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Conserved domains on  [gi|1889634276|ref|WP_182721302|]
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MULTISPECIES: peptide chain release factor N(5)-glutamine methyltransferase [unclassified Pseudoalteromonas]

Protein Classification

peptide chain release factor N(5)-glutamine methyltransferase( domain architecture ID 11497022)

peptide chain release factor N(5)-glutamine methyltransferase modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 26-275 9.61e-128

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


:

Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 362.94  E-value: 9.61e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  26 DAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFWSLSLEVNATTLIPRPDTETLVEQA 105
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 106 LEVtVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSELHGEKFNLIVT 185
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 186 NPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLLIEHGFEQGEAVRHFFKKMAFVNIKTV 264
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 1889634276 265 KDLGNNDRVTL 275
Cdd:TIGR03534 240 KDLAGKDRVVL 250
 
Name Accession Description Interval E-value
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 26-275 9.61e-128

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 362.94  E-value: 9.61e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  26 DAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFWSLSLEVNATTLIPRPDTETLVEQA 105
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 106 LEVtVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSELHGEKFNLIVT 185
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 186 NPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLLIEHGFEQGEAVRHFFKKMAFVNIKTV 264
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 1889634276 265 KDLGNNDRVTL 275
Cdd:TIGR03534 240 KDLAGKDRVVL 250
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 4-278 1.02e-126

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 361.40  E-value: 1.02e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   4 TLEQAIAAGADLLAlsseSAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFWSL 83
Cdd:PRK09328    3 TIAEALREATARLA----SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  84 SLEVNATTLIPRPDTETLVEQALEVTV-PATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAIN 162
Cdd:PRK09328   79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 163 NVHVKQSNWFSELHGEKFNLIVTNPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLLIEH 241
Cdd:PRK09328  159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1889634276 242 GFEQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLALW 278
Cdd:PRK09328  239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 3-279 2.84e-121

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 347.91  E-value: 2.84e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   3 HTLEQAIAAGADLL-ALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFW 81
Cdd:COG2890     1 MTIRELLRWAAARLaAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  82 SLSLEVNATTLIPRPDTETLVEQALE-VTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLA 160
Cdd:COG2890    81 GLEFKVDPGVLIPRPETEELVELALAlLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 161 INN-VHVKQSNWFSELHG-EKFNLIVTNPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYL 237
Cdd:COG2890   161 LEDrVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1889634276 238 LIEHGFEQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLALWP 279
Cdd:COG2890   241 LLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARRP 282
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 7-76 9.98e-22

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 86.00  E-value: 9.98e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889634276   7 QAIAAGADLL-ALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITG 76
Cdd:pfam17827   1 EALRWASSRLkEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-189 1.51e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 1.51e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1889634276 115 KVLDLGTGTGAIALALGSEmPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNW--FSELHGEKFNLIVTNPPY 189
Cdd:cd02440     1 RVLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAeeLPPEADESFDVIISDPPL 76
 
Name Accession Description Interval E-value
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 26-275 9.61e-128

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 362.94  E-value: 9.61e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  26 DAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFWSLSLEVNATTLIPRPDTETLVEQA 105
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 106 LEVtVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSELHGEKFNLIVT 185
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 186 NPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLLIEHGFEQGEAVRHFFKKMAFVNIKTV 264
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 1889634276 265 KDLGNNDRVTL 275
Cdd:TIGR03534 240 KDLAGKDRVVL 250
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 4-278 1.02e-126

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 361.40  E-value: 1.02e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   4 TLEQAIAAGADLLAlsseSAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFWSL 83
Cdd:PRK09328    3 TIAEALREATARLA----SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  84 SLEVNATTLIPRPDTETLVEQALEVTV-PATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAIN 162
Cdd:PRK09328   79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 163 NVHVKQSNWFSELHGEKFNLIVTNPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLLIEH 241
Cdd:PRK09328  159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1889634276 242 GFEQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLALW 278
Cdd:PRK09328  239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 3-279 2.84e-121

