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Conserved domains on  [gi|1883916791|ref|WP_181522750|]
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quinol dehydrogenase ferredoxin subunit NapH [Citrobacter freundii]

Protein Classification

quinol dehydrogenase ferredoxin subunit NapH( domain architecture ID 11484278)

quinol dehydrogenase ferredoxin subunit NapH is required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
napH PRK09477
quinol dehydrogenase membrane component; Provisional
 17-287 3.34e-157

quinol dehydrogenase membrane component; Provisional


:

Pssm-ID: 236535 [Multi-domain]  Cd Length: 271  Bit Score: 438.57  E-value: 3.34e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  17 GWWKSHRWLLLHRLSQFLILAMFLSGPWLGVWILHGNYSSSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITVLY 96
Cdd:PRK09477    1 GWWRAHRFLILRRLSQLSILALFLSGPWFGVWILKGNLSSSLLFDTIPLTDPLATLQSLAAGHLPATVALIGALIITVFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  97 ALAGKRLFCSWVCPMNPVTDLASWLRRRFDLNQSATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGRSLVMGFGS 176
Cdd:PRK09477   81 ALAGGRAFCSWVCPVNLVTDLANWLRRKLGLNQSATLPRNLRYWLLVLVLVGSALTGTLAWEWINPVSMLHRGLVFGFGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 177 GALLILALFLFDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAKERNRCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVT 256
Cdd:PRK09477  161 GWWLILAIFLFDLFVVEHGWCGHLCPLGAFYGLIGKKSLIRVKAHDRQKCTRCMDCFHVCPEPQVLRPPLKGKQSPSQVT 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1883916791 257 SRDCMACGRCVDVCSEDVFTITTRWSSGAKS 287
Cdd:PRK09477  241 SGDCITCGRCIDVCSEDVFNFTIRFKSGAKS 271
 
Name Accession Description Interval E-value
napH PRK09477
quinol dehydrogenase membrane component; Provisional
 17-287 3.34e-157

quinol dehydrogenase membrane component; Provisional


Pssm-ID: 236535 [Multi-domain]  Cd Length: 271  Bit Score: 438.57  E-value: 3.34e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  17 GWWKSHRWLLLHRLSQFLILAMFLSGPWLGVWILHGNYSSSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITVLY 96
Cdd:PRK09477    1 GWWRAHRFLILRRLSQLSILALFLSGPWFGVWILKGNLSSSLLFDTIPLTDPLATLQSLAAGHLPATVALIGALIITVFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  97 ALAGKRLFCSWVCPMNPVTDLASWLRRRFDLNQSATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGRSLVMGFGS 176
Cdd:PRK09477   81 ALAGGRAFCSWVCPVNLVTDLANWLRRKLGLNQSATLPRNLRYWLLVLVLVGSALTGTLAWEWINPVSMLHRGLVFGFGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 177 GALLILALFLFDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAKERNRCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVT 256
Cdd:PRK09477  161 GWWLILAIFLFDLFVVEHGWCGHLCPLGAFYGLIGKKSLIRVKAHDRQKCTRCMDCFHVCPEPQVLRPPLKGKQSPSQVT 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1883916791 257 SRDCMACGRCVDVCSEDVFTITTRWSSGAKS 287
Cdd:PRK09477  241 SGDCITCGRCIDVCSEDVFNFTIRFKSGAKS 271
napH_ TIGR02163
ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, ...
 24-279 2.64e-130

ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.


Pssm-ID: 274004 [Multi-domain]  Cd Length: 255  Bit Score: 370.14  E-value: 2.64e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  24 WLLLHRLSQFLILAMFLSGPWLGVWILHGNYSSSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITVLYALAGKRL 103
Cdd:TIGR02163   1 FLILRRLVQLSILGLFLLGPYAGVWILKGNLSSSRLLGTIPLSDPLITLQILLAGHSPPTNALIGALIIVAFYALFGGRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 104 FCSWVCPMNPVTDLASWLRRRFDLNQSATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGRSLVMGFGSGALLILA 183
Cdd:TIGR02163  81 FCSWVCPVNLVTDFAAWLRRKLGINKIIKLPRNLRYWVLVLFLLLSFLSGLLIWEWFNPVGILHRGIIFGMGAGIWLILL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 184 LFLFDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAKERNRCNRCMDCFHVCPEPHVLRAPVLDEQSPvQVTSRDCMAC 263
Cdd:TIGR02163 161 VFLFDLLFSERGWCGHLCPLGAFYGLIGRKSLIKIAASDREKCTNCMDCFNVCPEPQVLRMPLKKGGST-LVLSGDCTLC 239

