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Conserved domains on  [gi|1869622418|ref|WP_179507274|]
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bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Sphingomonas melonis]

Protein Classification

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase( domain architecture ID 10001245)

bifunctional enzyme, phosphomethylpyrimidine (HMP-P) kinase/hydroxymethylpyrimidine (HMP) kinase; bifunctional hydroxymethylpyrimidine (HMP) kinase/phosphomethylpyrimidine (HMP-P) kinase catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

CATH:  3.40.1190.20
EC:  2.7.4.7|2.7.1.49
Gene Symbol:  thiD
Gene Ontology:  GO:0005524|GO:0016310|GO:0042724|GO:0008902|GO:0008972|GO:0009228|GO:0005829
PubMed:  8382990|11839308
SCOP:  3001268

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 19-225 8.36e-85

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


:

Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 253.04  E-value: 8.36e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:COG0351    14 IQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEIIEAVAEILADYPL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 -PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGHA 163
Cdd:COG0351    94 vPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPeaeallgieittLDDMREAAKALLELGAkAVLVKGGHL 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1869622418 164 EGDIIEDRLIDAEGVQaLWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:COG0351   174 PGDEAVDVLYDGDGVR-EFSAPRIDTGNTHGTGCTLSSAIAALLAKGLDLEEAVREAKEYVT 234
 
Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 19-225 8.36e-85

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 253.04  E-value: 8.36e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:COG0351    14 IQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEIIEAVAEILADYPL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 -PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGHA 163
Cdd:COG0351    94 vPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPeaeallgieittLDDMREAAKALLELGAkAVLVKGGHL 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1869622418 164 EGDIIEDRLIDAEGVQaLWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:COG0351   174 PGDEAVDVLYDGDGVR-EFSAPRIDTGNTHGTGCTLSSAIAALLAKGLDLEEAVREAKEYVT 234
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 19-225 2.78e-83

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 248.94  E-value: 2.78e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:pfam08543   8 IQADLKTFSALGVYGMSVITALTAQNTLGVQGVHPLPPEFVAAQLDAVLEDIPVDAVKTGMLGSAEIIEAVAEKLDKYGV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMG-TAVLVKGGHAE 164
Cdd:pfam08543  88 PVVLDPVMVAKSGDSLLDDEAIEALkEELLPLATLITPNLPeaealtgrkiktLEDMKEAAKKLLALGaKAVLIKGGHLE 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1869622418 165 GD--IIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:pfam08543 168 GEeaVVTDVLYDGGGFYTL-EAPRIPTKNTHGTGCTLSAAIAANLAKGLSLPEAVREAKEYVT 229
HMPP_kinase cd01169
4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two ...
 19-225 3.32e-80

4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.


Pssm-ID: 238574 [Multi-domain]  Cd Length: 242  Bit Score: 241.25  E-value: 3.32e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:cd01169    16 IQADLKTFAALGVYGMSVITALTAQNTLGVFGVHPVPPEFVAAQLDAVLEDIPVDAIKIGMLGSAEIIEAVAEALKDYPD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 -PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMG-TAVLVKGGHA 163
Cdd:cd01169    96 iPVVLDPVMVAKSGDSLLDDDAIEALrELLLPLATLITPNLPeaelltgleiatEEDMMKAAKALLALGaKAVLIKGGHL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1869622418 164 EGDIIEDRLIDAEGVQALWThPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:cd01169   176 PGDEAVDVLYDGGGFFEFES-PRIDTKNTHGTGCTLSSAIAANLAKGLSLEEAVREAKEYVT 236
PRK06427 PRK06427
bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
 18-225 4.48e-74

bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed


Pssm-ID: 180561 [Multi-domain]  Cd Length: 266  Bit Score: 226.55  E-value: 4.48e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  18 GIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRID 97
Cdd:PRK06427   20 GIQADLKTFQALGVYGMSAITALTAQNTLGVQRVHPIPPEFVAAQLDAVFSDIRIDAVKIGMLASAEIIETVAEALKRYP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  98 -APMVFDPVMIATSGAVLADAATVAA-FERLIRRATLVTPNLP-------------ELDGLGGEGGLRAMGT-AVLVKGG 161
Cdd:PRK06427  100 iPPVVLDPVMIAKSGDPLLADDAVAAlRERLLPLATLITPNLPeaealtglpiadtEDEMKAAARALHALGCkAVLIKGG 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1869622418 162 HA-EGDIIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:PRK06427  180 HLlDGEESVDWLFDGEGEERF-SAPRIPTKNTHGTGCTLSAAIAAELAKGASLLDAVQTAKDYVT 243
HMP-P_kinase TIGR00097
hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a ...
 18-225 1.75e-64

hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a bifunctional enzyme, phosphomethylpyrimidine kinase (EC 2.7.4.7)/Hydroxymethylpyrimidine kinase (EC 2.7.1.49), the ThiD/J protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 272904 [Multi-domain]  Cd Length: 254  Bit Score: 201.37  E-value: 1.75e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  18 GIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRID 97
Cdd:TIGR00097  14 GIQADLKTFSALGVFGTSVITALTAQNTRGVTGVYPIPPDFVEAQLDAVFSDIPVDAAKTGMLASAEIVEAVARKLREYP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  98 A-PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGH 162
Cdd:TIGR00097  94 VrPLVVDPVMVAKSGAPLLEEEAIEALrKRLLPLATLITPNLPeaeallgtkirtEQDMIKAAKKLRELGPkAVLIKGGH 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1869622418 163 AEGDIIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:TIGR00097 174 LEGDQAVDVLFDGGEIHIL-KAPRIETKNTHGTGCTLSAAIAANLAKGLSLKEAVKEAKEFVT 235
 
Name Accession Description Interval E-value
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 19-225 8.36e-85

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 253.04  E-value: 8.36e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:COG0351    14 IQADLKTFAALGVYGMSVITALTAQNTLGVTGVHPVPPEFVAAQLRAVLEDIPVDAIKIGMLGSAEIIEAVAEILADYPL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 -PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGHA 163
Cdd:COG0351    94 vPVVLDPVMVAKSGDRLLDEDAVEALrELLLPLATVVTPNLPeaeallgieittLDDMREAAKALLELGAkAVLVKGGHL 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1869622418 164 EGDIIEDRLIDAEGVQaLWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:COG0351   174 PGDEAVDVLYDGDGVR-EFSAPRIDTGNTHGTGCTLSSAIAALLAKGLDLEEAVREAKEYVT 234
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 19-225 2.78e-83

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 248.94  E-value: 2.78e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:pfam08543   8 IQADLKTFSALGVYGMSVITALTAQNTLGVQGVHPLPPEFVAAQLDAVLEDIPVDAVKTGMLGSAEIIEAVAEKLDKYGV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMG-TAVLVKGGHAE 164
Cdd:pfam08543  88 PVVLDPVMVAKSGDSLLDDEAIEALkEELLPLATLITPNLPeaealtgrkiktLEDMKEAAKKLLALGaKAVLIKGGHLE 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1869622418 165 GD--IIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:pfam08543 168 GEeaVVTDVLYDGGGFYTL-EAPRIPTKNTHGTGCTLSAAIAANLAKGLSLPEAVREAKEYVT 229
HMPP_kinase cd01169
4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two ...
 19-225 3.32e-80

4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.


Pssm-ID: 238574 [Multi-domain]  Cd Length: 242  Bit Score: 241.25  E-value: 3.32e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:cd01169    16 IQADLKTFAALGVYGMSVITALTAQNTLGVFGVHPVPPEFVAAQLDAVLEDIPVDAIKIGMLGSAEIIEAVAEALKDYPD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 -PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMG-TAVLVKGGHA 163
Cdd:cd01169    96 iPVVLDPVMVAKSGDSLLDDDAIEALrELLLPLATLITPNLPeaelltgleiatEEDMMKAAKALLALGaKAVLIKGGHL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1869622418 164 EGDIIEDRLIDAEGVQALWThPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:cd01169   176 PGDEAVDVLYDGGGFFEFES-PRIDTKNTHGTGCTLSSAIAANLAKGLSLEEAVREAKEYVT 236
PRK06427 PRK06427
bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
 18-225 4.48e-74

bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed


Pssm-ID: 180561 [Multi-domain]  Cd Length: 266  Bit Score: 226.55  E-value: 4.48e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  18 GIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRID 97
Cdd:PRK06427   20 GIQADLKTFQALGVYGMSAITALTAQNTLGVQRVHPIPPEFVAAQLDAVFSDIRIDAVKIGMLASAEIIETVAEALKRYP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  98 -APMVFDPVMIATSGAVLADAATVAA-FERLIRRATLVTPNLP-------------ELDGLGGEGGLRAMGT-AVLVKGG 161
Cdd:PRK06427  100 iPPVVLDPVMIAKSGDPLLADDAVAAlRERLLPLATLITPNLPeaealtglpiadtEDEMKAAARALHALGCkAVLIKGG 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1869622418 162 HA-EGDIIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:PRK06427  180 HLlDGEESVDWLFDGEGEERF-SAPRIPTKNTHGTGCTLSAAIAAELAKGASLLDAVQTAKDYVT 243
HMP-P_kinase TIGR00097
hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a ...
 18-225 1.75e-64

hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; This model represents a bifunctional enzyme, phosphomethylpyrimidine kinase (EC 2.7.4.7)/Hydroxymethylpyrimidine kinase (EC 2.7.1.49), the ThiD/J protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 272904 [Multi-domain]  Cd Length: 254  Bit Score: 201.37  E-value: 1.75e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  18 GIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRID 97
Cdd:TIGR00097  14 GIQADLKTFSALGVFGTSVITALTAQNTRGVTGVYPIPPDFVEAQLDAVFSDIPVDAAKTGMLASAEIVEAVARKLREYP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  98 A-PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGH 162
Cdd:TIGR00097  94 VrPLVVDPVMVAKSGAPLLEEEAIEALrKRLLPLATLITPNLPeaeallgtkirtEQDMIKAAKKLRELGPkAVLIKGGH 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1869622418 163 AEGDIIEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYVQ 225
Cdd:TIGR00097 174 LEGDQAVDVLFDGGEIHIL-KAPRIETKNTHGTGCTLSAAIAANLAKGLSLKEAVKEAKEFVT 235
PLN02898 PLN02898
HMP-P kinase/thiamin-monophosphate pyrophosphorylase
 2-224 3.88e-58

HMP-P kinase/thiamin-monophosphate pyrophosphorylase


Pssm-ID: 215486 [Multi-domain]  Cd Length: 502  Bit Score: 192.29  E-value: 3.88e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   2 IPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIG 81
Cdd:PLN02898    9 VPHVLTVAGSDSGAGAGIQADIKACAARGVYCTTAITAVTAQNTVGVQGVHAVPLDFVAEQLKSVLSDMPVDVVKTGMLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  82 SAAIAHAVADTLDRIDA-PMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNLPELDG---LGGEGGLRAMGTA- 155
Cdd:PLN02898   89 SAEIVKVLCQALKEFPVkALVVDPVMVSTSGDVLAGPSILSALrEELLPLATIVTPNVKEASAllgGDPLETVADMRSAa 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 156 ----------VLVKGGHAEGDI-IEDRLIDAEGVQALwTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:PLN02898  169 kelhklgpryVLVKGGHLPDSLdAVDVLYDGTEFHEL-RSSRIKTRNTHGTGCTLASCIAAELAKGSDMLSAVKVAKRYV 247
PRK14713 PRK14713
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
1-210 1.65e-57

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 237797 [Multi-domain]  Cd Length: 530  Bit Score: 191.16  E-value: 1.65e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   1 MIPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMI 80
Cdd:PRK14713   28 ATPRVLSIAGTDPSGGAGIQADLKSIAAAGGYGMAVITALVAQNTRGVRAVHVPPADFLRAQLDAVSDDVTVDAVKIGML 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  81 GSAAIAHAVADTLDRIDAP-MVFDPVMIATSGAVLADAATVAAFERLIRRATLVTPNLP--------------ELDGLGG 145
Cdd:PRK14713  108 GDAEVIDAVRTWLAEHRPPvVVLDPVMVATSGDRLLEEDAEAALRELVPRADLITPNLPelavllgeppattwEEALAQA 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1869622418 146 EGGLRAMGTAVLVKGGHAEGDIIEDRLIDAEGVQALWTHPRVDTRHSHGTGCTLASGIATGLAAG 210
Cdd:PRK14713  188 RRLAAETGTTVLVKGGHLDGQRAPDALVGPDGAVTEVPGPRVDTRNTHGTGCSLSSALATRLGRG 252
PRK08573 PRK08573
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
1-220 5.37e-51

