NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1878327751|ref|WP_180728686|]
View 

phytanoyl-CoA dioxygenase family protein [Paraburkholderia sp. PGU19]

Protein Classification

phytanoyl-CoA dioxygenase family protein( domain architecture ID 10009183)

phytanoyl-CoA dioxygenase (PhyH) family protein may act as a dioxygenase that catalyzes the oxidation of a substrate without the reduction of one oxygen atom from dioxygen into a water molecule

CATH:  2.60.120.620
EC:  1.14.-.-
Gene Ontology:  GO:0051213|GO:0046872

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
30-237 2.91e-35

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 444095  Cd Length: 237  Bit Score: 126.69  E-value: 2.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751  30 GYTVVNDVLPESELDDWRKRIDEIYERQEVECGGREVLLAIGDQDLCRAPLLYDQAFLSLARQAKVLAIVNRILGDWFIL 109
Cdd:COG5285    14 GYLVLRGVLSPEEVAALRAALDRLLAEAPDEGDLEYSEADGGRLRRIYNLHRRDPAFRDLARHPRILAVAEQLLGPDVRL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751 110 NLQNAIINRPDERHQQsAWHRDLPYqsWVASRPLAIGALFAIDPFTETTGSTAILPHSHRRELIP--------SEAYINA 181
Cdd:COG5285    94 HHSQLFFKPPGGGGAT-PWHQDFPY--WPLEPPRAVTVWIALDDVTEENGCLRVVPGSHRWGLLPhrdddgslDDALDEE 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1878327751 182 HATTVTVPPGSVVMFDAMVFHRAGYNRSQHIRRGVNHLYTVPILKQQYDFPRALGD 237
Cdd:COG5285   171 EAVPVELKAGDVLIFHGLTLHGSGPNRSDRPRRALVLRYNAADNRPQERQWLAVPR 226
 
Name Accession Description Interval E-value
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
30-237 2.91e-35

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 126.69  E-value: 2.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751  30 GYTVVNDVLPESELDDWRKRIDEIYERQEVECGGREVLLAIGDQDLCRAPLLYDQAFLSLARQAKVLAIVNRILGDWFIL 109
Cdd:COG5285    14 GYLVLRGVLSPEEVAALRAALDRLLAEAPDEGDLEYSEADGGRLRRIYNLHRRDPAFRDLARHPRILAVAEQLLGPDVRL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751 110 NLQNAIINRPDERHQQsAWHRDLPYqsWVASRPLAIGALFAIDPFTETTGSTAILPHSHRRELIP--------SEAYINA 181
Cdd:COG5285    94 HHSQLFFKPPGGGGAT-PWHQDFPY--WPLEPPRAVTVWIALDDVTEENGCLRVVPGSHRWGLLPhrdddgslDDALDEE 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1878327751 182 HATTVTVPPGSVVMFDAMVFHRAGYNRSQHIRRGVNHLYTVPILKQQYDFPRALGD 237
Cdd:COG5285   171 EAVPVELKAGDVLIFHGLTLHGSGPNRSDRPRRALVLRYNAADNRPQERQWLAVPR 226
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
30-215 5.60e-23

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 93.67  E-value: 5.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751  30 GYTVVNDVLPESELDDWRKRIDEIYERQEVECGGREVLLAIGDQDLCRAPLLYDQAFLSLAR-QAKVLAIVNRILGD--- 105
Cdd:pfam05721   5 GYLVIEGFLSPEEVAALRAEAERLLDRAAESGPDKDDFFDEKAAGDETGLLEKSITKRDHFLhPFYLADLARAILGSpvy 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751 106 ---WFILNLQ-NAIINRPDERHQQSAWHRDLPYQSWVAsRPLAIGALFAIDPFTETTGSTAILPHSHRRELIPSEAYINA 181
Cdd:pfam05721  85 vanVLQSMYQdLSIFKQPGTGGEVSPWHQDYTFLPTRP-AELVVNVWIALDDATEENGCLRVIPGSHKWEVGPLARRLPE 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1878327751 182 HATT----------------VTVPPGSVVMFDAMVFHRAGYNRSQHIRRG 215
Cdd:pfam05721 164 DDYYaeddeapkrdeepavpVPMKAGDAVLFHPRLLHGSGANRSDGSRRA 213
 
Name Accession Description Interval E-value
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
30-237 2.91e-35

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 126.69  E-value: 2.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751  30 GYTVVNDVLPESELDDWRKRIDEIYERQEVECGGREVLLAIGDQDLCRAPLLYDQAFLSLARQAKVLAIVNRILGDWFIL 109
Cdd:COG5285    14 GYLVLRGVLSPEEVAALRAALDRLLAEAPDEGDLEYSEADGGRLRRIYNLHRRDPAFRDLARHPRILAVAEQLLGPDVRL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751 110 NLQNAIINRPDERHQQsAWHRDLPYqsWVASRPLAIGALFAIDPFTETTGSTAILPHSHRRELIP--------SEAYINA 181
Cdd:COG5285    94 HHSQLFFKPPGGGGAT-PWHQDFPY--WPLEPPRAVTVWIALDDVTEENGCLRVVPGSHRWGLLPhrdddgslDDALDEE 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1878327751 182 HATTVTVPPGSVVMFDAMVFHRAGYNRSQHIRRGVNHLYTVPILKQQYDFPRALGD 237
Cdd:COG5285   171 EAVPVELKAGDVLIFHGLTLHGSGPNRSDRPRRALVLRYNAADNRPQERQWLAVPR 226
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
30-215 5.60e-23

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 93.67  E-value: 5.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751  30 GYTVVNDVLPESELDDWRKRIDEIYERQEVECGGREVLLAIGDQDLCRAPLLYDQAFLSLAR-QAKVLAIVNRILGD--- 105
Cdd:pfam05721   5 GYLVIEGFLSPEEVAALRAEAERLLDRAAESGPDKDDFFDEKAAGDETGLLEKSITKRDHFLhPFYLADLARAILGSpvy 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878327751 106 ---WFILNLQ-NAIINRPDERHQQSAWHRDLPYQSWVAsRPLAIGALFAIDPFTETTGSTAILPHSHRRELIPSEAYINA 181
Cdd:pfam05721  85 vanVLQSMYQdLSIFKQPGTGGEVSPWHQDYTFLPTRP-AELVVNVWIALDDATEENGCLRVIPGSHKWEVGPLARRLPE 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1878327751 182 HATT----------------VTVPPGSVVMFDAMVFHRAGYNRSQHIRRG 215
Cdd:pfam05721 164 DDYYaeddeapkrdeepavpVPMKAGDAVLFHPRLLHGSGANRSDGSRRA 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH