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Conserved domains on  [gi|1878327620|ref|WP_180728567|]
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urease accessory protein UreE [Paraburkholderia sp. PGU19]

Protein Classification

urease accessory protein UreE( domain architecture ID 11486508)

urease accessory protein UreE is involved in urease metallocenter assembly by assisting in the insertion of Ni(2+) ions in the active site of urease

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ureE PRK13263
urease accessory protein UreE; Provisional
1-170 1.57e-106

urease accessory protein UreE; Provisional


:

Pssm-ID: 237323  Cd Length: 206  Bit Score: 304.79  E-value: 1.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   1 MRTIDKLLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESV 80
Cdd:PRK13263    1 MLTIDKRIAPNVGLAAVLVKRAPTLTLAFDARCKSRLAATLDTGREVAVVLPRGTVLRDGDVLVAEDGALVRVAAAPEAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  81 LVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGGGHRHGHDETFAED 160
Cdd:PRK13263   81 LRVRAGDPLTLMRAAYHLGNRHTPVEVGADYLKLEYDPVLADMLRRLGVTVERASAPFEPEAGAYGGGHRHGHDATFAED 160
                         170
                  ....*....|
gi 1878327620 161 YALAQQVYGE 170
Cdd:PRK13263  161 YALAQQVFHE 170
 
Name Accession Description Interval E-value
ureE PRK13263
urease accessory protein UreE; Provisional
1-170 1.57e-106

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 304.79  E-value: 1.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   1 MRTIDKLLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESV 80
Cdd:PRK13263    1 MLTIDKRIAPNVGLAAVLVKRAPTLTLAFDARCKSRLAATLDTGREVAVVLPRGTVLRDGDVLVAEDGALVRVAAAPEAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  81 LVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGGGHRHGHDETFAED 160
Cdd:PRK13263   81 LRVRAGDPLTLMRAAYHLGNRHTPVEVGADYLKLEYDPVLADMLRRLGVTVERASAPFEPEAGAYGGGHRHGHDATFAED 160
                         170
                  ....*....|
gi 1878327620 161 YALAQQVYGE 170
Cdd:PRK13263  161 YALAQQVFHE 170
UreE COG2371
Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];
3-129 7.87e-53

Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441938  Cd Length: 126  Bit Score: 165.77  E-value: 7.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   3 TIDKLLGAHiklAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESVLV 82
Cdd:COG2371     2 RATEILGNG---AALAAAAVDTVTLDYDERQKRRLRLTTDDGREVGLDLPRGTVLRDGDVLVLEDGRLVVVRAAPEPVLV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1878327620  83 VRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGA 129
Cdd:COG2371    79 VRAADPLDLARLAYHLGNRHVPLQIEEDRLRIPPDHVLEDMLEGLGL 125
UreE cd00571
UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ...
4-138 2.70e-48

UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-terminal region of UreE contains a histidine rich nickel binding site.


Pssm-ID: 238320 [Multi-domain]  Cd Length: 136  Bit Score: 154.69  E-value: 2.70e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   4 IDKLLGaHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESVLVV 83
Cdd:cd00571     3 ITRILG-NIKDIALTDGQIDTVVLTWDDRQKRRLRLKSDHGEELGIRLPRGQVLRDGDVLFLDDGRLVVVRAAPEDVLVI 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1878327620  84 RAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPF 138
Cdd:cd00571    82 TPKDMLELARLAYHLGNRHVPLQIEEDELYIPYDHVLEDMLRKLGVRYERVERPF 136
UreE_C pfam05194
UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease ...
78-154 2.51e-30

UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.


Pssm-ID: 461580  Cd Length: 86  Bit Score: 106.95  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  78 ESVLVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGG------GHRH 151
Cdd:pfam05194   1 EPVLEVRAGDPPELARAAYHLGNRHVPLQIGEDRLRIPPDHVLEDMLRGLGATVEPVLAPFEPEGGAYGGhghghhDHDH 80

                  ...
gi 1878327620 152 GHD 154
Cdd:pfam05194  81 GHD 83
UreE_N smart00988
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
7-71 2.10e-17

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 214958  Cd Length: 65  Bit Score: 73.03  E-value: 2.10e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1878327620    7 LLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLV 71
Cdd:smart00988   1 MLTLTQRLDKPADAAADTVTLTADERQKSRLRLTTDDGREVGLFLPRGTVLRDGDVLVADDGRLI 65
 
Name Accession Description Interval E-value
ureE PRK13263
urease accessory protein UreE; Provisional
1-170 1.57e-106

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 304.79  E-value: 1.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   1 MRTIDKLLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESV 80
Cdd:PRK13263    1 MLTIDKRIAPNVGLAAVLVKRAPTLTLAFDARCKSRLAATLDTGREVAVVLPRGTVLRDGDVLVAEDGALVRVAAAPEAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  81 LVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGGGHRHGHDETFAED 160
Cdd:PRK13263   81 LRVRAGDPLTLMRAAYHLGNRHTPVEVGADYLKLEYDPVLADMLRRLGVTVERASAPFEPEAGAYGGGHRHGHDATFAED 160
                         170
                  ....*....|
gi 1878327620 161 YALAQQVYGE 170
Cdd:PRK13263  161 YALAQQVFHE 170
ureE PRK13261
urease accessory protein UreE; Provisional
1-154 7.07e-55

urease accessory protein UreE; Provisional


Pssm-ID: 237322 [Multi-domain]  Cd Length: 159  Bit Score: 172.06  E-value: 7.07e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   1 MRTIDKLLGaHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESV 80
Cdd:PRK13261    1 MMIITQILG-NISDLPLAAGAVETVTLEADERVKRRLRVTTDHGEEIGLRLPRGTVLRDGDVLFLDDGRVIVVRAAPEDV 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1878327620  81 LVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGGGHR-HGHD 154
Cdd:PRK13261   80 LVVRPRDPLELARAAYHLGNRHVPLQIEGDELLVPYDHVLEDMLEGLGLTVTEVEAPFEPERGAYGGAFRhHGHS 154
UreE COG2371
Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];
3-129 7.87e-53

Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441938  Cd Length: 126  Bit Score: 165.77  E-value: 7.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   3 TIDKLLGAHiklAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESVLV 82
Cdd:COG2371     2 RATEILGNG---AALAAAAVDTVTLDYDERQKRRLRLTTDDGREVGLDLPRGTVLRDGDVLVLEDGRLVVVRAAPEPVLV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1878327620  83 VRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGA 129
Cdd:COG2371    79 VRAADPLDLARLAYHLGNRHVPLQIEEDRLRIPPDHVLEDMLEGLGL 125
UreE cd00571
UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ...
4-138 2.70e-48

UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-terminal region of UreE contains a histidine rich nickel binding site.


Pssm-ID: 238320 [Multi-domain]  Cd Length: 136  Bit Score: 154.69  E-value: 2.70e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   4 IDKLLGaHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESVLVV 83
Cdd:cd00571     3 ITRILG-NIKDIALTDGQIDTVVLTWDDRQKRRLRLKSDHGEELGIRLPRGQVLRDGDVLFLDDGRLVVVRAAPEDVLVI 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1878327620  84 RAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPF 138
Cdd:cd00571    82 TPKDMLELARLAYHLGNRHVPLQIEEDELYIPYDHVLEDMLRKLGVRYERVERPF 136
UreE_C pfam05194
UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease ...
78-154 2.51e-30

UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.


Pssm-ID: 461580  Cd Length: 86  Bit Score: 106.95  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  78 ESVLVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGG------GHRH 151
Cdd:pfam05194   1 EPVLEVRAGDPPELARAAYHLGNRHVPLQIGEDRLRIPPDHVLEDMLRGLGATVEPVLAPFEPEGGAYGGhghghhDHDH 80

                  ...
gi 1878327620 152 GHD 154
Cdd:pfam05194  81 GHD 83
PRK14113 PRK14113
urease accessory protein UreE; Provisional
24-154 7.31e-30

urease accessory protein UreE; Provisional


Pssm-ID: 237614  Cd Length: 152  Bit Score: 108.09  E-value: 7.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  24 TLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESVLVVRAPDVLTLTRAAYHLGNRHT 103
Cdd:PRK14113   18 SITLDHDTRKKGRIKSVTDNGEEIGVFLERGHPLLVGEILKTECGKIIQVKGKAEDVATASAEDWLAFSKACYHLGNRHT 97
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1878327620 104 PVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQPETGAYGG---GHRHGHD 154
Cdd:PRK14113   98 KLQIGERWVRFKPDHVLEDLAENYGLSVNHEPAVFEPESGAYGVrshGHSHHHD 151
UreE_N pfam02814
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
10-71 6.16e-19

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 460708  Cd Length: 62  Bit Score: 76.89  E-value: 6.16e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1878327620  10 AHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLV 71
Cdd:pfam02814   1 DHRAAEKADAATADTVVLDWDERQKRRLRLTTDDGREVGLRLPRGTVLRDGDILYADDGRLI 62
UreE_N smart00988
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
7-71 2.10e-17

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 214958  Cd Length: 65  Bit Score: 73.03  E-value: 2.10e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1878327620    7 LLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLV 71
Cdd:smart00988   1 MLTLTQRLDKPADAAADTVTLTADERQKSRLRLTTDDGREVGLFLPRGTVLRDGDVLVADDGRLI 65
PRK14112 PRK14112
urease accessory protein UreE; Provisional
1-139 9.65e-08

urease accessory protein UreE; Provisional


Pssm-ID: 172602  Cd Length: 149  Bit Score: 49.65  E-value: 9.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620   1 MRTIDKLLGAHIKLAPVLVKRAPTLTLAFDARCKSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAPESV 80
Cdd:PRK14112    1 MTVFKEILDNIANIKNVESYQIENIHLTSDDVLKRVIIISSDQNVEYGIRLEEDKKLMDGDILYKDDYKLVVIRLELSDV 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1878327620  81 LVVRAPDVLTLTRAAYHLGNRHTPVEVGTDYLKLEYDPVLADMLKRLGALVDQVEMPFQ 139
Cdd:PRK14112   81 LIITAHTIGEMAKIAHNLGNRHMPAQFTETQMIVPYDYLVEEYLQDNKALYERKKIKLK 139
ureE PRK14711
urease accessory protein UreE; Provisional
34-107 1.86e-03

urease accessory protein UreE; Provisional


Pssm-ID: 173174  Cd Length: 191  Bit Score: 37.70  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327620  34 KSRLAATLDSGEEVALLLPRGTVLRDGDVLVADDGGLVRVVAAP--ESVLVVRAPDVL---------TLTRAAYHLGNRH 102
Cdd:PRK14711   37 KSRLRKATSGDVELALSLDRNTHLHDGDILLWNEGDKCAVVARVhlKEVMVIDLASVIgedgnaivrTVFELGHALGNQH 116

                  ....*
gi 1878327620 103 TPVEV 107
Cdd:PRK14711  117 WPAVV 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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