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 236297 [Multi-domain]  Cd Length: 448  Bit Score: 172.22  E-value: 5.37e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   1 MIPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMI 80
Cdd:PRK08573    1 LIPVALTIAGSDSGGGAGIEADLKTFAALGVHGAVAITSVTAQNTYEVRAIHDLPPEVVAAQIEAVWEDMGIDAAKTGML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  81 GSAAIAHAVADTLDRIDAPMVFDPVMIATSGA-VLADAATVAAFERLIRRATLVTPNLPEL-------------DGLGGE 146
Cdd:PRK08573   81 SNREIIEAVAKTVSKYGFPLVVDPVMIAKSGApLLREDAVDALIKRLLPLATVVTPNRPEAekltgmkirsvedARKAAK 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1869622418 147 GGLRAMGT-AVLVKGGHAEGDIIEDRLIdAEGVQALWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARA 220
Cdd:PRK08573  161 YIVEELGAeAVVVKGGHLEGEEAVDVLY-HNGTFREFRAPRVESGCTHGTGCSFSAAIAAGLAKGLDPEEAIKTA 234
PTZ00347 PTZ00347
phosphomethylpyrimidine kinase; Provisional
 2-224 9.54e-46

phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 240375 [Multi-domain]  Cd Length: 504  Bit Score: 159.74  E-value: 9.54e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   2 IPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIG 81
Cdd:PTZ00347  230 IPTVLTVSGSDSGGGAGHQADLKTLEALGVYSTSALTSLTAQNTKGVQQIQVVNEDFFAAQIDSVMSDFNISVVKLGLVP 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  82 SAAIAHAVADTLDRIdaPMVFDPVMIATSGAVL-----ADAATVAAFERLIRRATLVTPNLPEL------DGLGGEGGLR 150
Cdd:PTZ00347  310 TARQLEIVIEKLKNL--PMVVDPVLVATSGDDLvaqknADDVLAMYKERIFPMATIITPNIPEAerilgrKEITGVYEAR 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 151 AMGTA--------VLVKGGHAEGD--IIEDRLIDAEGVQAL-WTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVAR 219
Cdd:PTZ00347  388 AAAQAlaqygsryVLVKGGHDLIDpeACRDVLYDREKDRFYeFTANRIATINTHGTGCTLASAISSFLARGYTVPDAVER 467


                  ....*
gi 1869622418 220 AIAYV 224
Cdd:PTZ00347  468 AIGYV 472
PRK09517 PRK09517
multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; ...
 2-224 1.94e-41

multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 169939 [Multi-domain]  Cd Length: 755  Bit Score: 150.51  E-value: 1.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   2 IPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIG 81
Cdd:PRK09517  241 APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTALVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAVKLGMLG 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  82 SAAIAHAVADTL-DRIDAPMVFDPVMIATSGAVLADAATVAAFERLIRRATLVTPNLPELDG--------------LGGE 146
Cdd:PRK09517  321 SADTVDLVASWLgSHEHGPVVLDPVMVATSGDRLLDADATEALRRLAVHVDVVTPNIPELAVlcgeapaitmdeaiAQAR 400

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1869622418 147 GGLRAMGTAVLVKGGHAEGDIIEDRLIDAEGVQALWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:PRK09517  401 GFARTHGTIVIVKGGHLTGDLADNAVVRPDGSVHQVENPRVNTTNSHGTGCSLSAALATLIAAGESVEKALEWATRWL 478
PRK12412 PRK12412
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
2-224 3.46e-26

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183512 [Multi-domain]  Cd Length: 268  Bit Score: 102.74  E-value: 3.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   2 IPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDM--VVAQMRAVIDDIGVDAVKIGM 79
Cdd:PRK12412    1 LNKALTIAGSDTSGGAGIQADLKTFQELGVYGMTSLTTIVTMDPHNGWAHNVFPIPAstLKPQLETTIEGVGVDALKTGM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  80 IGSAAIAHAVADTLDRID-APMVFDPVMIAT-SGAVLADAATVAAFERLIRRATLVTPNL------------PELDGLGG 145
Cdd:PRK12412   81 LGSVEIIEMVAETIEKHNfKNVVVDPVMVCKgADEALHPETNDCLRDVLVPKALVVTPNLfeayqlsgvkinSLEDMKEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 146 EGGLRAMGTA-VLVKGGHAEG-DIIEDRLIDAEGVQALWTHpRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAY 223
Cdd:PRK12412  161 AKKIHALGAKyVLIKGGSKLGtETAIDVLYDGETFDLLESE-KIDTTNTHGAGCTYSAAITAELAKGKPVKEAVKTAKEF 239


