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Conserved domains on  [gi|1865871119|ref|WP_177547395|]
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LytTR family DNA-binding domain-containing protein [Intestinibacter bartlettii]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 2.85e-59

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 186.95  E-value: 2.85e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKYEkerGTQIfLKKYLSGLDLEDSLN-LKFDIVFLDINMPGINGMELAKGIRKKDEHT 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYP---DLEV-VGEASNGEEALELLEeHKPDLVFLDIQMPGLDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  80 IIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKKVLRDSAL--------FISIKNNNDYFNINCCSIYYFD 151
Cdd:COG3279    77 PIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAeaspeekdRIFVKSGGKLVKIPLDDILYIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 152 VVNRIINIHTADTTYLcSNKTLQDFEKELDPYLFFRCYNSVIINLMYVESIKGY---EISLINGEKMPLSRSKKKDLLKK 228
Cdd:COG3279   157 AEGNYVKIHTKDKKYL-VRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNfngEVVLKNGEEIPVSRRYKKEFKEW 235
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 2.85e-59

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 186.95  E-value: 2.85e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKYEkerGTQIfLKKYLSGLDLEDSLN-LKFDIVFLDINMPGINGMELAKGIRKKDEHT 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYP---DLEV-VGEASNGEEALELLEeHKPDLVFLDIQMPGLDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  80 IIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKKVLRDSAL--------FISIKNNNDYFNINCCSIYYFD 151
Cdd:COG3279    77 PIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAeaspeekdRIFVKSGGKLVKIPLDDILYIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 152 VVNRIINIHTADTTYLcSNKTLQDFEKELDPYLFFRCYNSVIINLMYVESIKGY---EISLINGEKMPLSRSKKKDLLKK 228
Cdd:COG3279   157 AEGNYVKIHTKDKKYL-VRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNfngEVVLKNGEEIPVSRRYKKEFKEW 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 49-122 4.94e-20

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 82.20  E-value: 4.94e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:cd17532    43 LKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKR 116
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 137-228 1.75e-19

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 79.93  E-value: 1.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  137 NDYFNINCCSIYYFDVVNRIINIHTADTTYLCsNKTLQDFEKELDPYLFFRCYNSVIINLMYVESIK-----GYEISLIN 211
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLV-RGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEpwfngTYLLILKN 79

                           90
                   ....*....|....*..
gi 1865871119  212 GEKMPLSRSKKKDLLKK 228
Cdd:smart00850  80 GEEVPVSRRYLKELKER 96
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 139-230 2.33e-18

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 77.25  E-value: 2.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 139 YFNINCCSIYYFDVVNRIINIHTADTTYLCSNkTLQDFEKELDPYLFFRCYNSVIINLMYVESIK-----GYEISLINGE 213
Cdd:pfam04397   3 IILVPIDDILYIEAEDKYVTIHTANGEYLTRG-TLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDpdfngTYELTLKNGE 81

                          90
                  ....*....|....*..
gi 1865871119 214 KMPLSRSKKKDLLKKMS 230
Cdd:pfam04397  82 KIPVSRRYLKELKELLG 98
PRK14084 PRK14084
DNA-binding response regulator;
43-224 1.55e-17

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 78.64  E-value: 1.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:PRK14084   39 LEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRAT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 123 VLRDSA--------------LFISIKNNNDYFNINCCSIYYFDVVNRIINIHTADTTYLcSNKTLQDFEKELDPYLFFRC 188
Cdd:PRK14084  119 KAKDDNnasaiandmsanfdQSLPIEIDDKIHMLNQQDIIAIGVHNGITTIHTTNHKYE-TTEPLNRYEKRLNPTYFIRI 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1865871119 189 YNSVIINLMYVESIK-----GYEISLINGEKMPLSRSKKKD 224
Cdd:PRK14084  198 HRSYIINKKHIKEVEqwfnyTYQVILTNGVKMQVSRSFMKD 238
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 2.85e-59

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 186.95  E-value: 2.85e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKYEkerGTQIfLKKYLSGLDLEDSLN-LKFDIVFLDINMPGINGMELAKGIRKKDEHT 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYP---DLEV-VGEASNGEEALELLEeHKPDLVFLDIQMPGLDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  80 IIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKKVLRDSAL--------FISIKNNNDYFNINCCSIYYFD 151
Cdd:COG3279    77 PIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAeaspeekdRIFVKSGGKLVKIPLDDILYIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 152 VVNRIINIHTADTTYLcSNKTLQDFEKELDPYLFFRCYNSVIINLMYVESIKGY---EISLINGEKMPLSRSKKKDLLKK 228
Cdd:COG3279   157 AEGNYVKIHTKDKKYL-VRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNfngEVVLKNGEEIPVSRRYKKEFKEW 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 49-122 4.94e-20

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 82.20  E-value: 4.94e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:cd17532    43 LKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKR 116
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 137-228 1.75e-19

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 79.93  E-value: 1.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  137 NDYFNINCCSIYYFDVVNRIINIHTADTTYLCsNKTLQDFEKELDPYLFFRCYNSVIINLMYVESIK-----GYEISLIN 211
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLV-RGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEpwfngTYLLILKN 79

                           90
                   ....*....|....*..
gi 1865871119  212 GEKMPLSRSKKKDLLKK 228
Cdd:smart00850  80 GEEVPVSRRYLKELKER 96
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 139-230 2.33e-18

