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Conserved domains on  [gi|1872301160|ref|WP_180175251|]
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MULTISPECIES: prepilin-type N-terminal cleavage/methylation domain-containing protein [Acinetobacter]

Protein Classification

pilin( domain architecture ID 11471942)

pilin similar to Pseudomonas aeruginosa fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0007155|GO:0009289|GO:0015628|GO:0015627
SCOP:  4001055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
2-132 6.19e-22

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


:

Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 84.76  E-value: 6.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   2 NAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALASCDtAAEIGetLPSGLT 81
Cdd:COG4969     3 KKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCN-AGDNG--LPATIA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1872301160  82 NKALNKIEITeeTAAIVATPNAykgiDATNDTCTLTPTVAGQRLEWNYSGG 132
Cdd:COG4969    80 TKYVSSVSVD--NGVITVTGTA----ALAGLTLTLTPTLNNGAITWTCSCS 124
 
Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
2-132 6.19e-22

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 84.76  E-value: 6.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   2 NAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALASCDtAAEIGetLPSGLT 81
Cdd:COG4969     3 KKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCN-AGDNG--LPATIA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1872301160  82 NKALNKIEITeeTAAIVATPNAykgiDATNDTCTLTPTVAGQRLEWNYSGG 132
Cdd:COG4969    80 TKYVSSVSVD--NGVITVTGTA----ALAGLTLTLTPTLNNGAITWTCSCS 124
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-92 2.55e-15

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 67.75  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   1 MNAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALASCDTAAeigETLPSGL 80
Cdd:PRK10574    1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVELCALEHGGLDTCDAGS---NGIPSPT 77

                          90
                  ....*....|..
gi 1872301160  81 TNKALNKIEITE 92
Cdd:PRK10574   78 TSRYVSAMSVAK 89
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-16 9.01e-04

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 34.66  E-value: 9.01e-04
                          10
                  ....*....|....*.
gi 1872301160   1 MNAQKGFTLIELMIVV 16
Cdd:pfam07963   1 MRKQRGFTLIELLVAL 16
 
Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
2-132 6.19e-22

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 84.76  E-value: 6.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   2 NAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALASCDtAAEIGetLPSGLT 81
Cdd:COG4969     3 KKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCN-AGDNG--LPATIA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1872301160  82 NKALNKIEITeeTAAIVATPNAykgiDATNDTCTLTPTVAGQRLEWNYSGG 132
Cdd:COG4969    80 TKYVSSVSVD--NGVITVTGTA----ALAGLTLTLTPTLNNGAITWTCSCS 124
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-92 2.55e-15

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 67.75  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   1 MNAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALASCDTAAeigETLPSGL 80
Cdd:PRK10574    1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVELCALEHGGLDTCDAGS---NGIPSPT 77

                          90
                  ....*....|..
gi 1872301160  81 TNKALNKIEITE 92
Cdd:PRK10574   78 TSRYVSAMSVAK 89
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-119 2.86e-10

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 54.31  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1872301160   1 MNAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAIDVCYAQESALAscDTAAEIGetLPSGL 80
Cdd:COG4968     6 RRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYP--SALADLG--LPAST 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1872301160  81 TNKALNKIEITEETAAIVATPNAykgidatNDTCTLTPT 119
Cdd:COG4968    82 SGYYTISIAAAATTYTLTATPQA-------DGTLTLDQT 113
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-54 3.01e-07

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 45.67  E-value: 3.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1872301160   1 MNAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKAAYSEVTTAMAAVKSAID 54
Cdd:COG2165     7 RRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALE 60
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-65 6.91e-04

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 35.98  E-value: 6.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1872301160   1 MNAQKGFTLIELMIVVAIIGILAAIALPAYQNYMKKaaySEVTTAMAAVKSAIDvcYAQESALAS 65
Cdd:COG4970     5 RRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIAR---QRLRAAANELAAALR--LARSEAIRR 64
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-16 9.01e-04

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 34.66  E-value: 9.01e-04
                          10
                  ....*....|....*.
gi 1872301160   1 MNAQKGFTLIELMIVV 16
Cdd:pfam07963   1 MRKQRGFTLIELLVAL 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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