                  .
gi 1869622418 224 V 224
Cdd:PRK12412  240 I 240
COG1992 COG1992
Predicted transcriptional regulator fused phosphomethylpyrimidine kinase (thiamin biosynthesis) ...
 19-224 1.01e-24

Predicted transcriptional regulator fused phosphomethylpyrimidine kinase (thiamin biosynthesis) [General function prediction only];


Pssm-ID: 441595 [Multi-domain]  Cd Length: 432  Bit Score: 101.76  E-value: 1.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRIDA 98
Cdd:COG1992     6 GGADAKTAAALGAGGGGTTTAVTVTATTTVTGVGSDPPPPVEVQQQAVAADDDVDDAKTGMLMTATIVEVVAVVVKSRDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  99 PMVFDPVMIATSGAVLADAATVAAFERLIRRATLVTPNLPELDGLGGEGGLRAMGT---------------AVLVKGGHA 163
Cdd:COG1992    86 PLVVVVVPVAVAAAGLGLLLAEAELAKLLLPLLATVTPNEPEVEELLLPTIRSLLAearaarlalqeegadALGVKGGHV 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1869622418 164 EGDIIEDRLIDaEGVQALWTHPRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:COG1992   166 SGDAVVDVLED-ERDVETFRHPRLVTEATHGSGCTFSAAIAALLAKGLSLEEAVRGAKLFL 225
PRK12616 PRK12616
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
19-224 1.38e-19

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183624  Cd Length: 270  Bit Score: 85.10  E-value: 1.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVD--MVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTLDRI 96
Cdd:PRK12616   20 IQADLKTFQEKNVYGMTALTVVVAMDPENSWDHQVFPIDtdTIRAQLSTIVDGIGVDAMKTGMLPTVDIIELAADTIKEK 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  97 DAP-MVFDPVMIAT-SGAVLADAATVAAFERLIRRATLVTPNL-------------PELDGLGGEGGLRAMGT--AVLVK 159
Cdd:PRK12616  100 QLKnVVIDPVMVCKgANEVLYPEHAEALREQLAPLATVITPNLfeagqlsgmgeikTVEQMKEAAKKIHELGAqyVVITG 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1869622418 160 GGHAEGDIIEDRLIDAEGVQALWTHpRVDTRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:PRK12616  180 GGKLKHEKAVDVLYDGETAEVLESE-MIDTPYTHGAGCTFSAAVTAELAKGSEVKEAIYAAKEFI 243
PRK12413 PRK12413
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
19-224 3.97e-17

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183513 [Multi-domain]  Cd Length: 253  Bit Score: 78.18  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  19 IQADIKTVTMLGGHAMTAITALTAQNTRGVQaVHAVPVDmVVAQMRAVIDDIGVDAVKIGMIGSAAIAHAVADTL-DRID 97
Cdd:PRK12413   20 LHADLATYTRNGLHGFVAVTCLTAMTEKGFE-VFPVDKE-IFQQQLDSLKDVPFSAIKIGLLPNVEIAEQALDFIkGHPG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  98 APMVFDPVMIATSGAVLADAATVAAFERLIRRATLVTPNLP------------ELDGLGGEGGLRAMGT-AVLVKGGHA- 163
Cdd:PRK12413   98 IPVVLDPVLVCKETHDVEVSELRQELIQFFPYVTVITPNLVeaellsgkeiktLEDMKEAAKKLYDLGAkAVVIKGGNRl 177

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1869622418 164 EGDIIEDRLIDAEGVQALwTHPRVDtRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:PRK12413  178 SQKKAIDLFYDGKEFVIL-ESPVLE-KNNIGAGCTFASSIASQLVKGKSPLEAVKNSKDFV 236
PTZ00493 PTZ00493
phosphomethylpyrimidine kinase; Provisional
 2-137 5.49e-16

phosphomethylpyrimidine kinase; Provisional


Pssm-ID: 240440  Cd Length: 321  Bit Score: 75.80  E-value: 5.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418   2 IPRVLIVAGSDSGGGAGIQADIKTVTMLGGHAMTAITALTAQNTRGVQAVHAVPVDMVVAQMRAVIDDIGVDAVKIGMIG 81
Cdd:PTZ00493    4 VSNILSIAGSDSCGGAGMQADIKTAMGLGCHCCTALVVLTAQNTKEVKRIVEIEEKFIVEQLDSIFADVTIDVVKLGVLY 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1869622418  82 SAAIAHAVADTLDRIDAP------MVFDPVMIATSGAVLADAATVAAF--ERLIRRATLVTPNL 137
Cdd:PTZ00493   84 SKKIISLVHNYITNMNKKrgkkllVVFDPVFVSSSGCLLVENLEYIKFalDLICPISCIITPNF 147
PdxK COG2240
Pyridoxal/pyridoxine/pyridoxamine kinase [Coenzyme transport and metabolism]; Pyridoxal ...
 57-224 1.41e-13

