NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1887529667|ref|WP_182093619|]
View 

MULTISPECIES: ROK family transcriptional regulator [Mammaliicoccus]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 20650276)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains a DNA-binding helix-turn-helix (HTH) domain

CATH:  3.30.420.40|1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0005524|GO:0003677
PubMed:  20512568|17979299|7952186|15808743|2644244|8831795|7781919|8800467
SCOP:  3000034|3000092|4000330

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 81-373 1.50e-87

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24077:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 295  Bit Score: 266.71  E-value: 1.50e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLELLKYHINA--DENFGTHFGLLGIAISVHGIVNnEQEII 158
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQEliSQAPKTPYGLVGIGIGIHGIVD-ENEII 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNslEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIG 238
Cdd:cd24077    80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 239 KTLVS--SIEDNERTYHKIEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNMQLN 315
Cdd:cd24077   158 HMIIVpnGKPCPCGNKGCLEQYASEKALLKELSEKKGLETlTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIINTFN 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1887529667 316 PKVIYINCPLINEITDLLDNIKTTFNQYTQKEIEISLTSNVKFATLFGATLAITQKIL 373
Cdd:cd24077   238 PEIIIINSSLINEIPELLEKIKEQLSSSFNKYVEILISTLGKNATLLGGAAVAIKNFL 295
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-55 2.66e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 41.42  E-value: 2.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1887529667   7 TNLDSNQKLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLV 55
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 81-373 1.50e-87

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 266.71  E-value: 1.50e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLELLKYHINA--DENFGTHFGLLGIAISVHGIVNnEQEII 158
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQEliSQAPKTPYGLVGIGIGIHGIVD-ENEII 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNslEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIG 238
Cdd:cd24077    80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 239 KTLVS--SIEDNERTYHKIEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNMQLN 315
Cdd:cd24077   158 HMIIVpnGKPCPCGNKGCLEQYASEKALLKELSEKKGLETlTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIINTFN 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1887529667 316 PKVIYINCPLINEITDLLDNIKTTFNQYTQKEIEISLTSNVKFATLFGATLAITQKIL 373
Cdd:cd24077   238 PEIIIINSSLINEIPELLEKIKEQLSSSFNKYVEILISTLGKNATLLGGAAVAIKNFL 295
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 77-364 8.36e-43

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 151.20  E-value: 8.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  77 NKNFGYVISLDIAYHSIEIIYSYFNGELLKYESIPL-ANQKITHVLELLKYHINA--DENFGTHFGLLGIAISVHGIVNN 153
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTpAGAGPEAVLEAIAELIEEllAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 154 EQEIIHLP--FHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVN 231
Cdd:COG1940    81 ETGVVLNApnLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 232 GEAGEIGKTLVSsiEDNERTY--HK--IEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAIL 306
Cdd:COG1940   161 GNAGEIGHMPVD--PDGPLCGcgNRgcLETYASGPALLRRARELGGAEKlTAEELFAAARAGDPLALEVLDEAARYLGIG 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1887529667 307 MYNLNMQLNPKVIYINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFATLFGA 364
Cdd:COG1940   239 LANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYAlppaREDPRIVPASLGDDAGLLGA 300
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 84-352 6.55e-23

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 97.41  E-value: 6.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  84 ISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLellkyhINADENFGTHF-----GLLGIAISVHGIVNNEQEII 158
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEETL------VDAIAFFVDSAqrkfgELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPFH-ELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEI 237
Cdd:pfam00480  75 TNTPNiGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 238 GKTLvssIEDNERT----YHK-IEDLCSQDALVNKINKRLNTQnTLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNM 312
Cdd:pfam00480 155 GHIQ---LDPNGPKcgcgNHGcLETIASGRALEKRYQQKGEDL-EGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLIN 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1887529667 313 QLNPKVIYINCPLINEiTDLLDNIKTTFNQYTQKEIEISL 352
Cdd:pfam00480 231 LFDPQAIVLGGGVSNA-DGLLEAIRSLVKKYLNGYLPVPP 269
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 143-242 3.20e-07

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 51.45  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 143 IAISVHGIVNNEqeII------------HLPFHElekvsmieSIKEIADVPVIVENEANFSAIYECNVNNSlEINNL--I 208
Cdd:PRK05082   59 VAVASTGIINDG--ILtalnphnlggllHFPLVQ--------TLEQLTDLPTIALNDAQAAAWAEYQALPD-DIRNMvfI 127

