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Conserved domains on  [gi|1888650333|ref|WP_182439832|]
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AraC family transcriptional regulator [Jutongia huaianensis]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11454391)

helix-turn-helix (HTH) domain-containing protein with an AraC family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
19-107 6.12e-31

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 110.25  E-value: 6.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  19 LTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFG 98
Cdd:COG2207   165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFG 244


                  ....*....
gi 1888650333  99 MTPGEARRK 107
Cdd:COG2207   245 VTPSEYRKR 253
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
19-107 6.12e-31

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 110.25  E-value: 6.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  19 LTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFG 98
Cdd:COG2207   165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFG 244


                  ....*....
gi 1888650333  99 MTPGEARRK 107
Cdd:COG2207   245 VTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
22-105 1.01e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 104.56  E-value: 1.01e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   22 KLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFGMTP 101
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1888650333  102 GEAR 105
Cdd:smart00342  81 SEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
28-107 6.39e-26

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 92.27  E-value: 6.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  28 IAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLL-YNTERRISDIAYDSGFEHESSFIRSFKREFGMTPGEARR 106
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1888650333 107 K 107
Cdd:pfam12833  81 R 81
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
5-105 2.66e-18

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 73.81  E-value: 2.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   5 DDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFE 84
Cdd:PRK10219    4 QKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYV 83

                          90       100
                  ....*....|....*....|.
gi 1888650333  85 HESSFIRSFKREFGMTPGEAR 105
Cdd:PRK10219   84 SQQTFSRVFRRQFDRTPSDYR 104
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
19-107 6.12e-31

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 110.25  E-value: 6.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  19 LTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFG 98
Cdd:COG2207   165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFG 244


                  ....*....
gi 1888650333  99 MTPGEARRK 107
Cdd:COG2207   245 VTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
22-105 1.01e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 104.56  E-value: 1.01e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   22 KLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFGMTP 101
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1888650333  102 GEAR 105
Cdd:smart00342  81 SEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 4-107 1.71e-28

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 104.85  E-value: 1.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   4 EDDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGF 83
Cdd:COG4977   208 RDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGF 287

                          90       100
                  ....*....|....*....|....
gi 1888650333  84 EHESSFIRSFKREFGMTPGEARRK 107
Cdd:COG4977   288 GSASHFRRAFRRRFGVSPSAYRRR 311
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 14-106 9.08e-28

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 103.98  E-value: 9.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  14 YIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLyNTERRISDIAYDSGFEHESSFIRSF 93
Cdd:COG2169    92 LIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSRFYEAF 170

                          90
                  ....*....|...
gi 1888650333  94 KREFGMTPGEARR 106
Cdd:COG2169   171 KKLLGMTPSAYRR 183
HTH_18 pfam12833
Helix-turn-helix domain;
28-107 6.39e-26

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 92.27  E-value: 6.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  28 IAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLL-YNTERRISDIAYDSGFEHESSFIRSFKREFGMTPGEARR 106
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1888650333 107 K 107
Cdd:pfam12833  81 R 81
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
5-105 2.66e-18

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 73.81  E-value: 2.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   5 DDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFE 84
Cdd:PRK10219    4 QKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYV 83

                          90       100
                  ....*....|....*....|.
gi 1888650333  85 HESSFIRSFKREFGMTPGEAR 105
Cdd:PRK10219   84 SQQTFSRVFRRQFDRTPSDYR 104
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
14-107 6.53e-17

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 73.85  E-value: 6.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  14 YIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSF 93
Cdd:PRK10572  191 YISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVF 270

                          90
                  ....*....|....
gi 1888650333  94 KREFGMTPGEARRK 107
Cdd:PRK10572  271 KKCTGASPSEFRAR 284
PRK10371 PRK10371
transcriptional regulator MelR;
13-106 2.88e-16

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 72.16  E-value: 2.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  13 TYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRS 92
Cdd:PRK10371  198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYST 277

                          90
                  ....*....|....
gi 1888650333  93 FKREFGMTPGEARR 106
Cdd:PRK10371  278 FGKYVGMSPQQYRK 291
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 8-107 1.54e-15

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 70.06  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   8 FNSVFTYIEDNLT-EKLTVEEIAKHVYLSPTYLQSVFKEHfGIPLAEYVRSQKLKRAMDLLYNTERR--ISDIAYDSGFE 84
Cdd:PRK09685  199 FQKVVALIDQSIQeEILRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPAADDekITSIAYKWGFS 277

                          90       100
                  ....*....|....*....|...
gi 1888650333  85 HESSFIRSFKREFGMTPGEARRK 107
Cdd:PRK09685  278 DSSHFSTAFKQRFGVSPGEYRRK 300
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
9-114 4.39e-13

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 60.89  E-value: 4.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   9 NSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESS 88
Cdd:PRK11511   12 HSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQT 91