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 347.91  E-value: 2.84e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   3 HTLEQAIAAGADLL-ALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFW 81
Cdd:COG2890     1 MTIRELLRWAAARLaAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  82 SLSLEVNATTLIPRPDTETLVEQALE-VTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLA 160
Cdd:COG2890    81 GLEFKVDPGVLIPRPETEELVELALAlLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 161 INN-VHVKQSNWFSELHG-EKFNLIVTNPPYIESSDIHLNQGDVR-FEPLSALVADDCGMSDIKQIITQSRDYLLSSGYL 237
Cdd:COG2890   161 LEDrVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1889634276 238 LIEHGFEQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLALWP 279
Cdd:COG2890   241 LLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARRP 282
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 4-278 1.88e-90

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 269.61  E-value: 1.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   4 TLEQAI--AAGADLLALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQREFW 81
Cdd:TIGR00536   2 TIQEFLrwASSALSRAIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  82 SLSLEVNATTLIPRPDTETLVEQALE--VTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRL 159
Cdd:TIGR00536  82 GLEFFVNEHVLIPRPETEELVEKALAslISQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 160 AIN-NVHVKQSNWFSELHGEKFNLIVTNPPYIESSDIHLNQGDVRFEPLSALVADDCGMSDIKQIITQSRDYLLSSGYLL 238
Cdd:TIGR00536 162 QLEhRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLV 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1889634276 239 IEHGF-EQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLALW 278
Cdd:TIGR00536 242 CEIGNwQQKSLKELLRIKFTWYDVENGRDLNGKERVVLGFY 282
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 6-276 1.40e-53

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 179.51  E-value: 1.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   6 EQAIAAGADLLALS-------SESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQR 78
Cdd:PRK14966  139 ERKAASAADGIKMTfdewlglSKLPKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVR 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  79 EFWSLSLEVNATTLIPRPDTETLVEQALeVTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQR 158
Cdd:PRK14966  219 EFYGRRFAVNPNVLIPRPETEHLVEAVL-ARLPENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAAD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 159 LAINnVHVKQSNWF-SELHGE-KFNLIVTNPPYIESSDIHLNQGDVRFEPLSALVADDCGMSDIKQIITQSRDYLLSSGY 236
Cdd:PRK14966  298 LGAR-VEFAHGSWFdTDMPSEgKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGF 376

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1889634276 237 LLIEHGFEQGEAVRHFFKKMAFVNIKTVKDLGNNDRVTLA 276
Cdd:PRK14966  377 LLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLG 416
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 1-275 1.80e-48

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 167.73  E-value: 1.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276   1 MAHTLEQAIAAGADLL-ALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITGQRE 79
Cdd:PRK01544    1 MQYSIKQILSDATDKLnKIGISSPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  80 FWSLSLEVNATTLIPRPDTETLVEQAL-------------------------EVTVPATAKVLDLGTGTGAIALALGSEM 134
Cdd:PRK01544   81 FYSREFIVNKHVLIPRSDTEVLVDVVFqchsresgnpekkqlnpcfrgndisSNCNDKFLNILELGTGSGCIAISLLCEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 135 PNWQITAVDRVSDAVALATRNQQRLAINN-VHVKQSNWFSELHGEKFNLIVTNPPYIESSD-IHLNQGDVRFEPLSALVA 212
Cdd:PRK01544  161 PNANVIATDISLDAIEVAKSNAIKYEVTDrIQIIHSNWFENIEKQKFDFIVSNPPYISHSEkSEMAIETINYEPSIALFA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1889634276 213 DDCGMSDIKQIITQSRDYLLSSGYLLIEHGFEQGEAVRHFFKKMAFvNIKTV-KDLGNNDRVTL 275
Cdd:PRK01544  241 EEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDHGY-NIESVyKDLQGHSRVIL 303
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 7-76 9.98e-22