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 77.25  E-value: 2.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 139 YFNINCCSIYYFDVVNRIINIHTADTTYLCSNkTLQDFEKELDPYLFFRCYNSVIINLMYVESIK-----GYEISLINGE 213
Cdd:pfam04397   3 IILVPIDDILYIEAEDKYVTIHTANGEYLTRG-TLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDpdfngTYELTLKNGE 81

                          90
                  ....*....|....*..
gi 1865871119 214 KMPLSRSKKKDLLKKMS 230
Cdd:pfam04397  82 KIPVSRRYLKELKELLG 98
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 2-116 3.61e-18

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 77.66  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTFLDNIEMFVKKYEKERGTQIFLKKYLSGLDLEDSL----NLKFDIVFLDINMPGINGMELAKGIRKKDE 77
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIELTGKTEELLEKIkergKNGIYFLDIDIKMEEKNGLEVAQKIRKYDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1865871119  78 HTIIMFLTSLKEYVFEG--YQVEASGYLTKPISYKRFSSEL 116
Cdd:cd17533    81 YAIIIFVTTHSEFAPLTfeYKVAALDFILKPLKLEEFKKRI 121
PRK14084 PRK14084
DNA-binding response regulator;
43-224 1.55e-17

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 78.64  E-value: 1.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:PRK14084   39 LEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRAT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 123 VLRDSA--------------LFISIKNNNDYFNINCCSIYYFDVVNRIINIHTADTTYLcSNKTLQDFEKELDPYLFFRC 188
Cdd:PRK14084  119 KAKDDNnasaiandmsanfdQSLPIEIDDKIHMLNQQDIIAIGVHNGITTIHTTNHKYE-TTEPLNRYEKRLNPTYFIRI 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1865871119 189 YNSVIINLMYVESIK-----GYEISLINGEKMPLSRSKKKD 224
Cdd:PRK14084  198 HRSYIINKKHIKEVEqwfnyTYQVILTNGVKMQVSRSFMKD 238
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-108 5.70e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 73.72  E-value: 5.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   4 IAICDDESTFLDNIEMFVKKYEKERGTqiflkkYLSGLDLEDSL-NLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIM 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAE------ADDGKEALELLkEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVI 74

                          90       100
                  ....*....|....*....|....*...
gi 1865871119  83 FLTSL--KEYVFEGYQVEASGYLTKPIS 108
Cdd:pfam00072  75 ILTAHgdEDDAVEALEAGADDFLSKPFD 102
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-122 7.89e-17

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 74.24  E-value: 7.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKYEKERGTQIFLkkylsglDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKD 76
Cdd:COG4565     3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVAS-------SGEEALALlaehRPDLILLDIYLPDGDGLELLRELRARG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1865871119  77 EHTIIMFLTS--LKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:COG4565    76 PDVDVIVITAarDPETVREALRAGVVDYLIKPFTFERLREALERYLEY 123
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-106 9.03e-17

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 73.27  E-value: 9.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTFLDNIEMFVkkyEKERGTQIFLKkYLSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTII 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRIL---EWEAGFEVVGE-AENGEEaLELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKI 76

                          90       100
                  ....*....|....*....|....*..
gi 1865871119  82 MFLTSL--KEYVFEGYQVEASGYLTKP 106
Cdd:COG4753    77 IILSGYsdFEYAQEAIKLGADDYLLKP 103
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-106 3.26e-16

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 71.49  E-value: 3.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   6 ICDDESTFLDNIEMFVKKYekerGTQIFLkkYLSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFL 84
Cdd:cd00156     2 IVDDDPAIRELLKSLLERE----GYEVDT--AADGEEaLELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVL 75

                          90       100
                  ....*....|....*....|....
gi 1865871119  85 TSL--KEYVFEGYQVEASGYLTKP 106
Cdd:cd00156    76 TAKadEEDAVRALELGADDYLVKP 99
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-120 1.16e-15

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 72.25  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKyekeRGTQIFLKKylsglDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRK-- 74
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEA----AGYEVVEAA-----DGEEALELlqehRPDLILLDLEMPDMDGLELCRRLRAdp 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1865871119  75 KDEHTIIMFLTSL--KEYVFEGYQVEASGYLTKPISYKRFSSELDRVA 120
Cdd:COG3706    72 RTADIPIIFLTALddEEDRARALEAGADDYLTKPFDPEELLARVDLVA 119
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-122 2.07e-15

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 70.26  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKKYekerGTQIFLkkYLSGLDLEDSL-NLKFDIVFLDINMPGINGMELAKGIRKKDE-- 77
Cdd:COG0784     5 GKRILVVDDNPDNRELLRRLLERL----GYEVTT--AEDGAEALELLrAGPPDLILLDINMPGMDGLELLRRIRALPRlp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1865871119  78 HTIIMFLT--SLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:COG0784    79 DIPIIALTayADEEDRERALEAGADDYLTKPVDPEELLEALRRLLAR 125
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-130 6.30e-15

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 70.76  E-value: 6.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDniemfvkkyekergtqiFLKKYLSGL--------DLEDSLNL----KFDIVFLDINMPGINGMEL 68
Cdd:COG0745     1 MPRILVVEDDPDIRE-----------------LLADALEREgyevdtaaDGEEALELleeeRPDLILLDLMLPGMDGLEV 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  69 AKGIRKKDEHTIIMFLTSL--KEYVFEGYQVEASGYLTKPISYK----RFSSELDRVAKKVLRDSALF 130
Cdd:COG0745    64 CRRLRARPSDIPIIMLTARddEEDRVRGLEAGADDYLTKPFDPEellaRIRALLRRRAAEVLRVGDLL 131
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 48-122 9.48e-14

