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Conserved domains on  [gi|1870254859|ref|WP_179914716|]
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pyrroline-5-carboxylate reductase [Sanguibacter inulinus]

Protein Classification

pyrroline-5-carboxylate reductase family protein( domain architecture ID 11417420)

pyrroline-5-carboxylate reductase family protein similar to pyrroline-5-carboxylate reductase that catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline

CATH:  1.10.3730.10|3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0004735|GO:0055129

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-271 2.05e-86

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


:

Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 258.45  E-value: 2.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIAERRrVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:COG0345    82 LAPLLDPDK-LVISIAAGVTLATLEEAL------GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGT 240
Cdd:COG0345   155 KVVWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGT 234

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1870254859 241 TVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:COG0345   235 TIAGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-271 2.05e-86

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 258.45  E-value: 2.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIAERRrVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:COG0345    82 LAPLLDPDK-LVISIAAGVTLATLEEAL------GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGT 240
Cdd:COG0345   155 KVVWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGT 234

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1870254859 241 TVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:COG0345   235 TIAGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 1-271 6.45e-80

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 241.97  E-value: 6.45e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:PRK11880    3 KKIGFIGGGNMASAIIGGLLASG-VPAKDIIVSDPSPEKRAALAEEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLSE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIaerRRVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:PRK11880   82 LKGQL---DKLVVSIAAGVTLARLERLL------GADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIP-ESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGG 239
Cdd:PRK11880  153 KVVWVDdEKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGG 232

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1870254859 240 TTVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:PRK11880  233 TTIAALRVLEEKGLRAAVIEAVQAAAKRSKEL 264
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 19-270 3.57e-69

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 214.05  E-value: 3.57e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  19 MVGSGGFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRGLAGRIAeRRRVVLSIAAG 98
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRSPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKG-KDKLLISIAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  99 TPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVGEVVEIPESQFSTYTAIAG 178
Cdd:TIGR00112  80 VTLEKLSQLL------GGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 179 SSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGTTVAGLLALEDRGFLSTVA 258
Cdd:TIGR00112 154 SGPAYVFLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVI 233

                         250
                  ....*....|..
gi 1870254859 259 HGVKATIDRDRE 270
Cdd:TIGR00112 234 EAIEAAVRRSRE 245
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-270 1.85e-33

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 117.50  E-value: 1.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 167 ESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGTTVAGLL 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1870254859 247 ALEDRGFLSTVAHGVKATIDRDRE 270
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-271 2.05e-86

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 258.45  E-value: 2.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIAERRrVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:COG0345    82 LAPLLDPDK-LVISIAAGVTLATLEEAL------GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGT 240
Cdd:COG0345   155 KVVWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGT 234

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1870254859 241 TVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:COG0345   235 TIAGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 1-271 6.45e-80

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 241.97  E-value: 6.45e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:PRK11880    3 KKIGFIGGGNMASAIIGGLLASG-VPAKDIIVSDPSPEKRAALAEEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLSE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIaerRRVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:PRK11880   82 LKGQL---DKLVVSIAAGVTLARLERLL------GADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIP-ESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGG 239
Cdd:PRK11880  153 KVVWVDdEKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGG 232

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1870254859 240 TTVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:PRK11880  233 TTIAALRVLEEKGLRAAVIEAVQAAAKRSKEL 264
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 19-270 3.57e-69

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 214.05  E-value: 3.57e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  19 MVGSGGFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRGLAGRIAeRRRVVLSIAAG 98
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRSPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKG-KDKLLISIAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  99 TPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVGEVVEIPESQFSTYTAIAG 178
Cdd:TIGR00112  80 VTLEKLSQLL------GGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 179 SSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGTTVAGLLALEDRGFLSTVA 258
Cdd:TIGR00112 154 SGPAYVFLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVI 233

                         250
                  ....*....|..
gi 1870254859 259 HGVKATIDRDRE 270
Cdd:TIGR00112 234 EAIEAAVRRSRE 245
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 1-271 3.49e-57

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 184.00  E-value: 3.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGGFPADEVVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLRG 80
Cdd:PLN02688    1 FRVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSNPARRDVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLTE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  81 LAGRIAERRrVVLSIAAGTPLARLEsflttDAAPGSdsAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAVG 160
Cdd:PLN02688   81 LRPLLSKDK-LLVSVAAGITLADLQ-----EWAGGR--RVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 161 EVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGT 240
Cdd:PLN02688  153 KIWVVDEKLLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGT 232