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 86.00  E-value: 9.98e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889634276   7 QAIAAGADLL-ALSSESAKLDAQVLLLHILQKPRSYLFTWPEHALSDEQQSQFNVFIQRRLKGEPVAHITG 76
Cdd:pfam17827   1 EALRWASSRLkEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 98-239 4.32e-20

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 85.24  E-value: 4.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  98 TETLVEQaleVTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSELHG 177
Cdd:COG2813    38 TRLLLEH---LPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPD 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1889634276 178 EKFNLIVTNPPyiessdIHlnQG-DVRFEPLsalvaddcgmsdiKQIITQSRDYLLSSGYLLI 239
Cdd:COG2813   115 GSFDLILSNPP------FH--AGrAVDKEVA-------------HALIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 110-239 1.63e-18

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 80.33  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 110 VPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSELHGEKFNLIVTNPPY 189
Cdd:pfam05175  29 KDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPF 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1889634276 190 IESSDIHLNQGDvrfeplsalvaddcgmsdikQIITQSRDYLLSSGYLLI 239
Cdd:pfam05175 109 HAGLATTYNVAQ--------------------RFIADAKRHLRPGGELWI 138
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 108-189 4.35e-18

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 80.96  E-value: 4.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 108 VTVPATAKVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNqqrLAINN----VHVKQS---NWFSELHGEKF 180
Cdd:COG4123    33 APVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRN---VALNGledrITVIHGdlkEFAAELPPGSF 109


                  ....*....
gi 1889634276 181 NLIVTNPPY 189
Cdd:COG4123   110 DLVVSNPPY 118
PRK14967 PRK14967
putative methyltransferase; Provisional
 94-194 4.83e-15

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 72.39  E-value: 4.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  94 PRPDTETLVEQALEVTVPATAKVLDLGTGTGAIALA---LGSEmpnwQITAVDRVSDAVALATRNqQRLAINNVHVKQSN 170
Cdd:PRK14967   18 PQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVAaaaAGAG----SVTAVDISRRAVRSARLN-ALLAGVDVDVRRGD 92

                          90       100
                  ....*....|....*....|....
gi 1889634276 171 WFSELHGEKFNLIVTNPPYIESSD 194
Cdd:PRK14967   93 WARAVEFRPFDVVVSNPPYVPAPP 116
PRK14968 PRK14968
putative methyltransferase; Provisional
 87-265 1.31e-13

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 67.62  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  87 VNATTLIPRPDTETLVEQALEVtvpATAKVLDLGTGTGAIALALGSEmpNWQITAVDRVSDAVALATRNQQRLAINN--V 164
Cdd:PRK14968    1 LNDEVYEPAEDSFLLAENAVDK---KGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNngV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 165 HVKQSNWFSELHGEKFNLIVTNPPYIESSDIHLNQGDVRFeplsALVADDCGMSDIKQIITQSRDYLLSSG-YLLIEHGF 243
Cdd:PRK14968   76 EVIRSDLFEPFRGDKFDVILFNPPYLPTEEEEEWDDWLNY----ALSGGKDGREVIDRFLDEVGRYLKPGGrILLLQSSL 151

                         170       180
                  ....*....|....*....|..
gi 1889634276 244 EQGEAVRHFFKKMAFVNIKTVK 265
Cdd:PRK14968  152 TGEDEVLEYLEKLGFEAEVVAE 173
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-189 1.51e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 1.51e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1889634276 115 KVLDLGTGTGAIALALGSEmPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNW--FSELHGEKFNLIVTNPPY 189
Cdd:cd02440     1 RVLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAeeLPPEADESFDVIISDPPL 76
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 98-188 4.46e-12

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 65.58  E-value: 4.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  98 TETLVEQALE-VTVPATAKVLDLGTGTGAIALALGSemPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWF---- 172
Cdd:COG2265   218 AEALYAAALEwLDLTGGERVLDLYCGVGTFALPLAR--RAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEevlp 295