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 65.44  E-value: 9.48e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  48 NLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLK--EYVFEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:cd17536    43 EHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILSGYDdfEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEE 119
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-129 5.98e-13

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 67.30  E-value: 5.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVKkyekERGTQIFLkkYLSGLDLEDSL-NLKFDIVFLDINMPGINGMELAKGIRKKDEHT 79
Cdd:COG2204     2 MARILVVDDDPDIRRLLKELLE----RAGYEVET--AASGEEALALLrEEPPDLVLLDLRMPGMDGLELLRELRALDPDL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1865871119  80 IIMFLT--SLKEYVFEGYQVEASGYLTKPISYKrfssELDRVAKKVLRDSAL 129
Cdd:COG2204    76 PVILLTgyGDVETAVEAIKAGAFDYLTKPFDLE----ELLAAVERALERRRL 123
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 50-140 2.58e-12

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 64.03  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDE--HTIIMFLTSL--KEYVFEGYQVEASGYLTKPISykrfSSELDRVAKKVLR 125
Cdd:COG3437    50 PPDLILLDVRMPGMDGFELLRLLRADPStrDIPVIFLTALadPEDRERALEAGADDYLTKPFD----PEELLARVRNALE 125

                          90
                  ....*....|....*
gi 1865871119 126 DSALFISIKNNNDYF 140
Cdd:COG3437   126 LRRLQRELDDLVLYL 140
PRK11697 PRK11697
two-component system response regulator BtsR;
49-219 5.41e-12

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 63.33  E-value: 5.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIrkkDEHTI--IMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVaKKVLRD 126
Cdd:PRK11697   46 LKPDVVFLDIQMPRISGLELVGML---DPEHMpyIVFVTAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARL-RQERSP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119 127 SALFISIKNNN-DYfnINCCSiyyfdvVNRIINIHTADTTYLCSN-------------------KTLQdfekELDPylFF 186
Cdd:PRK11697  122 QDVLLPEAQPPlKH--IPCTG------HNRIKLLPLEEVEFVSSRlsgvhvvsaegkgfteltlKTLE----EKTP--LL 187

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1865871119 187 RCYNSVIINLMYVESIK-----GYEISLINGEKMPLSR 219
Cdd:PRK11697  188 RCHRQYLVNPAAIQEIRlldngQAEIITRSGHTVPVSR 225
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-108 9.17e-12

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 60.22  E-value: 9.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   4 IAICDDESTFLDNIEMFVkkyEKERGTQIFLKkYLSGLDLEDSLN-LKFDIVFLDINMPGINGMELAKGIRKKDEHTIIM 82
Cdd:cd17535     1 VLIVDDHPLVREGLRRLL---ESEPDIEVVGE-AADGEEALALLReLRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVI 76

                          90       100
                  ....*....|....*....|....*...
gi 1865871119  83 FLTSLKE--YVFEGYQVEASGYLTKPIS 108
Cdd:cd17535    77 VLTAHDDpeYVLRALKAGAAGYLLKDSS 104
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-106 9.44e-11

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 57.03  E-value: 9.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   6 ICDDESTFLDNIEMFVKK--YEkergtqifLKKYLSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIM 82
Cdd:cd17574     2 VVEDDEEIAELLSDYLEKegYE--------VDTAADGEEaLELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPII 73

                          90       100
                  ....*....|....*....|....*.
gi 1865871119  83 FLTSL--KEYVFEGYQVEASGYLTKP 106
Cdd:cd17574    74 MLTAKdeEEDKVLGLELGADDYITKP 99
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 52-112 3.13e-10

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 56.27  E-value: 3.13e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  52 DIVFLDINMPGINGMELAKGIrKKDEHT----IIMFLTS-LKEYVFEGYQVEASGYLTKPISYKRF 112
Cdd:cd17557    54 DLILLDLNMPRMDGFEVLREI-KADPDLrripVVVLTTSdAEEDIERAYELGANSYIVKPVDFEEF 118
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 50-116 5.10e-10

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 55.17  E-value: 5.10e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDE---HTIIMFLT--SLKEYVFEGYQVEASGYLTKPISYKRFSSEL 116
Cdd:cd17546    42 PFDLVLMDLQMPVMDGLEATRRIRELEGggrRTPIIALTanALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 50-118 5.29e-09

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 52.54  E-value: 5.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDE--HTIIMFLTSL-----KEYVFEGyqvEASGYLTKPISYKRFSSELDR 118
Cdd:cd17548    43 KPDLILMDIQLPGMDGLEATRLLKEDPAtrDIPVIALTAYamkgdREKILEA---GCDGYISKPIDTREFLETVAK 115
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 43-108 6.25e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 52.22  E-value: 6.25e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLK--EYVFEGYQVEASGYLTKPIS 108
Cdd:cd17625    34 LEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDavEDRVKGLDLGADDYLPKPFS 101
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 49-107 9.02e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 51.74  E-value: 9.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIrKKDEHT--I-IMFLTSL--KEYVFEGYQVEASGYLTKPI 107
Cdd:cd19920    41 EPPDLILLDVMMPGMDGFEVCRRL-KADPATrhIpVIFLTALtdTEDKVKGFELGAVDYITKPF 103
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 25-106 9.90e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 51.29  E-value: 9.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  25 EKERGTQIFLKKYLSG--------LDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKE 89
Cdd:cd19935     5 EDEKKLAEYLKKGLTEegyavdvaYDGEDGLHLaltnEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTardSVED 84

                          90
                  ....*....|....*..
gi 1865871119  90 YVfEGYQVEASGYLTKP 106
Cdd:cd19935    85 RV-KGLDLGADDYLVKP 100
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 42-124 1.22e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 51.53  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  42 DLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDEH--TIIMFLT-----SLKEyvfEGYQVEASGYLTKPISYK 110
Cdd:cd17562    32 DGRDALSKaqskKFDLIITDQNMPNMDGIELIKELRKLPAYkfTPILMLTtessdEKKQ---EGKAAGATGWLVKPFDPE 108

                          90
                  ....*....|....
gi 1865871119 111 RfsseLDRVAKKVL 124
Cdd:cd17562   109 Q----LLEVVKKVL 118
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 6-125 1.88e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 51.12  E-value: 1.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   6 ICDDEStflDNIEMFVKKYEKErGTQIflkkyLSGLDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDEH--T 79
Cdd:cd19937     2 VVDDEE---DIVELLKYNLEKE-GYEV-----VTAYDGEEALKRakdeKPDLIILDLMLPGIDGLEVCRILRSDPKTssI 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1865871119  80 IIMFLTSLKEYVFE--GYQVEASGYLTKPISYKRFsseLDRVaKKVLR 125
Cdd:cd19937    73 PIIMLTAKGEEFDKvlGLELGADDYITKPFSPREL---LARV-KAVLR 116
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-108 1.97e-08

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 51.05  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTFLDNIEMFVKkyekERGTQIflkkyLSGLDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDEH 78
Cdd:cd17555     2 TILVIDDDEVVRESIAAYLE----DSGFQV-----LQAADGRQGLELfrseQPDLVLCDLRMPEMDGLEVLKQITKESPD 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1865871119  79 T--IIMFLTSLKEYVFEGYQVEASGYLTKPIS 108
Cdd:cd17555    73 TpvIVVSGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 3-90 2.42e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 50.68  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDEStfldNIEMFVKKYEKERGTQIFLKKylSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTII 81
Cdd:cd17554     2 KILVVDDEE----NIRELYKEELEDEGYEVVTAG--NGEEaLEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPV 75


                  ....*....
gi 1865871119  82 MFLTSLKEY 90
Cdd:cd17554    76 IICTAYSEY 84
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 43-112 5.05e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 51.50  E-value: 5.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFL-TSLKEYVFEGYQVEASGYLTKPISYKRF 112
Cdd:COG3707    41 VELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLTaYSDPELIERALEAGVSAYLVKPLDPEDL 111
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-107 1.11e-07

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 48.65  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDEstfLDNIEMFvKKYEKERGTQIFLKKylSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIrKKDEHT-- 79
Cdd:cd17538     1 KILVVDDE---PANRELL-EALLSAEGYEVLTAD--SGQEaLALAEEELPDLILLDVMMPGMDGFEVCRRL-KEDPETrh 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1865871119  80 --IIMfLTSL--KEYVFEGYQVEASGYLTKPI 107
Cdd:cd17538    74 ipVIM-ITALddREDRIRGLEAGADDFLSKPI 104
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 51-106 1.60e-07

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 48.64  E-value: 1.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKP 106
Cdd:cd17624    43 YDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTardGVDDRV-AGLDAGADDYLVKP 100
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-120 1.75e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 48.39  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTFLDNIEMFVKKYekeRGTQIFLK--KYLSGLDLEDSLnlKFDIVFLDINMPGINGMELAKGIRKKDEHT 79
Cdd:cd19925     1 INVLIVEDDPMVAEIHRAYVEQV---PGFTVIGTagTGEEALKLLKER--QPDLILLDIYLPDGNGLDLLRELRAAGHDV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1865871119  80 IIMFLTSLKE--YVFEGYQVEASGYLTKPISYKRFSSELDRVA 120
Cdd:cd19925    76 DVIVVTAANDveTVREALRLGVVDYLIKPFTFERLRQRLERYR 118
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 2-119 1.81e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 48.49  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTFLDNIEMFVKkyekergtQIFLKKYLSGLDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDE 77
Cdd:cd19923     1 MKVLVVDDFSTMRRIIKNLLK--------ELGFNNVEEAEDGVDALEKlkagGFDFVITDWNMPNMDGLELLKTIRADGA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1865871119  78 --HTIIMFLTSL--KEYVFEGYQVEASGYLTKPISYKRFSSELDRV 119
Cdd:cd19923    73 lsHLPVLMVTAEakKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 47-106 2.68e-07

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 47.36  E-value: 2.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1865871119  47 LNLKFDIVFLDINMPGINGMELAKGIRKKD--EHTIIMFLTSlKEYVFEGYQ---VEASGYLTKP 106
Cdd:cd17602    39 LNSKPDLILIDIDMPDLDGYELCSLLRKSSalKDTPIIMLTG-KDGLVDRIRakmAGASGYLTKP 102
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-107 3.91e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 47.44  E-value: 3.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTfldNIEMFVKKYEKERGTQIFLkkYLSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHT-- 79
Cdd:cd17551     2 RILIVDDNPT---NLLLLEALLRSAGYLEVVS--FTDPREaLAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEdv 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1865871119  80 -IIMfLTSL--KEYVFEGYQVEASGYLTKPI 107
Cdd:cd17551    77 pIVM-ITADtdREVRLRALEAGATDFLTKPF 106
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 48-119 4.48e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 47.27  E-value: 4.48e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1865871119  48 NLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSL--KEYVFEGYQVEASGYLTKPISYKRFSSELDRV 119
Cdd:cd17542    43 ELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAMgqEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-106 6.16e-07