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1870254859 241 TVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:PLN02688  233 TIAGVHELEKGGFRAALMNAVVAAAKRSREL 263
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-270 1.85e-33

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 117.50  E-value: 1.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 167 ESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGGTTVAGLL 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1870254859 247 ALEDRGFLSTVAHGVKATIDRDRE 270
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
PTZ00431 PTZ00431
pyrroline carboxylate reductase; Provisional
 3-271 1.04e-31

pyrroline carboxylate reductase; Provisional


Pssm-ID: 173621 [Multi-domain]  Cd Length: 260  Bit Score: 117.75  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   3 VGFIGTGNMANAIVRGMVGSGgfpadevVVFDRNADKRELLGADLGVQVAGSAEDLVDASDVVVVAVKPQgipallrgLA 82
Cdd:PTZ00431    6 VGFIGLGKMGSALAYGIENSN-------IIGKENIYYHTPSKKNTPFVYLQSNEELAKTCDIIVLAVKPD--------LA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  83 GRIAER------RRVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIF 156
Cdd:PTZ00431   71 GKVLLEikpylgSKLLISICGGLNLKTLEEMV------GVEAKIVRVMPNTPSLVGQGSLVFCANNNVDSTDKKKVIDIF 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 157 QAVGEVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCS 236
Cdd:PTZ00431  145 SACGIIQEIKEKDMDIATAISGCGPAYVFLFIESLIDAGVKNGLNRDVSKNLVLQTILGSVHMVKASDQPVQQLKDDVCS 224

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1870254859 237 PGGTTVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:PTZ00431  225 PGGITIVGLYTLEKHAFKYTVMDAVESACQKSKSM 259
PRK07679 PRK07679
pyrroline-5-carboxylate reductase; Reviewed
 1-271 8.66e-31

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 181079 [Multi-domain]  Cd Length: 279  Bit Score: 116.02  E-value: 8.66e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGGFPADEVVVFDRNADKR-ELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLR 79
Cdd:PRK07679    4 QNISFLGAGSIAEAIIGGLLHANVVKGEQITVSNRSNETRlQELHQKYGVKGTHNKKELLTDANILFLAMKPKDVAEALI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  80 GLAGRIAERRrVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAV 159
Cdd:PRK07679   84 PFKEYIHNNQ-LIISLLAGVSTHSIRNLL------QKDVPIIRAMPNTSAAILKSATAISPSKHATAEHIQTAKALFETI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 160 GEVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPGG 239
Cdd:PRK07679  157 GLVSVVEEEDMHAVTALSGSGPAYIYYVVEAMEKAAKKIGLKEDVAKSLILQTMIGAAEMLKASEKHPSILRKEITSPGG 236

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1870254859 240 TTVAGLLALEDRGFLSTVAHGVKATIDRDREM 271
Cdd:PRK07679  237 TTEAGIEVLQEHRFQQALISCITQATQRSHNL 268
PRK07680 PRK07680
late competence protein ComER; Validated
 1-250 7.93e-16

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 75.39  E-value: 7.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGGFPADEVVVFDRNADK-RELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLR 79
Cdd:PRK07680    1 MNIGFIGTGNMGTILIEAFLESGAVKPSQLTITNRTPAKaYHIKERYPGIHVAKTIEEVISQSDLIFICVKPLDIYPLLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  80 GLAGRIAERRRVVlSIAAGTPLARLESFLttdaapgsDSAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAV 159
Cdd:PRK07680   81 KLAPHLTDEHCLV-SITSPISVEQLETLV--------PCQVARIIPSITNRALSGASLFTFGSRCSEEDQQKLERLFSNI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 160 GEVVEIPESQFSTYTAIAGSSPAF-TYL---FIDAlsrAAVAGGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVC 235
Cdd:PRK07680  152 STPLVIEEDITRVSSDIVSCGPAFfSYLlqrFIDA---AVEETNISKEEATTLASEMLIGMGKLLEKGLYTLPTLQEKVC 228

                         250
                  ....*....|....*
gi 1870254859 236 SPGGTTVAGLLALED 250
Cdd:PRK07680  229 VKGGITGEGIKVLEE 243
PRK06928 PRK06928
pyrroline-5-carboxylate reductase; Reviewed
 2-244 2.26e-15