                          90
                  ....*....|....*.
gi 1889634276 173 SELHGEKFNLIVTNPP 188
Cdd:COG2265   296 ELLWGGRPDVVVLDPP 311
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 115-186 7.13e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 58.97  E-value: 7.13e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1889634276 115 KVLDLGTGTGAIALALGSEM-PNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFSE---LHGEKFNLIVTN 186
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELpelLEDDKFDVVISN 81
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 95-184 1.54e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.46  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  95 RPDTETLVEQALEVTVPATAKVLDLGTGTGAIALALGsEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNW--F 172
Cdd:COG0500     9 ELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLaeL 87

                          90
                  ....*....|..
gi 1889634276 173 SELHGEKFNLIV 184
Cdd:COG0500    88 DPLPAESFDLVV 99
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
111-200 1.61e-09

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 57.64  E-value: 1.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 111 PATAKVLDLGTGTGAIALALGSEMPNWQITavdrVSDAVALATRNQQR-LAINNV--HVKQSNWFSELHGeKFNLIVTNP 187
Cdd:PRK09489  195 HTKGKVLDVGCGAGVLSAVLARHSPKIRLT----LSDVSAAALESSRAtLAANGLegEVFASNVFSDIKG-RFDMIISNP 269

                          90       100
                  ....*....|....*....|....*..
gi 1889634276 188 PY--------------IESSDIHLNQG 200
Cdd:PRK09489  270 PFhdgiqtsldaaqtlIRGAVRHLNSG 296
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
116-186 3.78e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.21  E-value: 3.78e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889634276 116 VLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALAtrnQQRLAinNVHVKQSNWFSELHGEKFNLIVTN 186
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARA---RARLP--NVRFVVADLRDLDPPEPFDLVVSN 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 90-186 3.97e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.79  E-value: 3.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  90 TTLIPRPDTETLVEQALEVTVPATAKVLDLGTGTGAIALALGSEmpNWQITAVDRVSDAVALAtrnQQRLAINNVHVKQS 169
Cdd:COG2227     2 SDPDARDFWDRRLAALLARLLPAGGRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIA---RERAAELNVDFVQG 76

                          90
                  ....*....|....*...
gi 1889634276 170 NWFS-ELHGEKFNLIVTN 186
Cdd:COG2227    77 DLEDlPLEDGSFDLVICS 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 116-186 1.06e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 48.71  E-value: 1.06e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1889634276 116 VLDLGTGTGAIALALgSEMPNWQITAVDRVSDAVALATRNQQRLAInNVHVKQSNWFS-ELHGEKFNLIVTN 186
Cdd:pfam13649   1 VLDLGCGTGRLTLAL-ARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDlPFPDGSFDLVVSS 70
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
115-166 2.38e-07

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 50.00  E-value: 2.38e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1889634276 115 KVLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHV 166
Cdd:PRK08287   34 HLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDI 85
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 116-166 5.30e-07

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 50.17  E-value: 5.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1889634276 116 VLDLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHV 166
Cdd:COG2242   251 LWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEV 301
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
115-188 6.34e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 48.75  E-value: 6.34e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1889634276 115 KVLDLGTGTGAIALA---LGSEmpnwQITAVDRVSDAVALATRNQQRLAiNNVHVKQSNWFSELHGEKFNLIVTNPP 188
Cdd:COG2263    48 TVLDLGCGTGMLAIGaalLGAK----KVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIPLGGSVDTVVMNPP 119
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
118-170 1.27e-06