Pyridoxal/pyridoxine/pyridoxamine kinase [Coenzyme transport and metabolism]; Pyridoxal/pyridoxine/pyridoxamine kinase is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441841 [Multi-domain]  Cd Length: 272  Bit Score: 68.64  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  57 DMVVAQMRAVIDDI-------GVDAVKIGMIGSAAIAHAVADTLDRI-----DAPMVFDPVM-IATSGAVLADAATVAAF 123
Cdd:COG2240    53 DLPTDDIADILDGWkelgvllEFDAVLSGYLGSAEQGDIIADFVARVkaanpDALYLCDPVMgDNGKGYYVFPGIAEFIM 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 124 ERLIRRATLVTPNL------------PELDGLGGEGGLRAMGTA-VLVKGGHAEG---DIIEDRLIDAEGVQaLWTHPRV 187
Cdd:COG2240   133 RRLVPLADIITPNLtelalltgrpyeTLEEALAAARALLALGPKiVVVTSVPLDDtpaDKIGNLAVTADGAW-LVETPLL 211

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1869622418 188 DtRHSHGTGCTLASGIATGLAAGLPLTDAVARAIAYV 224
Cdd:COG2240   212 P-FSPNGTGDLFAALLLAHLLRGKSLEEALERAAAFV 247
PRK05756 PRK05756
pyridoxal kinase PdxY;
61-224 2.50e-05

pyridoxal kinase PdxY;


Pssm-ID: 235592 [Multi-domain]  Cd Length: 286  Bit Score: 44.47  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  61 AQMRAVIDDIG-------VDAVKIGMIGSAAIAHAVADTLDRI-----DAPMVFDPVM-IATSGAVLADAATVAAFERLI 127
Cdd:PRK05756   57 SHLTEIVQGIAdigwlgeCDAVLSGYLGSAEQGEAILDAVRRVkaanpQALYFCDPVMgDPEKGCIVAPGVAEFLRDRAL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 128 RRATLVTPNLP------------ELDGLGGEGGLRAMG-TAVLVKGGHAEG---DIIEDRLIDAEGVQALwTHPRVDTRH 191
Cdd:PRK05756  137 PAADIITPNLFelewlsgrpvetLEDAVAAARALIARGpKIVLVTSLARAGypaDRFEMLLVTADGAWHI-SRPLVDFMR 215

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1869622418 192 S-HGTGcTLASGIATG-LAAGLPLTDAVARAIAYV 224
Cdd:PRK05756  216 QpVGVG-DLTSALFLArLLQGGSLEEALEHTTAAV 249
pdxK PRK08176
pyridoxine/pyridoxal/pyridoxamine kinase;
74-224 4.39e-05

pyridoxine/pyridoxal/pyridoxamine kinase;


Pssm-ID: 181269 [Multi-domain]  Cd Length: 281  Bit Score: 43.87  E-value: 4.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418  74 AVKIGMIGSAAIAHAVADTLDRI-----DAPMVFDPVMIATSGAVLADAATVAAF-ERLIRRATLVTPNL---------P 138
Cdd:PRK08176   91 AVTTGYMGSASQIKILAEWLTALradhpDLLIMVDPVIGDIDSGIYVKPDLPEAYrQHLLPLAQGLTPNIfeleiltgkP 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1869622418 139 ELDGLGGEGGLRAMGT------AVLVKGGHAEGDIIEDRLIDAEGVQALwTHPRVDTrHSHGTGCTLASGIATGLAAGLP 212
Cdd:PRK08176  171 CRTLDSAIAAAKSLLSdtlkwvVITSAAGNEENQEMQVVVVTADSVNVI-SHPRVDT-DLKGTGDLFCAELVSGLLKGKA 248

                         170
                  ....*....|..
gi 1869622418 213 LTDAVARAIAYV 224
Cdd:PRK08176  249 LTDAAHRAGLRV 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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