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 46.28  E-value: 6.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   4 IAICDDESTFLDNIEMFVkkyEKErGTQIflKKYLSGLDLEDSLNLKF-DIVFLDINMPGINGMELAKGIRKKDEHTIIm 82
Cdd:cd19936     1 IALVDDDRNILTSVSMAL---EAE-GFSV--ETYTDGASALDGLNARPpDLAILDIKMPRMDGMELLQRLRQKSTLPVI- 73

                          90       100
                  ....*....|....*....|....*.
gi 1865871119  83 FLTSLKEYVFE--GYQVEASGYLTKP 106
Cdd:cd19936    74 FLTSKDDEIDEvfGLRMGADDYITKP 99
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-108 6.69e-07

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 47.02  E-value: 6.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTfldnIEMFVKKYEKERGTQIFLKKYLSGLDLEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTII 81
Cdd:cd19932     1 VRVLIAEDEAL----IRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIV 76

                          90       100
                  ....*....|....*....|....*....
gi 1865871119  82 MfLTSL--KEYVFEGYQVEASGYLTKPIS 108
Cdd:cd19932    77 L-LTAYsqQDLVERAKEAGAMAYLVKPFS 104
PRK10610 PRK10610
chemotaxis protein CheY;
2-123 1.52e-06

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 46.12  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTfldnIEMFVKKYEKERGtqifLKKYLSGLDLEDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDE 77
Cdd:PRK10610    6 LKFLVVDDFST----MRRIVRNLLKELG----FNNVEEAEDGVDALNKlqagGFGFVISDWNMPNMDGLELLKTIRADGA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1865871119  78 HTIIMFLT----SLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVAKKV 123
Cdd:PRK10610   78 MSALPVLMvtaeAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKL 127
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 50-120 2.22e-06

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 45.31  E-value: 2.22e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRK-KDEHTIIMFLTSLKEYVFEGYQVEASGYLTKPISYKRFSSELDRVA 120
Cdd:cd17584    44 EFDLVITDVHMPDMDGFEFLELIRLeMDLPVIMMSADGSTSTVMKGLAHGACDYLLKPVSIEDLKNIWQHVV 115
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-125 2.39e-06

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 45.11  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   4 IAICDDESTFLDNIEMFVKKyekeRGTQIFLKkYLSGLDLEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMf 83
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTK----EGYEVVTA-YDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIM- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1865871119  84 LTSLKEYVFE--GYQVEASGYLTKPISYKrfssELDRVAKKVLR 125
Cdd:cd17614    75 LTAKDSEVDKvlGLELGADDYVTKPFSNR----ELLARVKANLR 114
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 39-105 2.42e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 45.42  E-value: 2.42e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  39 SGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKD-EHTIIMFLTS-LKEYVFEGYQVEASGYLTK 105
Cdd:cd19931    32 SGEEgIELAERLDPDLILLDLNMKGMSGLDTLKALREEGvSARIVILTVSdAEDDVVTALRAGADGYLLK 101
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 52-105 3.19e-06

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 46.56  E-value: 3.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKD-EHTIIMFLTS-LKEYVFEGYQVEASGYLTK 105
Cdd:PRK10651   54 DLILLDLNMPGMNGLETLDKLREKSlSGRIVVFSVSnHEEDVVTALKRGADGYLLK 109
PRK09483 PRK09483
response regulator; Provisional
 52-105 3.44e-06

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 46.25  E-value: 3.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEG--YQVEASGYLTK 105
Cdd:PRK09483   49 DVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLTVHTENPLPAkvMQAGAAGYLSK 104
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 3-108 4.11e-06

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 44.71  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTFLDNIEMFVKK--YEkerGTQIFLkkylSGLD-LEDSLNLKFDIVFLDINMPG-INGMELAKGIRKKdEH 78
Cdd:cd17534     2 KILIVEDEAIIALDLKEILESlgYE---VVGIAD----SGEEaIELAEENKPDLILMDINLKGdMDGIEAAREIREK-FD 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1865871119  79 TIIMFLTSL--KEYVFEGYQVEASGYLTKPIS 108
Cdd:cd17534    74 IPVIFLTAYsdEETLERAKETNPYGYLVKPFN 105
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 52-106 7.05e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 43.91  E-value: 7.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIImFLTSLKEYV--FEGYQVEASGYLTKP 106
Cdd:cd17619    46 DLVLLDINLPGKDGLSLTRELREQSEVGII-LVTGRDDEVdrIVGLEIGADDYVTKP 101
orf27 CHL00148
Ycf27; Reviewed
 3-160 7.26e-06

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 45.48  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDEStfldNIEMFVKKYEKERGTQIflkkyLSGLDLEDSLNLKF----DIVFLDINMPGINGMELAKGIRKKDEH 78
Cdd:CHL00148    8 KILVVDDEA----YIRKILETRLSIIGYEV-----ITASDGEEALKLFRkeqpDLVILDVMMPKLDGYGVCQEIRKESDV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  79 TIIMfLTSLKEYV--FEGYQVEASGYLTKPISYKrfssELDRVAKKVLRDSalfisiknNNDYFNINCCSIYYFDVVNRI 156
Cdd:CHL00148   79 PIIM-LTALGDVSdrITGLELGADDYVVKPFSPK----ELEARIRSVLRRT--------NKKSFSSKIPNSSIIRIGFLK 145


                  ....
gi 1865871119 157 INIH 160
Cdd:CHL00148  146 IDLN 149
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 43-106 8.30e-06

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 43.83  E-value: 8.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSLKEYV--FEGYQVEASGYLTKP 106
Cdd:cd17623    35 LAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLM-LTARGDDIdrILGLELGADDYLPKP 99
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 50-106 9.26e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 43.14  E-value: 9.26e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDE--HTIIMFLTS--LKEYVFEGYQVEASGYLTKP 106
Cdd:cd19927    42 IPDLIISDIIMPGVDGYSLLGKLRKNADfdTIPVIFLTAkgMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 43-108 1.37e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 43.14  E-value: 1.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSLKEYVFE--GYQVEASGYLTKPIS 108
Cdd:cd17622    37 LEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILL-LTALDSDIDHilGLELGADDYVVKPVE 103
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 48-108 1.91e-05

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 42.45  E-value: 1.91e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1865871119  48 NLKFDIVFLDINMPGINGMELAKGIRKKD--EHTIIMFLTslkeyvfeGY-------QVEASGY---LTKPIS 108
Cdd:cd17580    40 RFRPDVILSDIGMPGMDGYELARRLRELPwlANTPAIALT--------GYgqpedreRALEAGFdahLVKPVD 104
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-72 2.09e-05

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 42.96  E-value: 2.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1865871119   1 MLKIAICDDESTFLDNIEMFVkkyEKERGTQIfLKKYLSGLDLEDSL-NLKFDIVFLDINMPGINGMELAKGI 72
Cdd:COG2197     1 MIRVLIVDDHPLVREGLRALL---EAEPDIEV-VGEAADGEEALELLeELRPDVVLLDIRMPGMDGLEALRRL 69
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 52-106 2.61e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 42.37  E-value: 2.61e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKP 106
Cdd:cd17627    44 DAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTardSVSDRV-AGLDAGADDYLVKP 100
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
25-105 3.14e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 43.71  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  25 EKERGTQIFLKKYLSGLDLEDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEG--YQVEASGY 102
Cdd:PRK09935   24 QKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSECFYAGraIQAGANGF 103


                  ...
gi 1865871119 103 LTK 105
Cdd:PRK09935  104 VSK 106
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 25-131 3.45e-05

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 43.76  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  25 EKERGTQIFLKKYLSG----LDLED--------SLNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLK--EY 90
Cdd:PRK09836    7 EDEKKTGEYLTKGLTEagfvVDLADnglngyhlAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALGtiEH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1865871119  91 VFEGYQVEASGYLTKPISykrFSSELDRVAKKVLRDSALFI 131
Cdd:PRK09836   87 RVKGLELGADDYLVKPFA---FAELLARVRTLLRRGAAVII 124
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 50-110 4.10e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 41.85  E-value: 4.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRkKDEHT----IIMfLT--SLKEYVFEGYQVEASGYLTKPISYK 110
Cdd:cd17618    44 RPDLILLDWMLPGGSGIQFIRRLK-RDEMTrdipIIM-LTarGEEEDKVRGLEAGADDYITKPFSPR 108
PRK11173 PRK11173
two-component response regulator; Provisional
 52-106 4.68e-05

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 43.08  E-value: 4.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEhTIIMFLTSLKEYVFE--GYQVEASGYLTKP 106
Cdd:PRK11173   49 NLVIMDINLPGKNGLLLARELREQAN-VALMFLTGRDNEVDKilGLEIGADDYITKP 104
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 51-106 5.60e-05

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 41.50  E-value: 5.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKP 106
Cdd:cd19934    43 YDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTardSWQDKV-EGLDAGADDYLTKP 100
PRK15479 PRK15479
transcriptional regulator TctD;
53-128 7.16e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 42.40  E-value: 7.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  53 IVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKPISYkrfsSELDRVAKKVLRDSA 128
Cdd:PRK15479   47 LAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTarsAVADRV-KGLNVGADDYLPKPFEL----EELDARLRALLRRSA 120
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
52-106 7.82e-05

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 43.30  E-value: 7.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEY--VFEGYQVEASGYLTKP 106
Cdd:PRK11361   50 DVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYAEVetAVEALRCGAFDYVIKP 106
PRK10336 PRK10336
two-component system response regulator QseB;
51-122 8.30e-05

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 42.57  E-value: 8.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKPISYKRFSSELDRVAKK 122
Cdd:PRK10336   45 YDAVILDLTLPGMDGRDILREWREKGQREPVLILTardALAERV-EGLRLGADDYLCKPFALIEVAARLEALMRR 118
PRK15347 PRK15347
two component system sensor kinase;
2-129 1.60e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 42.32  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   2 LKIAICDDESTFLDNIEMFVKkyekERGTQIFLKKylSGLD-LEDSLNLKFDIVFLDINMPGINGMELAKGIRKK----D 76
Cdd:PRK15347  691 LQILLVDDVETNRDIIGMMLV----ELGQQVTTAA--SGTEaLELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDpnnlD 764