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235888 [Multi-domain]  Cd Length: 277  Bit Score: 74.03  E-value: 2.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   2 TVGFIGTGNMANAIVRGMVGSGGFPADEVVVFDRNADKR--ELLGADLGVQVAGSAEDLVDASDVVVVAVKPQGIPALLR 79
Cdd:PRK06928    3 KIGFIGYGSMADMIATKLLETEVATPEEIILYSSSKNEHfnQLYDKYPTVELADNEAEIFTKCDHSFICVPPLAVLPLLK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859  80 GLAGRIAERRRVVlSIAAGTPLARLesfltTDAAPGSdsAVVRVMPNVNAMIGAGMSAVTGNAAATADDVATVVAIFQAV 159
Cdd:PRK06928   83 DCAPVLTPDRHVV-SIAAGVSLDDL-----LEITPGL--QVSRLIPSLTSAVGVGTSLVAHAETVNEANKSRLEETLSHF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859 160 GEVVEIPESQFSTYTAIAGSSPAFTYLFIDALSRAAVA-GGMPKAQATQIAAQAVLGSAKMVRESPKSPWDLIDTVCSPG 238
Cdd:PRK06928  155 SHVMTIREENMDIASNLTSSSPGFIAAIFEEFAEAAVRnSSLSDEEAFQFLNFALAGTGKLLVEEDYTFSGTIERVATKG 234


                  ....*.
gi 1870254859 239 GTTVAG 244
Cdd:PRK06928  235 GITAEG 240
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
4-98 1.74e-09

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 53.77  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   4 GFIGTGNMANAIVRGMVGSGgfPADEVVVFDRNADKRELLGADLGVQV-AGSAEDLVDASDVVVVAVKPQGIPALLRGLA 82
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAG--PHEVVVANSRNPEKAEELAEEYGVGAtAVDNEEAAEEADVVFLAVKPEDAPDVLSELS 78

                          90
                  ....*....|....*.
gi 1870254859  83 GriAERRRVVLSIAAG 98
Cdd:pfam03807  79 D--LLKGKIVISIAAG 92
PRK06476 PRK06476
pyrroline-5-carboxylate reductase; Reviewed
 1-125 6.41e-09

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235812 [Multi-domain]  Cd Length: 258  Bit Score: 55.41  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSgGFPADEVVVFDRNADKRELLGADLG-VQVAGSAEDLVDASDVVVVAVKPQGIPALLR 79
Cdd:PRK06476    1 MKIGFIGTGAITEAMVTGLLTS-PADVSEIIVSPRNAQIAARLAERFPkVRIAKDNQAVVDRSDVVFLAVRPQIAEEVLR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1870254859  80 GLAGRiaeRRRVVLSIAAGTPLARLESFLttdaapGSDSAVVRVMP 125
Cdd:PRK06476   80 ALRFR---PGQTVISVIAATDRAALLEWI------GHDVKLVRAIP 116
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-58 4.70e-06

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 47.03  E-value: 4.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgfpaDEVVVFDRNADKRELLgADLGVQVAGSAEDL 58
Cdd:COG2084     2 MKVGFIGLGAMGAPMARNLLKAG----HEVTVWNRTPAKAEAL-VAAGARVAASPAEA 54
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-58 4.37e-05

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 44.14  E-value: 4.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGGFpadEVV-VFDRNADKRELLGADLGVQVAGSAEDL 58
Cdd:COG0673     4 LRVGIIGAGGIGRAHAPALAALPGV---ELVaVADRDPERAEAFAEEYGVRVYTDYEEL 59
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 2-58 4.72e-05

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 42.84  E-value: 4.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1870254859   2 TVGFIGTGNMANAIVRGMVGSGgfpaDEVVVFDRNADKRELLgADLGVQVAGSAEDL 58
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAG----YTVTVYNRTPEKVEEL-VAAGAIAAASPAEF 52
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-58 6.02e-04

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 40.50  E-value: 6.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1870254859   1 MTVGFIGTGNMANAIVRGMVGSGgfpaDEVVVFDRNADKRELLgADLGVQVAGSAEDL 58
Cdd:PRK09599    1 MQLGMIGLGRMGGNMARRLLRGG----HEVVGYDRNPEAVEAL-AEEGATGADSLEEL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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