                         250
                  ....*....|....*.
gi 1883916791 264 GRCVDVCSEDVFTITT 279
Cdd:TIGR02163 240 GRCIDVCHEDVLGFTT 255
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
15-284 1.23e-57

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 185.65  E-value: 1.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  15 KKGWWKSHRWLLLHRLSQFLILAMFLSGPWLGVWilhgnyssSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITV 94
Cdd:COG0348     2 SYPRLVKGRFRRLRRLVQLLFLLLFLLGPWLRWL--------GDPAVLLDLAERRFYLFGLFWDFYLLALLLIGAALALF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  95 LYALAGKRLFCSWVCPMNPVTDLASWLRRRFDLNQ------SATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGR 168
Cdd:COG0348    74 LLTLLFGRVWCGWVCPQGVLTELFSWLERKLGDRRlklpwsLSKILRWLKYIILALWLLLALLTGLTFFGYFSPIGTLLR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 169 SLVMGFGSGALLILALFL--FDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAkERNRCNRCMDCFHVCPEPHVLRAPV 246
Cdd:COG0348   154 LLLFGVLGLWLLLILLAAflLLALFLRRQWCRYLCPYGAFQGLLSDLSTLRVRY-DRGDCIDCGLCVKVCPMGIDIRKGE 232

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1883916791 247 LDeqspvqvtSRDCMACGRCVDVCSEDVFTITTRWSSG 284
Cdd:COG0348   233 IN--------QSECINCGRCIDACPKDAIRFSSRGEKT 262
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 221-270 2.69e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 46.47  E-value: 2.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1883916791 221 KERNRCNRCMDCFHVCPEPH--VLRAPVLDEQSPVQVTSRDCMACGRCVDVC 270
Cdd:pfam13237   4 IDPDKCIGCGRCTAACPAGLtrVGAIVERLEGEAVRIGVWKCIGCGACVEAC 55
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 225-279 3.59e-06

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 45.70  E-value: 3.59e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1883916791 225 RCNRCMDCFHVCPEpHVLRapVLDEQSP-VQVTSRDCMACGRCVDVCSEDVFTITT 279
Cdd:cd10564    14 LCTRCGDCVEACPE-GIIV--RGDGGFPeLDFSRGECTFCGACAEACPEGALDPAR 66
 
Name Accession Description Interval E-value
napH PRK09477
quinol dehydrogenase membrane component; Provisional
 17-287 3.34e-157

quinol dehydrogenase membrane component; Provisional


Pssm-ID: 236535 [Multi-domain]  Cd Length: 271  Bit Score: 438.57  E-value: 3.34e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  17 GWWKSHRWLLLHRLSQFLILAMFLSGPWLGVWILHGNYSSSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITVLY 96
Cdd:PRK09477    1 GWWRAHRFLILRRLSQLSILALFLSGPWFGVWILKGNLSSSLLFDTIPLTDPLATLQSLAAGHLPATVALIGALIITVFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  97 ALAGKRLFCSWVCPMNPVTDLASWLRRRFDLNQSATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGRSLVMGFGS 176
Cdd:PRK09477   81 ALAGGRAFCSWVCPVNLVTDLANWLRRKLGLNQSATLPRNLRYWLLVLVLVGSALTGTLAWEWINPVSMLHRGLVFGFGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 177 GALLILALFLFDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAKERNRCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVT 256
Cdd:PRK09477  161 GWWLILAIFLFDLFVVEHGWCGHLCPLGAFYGLIGKKSLIRVKAHDRQKCTRCMDCFHVCPEPQVLRPPLKGKQSPSQVT 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1883916791 257 SRDCMACGRCVDVCSEDVFTITTRWSSGAKS 287
Cdd:PRK09477  241 SGDCITCGRCIDVCSEDVFNFTIRFKSGAKS 271
napH_ TIGR02163
ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, ...
 24-279 2.64e-130

ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.