                          90       100
                  ....*....|....*....|....*.
gi 1888650333  89 FIRSFKREFGMTPGEARRKKCHDSGK 114
Cdd:PRK11511   92 LTRTFKNYFDVPPHKYRMTNMQGESR 117
ftrA PRK09393
transcriptional activator FtrA; Provisional
 4-107 6.65e-13

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 63.06  E-value: 6.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   4 EDDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGF 83
Cdd:PRK09393  216 ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGF 295

                          90       100
                  ....*....|....*....|....
gi 1888650333  84 EHESSFIRSFKREFGMTPGEARRK 107
Cdd:PRK09393  296 GSEESLRHHFRRRAATSPAAYRKR 319
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
9-105 1.03e-11

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 59.69  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   9 NSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESS 88
Cdd:PRK13503  174 NQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNH 253

                          90
                  ....*....|....*..
gi 1888650333  89 FIRSFKREFGMTPGEAR 105
Cdd:PRK13503  254 FSTLFRREFSWSPRDIR 270
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
13-106 3.97e-11

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 58.10  E-value: 3.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  13 TYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRS 92
Cdd:PRK15121   12 IWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRA 91

                          90
                  ....*....|....
gi 1888650333  93 FKREFGMTPGEARR 106
Cdd:PRK15121   92 FKKQFAQTPALYRR 105
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
34-107 1.44e-10

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 56.45  E-value: 1.44e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1888650333  34 LSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFGMTPGEARRK 107
Cdd:PRK13501  204 LVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQR 277
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
2-105 1.54e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 50.87  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   2 SKEDDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDS 81
Cdd:PRK13500  202 TSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTEC 281

                          90       100
                  ....*....|....*....|....
gi 1888650333  82 GFEHESSFIRSFKREFGMTPGEAR 105
Cdd:PRK13500  282 GFEDSNYFSVVFTRETGMTPSQWR 305
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
1-105 2.75e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 50.05  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   1 MSKEDDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYD 80
Cdd:PRK13502  171 ATSRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQ 250

                          90       100
                  ....*....|....*....|....*
gi 1888650333  81 SGFEHESSFIRSFKREFGMTPGEAR 105
Cdd:PRK13502  251 CGFEDSNYFSVVFTRETGMTPSQWR 275
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 4-103 1.59e-07

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 47.75  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333   4 EDDVFNSVFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHfGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGF 83
Cdd:PRK15186  179 QNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGY 257

                          90       100
                  ....*....|....*....|
gi 1888650333  84 EHESSFIRSFKREFGMTPGE 103
Cdd:PRK15186  258 DSASYFTCVFKKHFKTTPSE 277
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 15-56 3.76e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 43.30  E-value: 3.76e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1888650333  15 IEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGIPLAEYVR 56
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
23-106 8.02e-06

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 43.24  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  23 LTVEEIAKHVYLSPTYLQSVFKEHFGI-PLA--EYVRSQKLKRAMdllyNTERRISDIAYDSGFEHESSFIRSFKREFGM 99
Cdd:PRK15435  100 VTLEALADQVAMSPFHLHRLFKATTGMtPKAwqQAWRARRLREAL----AKGESVTTSILNAGFPDSSSYYRKADETLGM 175


                  ....*..
gi 1888650333 100 TPGEARR 106
Cdd:PRK15435  176 TAKQFRH 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 68-106 1.50e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 39.06  E-value: 1.50e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1888650333  68 YNTERRISDIAYDSGFeHESSFIRSFKREFGMTPGEARR 106
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 63-107 2.09e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 38.97  E-value: 2.09e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1888650333  63 AMDLLYNTERRISDIAYDSGFEHESSFIRSFKREFGMTPGEARRK 107
Cdd:PRK10296  229 AKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 11-101 2.32e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 38.82  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  11 VFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHfGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFI 90
Cdd:PRK15185  211 VYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFI 289

                          90
                  ....*....|.
gi 1888650333  91 RSFKREFGMTP 101
Cdd:PRK15185  290 QCFKKYFKTTP 300
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
14-101 2.59e-04

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 38.75  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  14 YIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHFGI-PLA--EYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFI 90
Cdd:PRK10130  248 YVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIgPNAwlKRIRLNAVRRELISPWSQSTTVKDAAMQWGFWHLGQFA 327

                          90
                  ....*....|.
gi 1888650333  91 RSFKREFGMTP 101
Cdd:PRK10130  328 TDYQQLFAEKP 338
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 11-110 2.81e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 35.78  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888650333  11 VFTYIEDNLTEKLTVEEIAKHVYLSPTYLQSVFKEHfGIPLAEYVRSQKLKRAMDLLYNTERRISDIAYDSGFEHESSFI 90
Cdd:PRK15044  197 VYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAE-EVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFI 275

                          90       100
                  ....*....|....*....|
gi 1888650333  91 RSFKREFGMTPGEARRKKCH 110
Cdd:PRK15044  276 AIFKRHFKITPLSFMRTMNH 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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