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Conserved domains on  [gi|1889701151|ref|WP_182738180|]
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antitoxin Xre/MbcA/ParS toxin-binding domain-containing protein [Pseudoalteromonas sp. SG43-4]

Protein Classification

MbcA/ParS/Xre antitoxin family protein( domain architecture ID 10560704)

MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
82-125 5.39e-05

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


:

Pssm-ID: 462855  Cd Length: 51  Bit Score: 38.27  E-value: 5.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1889701151  82 IFNDRSRADEWVNKPNKEFNDQSALEFMLGgdIERLKQVREFVD 125
Cdd:pfam09722   5 VFGDDEAAARWLRTPNPALGGRTPLDLLDT--EEGLRLVEDYLD 46
 
Name Accession Description Interval E-value
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
82-125 5.39e-05

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 38.27  E-value: 5.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1889701151  82 IFNDRSRADEWVNKPNKEFNDQSALEFMLGgdIERLKQVREFVD 125
Cdd:pfam09722   5 VFGDDEAAARWLRTPNPALGGRTPLDLLDT--EEGLRLVEDYLD 46
 
Name Accession Description Interval E-value
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
82-125 5.39e-05

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 38.27  E-value: 5.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1889701151  82 IFNDRSRADEWVNKPNKEFNDQSALEFMLGgdIERLKQVREFVD 125
Cdd:pfam09722   5 VFGDDEAAARWLRTPNPALGGRTPLDLLDT--EEGLRLVEDYLD 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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