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Conserved domains on  [gi|1870273243|ref|WP_179931715|]
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sulfurtransferase TusA [Vreelandella salicampi]

Protein Classification

TusA-like sulfurtransferase( domain architecture ID 10130718)

sulfurtransferase similar to TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 15-81 2.45e-42

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


:

Pssm-ID: 239515  Cd Length: 69  Bit Score: 132.10  E-value: 2.45e-42
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLIR 68
 
Name Accession Description Interval E-value
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 15-81 2.45e-42

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 132.10  E-value: 2.45e-42
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLIR 68
PRK00299 PRK00299
sulfurtransferase TusA;
12-81 3.38e-40

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 127.06  E-value: 3.38e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870273243 12 DALLDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:PRK00299   9 DHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELLAQETEQLPYRYLIR 78
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 15-81 1.32e-28

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 97.19  E-value: 1.32e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIR 67
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 15-77 2.72e-19

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 73.76  E-value: 2.72e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYR 77
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEEDGEYR 64
 
Name Accession Description Interval E-value
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 15-81 2.45e-42

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 132.10  E-value: 2.45e-42
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLIR 68
PRK00299 PRK00299
sulfurtransferase TusA;
12-81 3.38e-40

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 127.06  E-value: 3.38e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870273243 12 DALLDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:PRK00299   9 DHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELLAQETEQLPYRYLIR 78
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 15-81 1.32e-28

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 97.19  E-value: 1.32e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIR 67
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 15-81 5.16e-24

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 85.68  E-value: 5.16e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:cd00291    2 LDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEEEGGVYRILIR 68
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 15-77 2.72e-19

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 73.76  E-value: 2.72e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYR 77
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEEDGEYR 64
SirA_RHOD_Pry_redox cd03420
SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown ...
 14-73 9.60e-13

SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that corresponds to COG2210. This fold is referred to as a two-layered alpha/beta sandwich, structurally similar to that of translation initiation factor 3.


Pssm-ID: 239512  Cd Length: 69  Bit Score: 57.00  E-value: 9.60e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870273243 14 LLDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSG 73
Cdd:cd03420    1 EVDACGLQCPGPILKLKKEIDKLQDGEQLEVKASDPGFARDAQAWCKSTGNTLISLETEK 60
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-81 4.10e-07

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 43.11  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870273243  1 MAENMEtlPDYDalLDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFI 80
Cdd:PRK11018   1 MMKNIV--PDYR--LDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLI 76


                 .
gi 1870273243 81 R 81
Cdd:PRK11018  77 Q 77
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 15-81 1.30e-06

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 41.64  E-value: 1.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870273243 15 LDTSGLYCPEPIMMMHNKVRDMAPGQVLQVVATDPATTRDVPKFCQFLEHELIAQETSGETYRYFIR 81
Cdd:cd03422    2 LDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVLAIEQSGPTIRYLIQ 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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