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 47.68  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1889634276 118 DLGTGTGAIALALGSEMPNWQITAVDRVSDAVALATRNQQRLAINNVHVKQSN 170
Cdd:PRK07402   46 DIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEGS 98
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 104-168 1.93e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 47.39  E-value: 1.93e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1889634276 104 QALEVTvpATAKVLDLGTGTG---AIALALGSEmpnwqITAVDRVSDAVALATRNQQRLAINNVHVKQ 168
Cdd:COG2518    60 EALDLK--PGDRVLEIGTGSGyqaAVLARLAGR-----VYSVERDPELAERARERLAALGYDNVTVRV 120
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 114-189 2.51e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.92  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 114 AKVLDLGTGTGAIAL-AL--GSEmpnwQITAVDRVSDAVALATRNQQRL-AINNVHVKQSN---WFSELHGEKFNLIVTN 186
Cdd:COG0742    43 ARVLDLFAGSGALGLeALsrGAA----SVVFVEKDRKAAAVIRKNLEKLgLEDRARVIRGDalrFLKRLAGEPFDLVFLD 118


                  ...
gi 1889634276 187 PPY 189
Cdd:COG0742   119 PPY 121
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 117-186 3.63e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.58  E-value: 3.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1889634276 117 LDLGTGTGAIALALGSEMPNWQITAVDrVSDAVALATRNQ----QRLAINNVHVKQSNwFSELHGEKFNLIVTN 186
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLD-ISPAALEAARERlaalGLLNAVRVELFQLD-LGELDPGSFDVVVAS 72
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 107-162 7.05e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.90  E-value: 7.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1889634276 107 EVTVPATAKVLDLGTGTGAIALALGSEmpNWQITAVDRVSDAVALATRNQQRLAIN 162
Cdd:COG2226    17 ALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLN 70
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
94-206 7.72e-05

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 42.87  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  94 PRPDTETLVEqalEVTVPATAKVLDLGTGTGA--------IALALGSEMPNWQITAVDRVSDAVALATRNqqrLA---IN 162
Cdd:COG0286    28 PREVVRLMVE---LLDPKPGETVYDPACGSGGflveaaeyLKEHGGDERKKLSLYGQEINPTTYRLAKMN---LLlhgIG 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1889634276 163 NVHVKQSNWFSE--LHGEKFNLIVTNPPYIESSDIHLNQGDV--RFEP 206
Cdd:COG0286   102 DPNIELGDTLSNdgDELEKFDVVLANPPFGGKWKKEELKDDLlgRFGY 149
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
104-186 1.22e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 42.47  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 104 QALEVTVPATAKVLDLGTGTG--AI-ALALGSEmpnwQITAVDRvsDAVAL------ATRNQqrlAINNVHVKQSNwfsE 174
Cdd:COG2264   140 EALEKLLKPGKTVLDVGCGSGilAIaAAKLGAK----RVLAVDI--DPVAVeaarenAELNG---VEDRIEVVLGD---L 207

                          90
                  ....*....|..
gi 1889634276 175 LHGEKFNLIVTN 186
Cdd:COG2264   208 LEDGPYDLVVAN 219
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 110-196 1.31e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.47  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 110 VPATAKVLD--LGTGTGAI-ALALGsempnWQITAVDRVSDAVALATRNQQRLAINNVHVKQSNWFS-ELHGEKFNLIVT 185
Cdd:COG1041    24 AKEGDTVLDpfCGTGTILIeAGLLG-----RRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDlPLADESVDAIVT 98

                          90
                  ....*....|.
gi 1889634276 186 NPPYIESSDIH 196
Cdd:COG1041    99 DPPYGRSSKIS 109
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
104-186 1.84e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 42.06  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 104 QALEVTVPATAKVLDLGTGTG--AIALA-LGsempNWQITAVDrvSDAVAL------ATRNQqrlAINNVHVKQSNwfse 174
Cdd:PRK00517  111 EALEKLVLPGKTVLDVGCGSGilAIAAAkLG----AKKVLAVD--IDPQAVeaarenAELNG---VELNVYLPQGD---- 177

