283 1.72e-54

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 180.24  E-value: 1.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   1 MIIKHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSS 80
Cdd:COG1566     1 MKALKKRRLLALVLLLLALGLALWAAGRNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  81 YLLAQQQRTAELAE---------------------------ARSVFEQRSAQLKRRNQLGD--AIAREEADNAARDLAVA 131
Cdd:COG1566    81 LQAALAQAEAQLAAaeaqlarleaelgaeaeiaaaeaqlaaAQAQLDLAQRELERYQALYKkgAVSQQELDEARAALDAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 132 RARLDAARSQ---------------------------LAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVD 184
Cdd:COG1566   161 QAQLEAAQAQlaqaqaglreeeelaaaqaqvaqaeaaLAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 185 SHSFWVTGYFEETKLAGVRVGAATSIKLMGF-SPLLEGHVASIGRGIADGNelrsnsglPQVAPTFswiRLAQRVPVRIE 263
Cdd:COG1566   241 LDDLWVEAYVPETDLGRVKPGQPVEVRVDAYpDRVFEGKVTSISPGAGFTS--------PPKNATG---NVVQRYPVRIR 309

                         330       340
                  ....*....|....*....|
gi 1864836872 264 LDKvPPGVELAAGMTASIEV 283
Cdd:COG1566   310 LDN-PDPEPLRPGMSATVEI 328
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 8-281 2.37e-43

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 151.10  E-value: 2.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   8 KTLVTLVLGLAALLFCTQLWRAYEL--APWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLA- 84
Cdd:TIGR00998   3 YFLLLLVVLLIVVAGAYAIYWFLVLrdYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAELAl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  85 ----------------------QQQRTAE-----LAEARSVFEQRSAQLKRRNQLGD--AIAREEADNAARDLAVARARL 135
Cdd:TIGR00998  83 akaeanlaalvrqtkqleitvqQLQAKVEslkikLEQAREKLLQAELDLRRRVPLFKkgLISREELDHARKALLSAKAAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 136 DAARSQ--------------------------LAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFW 189
Cdd:TIGR00998 163 NAAIQEqlnanqalvrgtplkkqpavqeakerLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQMY 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 190 VTGYFEETKLAGVRVGAATSIK--LMGFSPLLEGHVASIGRGiaDGNELrsnSGLPQVAPTFSWIRLAQRVPVRIELDK- 266
Cdd:TIGR00998 243 VEANFKETQLKNVRIGQPVTIRsdLYGSDVVFEGKVTGISMG--TGSAF---SLLPAQNATGNWIKVVQRLPVRIKLDPk 317

                         330
                  ....*....|....*..
gi 1864836872 267 --VPPGVELAAGMTASI 281
Cdd:TIGR00998 318 elDEHPLRIGLSAEVEI 334
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 34-237 7.09e-25

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 101.73  E-value: 7.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  34 PWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQID-----------RSSYLLAQQQR-------------- 88
Cdd:pfam00529   9 EAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDptdyqaaldsaEAQLAKAQAQVarlqaeldrlqale 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  89 -------------TAELAEARSVFEQRSAQLKR-RNQLG--------DAIAREEADNAARDLAVARARLDA--------- 137
Cdd:pfam00529  89 selaisrqdydgaTAQLRAAQAAVKAAQAQLAQaQIDLArrrvlapiGGISRESLVTAGALVAQAQANLLAtvaqldqiy 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 138 ---------------------------ARSQLAHARLDLDRTTIRSPVDGYVTQLRLQP-GDYAAAGETNIFVVDSHSFW 189
Cdd:pfam00529 169 vqitqsaaenqaevrselsgaqlqiaeAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVPEDNLL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1864836872 190 VTGYFEETKLAGVRVGAATSIKLMGFSPLLEGHVASIGRGIADGNELR 237
Cdd:pfam00529 249 VPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPV 296
 
Name Accession Description Interval E-value
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
2-301 4.68e-68

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 214.22  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   2 IIKHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSY 81
Cdd:PRK10559    4 LIRKISRTAITLVLVILAFIAIFRAWVFYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  82 LLAQQQRTAELAEARSVFEQRSAQLKRRNQLG-DAIAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDG 160
Cdd:PRK10559   84 QKALAEAEADVAYYQVLAQEKRREAGRRNRLGvQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 161 YVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVGAATSIKLMGFSPLLEGHVASIGRGIADGNELRSNS 240
Cdd:PRK10559  164 WVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNSSSTRDSK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864836872 241 GLPQVAPTFSWIRLAQRVPVRIELDKvPPGVELAAGMTASIEVAEEGT------APRWRLVQWLQAF 301
Cdd:PRK10559  244 GMATIDSNLEWVRLAQRVPVRIRLDN-QQGNLYPAGTTATVVITGKQDrdasqdSPFRKLAHRLREF 309
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
1-283 1.72e-54

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 180.24  E-value: 1.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   1 MIIKHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSS 80
Cdd:COG1566     1 MKALKKRRLLALVLLLLALGLALWAAGRNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  81 YLLAQQQRTAELAE---------------------------ARSVFEQRSAQLKRRNQLGD--AIAREEADNAARDLAVA 131
Cdd:COG1566    81 LQAALAQAEAQLAAaeaqlarleaelgaeaeiaaaeaqlaaAQAQLDLAQRELERYQALYKkgAVSQQELDEARAALDAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 132 RARLDAARSQ---------------------------LAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVD 184
Cdd:COG1566   161 QAQLEAAQAQlaqaqaglreeeelaaaqaqvaqaeaaLAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 185 SHSFWVTGYFEETKLAGVRVGAATSIKLMGF-SPLLEGHVASIGRGIADGNelrsnsglPQVAPTFswiRLAQRVPVRIE 263
Cdd:COG1566   241 LDDLWVEAYVPETDLGRVKPGQPVEVRVDAYpDRVFEGKVTSISPGAGFTS--------PPKNATG---NVVQRYPVRIR 309

                         330       340
                  ....*....|....*....|
gi 1864836872 264 LDKvPPGVELAAGMTASIEV 283
Cdd:COG1566   310 LDN-PDPEPLRPGMSATVEI 328
PRK10476 PRK10476
multidrug transporter subunit MdtN;
4-283 1.86e-47

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 162.12  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   4 KHILKTLVTLVLGLAALLFCtqLWRAyELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLL 83
Cdd:PRK10476   10 RKKLPALAIVALAIVALVFV--IWRT-DSAPSTDDAYIDADVVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYEL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  84 AQQQRTAELAEA--------RSVFEQRS------AQLKRRNQLGD----------------------------------- 114
Cdd:PRK10476   87 TVAQAQADLALAdaqimttqRSVDAERSnaasanEQVERARANAKlatrtlerlepllakgyvsaqqvdqartaqrdaev 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 115 --AIAREEADNAAR---DLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFW 189
Cdd:PRK10476  167 slNQALLQAQAAAAavgGVDALVAQRAAREAALAIAELHLEDTTVRAPFDGRVVGLKVSVGEFAAPMQPIFTLIDTDHWY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 190 VTGYFEETKLAGVRVGAATSIKLM-GFSPLLEGHVASIGRGIADGNELRSNSGLPQVAPTFSWIRLAQRVPVRIELDKVP 268
Cdd:PRK10476  247 AIANFRETDLKNIRVGDCATVYSMiDRGRPFEGKVDSIGWGVLPDDGGNVPRGLPYVPRSINWVRVAQRFPVRIMLDKPD 326

                         330
                  ....*....|....*
gi 1864836872 269 PGVeLAAGMTASIEV 283
Cdd:PRK10476  327 PEL-FRIGASAVVEL 340
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 8-281 2.37e-43

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 151.10  E-value: 2.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   8 KTLVTLVLGLAALLFCTQLWRAYEL--APWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLA- 84
Cdd:TIGR00998   3 YFLLLLVVLLIVVAGAYAIYWFLVLrdYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAELAl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  85 ----------------------QQQRTAE-----LAEARSVFEQRSAQLKRRNQLGD--AIAREEADNAARDLAVARARL 135
Cdd:TIGR00998  83 akaeanlaalvrqtkqleitvqQLQAKVEslkikLEQAREKLLQAELDLRRRVPLFKkgLISREELDHARKALLSAKAAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 136 DAARSQ--------------------------LAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFW 189
Cdd:TIGR00998 163 NAAIQEqlnanqalvrgtplkkqpavqeakerLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQMY 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 190 VTGYFEETKLAGVRVGAATSIK--LMGFSPLLEGHVASIGRGiaDGNELrsnSGLPQVAPTFSWIRLAQRVPVRIELDK- 266
Cdd:TIGR00998 243 VEANFKETQLKNVRIGQPVTIRsdLYGSDVVFEGKVTGISMG--TGSAF---SLLPAQNATGNWIKVVQRLPVRIKLDPk 317

                         330
                  ....*....|....*..
gi 1864836872 267 --VPPGVELAAGMTASI 281
Cdd:TIGR00998 318 elDEHPLRIGLSAEVEI 334
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 39-294 2.09e-39

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 140.46  E-value: 2.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  39 GRVSA-QVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQL--GDA 115
Cdd:COG0845    16 GTVEArREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAKAELERYKALlkKGA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 116 IAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFE 195
Cdd:COG0845    96 VSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFTIADLDPLEVEFDVP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 196 ETKLAGVRVGAATSIKLMGFS-PLLEGHVASIGrgiadgnelrsnsglPQVAPTfswirlAQRVPVRIELDkvPPGVELA 274
Cdd:COG0845   176 ESDLARLKVGQPVTVTLDAGPgKTFEGKVTFID---------------PAVDPA------TRTVRVRAELP--NPDGLLR 232

                         250       260
                  ....*....|....*....|
gi 1864836872 275 AGMTASIEVAEEGTAPRWRL 294
Cdd:COG0845   233 PGMFVRVRIVLGERENALLV 252
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
6-265 1.18e-29

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 115.95  E-value: 1.18e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   6 ILKTLVTLVLGLAALLFCTQLWRAYELapwTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQ 85
Cdd:PRK15136   25 LLLTLLFIIIGVAYGIYWFLVLRHHQE---TDDAYVAGNQVQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDAEQAF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  86 QQRTAELAEA---------------------RSVFEQRSAQLKRRNQLG--DAIAREEADNAARDLAVARARLDAAR--- 139
Cdd:PRK15136  102 EKAKTALANSvrqthqlminskqyqanielqKTALAQAQSDLNRRVPLGnaNLIGREELQHARDAVASAQAQLDVAIqqy 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 140 ----------------------SQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEET 197
Cdd:PRK15136  182 nanqamilntpledqpavqqaaTEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPTTPLMAVVPATNLWVDANFKET 261

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 198 KLAGVRVGAATSI--KLMGFSPLLEGHVASIGRGIADGNELrsnsgLPQVAPTFSWIRLAQRVPVRIELD 265
Cdd:PRK15136  262 QLANMRIGQPATItsDIYGDDVVYTGKVVGLDMGTGSAFSL-----LPAQNATGNWIKVVQRLPVRIELD 326
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 48-217 2.03e-29

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 113.95  E-value: 2.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  48 IAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQL--GDAIAREEADNAA 125
Cdd:TIGR01730  29 LAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQLELAQRSFERAERLvkRNAVSQADLDDAK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 126 RDLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVG 205
Cdd:TIGR01730 109 AAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDPLEADFSVPERDLPQLRRG 188

                         170
                  ....*....|..
gi 1864836872 206 AATSIKLMGFSP 217
Cdd:TIGR01730 189 QTLTVELDALPG 200
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 34-237 7.09e-25

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 101.73  E-value: 7.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  34 PWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQID-----------RSSYLLAQQQR-------------- 88
Cdd:pfam00529   9 EAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDptdyqaaldsaEAQLAKAQAQVarlqaeldrlqale 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  89 -------------TAELAEARSVFEQRSAQLKR-RNQLG--------DAIAREEADNAARDLAVARARLDA--------- 137
Cdd:pfam00529  89 selaisrqdydgaTAQLRAAQAAVKAAQAQLAQaQIDLArrrvlapiGGISRESLVTAGALVAQAQANLLAtvaqldqiy 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 138 ---------------------------ARSQLAHARLDLDRTTIRSPVDGYVTQLRLQP-GDYAAAGETNIFVVDSHSFW 189
Cdd:pfam00529 169 vqitqsaaenqaevrselsgaqlqiaeAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVPEDNLL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1864836872 190 VTGYFEETKLAGVRVGAATSIKLMGFSPLLEGHVASIGRGIADGNELR 237
Cdd:pfam00529 249 VPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPV 296
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 4-199 3.88e-13

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 68.84  E-value: 3.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872   4 KHILKTLVTLVLGLAALLFCTQLWRAYELAPWTRDGRVSAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLL 83
Cdd:PRK03598    2 KKKVVIGLAVVVLAAAVAGGWWWYQSRQDNGLTLYGNVDIRTVNLGFRVGGRLASLAVDEGDAVKAGQVLGELDAAPYEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  84 AQQQ-------------------RTAELAEARSVFEQRSAQL-------KRRNQL--GDAIAREEADNA--ARDLAVAR- 132
Cdd:PRK03598   82 ALMQakanvsvaqaqldlmlagyRDEEIAQARAAVKQAQAAYdyaqnfyNRQQGLwkSRTISANDLENArsSRDQAQATl 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 133 -----------------------ARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETnIFVVD-SHSF 188
Cdd:PRK03598  162 ksaqdklsqyregnrpqdiaqakASLAQAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNAGST-VFTLSlTRPV 240

                         250
                  ....*....|.
gi 1864836872 189 WVTGYFEETKL 199
Cdd:PRK03598  241 WVRAYVDERNL 251
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 39-279 7.51e-13

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 66.38  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  39 GRVSA---QVIRIAPEVSGQVEHLLV---GDnqWVAKGALLYQIDrSSYLLAQQQrtaELAEARsvfeqrsaqlkrrnQL 112
Cdd:pfam16576  10 GRVAYderRLAHVHARVEGWIEKLYVnatGD--PVKKGQPLAELY-SPELVAAQQ---EYLLAL--------------RS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 113 GDAIAREEADNAARDlavaRARL----DAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETnIFVVDSHS- 187
Cdd:pfam16576  70 GDALSKSELLRAARQ----RLRLlgmpEAQIAELERTGKVQPTVTVYAPISGVVTELNVREGMYVQPGDT-LFTIADLSt 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 188 FWVTGYFEETKLAGVRVGAATSIKLMGFS-PLLEGHVASIgrgiadgnelrsnsgLPQVAPTfswirlAQRVPVRIELDK 266
Cdd:pfam16576 145 VWVEADVPEQDLALVKVGQPAEVTLPALPgKTFEGKVDYI---------------YPTLDPK------TRTVRVRIELPN 203

                         250
                  ....*....|...
gi 1864836872 267 vpPGVELAAGMTA 279
Cdd:pfam16576 204 --PDGRLKPGMFA 214
8a0102 TIGR00999
Membrane Fusion Protein cluster 2 (function with RND porters); [Transport and binding proteins, ...
 65-227 1.87e-12

Membrane Fusion Protein cluster 2 (function with RND porters); [Transport and binding proteins, Other]


Pssm-ID: 273386 [Multi-domain]  Cd Length: 265  Bit Score: 65.92  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  65 QWVAKGALLYQIDRSSY-LLAQQQRTAE--LAEARSVFEQRSAQLKRRnqlgdAIAREEADNAARDLAVARARLDAARSQ 141
Cdd:TIGR00999   2 DPVKKGQVLAVVDSPELaKMAAELKVAQkrVELARKTYEREKKLFEQG-----VIPRQEFESAEYALEEAQAEVQAAKSE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 142 LAHARLDLDRT--TIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVGAATSIKLMGFSPlL 219
Cdd:TIGR00999  77 LRSAREAKDGSyvEVRSPFDGYITQKSVTLGDYVAPQAELFRVADLGAVWVEAEVPAKDVSRIRKGSKATVLLENGRP-L 155


                  ....*...
gi 1864836872 220 EGHVASIG 227
Cdd:TIGR00999 156 PARVDYVG 163
type_I_hlyD TIGR01843
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ...
 76-283 3.57e-11

type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130902 [Multi-domain]  Cd Length: 423  Bit Score: 63.10  E-value: 3.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  76 IDRSSYLLAQQQR----------TAELAEARSvfEQRSAQLKRRNQlgDAIAREEADNAARDlavARARLDAARSQLAHA 145
Cdd:TIGR01843 193 VSRLELLELERERaeaqgelgrlEAELEVLKR--QIDELQLERQQI--EQTFREEVLEELTE---AQARLAELRERLNKA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 146 RLDLDRTTIRSPVDGYVTQLRLQP-GDYAAAGETNIFVVDSH-SFWVTGYFEETKLAGVRVGAATSIKLMGFS----PLL 219
Cdd:TIGR01843 266 RDRLQRLIIRSPVDGTVQSLKVHTvGGVVQPGETLMEIVPEDdPLEIEAKLSPKDIGFVHVGQPAEIKFSAFPyrryGIL 345

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 220 EGHVASIGrgiadgnelrsnsglpqvAPTFSWIRLAQRV-PVRIELDKV-----PPGVELAAGMTASIEV 283
Cdd:TIGR01843 346 NGKVKSIS------------------PDTFTDERGGGPYyRVRISIDQNtlgigPKGLELSPGMPVTADI 397
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 51-165 9.72e-11

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 61.71  E-value: 9.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  51 EVSGQVEHLLVGDNQWVAKGALLYQIDRSSyllAQQQ---RTAELAEARSVFEQRSAQLK-------RRNQLG--DAIAR 118
Cdd:PRK11578   67 QVSGQLKTLSVAIGDKVKKDQLLGVIDPEQ---AENQikeVEATLMELRAQRQQAEAELKlarvtlsRQQRLAktQAVSQ 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1864836872 119 EEADNAARDLAVARAR---LDA----ARSQLAHARLDLDRTTIRSPVDGYVTQL 165
Cdd:PRK11578  144 QDLDTAATELAVKQAQigtIDAqikrNQASLDTAKTNLDYTRIVAPMAGEVTQI 197
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
42-183 4.93e-09

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 56.72  E-value: 4.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  42 SAQVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQLGDA--IARE 119
Cdd:PRK11556   84 AANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTnlVSRQ 163

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864836872 120 EADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFVV 183
Cdd:PRK11556  164 ELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVV 227
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
39-177 5.94e-09

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 56.65  E-value: 5.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  39 GRVSA-QVIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQL--GDA 115
Cdd:PRK15030   58 GRTSAyRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLlgTQY 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1864836872 116 IAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGE 177
Cdd:PRK15030  138 ISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQ 199
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
45-93 8.33e-08

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 47.82  E-value: 8.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1864836872  45 VIRIAPEVSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELA 93
Cdd:pfam13533   2 VVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
52-160 1.04e-07

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 52.49  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  52 VSGQVEHLLVGDNQWVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQL--GDAIAREEADNAARDLA 129
Cdd:PRK09578   70 VAGIVTARTYEEGQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLvrDRAVSERDYTEAVADER 149

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1864836872 130 VARARLDAARSQLAHARLDLDRTTIRSPVDG 160
Cdd:PRK09578  150 QAKAAVASAKAELARAQLQLDYATVTAPIDG 180
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 153-276 3.46e-07

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 47.74  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872 153 TIRSPVDGYVTQLRLQPGDYAAAGETNIFVVDSHSFWVTGYFEETKLAGVRVGAATSIKLMGFSPL-LEGHVASIGRGIA 231
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYtLEGKVVRISPTVD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1864836872 232 DGNelrsnsglpqvaptfswirlaQRVPVRIELDKVPPGVELAAG 276
Cdd:pfam13437  81 PDT---------------------GVIPVRVSIENPKTPIPLLPG 104
PRK09859 PRK09859
multidrug transporter subunit MdtE;
39-182 1.36e-06

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 49.33  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864836872  39 GR-VSAQVIRIAPEVSGQV--EHLLVGDNqwVAKGALLYQIDRSSYLLAQQQRTAELAEARSVFEQRSAQLKRRNQL--G 113
Cdd:PRK09859   54 GRtVPYEVAEIRPQVGGIIikRNFIEGDK--VNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLlkT 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864836872 114 DAIAREEADNAARDLAVARARLDAARSQLAHARLDLDRTTIRSPVDGYVTQLRLQPGDYAAAGETNIFV 182
Cdd:PRK09859  132 NYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLV 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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