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1887529667 209 TLSihKGIGAGLIIDQKLYRGVNGEAGEIGKTLV 242
Cdd:PRK05082  128 TVS--TGVGGGIVLNGKLLTGPGGLAGHIGHTLA 159
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-55 2.66e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 41.42  E-value: 2.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1887529667   7 TNLDSNQKLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLV 55
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
2-56 6.44e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 6.44e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1887529667    2 EKLDVTNLDSNQKLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLVN 56
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 30-62 9.19e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 9.19e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1887529667  30 QISKNLGINKATISSILNKLKEKKLVNEVGQGK 62
Cdd:cd00090    25 ELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
14-56 9.83e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 9.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1887529667  14 KLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLVN 56
Cdd:COG1321    13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 81-373 1.50e-87

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 266.71  E-value: 1.50e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLELLKYHINA--DENFGTHFGLLGIAISVHGIVNnEQEII 158
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQEliSQAPKTPYGLVGIGIGIHGIVD-ENEII 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNslEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIG 238
Cdd:cd24077    80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 239 KTLVS--SIEDNERTYHKIEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNMQLN 315
Cdd:cd24077   158 HMIIVpnGKPCPCGNKGCLEQYASEKALLKELSEKKGLETlTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIINTFN 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1887529667 316 PKVIYINCPLINEITDLLDNIKTTFNQYTQKEIEISLTSNVKFATLFGATLAITQKIL 373
Cdd:cd24077   238 PEIIIINSSLINEIPELLEKIKEQLSSSFNKYVEILISTLGKNATLLGGAAVAIKNFL 295
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 77-364 8.36e-43

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 151.20  E-value: 8.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  77 NKNFGYVISLDIAYHSIEIIYSYFNGELLKYESIPL-ANQKITHVLELLKYHINA--DENFGTHFGLLGIAISVHGIVNN 153
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTpAGAGPEAVLEAIAELIEEllAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 154 EQEIIHLP--FHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVN 231
Cdd:COG1940    81 ETGVVLNApnLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 232 GEAGEIGKTLVSsiEDNERTY--HK--IEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAIL 306
Cdd:COG1940   161 GNAGEIGHMPVD--PDGPLCGcgNRgcLETYASGPALLRRARELGGAEKlTAEELFAAARAGDPLALEVLDEAARYLGIG 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1887529667 307 MYNLNMQLNPKVIYINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFATLFGA 364
Cdd:COG1940   239 LANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYAlppaREDPRIVPASLGDDAGLLGA 300
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 82-370 1.76e-27

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 109.98  E-value: 1.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  82 YVISLDIAYHSIEIIYSYFNGELLKYESIPLANQK----ITHVLELLKYHINADENFGTHfgLLGIAISVHGIVNNEQEI 157
Cdd:cd24059     2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKEnpeeVLEKLYELIDRLLEKENIKSK--ILGIGIGAPGPLDVEKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 158 IHLP--FHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAG 235
Cdd:cd24059    80 ILNPpnFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 236 EIGKTLVSSieDNER----TYHKIEDLCSQDALVNKINKRL-NTQNTLSELKKMYYERNEIVLEEIQQFSIRIAILMYNL 310
Cdd:cd24059   160 EIGHTSIDI--NGPRcscgNRGCLELYASIPAIEKKARSALgSGRSFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNL 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1887529667 311 NMQLNPKVIYINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFATLFG-ATLAITQ 370
Cdd:cd24059   238 INLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLfgrnAREVRILKSSLGEDAPLLGaAALVLNK 302
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 142-321 7.47e-27

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 108.04  E-value: 7.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 142 GIAISVHGIVNNEQEIIH----LPFheLEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIG 217
Cdd:cd24152    56 GIAISAPGVIDPETGIIYgggaLPY--LKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 218 AGLIIDQKLYRGVNGEAGEIGKTLvssIEDNERTYHKIEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEI 296
Cdd:cd24152   134 GAIIIDGKLYRGSHFFAGEFSYLL---TDDDDKDLLFFSGLASMFGLVKRYNKAKGLEPlDGEEIFEKYAKGDEAAKKIL 210

                         170       180
                  ....*....|....*....|....*
gi 1887529667 297 QQFSIRIAILMYNLNMQLNPKVIYI 321
Cdd:cd24152   211 DEYIRNLAKLIYNIQYILDPEVIVI 235
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 84-364 8.06e-25