                          90
                  ....*....|..
gi 1889634276 175 lhgEKFNLIVTN 186
Cdd:PRK00517  178 ---LKADVIVAN 186
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
83-167 1.92e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 41.58  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  83 LSLEVNATtlIPRPDTETLVEQALEVTvpATAKVLDLGTGTGAIAlALGSEM--PNWQITAVDRVSDAVALATRNQQRLA 160
Cdd:pfam01135  48 LSIGYGQT--ISAPHMHAMMLELLELK--PGMRVLEIGSGSGYLT-ACFARMvgEVGRVVSIEHIPELVEIARRNLEKLG 122


                  ....*..
gi 1889634276 161 INNVHVK 167
Cdd:pfam01135 123 LENVIVV 129
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 110-184 2.96e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.30  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1889634276 110 VPATAKVLDLGTGTGAIALALGSEMpNWQITAVDRVSDAVALATRNQQRLAI-NNVHVKQSNWFSELHGEKFNLIV 184
Cdd:COG2230    49 LKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLaDRVEVRLADYRDLPADGQFDAIV 123
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 115-218 3.72e-04

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 40.39  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 115 KVLDLGTGTGAIALALGSEMPNWQITAVDRvSDAVALATRNQQRLAINN-VHVKQSNWFSELHGEKFNLivTNPPYIESS 193
Cdd:pfam10294  49 NVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALSSkVVVKVLDWGENLPPDLFDG--HPVDLILAA 125

                          90       100
                  ....*....|....*....|....*.
gi 1889634276 194 D-IHLNQGdvrFEPLSALVADDCGMS 218
Cdd:pfam10294 126 DcVYNEDS---FPLLEKTLKDLLGKE 148
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
93-168 5.70e-04

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 40.19  E-value: 5.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1889634276  93 IPRPDTETLVEQALEVTvpATAKVLDLGTGTG---AIaLALGSEmpnwQITAVDRVSDAVALATRNQQRLAINNVHVKQ 168
Cdd:PRK00312   61 ISQPYMVARMTELLELK--PGDRVLEIGTGSGyqaAV-LAHLVR----RVFSVERIKTLQWEAKRRLKQLGLHNVSVRH 132
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 104-186 6.77e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.33  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 104 QALEVTVPATAKVLDLGTGTGAIALA---LGSEmpnwQITAVDRVSDAVALATRNQQRLAIN-NVHVKQSNwfsELHGEK 179
Cdd:pfam06325 153 EALERLVKPGESVLDVGCGSGILAIAalkLGAK----KVVGVDIDPVAVRAAKENAELNGVEaRLEVYLPG---DLPKEK 225


                  ....*..
gi 1889634276 180 FNLIVTN 186
Cdd:pfam06325 226 ADVVVAN 232
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
65-188 1.70e-03

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 39.08  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276  65 RLKGEPVAHITGQRefwSLSLEVNATTLIPRP----DTETLVEQALEVTVPATAKVL------DLGTGTGAIALALGSem 134
Cdd:PRK03522  119 ILEGEEEIFLTEQQ---ALPERFNGVPLFIRPqsffQTNPAVAAQLYATARDWVRELpprsmwDLFCGVGGFGLHCAT-- 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1889634276 135 PNWQITAVDRVSDAVALATRNQQRLAINNVH--VKQSNWFSELHGEKFNLIVTNPP 188
Cdd:PRK03522  194 PGMQLTGIEISAEAIACAKQSAAELGLTNVQfqALDSTQFATAQGEVPDLVLVNPP 249
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 105-184 6.76e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 37.24  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889634276 105 ALEVTVPATAKVLDLGTGTGAIALALGSEMPNW-QITAVDRVSDAVALAtrnqQRLA--INNVHVKQSNWF-----SELH 176
Cdd:COG5459    73 AEAGPDFAPLTVLDVGAGPGTAAWAAADAWPSLlDATLLERSAAALALG----RRLAraAANPALETAEWRladlaAALP 148


                  ....*...
gi 1889634276 177 GEKFNLIV 184
Cdd:COG5459   149 APPADLVV 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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