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  77 EHTIIMFLTSlKEYVFEGYQVEASG---YLTKPISYKRFSSELDRVAK-KVLRDSAL 129
Cdd:PRK15347  765 PDCMIVALTA-NAAPEEIHRCKKAGmnhYLTKPVTLAQLARALELAAEyQLLRGIEL 820
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 52-108 1.81e-04

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 40.05  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEY-VFEGYQVEASGYLTKPIS 108
Cdd:cd19938    45 DLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTARVEEIdRLLGLELGADDYICKPYS 102
PRK10766 PRK10766
two-component system response regulator TorR;
3-106 2.17e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 41.18  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTfldnIEMFVKKYEKERGTQIFLKKylSGLDLEDSLNL-KFDIVFLDINMPGINGMELAKGIRKKDEHTII 81
Cdd:PRK10766    4 HILVVEDEPV----TRARLQGYFEQEGYTVSEAA--SGAGMREIMQNqHVDLILLDINLPGEDGLMLTRELRSRSTVGII 77

                          90       100
                  ....*....|....*....|....*..
gi 1865871119  82 MfLTSLKEYV--FEGYQVEASGYLTKP 106
Cdd:PRK10766   78 L-VTGRTDSIdrIVGLEMGADDYVTKP 103
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 52-108 2.44e-04

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 39.64  E-value: 2.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKPIS 108
Cdd:cd17615    45 DAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTakdSVEDRI-AGLTAGGDDYVTKPFS 103
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 47-121 2.80e-04

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 39.56  E-value: 2.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  47 LNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKE--YVFEGYQVEASGYLTKPISYKRFSSELDRVAK 121
Cdd:cd19930    41 LKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRpgYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-106 2.87e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 39.10  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   4 IAICDDESTFLDNIEMFVKKYEKERGTQIFLKKYLSGLDLEDSlnlkfDIVFLDINMPGINGMELAKGIRKKDEHTIIMf 83
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGA-----DIVLLDLMLPGLSGTEVCRQLRARSNVPVIM- 74

                          90       100
                  ....*....|....*....|....*
gi 1865871119  84 LTSLKEYVFE--GYQVEASGYLTKP 106
Cdd:cd17621    75 VTAKDSEIDKvvGLELGADDYVTKP 99
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 50-112 2.95e-04

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 39.49  E-value: 2.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLT---SLKEYVfEGYQVEASGYLTKPISYKRF 112
Cdd:cd17572    42 PPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITahgSVDIAV-EAMRLGAYDFLEKPFDADRL 106
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 52-110 3.06e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 39.28  E-value: 3.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSLKEYVFE--GYQVEASGYLTKPISYK 110
Cdd:cd19939    45 SLVVLDIMLPGMDGLTVCREVREHSHVPILM-LTARTEEMDRvlGLEMGADDYLCKPFSPR 104
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 44-106 3.71e-04

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 38.93  E-value: 3.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  44 EDSLNL----KFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLK--EYVFEGYQVEASGYLTKP 106
Cdd:cd17616    32 EEGLDLgklyDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLAdiEDKVKGLGFGADDYMTKP 100
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 52-106 3.87e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 38.79  E-value: 3.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEH--TIIMFLTSLKEYVFEGYQVEASGYLTKP 106
Cdd:cd19919    46 DVLISDIRMPGMDGLALLAQIKQRHPDlpVIIMTAHSDLDSAVSAYQGGAFEYLPKP 102
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 44-107 4.40e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 38.41  E-value: 4.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  44 EDSLNLKFDIVFLDINMPGINGMELAKGIRKKDEHT--IIMFLTSLKEYVFEGYQVEASGYLTKPI 107
Cdd:cd17565    38 DEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGkfIMISQVSDKEMIGKAYQAGIEFFINKPI 103
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 50-108 6.08e-04

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 38.19  E-value: 6.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTslkeyvfeGY-----QVE-----ASGYLTKPIS 108
Cdd:cd17563    44 KPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT--------GYasiatAVEaiklgADDYLAKPAD 104
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 50-108 7.10e-04

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 39.13  E-value: 7.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTslkeyvfeGY-----QVEASG-----YLTKPIS 108
Cdd:COG4567    48 PPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT--------GYasiatAVEAIKlgaddYLAKPAD 108
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 51-82 8.67e-04

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 37.86  E-value: 8.67e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHT-IIM 82
Cdd:cd17550    43 PDLVLLDIWLPDMDGLELLKEIKEKYPDLpVIM 75
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 49-110 9.23e-04

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.83  E-value: 9.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSLKEY--VFEGYQVEASGYLTKPISYK 110
Cdd:cd17626    43 VRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVM-LTAKSDTvdVVLGLESGADDYVAKPFKPK 105
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 49-125 1.02e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 37.76  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  49 LKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSL----KEYVFE----GyqveASGYLTKPISYkrFSSELDRVA 120
Cdd:cd17541    45 LKPDVITLDIEMPVMDGLEALRRIMAERPTPVVM-VSSLteegAEITLEalelG----AVDFIAKPSGG--ISLDLEEIA 117