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 101.39  E-value: 8.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  84 ISLDIAYHSIEIIYSYFNGELLKYESIPL-ANQKITHVLELLKYHIN-ADENFGTHFGLLGIAISVHGIVNNEQEIIHLP 161
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTpAEEGPEAVLDRIAELIEeLLAEAGVRERILGIGIGVPGPVDPETGIVLFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 162 --FHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIGK 239
Cdd:cd23763    81 pnLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIGH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 240 TLVssiednertyhkiedlcsqdalvnkinkrlntqntlselkkmyyerneivleeIQQFSIRIAILMYNLNMQLNPKVI 319
Cdd:cd23763   161 ITV-----------------------------------------------------LEEAARYLGIGLANLINLLNPELI 187

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1887529667 320 YINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFATLFGA 364
Cdd:cd23763   188 VLGGGVAEAGDLLLEPIREAVRRRAlpplRRRVRIVPSELGDDAGLLGA 236
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 84-352 6.55e-23

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 97.41  E-value: 6.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  84 ISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLellkyhINADENFGTHF-----GLLGIAISVHGIVNNEQEII 158
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEETL------VDAIAFFVDSAqrkfgELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPFH-ELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEI 237
Cdd:pfam00480  75 TNTPNiGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 238 GKTLvssIEDNERT----YHK-IEDLCSQDALVNKINKRLNTQnTLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNM 312
Cdd:pfam00480 155 GHIQ---LDPNGPKcgcgNHGcLETIASGRALEKRYQQKGEDL-EGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLIN 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1887529667 313 QLNPKVIYINCPLINEiTDLLDNIKTTFNQYTQKEIEISL 352
Cdd:pfam00480 231 LFDPQAIVLGGGVSNA-DGLLEAIRSLVKKYLNGYLPVPP 269
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 81-370 2.43e-22

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 95.71  E-value: 2.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITH-----VLELLKYHINADEnfGTHFGLLGIAISVHGIVNNEQ 155
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDevlaqLAALIREALAAAP--DSPLGILGIGVGVPGLVDSED 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 156 -EIIHLP---FHELEKVSMIEsikEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVN 231
Cdd:cd24076    79 gVVLLAPnlgWRDVPLRDLLE---EALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGAS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 232 GEAGEIGKTlvsSIEDNERTYH-----KIEDLCSQDALVNKINKRLNTQNTLS--ELKKMYYERNEIVLEEIQQFSIRIA 304
Cdd:cd24076   156 GFAGEIGHM---TVDPDGPPCScgnrgCWETYASERALLRAAGRLGAGGEPLSlaELVEAARAGDPAALAALEEVGEYLG 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1887529667 305 ILMYNL-NMqLNPKVIYINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFATLFGA-TLAITQ 370
Cdd:cd24076   233 IGLANLvNT-FNPELVVLGGALAPLGPWLLPPLRAEVARRAlpapARDVRIVVSRLGEDAAALGAaALAIDH 303
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 101-321 3.81e-21

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 92.24  E-value: 3.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 101 NGELLKYESIP-LANQKITHVLELLKYHInadENFGTHFGLLGIAISVHGIVNNEQEII-----HLPfhELEKVSMIESI 174
Cdd:cd24068    20 DGEILEKDSVPtPASKGGDAILERLLEII---AELKEKYDIEGIGISSAGQVDPKTGEViyatdNLP--GWTGTNLKEEL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 175 KEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIGKTLVSSIEDNERTYHK 254
Cdd:cd24068    95 EERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDPGGRPCCCGGK 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 255 --IEDLCSQDALVNKINKRLNTQN-TLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNMQLNPKVIYI 321
Cdd:cd24068   175 gcLEQYASGTALVRRVAEALGEPGiDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFDPEVIVI 244
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 81-342 8.53e-20