Pssm-ID: 274004 [Multi-domain]  Cd Length: 255  Bit Score: 370.14  E-value: 2.64e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  24 WLLLHRLSQFLILAMFLSGPWLGVWILHGNYSSSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITVLYALAGKRL 103
Cdd:TIGR02163   1 FLILRRLVQLSILGLFLLGPYAGVWILKGNLSSSRLLGTIPLSDPLITLQILLAGHSPPTNALIGALIIVAFYALFGGRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 104 FCSWVCPMNPVTDLASWLRRRFDLNQSATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGRSLVMGFGSGALLILA 183
Cdd:TIGR02163  81 FCSWVCPVNLVTDFAAWLRRKLGINKIIKLPRNLRYWVLVLFLLLSFLSGLLIWEWFNPVGILHRGIIFGMGAGIWLILL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 184 LFLFDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAKERNRCNRCMDCFHVCPEPHVLRAPVLDEQSPvQVTSRDCMAC 263
Cdd:TIGR02163 161 VFLFDLLFSERGWCGHLCPLGAFYGLIGRKSLIKIAASDREKCTNCMDCFNVCPEPQVLRMPLKKGGST-LVLSGDCTLC 239

                         250
                  ....*....|....*.
gi 1883916791 264 GRCVDVCSEDVFTITT 279
Cdd:TIGR02163 240 GRCIDVCHEDVLGFTT 255
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
15-284 1.23e-57

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 185.65  E-value: 1.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  15 KKGWWKSHRWLLLHRLSQFLILAMFLSGPWLGVWilhgnyssSLLLDAIPFTDPLITLQSLASGHLPATVALTGAAIITV 94
Cdd:COG0348     2 SYPRLVKGRFRRLRRLVQLLFLLLFLLGPWLRWL--------GDPAVLLDLAERRFYLFGLFWDFYLLALLLIGAALALF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791  95 LYALAGKRLFCSWVCPMNPVTDLASWLRRRFDLNQ------SATLPRHIRYVLLVVILVGSALTGTLLWEWINPVSLLGR 168
Cdd:COG0348    74 LLTLLFGRVWCGWVCPQGVLTELFSWLERKLGDRRlklpwsLSKILRWLKYIILALWLLLALLTGLTFFGYFSPIGTLLR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 169 SLVMGFGSGALLILALFL--FDLLVVEHGWCGHLCPLGALYSVVGSKGALTVSAkERNRCNRCMDCFHVCPEPHVLRAPV 246
Cdd:COG0348   154 LLLFGVLGLWLLLILLAAflLLALFLRRQWCRYLCPYGAFQGLLSDLSTLRVRY-DRGDCIDCGLCVKVCPMGIDIRKGE 232

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1883916791 247 LDeqspvqvtSRDCMACGRCVDVCSEDVFTITTRWSSG 284
Cdd:COG0348   233 IN--------QSECINCGRCIDACPKDAIRFSSRGEKT 262
NapF COG1145
Ferredoxin [Energy production and conversion];
222-280 1.95e-07

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 50.88  E-value: 1.95e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 222 ERNRCNRCMDCFHVCPEphvlRAPVLDEQSP-VQVTSRDCMACGRCVDVCSEDVFTITTR 280
Cdd:COG1145   180 DAEKCIGCGLCVKVCPT----GAIRLKDGKPqIVVDPDKCIGCGACVKVCPVGAISLEPK 235
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 221-270 2.69e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 46.47  E-value: 2.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1883916791 221 KERNRCNRCMDCFHVCPEPH--VLRAPVLDEQSPVQVTSRDCMACGRCVDVC 270
Cdd:pfam13237   4 IDPDKCIGCGRCTAACPAGLtrVGAIVERLEGEAVRIGVWKCIGCGACVEAC 55
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 225-277 1.51e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 45.43  E-value: 1.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1883916791 225 RCNRCMDCFHVCPEPhVLRapvLDEQSPVQVTSRDCMACGRCVDVCSEDVFTI 277
Cdd:COG1144    31 KCIGCGLCWIVCPDG-AIR---VDDGKYYGIDYDYCKGCGICAEVCPVKAIEM 79
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 224-277 1.75e-06

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 44.70  E-value: 1.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1883916791 224 NRCNRCMDCFHVCPEpHVLRaPVLDEQSPVQVTSRDCMACGRCVDVCSEDVFTI 277
Cdd:COG1146     8 DKCIGCGACVEVCPV-DVLE-LDEEGKKALVINPEECIGCGACELVCPVGAITV 59
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 225-279 3.59e-06

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 45.70  E-value: 3.59e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1883916791 225 RCNRCMDCFHVCPEpHVLRapVLDEQSP-VQVTSRDCMACGRCVDVCSEDVFTITT 279
Cdd:cd10564    14 LCTRCGDCVEACPE-GIIV--RGDGGFPeLDFSRGECTFCGACAEACPEGALDPAR 66
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 222-280 3.68e-06

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 43.95  E-value: 3.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1883916791 222 ERNRCNRCMDCFHVCPEphvlRAPVLDEQSPVQVTSRDCMACGRCVDVCSEDVFTITTR 280
Cdd:COG1149     9 DEEKCIGCGLCVEVCPE----GAIKLDDGGAPVVDPDLCTGCGACVGVCPTGAITLEER 63
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 223-277 4.13e-06

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 43.50  E-value: 4.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1883916791 223 RNRCNRCMDCFHVCPEphvlRAPVLDEQSPVqVTSRDCMACGRCVDVCSEDVFTI 277
Cdd:COG2221    14 EEKCIGCGLCVAVCPT----GAISLDDGKLV-IDEEKCIGCGACIRVCPTGAIKG 63
Fer4_5 pfam12801
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 82-124 5.14e-06

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 432796 [Multi-domain]  Cd Length: 48  Bit Score: 42.93  E-value: 5.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1883916791  82 ATVALTGAAIITVLYALAGkRLFCSWVCPMNPVTDLASWLRRR 124
Cdd:pfam12801   2 GPAGLILFLAVLVLTLLFG-RVFCGWLCPFGALQELLAKLLRR 43
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 223-279 9.37e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 42.43  E-value: 9.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1883916791 223 RNRCNRCMDCFHVCPePHVLRAPVLDEQSPVQVTSRDCMACGRCVDVCSEDVFTITT 279
Cdd:COG1143     1 EDKCIGCGLCVRVCP-VDAITIEDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP 56
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 208-273 1.65e-05

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 43.09  E-value: 1.65e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883916791 208 SVVGSKGALTVSAKE--RNRCNRCMDCFHVCPEPhvlrAPVLDEQSPVQVTSRDCMACGRCVDVCSED 273
Cdd:PRK09624   33 SVINKTGSWRVFMPEfnRDKCVRCYLCYIYCPEP----AIYLDEEGYPVFDYDYCKGCGICANECPTK 96
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 225-275 5.57e-05

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 41.47  E-value: 5.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1883916791 225 RCNRCMDCFHVCPEPHVLRAPvlDEQSPVQVTSRDCMACGRCVDVCSEDVF 275
Cdd:TIGR00402  35 VCTRCGECASACENNILQLGQ--QGQPTVEFDNAECDFCGKCAEACPTNAF 83
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 222-273 7.50e-05

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 41.36  E-value: 7.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1883916791 222 ERNRCNRCMDCFHVCPEPHVLRAPvldEQSPVQVTSRDCMACGRCVDVCSED 273
Cdd:PRK08348   40 DVDKCVGCRMCVTVCPAGVFVYLP---EIRKVALWTGRCVFCGQCVDVCPTG 88
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 225-280 2.02e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 40.46  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1883916791 225 RCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVTSRDCMACGRCVDVCSEDVFTITTR 280
Cdd:cd10549     7 KCIGCGICVKACPTDAIELGPNGAIARGPEIDEDKCVFCGACVEVCPTGAIELTPE 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 226-270 2.83e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 37.89  E-value: 2.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1883916791 226 CNRCMDCFHVCPEpHVLRAPVLDEQSP---VQVTSRDCMACGRCVDVC 270
Cdd:pfam12838   1 CIGCGACVAACPV-GAITLDEVGEKKGtktVVIDPERCVGCGACVAVC 47
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 224-277 3.01e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.49  E-value: 3.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1883916791 224 NRCNRCMDCFHVCPephvlrAPVLDEQS-PVQVTSRDCMACGRCVDVCSEDVFTI 277
Cdd:COG4231    22 DKCTGCGACVKVCP------ADAIEEGDgKAVIDPDLCIGCGSCVQVCPVDAIKL 70
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 197-278 3.44e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.69  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 197 CGHLCPLGALySVVGSKGALTVSAKERNRCNRCMDCFHVCPEpHVLRAPVLDEQSPVQ-----VTSRDCMACGRCVDVCS 271
Cdd:cd10549    14 CVKACPTDAI-ELGPNGAIARGPEIDEDKCVFCGACVEVCPT-GAIELTPEGKEYVPKekeaeIDEEKCIGCGLCVKVCP 91


                  ....*..
gi 1883916791 272 EDVFTIT 278
Cdd:cd10549    92 VDAITLE 98
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
224-277 3.85e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 38.17  E-value: 3.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1883916791 224 NRCNRCMDCFHVCPEphvlRAPVLDEQSPVqVTSRDCMACGRCVDVCSEDVFTI 277
Cdd:COG2768    11 EKCIGCGACVKVCPV----GAISIEDGKAV-IDPEKCIGCGACIEVCPVGAIKI 59
Fer4_9 pfam13187
4Fe-4S dicluster domain;
225-274 7.49e-04

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 36.76  E-value: 7.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1883916791 225 RCNRCMDCFHVCPEPHVlrAPVLDEQSPVQVTSRD-CMACGRCVDVCSEDV 274
Cdd:pfam13187   1 KCTGCGACVAACPAGAI--VPDLVGQTIRGDIAGLaCIGCGACVDACPRGA 49
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 195-277 1.36e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.09  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 195 GWCGHLCPLGALYSvvGSKGALTVSAKErnrCNRCMDCFHVCPEpHVLRapvldeQSPVQVTSRDCMACGRCVDVCSEDV 274
Cdd:cd16372    53 GECIDVCPTGAITR--DANGVVMINKKL---CVGCLMCVGFCPE-GAMF------KHEDYPEPFKCIACGICVKACPTGA 120


                  ...
gi 1883916791 275 FTI 277
Cdd:cd16372   121 LEL 123
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 225-274 2.01e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 35.90  E-value: 2.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1883916791 225 RCNRCMDCFHVCP-------EPHVLR----APVLDEQSPVQVTSRdCMACGRCVDVCSEDV 274
Cdd:pfam13534   1 RCIQCGCCVDECPryllngdEPKKLMraayLGDLEELQANKVANL-CSECGLCEYACPMGL 60
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 195-278 3.74e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.61  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 195 GWCGHLCPLGALYsvVGSKGALTVSAKER-----NRCNRCMDCFHVCPEphvlRAPVLDEQSPVQVTSRDCMACGRCVDV 269
Cdd:cd10549    46 GACVEVCPTGAIE--LTPEGKEYVPKEKEaeideEKCIGCGLCVKVCPV----DAITLEDELEIVIDKEKCIGCGICAEV 119


                  ....*....
gi 1883916791 270 CSEDVFTIT 278
Cdd:cd10549   120 CPVNAIKLV 128
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
212-270 4.93e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 38.30  E-value: 4.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1883916791 212 SKGALTVSAK----ERNRCNRCMDCFHVCPephvLRAPVLDEQSPVQVTSRDCMACGRCVDVC 270
Cdd:COG1148   480 SKGELGVEPSvaevDPEKCTGCGRCVEVCP----YGAISIDEKGVAEVNPALCKGCGTCAAAC 538
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 220-270 5.68e-03

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 38.16  E-value: 5.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1883916791 220 AKERNRCNRCMDCFHVCPE----PHVLRAPVLDEQSPVQVTSRDCMACGRCVDVC 270
Cdd:cd01916   361 QELAAKCTDCGWCTRACPNslriKEAMEAAKEGDFSGLADLFDQCVGCGRCEQEC 415
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 195-238 5.73e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 34.70  E-value: 5.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883916791 195 GWCGHLCPLGALYsvVGSKGALTVSAkerNRCNRCMDCFHVCPE 238
Cdd:COG1149    17 GLCVEVCPEGAIK--LDDGGAPVVDP---DLCTGCGACVGVCPT 55
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 196-270 6.39e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 36.46  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883916791 196 WCGHLCPLGALysVVGSKGALTVS---AK-ERNRC------NRCMDCFHVCPEPHVLRAPVLDEQSPVQVTSRdCMACGR 265
Cdd:cd16373    61 ACVEVCPTGAL--RPLDLEEQKVKmgvAViDKDRClawqggTDCGVCVEACPTEAIAIVLEDDVLRPVVDEDK-CVGCGL 137


                  ....*
gi 1883916791 266 CVDVC 270
Cdd:cd16373   138 CEYVC 142
PRK07569 PRK07569
bidirectional hydrogenase complex protein HoxU; Validated
 222-270 8.57e-03

bidirectional hydrogenase complex protein HoxU; Validated


Pssm-ID: 181037 [Multi-domain]  Cd Length: 234  Bit Score: 36.94  E-value: 8.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1883916791 222 ERNRCNRCMDCFHVCPE---PHVLRAPVLDEQSPVQV-------TSRDCMACGRCVDVC 270
Cdd:PRK07569  144 DHNRCVLCTRCVRVCDEiegAHTWDVAGRGAKSRVITdlnqpwgTSETCTSCGKCVQAC 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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