                  ....*
gi 1865871119 121 KKVLR 125
Cdd:cd17541   118 EELIE 122
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 51-116 1.32e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 37.38  E-value: 1.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHT----IIMFLTSLKEYVFEG-YQVEASGYLTKPISYKRFSSEL 116
Cdd:cd19933    47 FQLVLLDLCMPEMDGFEVALRIRKLFGRRerplIVALTANTDDSTREKcLSLGMNGVITKPVSLHALGDEL 117
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 50-107 1.45e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 39.45  E-value: 1.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIRK--KDEHTIIMFLTS--LKEyvfEGYQVEASG---YLTKPI 107
Cdd:PRK11107  711 PFDLILMDIQMPGMDGIRACELIRQlpHNQNTPIIAVTAhaMAG---ERERLLSAGmddYLAKPI 772
ompR PRK09468
osmolarity response regulator; Provisional
 3-125 2.69e-03

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 38.03  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119   3 KIAICDDESTFLDNIEmfvkKYEKERGTQIFLKKYLSGLD--LEDSLnlkFDIVFLDINMPGINGMELAKGIRKKDEHTI 80
Cdd:PRK09468    7 KILVVDDDMRLRALLE----RYLTEQGFQVRSAANAEQMDrlLTRES---FHLMVLDLMLPGEDGLSICRRLRSQNNPTP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1865871119  81 IMFLTSLKEYV--FEGYQVEASGYLTKPISYKrfssELDRVAKKVLR 125
Cdd:PRK09468   80 IIMLTAKGEEVdrIVGLEIGADDYLPKPFNPR----ELLARIRAVLR 122
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 52-106 2.73e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 38.31  E-value: 2.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEH--TIIMFLTSLKEYVFEGYQVEASGYLTKP 106
Cdd:PRK10923   49 DVLLSDIRMPGMDGLALLKQIKQRHPMlpVIIMTAHSDLDAAVSAYQQGAFDYLPKP 105
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 51-106 2.76e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 36.33  E-value: 2.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYVFEGYQ--VEASGYLTKP 106
Cdd:cd18160    45 IDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGGAAAAPELLSdaVGDNATLKKP 102
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 52-76 3.07e-03

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 36.70  E-value: 3.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKD 76
Cdd:cd17549    44 GVVISDIRMPGMDGLELLAQIRELD 68
PRK11517 PRK11517
DNA-binding response regulator HprR;
41-134 3.40e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 37.57  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  41 LDLEDSlnlkFDIVFLDINMPGINGMELAKGIRKKDEhTIIMFLT---SLKEYVfEGYQVEASGYLTKPISykrFSSELD 117
Cdd:PRK11517   39 LALKDD----YALIILDIMLPGMDGWQILQTLRTAKQ-TPVICLTardSVDDRV-RGLDSGANDYLVKPFS---FSELLA 109

                          90
                  ....*....|....*..
gi 1865871119 118 RVAKKVLRDSALFISIK 134
Cdd:PRK11517  110 RVRAQLRQHHALNSTLE 126
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 51-108 4.07e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 37.25  E-value: 4.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  51 FDIVFLDINMPGINGMELAKGIRKKDEHTIIMFLTSLKEYV--FEGYQVEASGYLTKPIS 108
Cdd:PRK11083   48 PDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTARSDEVdrLVGLEIGADDYVAKPFS 107
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
43-105 4.74e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 37.18  E-value: 4.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1865871119  43 LEDSLNLKFDIVFLDINMPGINGMELAKGIRKKdEHTIIMFLTSLKEYVFEG---YQVEASGYLTK 105
Cdd:PRK09958   38 VQRVETLKPDIVIIDVDIPGVNGIQVLETLRKR-QYSGIIIIVSAKNDHFYGkhcADAGANGFVSK 102
pleD PRK09581
response regulator PleD; Reviewed
 50-134 5.74e-03

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 37.57  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  50 KFDIVFLDINMPGINGMELAKGIrKKDEHT----IIMF--LTSLKEYVfEGYQVEASGYLTKPISykrfsseldrvakkv 123
Cdd:PRK09581   46 QPDIILLDVMMPGMDGFEVCRRL-KSDPATthipVVMVtaLDDPEDRV-RGLEAGADDFLTKPIN--------------- 108

                          90
                  ....*....|.
gi 1865871119 124 lrDSALFISIK 134
Cdd:PRK09581  109 --DVALFARVK 117
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
47-138 5.87e-03

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 37.09  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1865871119  47 LNLKFDIVFLDINMPGINGMELAKGIRKKDEHTIIMfLT---SLKEYVFeGYQVEASGYLTKPISYKrfssELDRVAKKV 123
Cdd:PRK10955   41 LDDSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIM-LTargSELDRVL-GLELGADDYLPKPFNDR----ELVARIRAI 114

                          90
                  ....*....|....*
gi 1865871119 124 LRDSALFISIKNNND 138
Cdd:PRK10955  115 LRRSHWSEQQQNNDN 129
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 34-106 5.89e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 35.43  E-value: 5.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1865871119  34 LKKYLSGLDLEDSLNLKFDIVFLDINMPGINGMELAKGIRK--KDEHTIIMFLTSL--KEYVFEGYQVEASGYLTKP 106
Cdd:cd19924    35 LNKLENLAKEGNDLSKELDLIITDIEMPKMDGYELTFELRDdpRLANIPVILNSSLsgEFSRARGKKVGADAYLAKF 111
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 52-108 9.55e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 36.20  E-value: 9.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1865871119  52 DIVFLDINMPGINGMELAKGIRKKDEHTIIMfLTSLKEYV--FEGYQVEASGYLTKPIS 108
Cdd:PRK10710   56 DLILLDLMLPGTDGLTLCREIRRFSDIPIVM-VTAKIEEIdrLLGLEIGADDYICKPYS 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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