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 88.88  E-value: 8.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIP-LANQKITHVLELLKYHINA-DENFGTHFGLLGIAISVHGIVNNEQ-EI 157
Cdd:cd24071     1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPfDHETDPEKVIELIAENIKKlIKNKHVEKKLLGIGIAVSGLVDSKKgIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 158 IHLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEI 237
Cdd:cd24071    81 IRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 238 GKTLVSsiEDNERTYHK----IEDLCSQDALVNKInKRLNTQNTLSELK----------KMYYERNEIVLEEI-QQFSIR 302
Cdd:cd24071   161 GHMTIQ--PDGRKCYCGqkgcLEAYASFEALVNEI-KELTESYPLSLLKeledfeiekvREAAEEGDSVATELfKKAGEY 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1887529667 303 IAILMYNLNMQLNPKVIYINCPLINEITDLLDNIKTTFNQ 342
Cdd:cd24071   238 LGIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKE 277
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 139-361 2.33e-15

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 75.91  E-value: 2.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 139 GLLGIAISVHGIVNNEQ-EIIHLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIG 217
Cdd:cd24072    59 RVKGIALAIQGLVDSHKgVSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 218 AGLIIDQKLYRGVNGEAGEIGKTLVSsiEDNER----TYHKIEDLCSQDALVNKINKRL--------NTQNTLSELKKMY 285
Cdd:cd24072   139 SAIVIDNKLYIGASSGSGEIGHTKVN--PDGARcdcgRRGCLETVASNSALKRNARVTLklgpvsadPEKLTMEQLIEAL 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1887529667 286 YERNEIVLEEIQQFSIRIAILMYNLNMQLNPKVIYINCPLIneitDLLDNIKTTFNQYTQKEIEISLTSNVKFATL 361
Cdd:cd24072   217 EEGEPIATQIFDRAANAIGRSLANILNLLNPEQVLLYGRGC----RAGDLLLPAIRRAIAENPFSQHATQIGFGQL 288
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 82-281 3.53e-15

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 75.48  E-value: 3.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  82 YVISLDIAYHSIEIIYSYFNGELLKYESIPL--ANQK------ITHVLELLKYHINADENfgthfgLLGIAISVHGIVNN 153
Cdd:cd24075     2 HILAVRLGRHDLTLGLYDLSGELLAEHTVPLtaLNQEallsqlIEEIAQFLKSHRRKTQR------LIAISITLPGLINP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 154 EQEIIH-LPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNG 232
Cdd:cd24075    76 KTGVVHyMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNG 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1887529667 233 EAGEIGKTLV--SSIEDNERTYHKIEDLCSQDALVNKINKRL----NTQNTLSEL 281
Cdd:cd24075   156 NAGEIGHIQIepLGERCHCGNFGCLETVASNAAIEQRVKKLLkqgyASQLTLQDC 210
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 81-242 1.22e-14

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 73.74  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  81 GYVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITHVLELLKYHIN---ADENFGTHfGLLGIAISVHGIVNNEQEI 157
Cdd:cd24073     1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAellAQAGLSPD-RLLGIGVGLPGLVDAETGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 158 IH-LPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGE 236
Cdd:cd24073    80 CRwSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE 159


                  ....*.
gi 1887529667 237 IGKTLV 242
Cdd:cd24073   160 IGHTTV 165
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 82-364 1.31e-12

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 67.75  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  82 YVISLDIAYHSIEIIYSYFNGELLKYESIP-----LANQKITHVLELLKYHINADENFGTHfgllGIAISVHG-IVNNEQ 155
Cdd:cd24063     1 YYVAVDIGGTWIRAGLVDEDGRILLKIRQPtpktgDPGTVSEQVLGLIETLLSKAGKDSIE----GIGVSSAGpLDLRKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 156 EIIHLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAG 235
Cdd:cd24063    77 TIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 236 EIGKtLVSSIEDNERT----YHKIEDLCSQDALVNKINKRLNTQNTLSELKKMYYERNEIVLEEIQQ------------- 298
Cdd:cd24063   157 EVGH-LVVDTESGLKCgcggYGHWEAFASGRGIPRFAREWAEGFSSRTSLKLRNPGGEGITAKEVFSaarkgdplalkii 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 299 -FSIRI-AILMYNLNMQLNPKVIYINCPLINEITDLLDNIKTTF--NQYTQKEIEISLTSNVKFATLFGA 364
Cdd:cd24063   236 eKLARYnGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLekNPAISKGPEIVLSELGDDVGLIGA 305
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 117-344 8.17e-12

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 65.39  E-value: 8.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 117 ITHVLELLKYHINAdenfgthfgLLGIAISVHGIVNNEQ----EIIHLPFHeleKVSMIESIKEIADVPVIVENEANFSA 192
Cdd:cd24062    48 IQQLLEELGYSKED---------LIGIGVGVPGPVDVETgtveVAVNLGWK---NFPLKDKLEALTGIPVVIDNDANAAA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 193 IYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIGKTLVSSIEDNERTYHK---IEDLCSQDALVNKIN 269
Cdd:cd24062   116 LGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIGHITVNPEGGAPCNCGKtgcLETVASATGIVRIAR 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 270 KRLNTQNTLSELKkmYYERNEIV----------------LEEIQQFSIRIAILMYNLNMQLNPKVIYINCPLINEITDLL 333
Cdd:cd24062   196 EELEEGKGSSALR--ILALGGELtakdvfeaakagdelaLAVVDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLL 273

                         250
                  ....*....|.
gi 1887529667 334 DNIKTTFNQYT 344
Cdd:cd24062   274 SPVKEYFDRFT 284
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 82-238 8.93e-11

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 62.18  E-value: 8.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  82 YVISLDIAYHSIEIIYSYFNGELLKYESIPLANQKITH-VLELLKYHINAD-ENFGTHfgLLGIAISVHGIVNNE-QEII 158
Cdd:cd24070     2 YVLGIDIGGTNIRIGLVDEDGKLLDFEKVPSKDLLRAGdPVEVLADLIREYiEEAGLK--PAAIVIGVPGTVDKDrRTVI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 159 HLPF-HELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEI 237
Cdd:cd24070    80 STPNiPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAGEL 159


                  .
gi 1887529667 238 G 238
Cdd:cd24070   160 G 160
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 101-333 3.52e-10

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 60.79  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 101 NGELLKYESIPLANQKITHVLELLKYHInaDENFGTHFG----LLGIAISVHGIVNNEQEIIH-LPFHELEKVSMIESIK 175
Cdd:cd24074    22 NGRLLAEERYPLPAKDNDPFLDRLLESI--SEFFSRHQKklerLTAIAITLPGIIDPESGIVHrLPFYDIKNLPLGEALE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 176 EIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIGKTlvsSIED-NERTYHK 254
Cdd:cd24074   100 QHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHT---QIDPyGKRCYCG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 255 ----IEDLCSQDALVNKINKRLNtQNTLSELKKMYYERNEI----------VLEEIQQFSIRIAILMYNLNMQLNPKVIY 320
Cdd:cd24074   177 nhgcLETVASIPAILEQANQLLE-QSPDSMLHGQPISIESLcqaalagdplAQDIIIQVGRHLGRILAILVNLFNPEKIL 255

                         250
                  ....*....|...
gi 1887529667 321 INCPLiNEITDLL 333
Cdd:cd24074   256 IGSPL-NNAAEIL 267
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 164-345 4.05e-10

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 4.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 164 ELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVNGEAGEIGKTLV- 242
Cdd:cd24065    82 GLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTVl 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 243 -SSIEDNERTYHKIEDLCSQDALVNKINKRLNTQNTLSELKKMYYERNEIVLEEIQQFSIRIAILMYNLNMQLNPKVIYI 321
Cdd:cd24065   162 pGGPMCGCGLVGCLEALASGRALARDASFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDPEVFVL 241

                         170       180
                  ....*....|....*....|....
gi 1887529667 322 NCPLINEITDLLDNIKTTFNQYTQ 345
Cdd:cd24065   242 GGGVAQVGDYYLLPVQEAARRYTE 265
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 138-238 1.12e-09

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 58.90  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 138 FGLLGIAISVHGIVNNEQEII-HLPFHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGI 216
Cdd:cd24061    52 HDVSAVGVAAAGFVDADRATVlFAPNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGL 131

                          90       100
                  ....*....|....*....|..
gi 1887529667 217 GAGLIIDQKLYRGVNGEAGEIG 238
Cdd:cd24061   132 GGGIVIGGKLLRGAFGIAGEFG 153
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 137-243 4.53e-08

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 53.83  E-value: 4.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 137 HFGLLGIA---ISVHGIVN--NEQEIIHLPFHELEkvsmiESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLS 211
Cdd:cd24069    51 QFDRVAVAstgIIRDGVLTalNPKNLGGLSGFPLA-----DALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFIT 125

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1887529667 212 IHKGIGAGLIIDQKLYRGVNGEAGEIGKTLVS 243
Cdd:cd24069   126 VSTGVGGGLVLNGQLLTGPNGLAGHIGHTLAD 157
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 140-243 6.69e-08

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 53.57  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 140 LLGIAISVHGIVN-NEQEIIH----LPfhELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHK 214
Cdd:cd24060    60 ILGVGISTGGRVNpREGIVLHstklIQ--EWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGT 137

                          90       100
                  ....*....|....*....|....*....
gi 1887529667 215 GIGAGLIIDQKLYRGVNGEAGEIGKTLVS 243
Cdd:cd24060   138 GIGGGIILNHELIHGSSFCAAELGHIVVS 166
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 139-364 1.03e-07

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 52.88  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 139 GLLGIAISVHGIVNNEQEIIHLP--FHELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGI 216
Cdd:cd24064    55 ELLGIGIGSPGSIDRENGIVRFSpnFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 217 GAGLIIDQKLYRGVNGEAGEIGKTLVSS--IEDNERTYHKIEDLCSQDA---LVNKINKR----LNTQNTLSELKKMY-- 285
Cdd:cd24064   135 GSGVICHGQLLTGYDGIAAELGHVIVEPngPICGCGNRGCVEAFASATAiirYARESRKRypdsLAGESEKINAKHVFda 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 286 YERNEIVLEEIQQFSIR-IAILMYNLNMQLNPKVIYINCPLINEITDLLDNIKTTFNQYT----QKEIEISLTSNVKFAT 360
Cdd:cd24064   215 ARKNDPLATMVFRRVVDaLAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVmlsfQDTYSIELSNLVEDAG 294


                  ....
gi 1887529667 361 LFGA 364
Cdd:cd24064   295 ILGA 298
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 143-242 3.20e-07

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 51.45  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 143 IAISVHGIVNNEqeII------------HLPFHElekvsmieSIKEIADVPVIVENEANFSAIYECNVNNSlEINNL--I 208
Cdd:PRK05082   59 VAVASTGIINDG--ILtalnphnlggllHFPLVQ--------TLEQLTDLPTIALNDAQAAAWAEYQALPD-DIRNMvfI 127

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1887529667 209 TLSihKGIGAGLIIDQKLYRGVNGEAGEIGKTLV 242
Cdd:PRK05082  128 TVS--TGVGGGIVLNGKLLTGPGGLAGHIGHTLA 159
PRK09698 PRK09698
D-allose kinase; Provisional
 82-266 1.70e-06

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 49.21  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667  82 YVISLDIAYHSIEIIYSYFNGELLKYESIP----LANQKITHVLELLKYHINAdenfgTHFGLLGIAISVHGIVNNE-QE 156
Cdd:PRK09698    5 VVLGIDMGGTHIRFCLVDAEGEILHCEKKRtaevIAPDLVSGLGEMIDEYLRR-----FNARCHGIVMGFPALVSKDrRT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887529667 157 IIHLPF---HELEKVSMIESIKEIADVPVIVENEANFSAIYECNVNNsleINNLITLSIHKGIGAG--LIIDQKLYRGVN 231
Cdd:PRK09698   80 VISTPNlplTALDLYDLADKLENTLNCPVFFSRDVNLQLLWDVKENN---LTQQLVLGAYLGTGMGfaVWMNGAPWTGAH 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1887529667 232 GEAGEIGKTLVssiEDNERTYHK-----IEDLCSQDALVN 266
Cdd:PRK09698  157 GVAGELGHIPL---GDMTQHCGCgnpgcLETNCSGMALRR 193
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-55 2.66e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 41.42  E-value: 2.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1887529667   7 TNLDSNQKLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLV 55
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
2-56 6.44e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 6.44e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1887529667    2 EKLDVTNLDSNQKLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLVN 56
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 171-237 4.47e-03

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 38.68  E-value: 4.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1887529667 171 IESIKEIADVPVIVENEANFSAIYECNVNNSLEINNLITLSIHKGIGAGLIIDQKLYRGVN-GEAGEI 237
Cdd:cd24067    88 LGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLLhPEMGHI 155
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 30-62 9.19e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 9.19e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1887529667  30 QISKNLGINKATISSILNKLKEKKLVNEVGQGK 62
Cdd:cd00090    25 ELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
14-56 9.83e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 9.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1887529667  14 KLVLQQIFNNELISRIQISKNLGINKATISSILNKLKEKKLVN 56
Cdd:COG1321    13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH