|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
27-373 |
5.35e-88 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 273.74 E-value: 5.35e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 27 FRWSERAQYSVPAQPERELDEGLVRVLAVLRSAAVVLDDDDRVVRASPPAYALGVVREGQVVHAAIRDLIADVRRSGVIR 106
Cdd:COG5002 39 LLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 107 DEELELPRGPVGPGTLMLQVRVAQVGPRHLLVLAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQD-AANDP 185
Cdd:COG5002 119 LLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDgAADDP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 186 EAVRRFAGRMRGEAARLSALVHEIIELSRLQVAGALQDIAVVDVDAVVEESVDRARTAASAKQIRLDV-GGERGLTVYGD 264
Cdd:COG5002 199 EERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELdLPEDPLLVLGD 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 265 HALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIV 344
Cdd:COG5002 279 PDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIV 358
|
330 340
....*....|....*....|....*....
gi 1890773835 345 KHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG5002 359 KHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
103-371 |
1.93e-73 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 234.41 E-value: 1.93e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 103 GVIRDEELELPRgPVGPGtLMLQVRVAQVGPRHLLVLAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQDAA 182
Cdd:TIGR02966 66 AGRFSEPLELPS-PINSE-RVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 183 N-DPEAVRRFAGRMRGEAARLSALVHEIIELSRLQVAGALQDIAVVDVDAVVEESVDRARTAASAKQIRLDVGGERGLTV 261
Cdd:TIGR02966 144 DeDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 262 YGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGL 341
Cdd:TIGR02966 224 LGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGL 303
|
250 260 270
....*....|....*....|....*....|
gi 1890773835 342 SIVKHVAADHGGEVTVWSRPGKGSTFTLRL 371
Cdd:TIGR02966 304 AIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
139-375 |
1.07e-68 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 218.62 E-value: 1.07e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 139 LAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQD-AANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQv 217
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 218 AGALQ-DIAVVDVDAVVEESVDRARTAASAKQIRLDV-GGERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRA 295
Cdd:COG2205 81 SGKLSlELEPVDLAELLEEAVEELRPLAEEKGIRLELdLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 296 VDGLVEVAVVDQGIGIASDEQDRVFERFYRVDpaRSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGA 375
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
45-374 |
9.62e-64 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 208.99 E-value: 9.62e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 45 LDEGLVRVLAVLRSAAVVLDDDDRVVRASPPAYALGVVREGQVVHAAIRDLIADVRRSGVIRDEELELPRGPVGPGTLML 124
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 125 QVRVAQVGPRHLLVLAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQDAAndPEAVRRFAGRMRGEAARLSA 204
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 205 LVHEIIELSRLQVAGALQDIAVVDVDAVVEESVDRARTAASAKQIRLDVGGERGL-TVYGDHALLVTAVRNLLDNAVAYS 283
Cdd:COG0642 160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 284 PEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDParSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGK 363
Cdd:COG0642 240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
330
....*....|.
gi 1890773835 364 GSTFTLRLPVG 374
Cdd:COG0642 318 GTTFTVTLPLA 328
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
123-372 |
4.34e-51 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 178.67 E-value: 4.34e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 123 MLQVRVAQVGPRHLLVLAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARL 202
Cdd:PRK11006 174 HLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRM 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 203 SALVHEIIELSRLQVAGALqDIAVVDVDAVVEESVDRARTAASAKQ--IRLDVggERGLTVYGDHALLVTAVRNLLDNAV 280
Cdd:PRK11006 254 EGLVKQLLTLSKIEAAPTI-DLNEKVDVPMMLRVLEREAQTLSQGKhtITFEV--DNSLKVFGNEDQLRSAISNLVYNAV 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 281 AYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSR 360
Cdd:PRK11006 331 NHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESE 410
|
250
....*....|..
gi 1890773835 361 PGKGSTFTLRLP 372
Cdd:PRK11006 411 VGKGTRFSFVLP 422
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
146-375 |
9.23e-41 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 151.92 E-value: 9.23e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 146 ARRLEAIRR---------DFVVNVSHELKTPVGALSLLAETVQDAAnDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQ 216
Cdd:PRK11100 240 AQALESMRVklegkayveQYVQTLTHELKSPLAAIRGAAELLQEDP-PPEDRARFTGNILTQSARLQQLIDRLLELARLE 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 217 VAGALQDIAVVDVDAVVEESVDRARTAASAKQIRLDVGGErGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAV 296
Cdd:PRK11100 319 QRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 297 DGLVEVAVVDQGIGIASDEQDRVFERFY---RVDPARSrdtgGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:PRK11100 398 GEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
..
gi 1890773835 374 GA 375
Cdd:PRK11100 474 HF 475
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
74-375 |
1.52e-40 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 150.11 E-value: 1.52e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 74 PPAYALGVVREGQVVHAAIRDLIADVRRSGVirDEELELPRGpvgpGTLMLQVRVAQVGPRHLLVLAEDRT---QARRLE 150
Cdd:COG5000 126 PLEELIGKPLEELLPELDLAELLREALERGW--QEEIELTRD----GRRTLLVRASPLRDDGYVIVFDDITellRAERLA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 151 AIRrDFVVNVSHELKTPVGALSLLAETVQDA-----ANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQ--------V 217
Cdd:COG5000 200 AWG-ELARRIAHEIKNPLTPIQLSAERLRRKladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPepqlepvdL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 218 AGALQDIavvdvdavveesVDRARTAASAKQIRLDV-GGERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAV 296
Cdd:COG5000 279 NELLREV------------LALYEPALKEKDIRLELdLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE 346
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1890773835 297 DGLVEVAVVDQGIGIASDEQDRVFERFYrvdparSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGA 375
Cdd:COG5000 347 DGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
42-373 |
3.24e-37 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 142.62 E-value: 3.24e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 42 ERELDEGLVRVLAVLRSAAVVLDDDDRVVRASPPAYALGVVREGQVVHAAIRDLIADVRRSGVIRDEELELPRGPVGPGT 121
Cdd:COG4251 163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLI 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 122 LMLQVRVAQVGPRHLLVLAEDRTQ-----ARRLEAIRRD---FVVNVSHELKTPVGALSLLAETVQDAAND--PEAVRRF 191
Cdd:COG4251 243 LLLLLLILVLELLELRLELEELEEeleerTAELERSNEEleqFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGREY 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 192 AGRMRGEAARLSALVHEIIELSRLQ----------VAGALQDIavvdvdavveesVDRARTAASAKQIRLDVGGerGLTV 261
Cdd:COG4251 323 LERIRDAAERMQALIDDLLAYSRVGrqelefepvdLNELLEEV------------LEDLEPRIEERGAEIEVGP--LPTV 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 262 YGDHALLVTAVRNLLDNAVAYSPEG--AHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDParSRDTGGTGL 339
Cdd:COG4251 389 RGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS--RDEYEGTGI 466
|
330 340 350
....*....|....*....|....*....|....
gi 1890773835 340 GLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG4251 467 GLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
263-373 |
3.43e-37 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 132.00 E-value: 3.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 263 GDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPaRSRDTGGTGLGLS 342
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1890773835 343 IVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
268-371 |
1.03e-36 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 130.42 E-value: 1.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDParSRDTGGTGLGLSIVKHV 347
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1890773835 348 AADHGGEVTVWSRPGKGSTFTLRL 371
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
89-373 |
1.06e-36 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 138.06 E-value: 1.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 89 HAAIRDLIADVRRSG-VIRDEELELPRGpvGPGTLMLQVRVAQV----GPRHLLVLAEDRTQARRLEAIRR--------- 154
Cdd:COG3852 59 DSPLRELLERALAEGqPVTEREVTLRRK--DGEERPVDVSVSPLrdaeGEGGVLLVLRDITERKRLERELRraeklaavg 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 155 DFVVNVSHELKTPV----GALSLLAETVQDaandpEAVRRFAGRMRGEAARLSALVHEIIELSRLQVAG-ALQDIAVVdv 229
Cdd:COG3852 137 ELAAGLAHEIRNPLtgirGAAQLLERELPD-----DELREYTQLIIEEADRLNNLVDRLLSFSRPRPPErEPVNLHEV-- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 230 davveesVDRAR-----TAASAKQIRLDVGGERGLtVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGL----- 299
Cdd:COG3852 210 -------LERVLellraEAPKNIRIVRDYDPSLPE-VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlggl 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1890773835 300 -----VEVAVVDQGIGIASDEQDRVFERFYrvdparSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG3852 282 rprlyVRIEVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
274-373 |
1.76e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 119.13 E-value: 1.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 274 NLLDNAVAYSPEGaHVGIGVRAVD-----GLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVA 348
Cdd:cd16922 7 NLLGNAIKFTEEG-EVTLRVSLEEeeedgVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|....*
gi 1890773835 349 ADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:cd16922 86 ELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
28-373 |
1.63e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 124.14 E-value: 1.63e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 28 RWSERAQYSVPAQPERELDEGLVRVLAVLRSAAVVLDDDDRVVRASPPAYALGVVREGQVVHAAIRDLIADVRRSGVIRD 107
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 108 EELELPRGPVGPGTLMLQVRVAQVGPRHLLVLAEDRTQARRLEAIRRD----------------FVVNVSHELKTPVGAL 171
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRElqeqlvqseklaalgeLAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 172 SLLAETVQDAAN---DPEAVRRFAGRMRGEAARLSALVHEIIELSRLQ--------VAGALQDIavvdvdavveesVDRA 240
Cdd:COG4191 161 LGNAELLRRRLEdepDPEELREALERILEGAERAAEIVRSLRAFSRRDeeerepvdLNELIDEA------------LELL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 241 RTAASAKQIRLDVGGERGL-TVYGDHALLVTAVRNLLDNAV-AY-SPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQD 317
Cdd:COG4191 229 RPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIdAMeEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLE 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1890773835 318 RVFERFY---RVDparsrdtGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG4191 309 RIFEPFFttkPVG-------KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
263-373 |
2.59e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 113.23 E-value: 2.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 263 GDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGlVEVAVVDQGIGIASDEQDRVFERFYRVDparSRDTGGTGLGLS 342
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 1890773835 343 IVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
148-372 |
1.86e-29 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 119.80 E-value: 1.86e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 148 RLE-AIRR--DFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQVAGALQDI 224
Cdd:TIGR01386 233 RLEdAFQRlsQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALER 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 225 AVVDVDAVVEESVDRARTAASAKQIRLDVGGErgLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAV 304
Cdd:TIGR01386 313 VRLDLAAELAKVAEYFEPLAEERGVRIRVEGE--GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSV 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1890773835 305 VDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKgSTFTLRLP 372
Cdd:TIGR01386 391 SNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-371 |
2.15e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 105.57 E-value: 2.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 256 ERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVeVAVVDQGIGIASDEQDRVFERFYRVDParsRDTG 335
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNYG 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 1890773835 336 GTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRL 371
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
3.81e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 104.59 E-value: 3.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHV 347
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1890773835 348 AADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
154-364 |
8.46e-27 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 112.05 E-value: 8.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 154 RDFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQVAGALQDIAVVDVDAVV 233
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 234 EESV-DRARTA-ASAKQIRLDVGGeRGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAvdglVEVAVVDQGIGI 311
Cdd:PRK10337 318 QSAVmDIYHTAqQAGIDVRLTLNA-HPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNA----RNFTVRDNGPGV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1890773835 312 ASDEQDRVFERFYRvdPArSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKG 364
Cdd:PRK10337 393 TPEALARIGERFYR--PP-GQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
149-388 |
6.62e-26 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 109.31 E-value: 6.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 149 LEAIRRDFVVNVSHELKTPVGALSL-LAETVQDAANDPEAVRRfagrmrgEAARLSALVHEIIELSRL---QVAGALQDI 224
Cdd:PRK10604 208 LIASKKQLIDGIAHELRTPLVRLRYrLEMSDNLSAAESQALNR-------DIGQLEALIEELLTYARLdrpQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 225 AVVDVDAVVeesVDRARTAASAKQIRLDVGGeRGLTVYGDHALLVTAVRNLLDNAVAYSpeGAHVGIGVRAVDGLVEVAV 304
Cdd:PRK10604 281 DLPAWLSTH---LADIQAVTPEKTVRLDTPH-QGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIV 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 305 VDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGavpdqlLATP 384
Cdd:PRK10604 355 EDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVW------HNLP 428
|
....
gi 1890773835 385 PAAR 388
Cdd:PRK10604 429 QFTS 432
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
160-372 |
4.78e-25 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 107.33 E-value: 4.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 160 VSHELKTPVG----ALSLLaetvqdaandpeavRRFAG------RMRGEAARLSALVHEIIELSRLQVAGAL-------- 221
Cdd:PRK09470 250 ISHELRTPLTrlqlATALL--------------RRRQGeskeleRIETEAQRLDSMINDLLVLSRNQQKNHLeretfkan 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 222 ---QDIavvdvdavveesVDRARTAASAKQIRLDVGGERG-LTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAvD 297
Cdd:PRK09470 316 slwSEV------------LEDAKFEAEQMGKSLTVSAPPGpWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDK-D 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1890773835 298 GLVeVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:PRK09470 383 GLT-ITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
126-373 |
2.76e-24 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 105.10 E-value: 2.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 126 VRVAQVGPRHLLVLAEDRTQ-ARRLE---AIRRDFVVNVSHELKTPVGALSLLAETVQDAAN--DPEAVRRfagrMRGEA 199
Cdd:PRK10549 209 TRVTPTSRDELGRLAQDFNQlASTLEkneQMRRDFMADISHELRTPLAVLRGELEAIQDGVRkfTPESVAS----LQAEV 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 200 ARLSALVHEIIELSrLQVAGAL---QDIAVVDVDAVVEESVDRARTAAsaKQIRLDVGGERGLTVYGDHALLVTAVRNLL 276
Cdd:PRK10549 285 GTLTKLVDDLHQLS-LSDEGALayrKTPVDLVPLLEVAGGAFRERFAS--RGLTLQLSLPDSATVFGDPDRLMQLFNNLL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 277 DNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIaSDEQ-DRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEV 355
Cdd:PRK10549 362 ENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGV-SDEQlQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
250
....*....|....*...
gi 1890773835 356 TVWSRPGKGSTFTLRLPV 373
Cdd:PRK10549 441 IAAHSPFGGVSITVELPL 458
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
1.38e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 94.70 E-value: 1.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVRavDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHV 347
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQD--GDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 1890773835 348 AADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
160-373 |
2.73e-23 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 100.80 E-value: 2.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 160 VSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMR-GEAAR-----LSALVHEIIELSR------------LQVAGAL 221
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQlQDQARrqleeIERLITDLLEVGRtrwealrfnpqkLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 222 QDIavvdvdavveesVDRARTAASAKQIRLDVGGERGL-TVYGDHALLVTAVRNLLDNAVAYSPEGAHVgigvrAVDGL- 299
Cdd:PRK09303 238 QEV------------ILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTI-----TLSMLh 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1890773835 300 -----VEVAVVDQGIGIASDEQDRVFERFYRVDpaRSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:PRK09303 301 rttqkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
244-372 |
7.21e-23 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 101.00 E-value: 7.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 244 ASAKQIRLDVGGeRGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERF 323
Cdd:PRK09835 353 AEERGVELRFVG-DPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRF 431
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1890773835 324 YRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPgKGSTFTLRLP 372
Cdd:PRK09835 432 YRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
86-372 |
5.81e-22 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 97.23 E-value: 5.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 86 QVVHAAIRDLIADVRRSGViRDEELELPRGPVGPGTLMLQVRVAQVGprhLLVLAEDRTQARRL-----------EAIRR 154
Cdd:COG3290 120 DAIGRPIDEVLAEVLETGE-RDEEILLNGRVLVVNRVPIRDDGRVVG---AVATFRDRTELERLeeelegvkelaEALRA 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 155 dfvvnVSHELKTPVGALSLLAETvqdaaNDPEAVRRFAGRMRGEAARLSALVHEIIELSRLqvAGALQDiavvdvdavve 234
Cdd:COG3290 196 -----QRHDFRNHLHTISGLLQL-----GEYDEALEYIDEISEELQELIDSLLSRIGNPVL--AALLLG----------- 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 235 esvdrARTAASAKQIRLDVGGERGLTVYG-DHALLVTAVRNLLDNAV----AYSPEGAHVGIGVRAVDGLVEVAVVDQGI 309
Cdd:COG3290 253 -----KAARARERGIDLTIDIDSDLPDLPlSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGP 327
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1890773835 310 GIASDEQDRVFERFYRvdparSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:COG3290 328 GIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
136-373 |
1.26e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 97.35 E-value: 1.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 136 LLVLAEDRTQARRLE-AIRR--------DFVVNVSHELKTPVGALSLLAETVQDAANDPEavRRFAGRMRGEAARLSALV 206
Cdd:COG5809 244 IVIIFRDITERKKLEeLLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQ--KTYLDIMLSELDRIESII 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 207 HEIIELSRLQVA----GALQDIAVVDvdavveesVDRARTAASAK--QIRLDVGGERGLtVYGDHALLVTAVRNLLDNAV 280
Cdd:COG5809 322 SEFLVLAKPQAIkyepKDLNTLIEEV--------IPLLQPQALLKnvQIELELEDDIPD-ILGDENQLKQVFINLLKNAI 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 281 AYSPEGAHVGIGVRAVD-GLVEVAVVDQGIGIASDEQDRVFERFYrvdparSRDTGGTGLGLSIVKHVAADHGGEVTVWS 359
Cdd:COG5809 393 EAMPEGGNITIETKAEDdDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVES 466
|
250
....*....|....
gi 1890773835 360 RPGKGSTFTLRLPV 373
Cdd:COG5809 467 EVGKGTTFSITLPI 480
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-376 |
2.33e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 96.96 E-value: 2.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 105 IRDEELELPRGPvgpGTLMLQV-----RVAQVGPRHLLVLAEDRTQARRL-EAIRR--------DFVVNVSHELKTPVGA 170
Cdd:PRK11360 331 HVDLEISFPGRD---RTIELSVstsllHNTHGEMIGALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTA 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 171 LSLLAETVQDAANDPEAvRRFAGRMRGEAARLSALVHEIIELSR------LQVAgaLQDIavvdvdavveesVDRA---- 240
Cdd:PRK11360 408 IRGYVQIWRQQTSDPPS-QEYLSVVLREVDRLNKVIDQLLEFSRpresqwQPVS--LNAL------------VEEVlqlf 472
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 241 RTAASAKQIRLDVGGERGL-TVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGV-RAVDGLVEVAVVDQGIGIASDEQDR 318
Cdd:PRK11360 473 QTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKK 552
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1890773835 319 VFERFYRVDPArsrdtgGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGAV 376
Cdd:PRK11360 553 IFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
272-372 |
3.08e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 88.32 E-value: 3.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 272 VRNLLDNAVAYSPEGAHVGIGVRAVD-GLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAAD 350
Cdd:cd16925 9 VLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVEL 88
|
90 100
....*....|....*....|..
gi 1890773835 351 HGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16925 89 HGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-371 |
1.20e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 86.75 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 264 DHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTgGTGLGLSI 343
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 1890773835 344 VKHVAADHGGEVTVWSRPGkGSTFTLRL 371
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPD-GVLAFLTL 106
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-371 |
1.76e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 86.80 E-value: 1.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 256 ERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTG 335
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQ 88
|
90 100 110
....*....|....*....|....*....|....*.
gi 1890773835 336 GTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRL 371
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
2.93e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 85.46 E-value: 2.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVE--VAVVDQGIGIASDEQDRVFERFYRVDParSRDTGGTGLGLSIVK 345
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEwtFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1890773835 346 HVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-372 |
3.93e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.21 E-value: 3.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 274 NLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAADHGG 353
Cdd:cd16946 11 NLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIALAHGG 90
|
90
....*....|....*....
gi 1890773835 354 EVTVWSRPGKGSTFTLRLP 372
Cdd:cd16946 91 TISAEHSPLGGLRLVLTLP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
124-387 |
4.10e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 93.55 E-value: 4.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 124 LQVRVAQvgprHLLVLAEDRTQARRLEAIRRDFVVNVSHELKTP----VGALSLLaetvQDAANDPEAvRRFAGRMRGEA 199
Cdd:PRK15347 373 LENKVAE----RTQALAEAKQRAEQANKRKSEHLTTISHEIRTPlngvLGALELL----QNTPLTAEQ-MDLADTARQCT 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 200 ARLSALVHEIIELSRLQvAGALqdiavvdvdavveeSVDRARTA--ASAKQIRLDVGG---ERGLTVY---GDHA---LL 268
Cdd:PRK15347 444 LSLLAIINNLLDFSRIE-SGQM--------------TLSLEETAllPLLDQAMLTIQGpaqSKSLTLRtfvGAHVplyLH 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 269 VTAVR------NLLDNAVAYSPEGaHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDparsRDTGGTGLGLS 342
Cdd:PRK15347 509 LDSLRlrqilvNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----THSQGTGLGLT 583
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1890773835 343 IVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGAV-PDQLLATPPAA 387
Cdd:PRK15347 584 IASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEYaPPEPLKGELSA 629
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-372 |
9.53e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 83.98 E-value: 9.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 274 NLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDpaRSRDTGGTGLGLSIVKHVAADHGG 353
Cdd:cd16923 7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGD--NSRNTEGAGLGLSIAKAIIELHGG 84
|
90
....*....|....*....
gi 1890773835 354 EVTVWSRpGKGSTFTLRLP 372
Cdd:cd16923 85 SASAEYD-DNHDLFKVRLP 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
131-384 |
9.29e-19 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 89.23 E-value: 9.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 131 VGPRH-LLVLAEDRTQARR----LEAIRRD---FVVNVSHELKTPVGALSLLAETVQDAANDPEAvRRFAGRMRGEAARL 202
Cdd:PRK11091 253 VGKRHgLMGFGRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQ-RKYLKTIHVSAITL 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 203 SALVHEIIELS-----RLQVA-------GALQDIavvdvdavveesVDRARTAASAKQIRLDVggERGLTVygDHALLVT 270
Cdd:PRK11091 332 GNIFNDIIDMDkmerrKLQLDnqpidftDFLADL------------ENLSGLQAEQKGLRFDL--EPLLPL--PHKVITD 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 271 AVR------NLLDNAVAYSPEGaHVGIGVRAVDG-LVEVAVVDQGIGIASDEQDRVFERFYRV-DPARSRDTGGTGLGLS 342
Cdd:PRK11091 396 GTRlrqilwNLISNAVKFTQQG-GVTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLA 474
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1890773835 343 IVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGAVPDQLLATP 384
Cdd:PRK11091 475 VSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVEDAF 516
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
271-373 |
1.80e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 80.55 E-value: 1.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 271 AVRNLLDNAVAYSpeGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAAD 350
Cdd:cd16939 4 ALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 1890773835 351 HGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
137-378 |
2.26e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.17 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 137 LVLAEDRTQAR---RLEAIRRDFVVNVSHELKTPVGALSLLAETV-QDAANDPEAVRRFAGRMRGEAARLSALVHEIIEL 212
Cdd:PRK10490 645 LTLTASEEQARlasEREQLRNALLAALSHDLRTPLTVLFGQAEILtLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 213 SRLQVAG--------ALQDIAVVdvdavveeSVDRARTAASAKQIRLDVGGERGLtVYGDHALLVTAVRNLLDNAVAYSP 284
Cdd:PRK10490 725 ARIQSGGfnlrkewlTLEEVVGS--------ALQMLEPGLSGHPINLSLPEPLTL-IHVDGPLFERVLINLLENAVKYAG 795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 285 EGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSrdTGGTGLGLSIVKHVAADHGGEVTVWSRPGKG 364
Cdd:PRK10490 796 AQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGG 873
|
250
....*....|....
gi 1890773835 365 STFTLRLPVGAVPD 378
Cdd:PRK10490 874 ACFRVTLPLETPPE 887
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
160-375 |
8.70e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 85.22 E-value: 8.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 160 VSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSR-----LQvAGALQDIAVVdvdavve 234
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKpthlaLQ-AVDLNDLINH------- 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 235 eSVDRARTAASAKQIRLDVGGERGL-TVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIAS 313
Cdd:PRK10364 316 -SLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1890773835 314 DEQDRVFerfyrvDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGA 375
Cdd:PRK10364 395 DQLEAIF------TPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNI 450
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
274-391 |
1.02e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 86.06 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 274 NLLDNAVAYSPEGA-HVGIGVRAVDG---LVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVKHVAA 349
Cdd:PRK11107 415 NLVGNAIKFTESGNiDILVELRALSNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVN 494
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1890773835 350 DHGGEVTVWSRPGKGSTFTLRLPVGAVPDQLLATPPAARTIG 391
Cdd:PRK11107 495 EMGGDISFHSQPNRGSTFWFHLPLDLNPNPIIDGLPTDCLAG 536
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
146-366 |
1.98e-17 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 83.48 E-value: 1.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 146 ARRLEAIRRD--FVVNVSHELKTPVGA----LSLLAET-VQDAANdpeavrrfagrmrgEAARLSALVHEIIELsrLQVA 218
Cdd:PRK10755 128 SRLTSTLDQErlFTADVAHELRTPLAGirlhLELLEKQhHIDVAP--------------LIARLDQMMHTVEQL--LQLA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 219 GALQDIAVVDVDAVV------EESVDRARTAASAKQIRLDVG-GERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGI 291
Cdd:PRK10755 192 RAGQSFSSGHYQTVKlledviLPSQDELSEMLEQRQQTLLLPeSAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITI 271
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1890773835 292 GVRAVDGLVEVAVVDQGIGIasDEQDR--VFERFYRVDparSRdTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGST 366
Cdd:PRK10755 272 KLSQEDGGAVLAVEDEGPGI--DESKCgeLSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQFFLQNRQERSGT 342
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
247-373 |
8.37e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 82.47 E-value: 8.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 247 KQIRLDVGGERgLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYrv 326
Cdd:COG5805 376 IQIRLELLDED-PFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF-- 452
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1890773835 327 dparSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG5805 453 ----TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
161-372 |
1.62e-16 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 82.10 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 161 SHELKTPVGALSLLAETVQDAANDPEAvRRFAGRMRGEAARLSALVHEIIELSRLQVAGALQDIAVVDVDAVVEESVDRA 240
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLELQALEQEK-QKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGY 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 241 RTAASAKQIRLDVgGERGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVF 320
Cdd:TIGR03785 572 QMTYPPQRFELNI-PETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLF 650
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1890773835 321 ERFYRVDPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRP-GKGSTFTLRLP 372
Cdd:TIGR03785 651 DSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
139-394 |
2.23e-16 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 82.09 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 139 LAEDRTQARRLEAIRRDFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQVA 218
Cdd:PRK09959 698 LEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESG 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 219 GALQDIAVVDVDAVVEESVDRARTAASAKQIRLDVGgerglTVYGDHALLV-------TAVRNLLDNAVAYSPEGA-HVG 290
Cdd:PRK09959 778 NYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCS-----STFPDHYLVKidpqafkQVLSNLLSNALKFTTEGAvKIT 852
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 291 IGVRAVD---GLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDtgGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTF 367
Cdd:PRK09959 853 TSLGHIDdnhAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTF 930
|
250 260
....*....|....*....|....*..
gi 1890773835 368 TLRLPVGAVpDQLLATPPAARTIGTLP 394
Cdd:PRK09959 931 TITIPVEIS-QQVATVEAKAEQPITLP 956
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
145-375 |
2.64e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 81.65 E-value: 2.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 145 QARRLEAIRRdFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSRLQvAGALQDI 224
Cdd:PRK13837 443 HARRLEAVGT-LASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKG-ERNTKPF 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 225 AVVDVDAVVEESVdrarTAASAKQIRLDVGGE-RGLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDG----- 298
Cdd:PRK13837 521 DLSELVTEIAPLL----RVSLPPGVELDFDQDqEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLrapkv 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 299 ----------LVEVAVVDQGIGIASDEQDRVFERFYRVDParsrdtGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFT 368
Cdd:PRK13837 597 lshgvlppgrYVLLRVSDTGAGIDEAVLPHIFEPFFTTRA------GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFD 670
|
....*..
gi 1890773835 369 LRLPVGA 375
Cdd:PRK13837 671 VYLPPSS 677
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
266-373 |
9.93e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.84 E-value: 9.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 266 ALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSrdtgGTGLGLSIVK 345
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 1890773835 346 HVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
1.18e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 69.62 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARsRDTGGTGLGLSIVKHV 347
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 1890773835 348 AADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
267-372 |
1.22e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 69.73 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 267 LLVTAVRNLLDNAVAYSPEGAHVGIGV-RAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPArsrdtgGTGLGLSIVK 345
Cdd:cd16920 4 VLINLVRNGIEAMSEGGCERRELTIRTsPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICR 77
|
90 100
....*....|....*....|....*..
gi 1890773835 346 HVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
2.28e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 68.85 E-value: 2.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAV-AYSPEG---AHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRvdparSRDTGGTGLGLSI 343
Cdd:cd16915 1 LITIVGNLIDNALdALAATGapnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 1890773835 344 VKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
271-372 |
1.02e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 67.09 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 271 AVRNLLDNAVAYSpeGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARsrDTGGTGLGLSIVKHVAAD 350
Cdd:cd16950 4 VLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQRISDA 79
|
90 100
....*....|....*....|..
gi 1890773835 351 HGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16950 80 HGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
123-373 |
3.86e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 71.86 E-value: 3.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 123 MLQVRVAQVgprHLLVLA--EDRTQARRLEAIRRDFVVNVSHELKTPV-GALSllaeTVQDAANDP--EAVRRFAGRMRG 197
Cdd:PRK11466 415 QVKARTAEL---QELVIEhrQARAEAEKASQAKSAFLAAMSHEIRTPLyGILG----TAQLLADNPalNAQRDDLRAITD 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 198 EAARLSALVHEIIELSRLQVAGalQDIAVVDVDAVVEESVDRARTAASAK----QIRL--DVGGERGLTVYGDHALLVTA 271
Cdd:PRK11466 488 SGESLLTILNDILDYSAIEAGG--KNVSVSDEPFEPRPLLESTLQLMSGRvkgrPIRLatDIADDLPTALMGDPRRIRQV 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 272 VRNLLDNAVAYSPEGaHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARsrdtGGTGLGLSIVKHVAADH 351
Cdd:PRK11466 566 ITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAM 640
|
250 260
....*....|....*....|..
gi 1890773835 352 GGEVTVWSRPGKGSTFTLRLPV 373
Cdd:PRK11466 641 GGELSATSTPEVGSCFCLRLPL 662
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
140-392 |
6.73e-13 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 70.47 E-value: 6.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 140 AEDR-TQARRLEA-------IRRDFvvnvSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIE 211
Cdd:PRK13557 150 AEDAlRQAQKMEAlgqltggIAHDF----NNLLQVMSGYLDVIQAALSHPDADRGRMARSVENIRAAAERAATLTQQLLA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 212 LSRLQvagALQDIAVVDVDAVVEESVDRARTAASAKQIRLDVggERGL-TVYGDHALLVTAVRNLLDNAVAYSPEGAHVG 290
Cdd:PRK13557 226 FARKQ---RLEGRVLNLNGLVSGMGELAERTLGDAVTIETDL--APDLwNCRIDPTQAEVALLNVLINARDAMPEGGRVT 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 291 IGVRAV----------DGL-----VEVAVVDQGIGIASDEQDRVFERFYRvdparSRDTG-GTGLGLSIVKHVAADHGGE 354
Cdd:PRK13557 301 IRTRNVeiededlamyHGLppgryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGA 375
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1890773835 355 VTVWSRPGKGSTFTLRLPV--GAVPDQLLATPPAARTIGT 392
Cdd:PRK13557 376 VRIYSEVGEGTTVRLYFPAsdQAENPEQEPKARAIDRGGT 415
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
9.09e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.52 E-value: 9.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAhVGIGVRAVDG--LVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGLGLSIVK 345
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTgkMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 1890773835 346 HVAADHGGEVTVWSR--PG--KGSTFTLRLP 372
Cdd:cd16953 80 QIIEAHGGISVAENHnqPGqvIGARFTVQLP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
260-372 |
9.32e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 70.39 E-value: 9.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 260 TVYGDHALLVTAVRNLLDNAVAYSPEGAHVgIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSRDTGGTGL 339
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGL 633
|
90 100 110
....*....|....*....|....*....|...
gi 1890773835 340 GLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:PRK10841 634 GLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
150-214 |
1.35e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.62 E-value: 1.35e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1890773835 150 EAIRRDFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFAGRMRGEAARLSALVHEIIELSR 214
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-365 |
5.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.09 E-value: 5.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 264 DHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDpaRSRDTGG-TGLGLS 342
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDD--TSRRSGGhYGMGLY 78
|
90 100
....*....|....*....|...
gi 1890773835 343 IVKHVAADHGGEVTVwSRPGKGS 365
Cdd:cd16975 79 IAKNLVEKHGGSLII-ENSQKGG 100
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
268-372 |
5.45e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 62.40 E-value: 5.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAVAYSPEGAHVGIGVR----------AVDGL-----VEVAVVDQGIGIASDEQDRVFERFYRVDPARSr 332
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalNYRDLipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1890773835 333 dtgGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16919 80 ---GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-371 |
6.79e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.65 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 274 NLLDNAVAYSPEgaHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPARSrdtgGTGLGLSIVKHVAADHGG 353
Cdd:cd16954 44 NLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*...
gi 1890773835 354 EVTVWSRPGKGSTFTLRL 371
Cdd:cd16954 118 ELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
153-216 |
7.36e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.30 E-value: 7.36e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1890773835 153 RRDFVVNVSHELKTPVGALSLLAETVQDAANDPEaVRRFAGRMRGEAARLSALVHEIIELSRLQ 216
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEE-QREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
268-372 |
1.01e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 66.86 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDN---AVAYSPEGaHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYrvdparSRDTGGTGLGLSIV 344
Cdd:PRK11086 434 LITILGNLIENaleAVGGEEGG-EISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLV 506
|
90 100
....*....|....*....|....*...
gi 1890773835 345 KHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:PRK11086 507 KQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
153-216 |
4.67e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.35 E-value: 4.67e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1890773835 153 RRDFVVNVSHELKTPVGALSLLAETVQDAANDPEAvRRFAGRMRGEAARLSALVHEIIELSRLQ 216
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIE 64
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
271-375 |
1.33e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 63.01 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 271 AVRNLLDNAVAYSPEGAHVGIGVravDG-LVEVAVVDQGIGIASDEQDRVFERFYRVDPARSrdTGGTGLGLSIVKHVAA 349
Cdd:PRK09467 335 ALANLVVNAARYGNGWIKVSSGT---EGkRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVD 409
|
90 100
....*....|....*....|....*.
gi 1890773835 350 DHGGEVTVWSRPGKGSTFTLRLPVGA 375
Cdd:PRK09467 410 QHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-372 |
1.70e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 57.80 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 268 LVTAVRNLLDNAV-AYSPEGAHVGIGVRAVDGL----------VEVAVVDQGIGIASDEQDRVFerfyrvDPARSRDTGG 336
Cdd:cd16918 1 LIQVFLNLVRNAAqALAGSGGEIILRTRTQRQVtlghprhrlaLRVSVIDNGPGIPPDLQDTIF------YPMVSGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 1890773835 337 TGLGLSIVKHVAADHGGEVTVWSRPGKgSTFTLRLP 372
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
267-371 |
3.14e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.08 E-value: 3.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 267 LLVTAVRNLLDnAVAYSPEGAhVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRvdparSRDTG-GTGLGLSIVK 345
Cdd:cd16976 4 VLMNLLQNALD-AMGKVENPR-IRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISY 76
|
90 100
....*....|....*....|....*.
gi 1890773835 346 HVAADHGGEVTVWSRPGKGSTFTLRL 371
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-372 |
1.44e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.24 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 264 DHALLVTAVRNLLDNAvAYSPEGA-----HVGIGVRA-VDGLVEVAVVDQGIGIASDEQDRVFERFYRVDPArsrdtgGT 337
Cdd:cd16944 1 DTTQISQVLTNILKNA-AEAIEGRpsdvgEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 1890773835 338 GLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
122-373 |
3.65e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 55.09 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 122 LMLQVRVAQVGPRHLLVLAEDRTQARRL---------EAIRRDFVVNVSHELKTPVGALSLLAETVQDAANDPeAVRRFA 192
Cdd:PRK11073 90 HILSLTAQRLPEGMILLEMAPMDNQRRLsqeqlqhaqQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDP-ALTEYT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 193 GRMRGEAARLSALV-----------------HEIIELSRLQVAGALQDiavvdvdavveesvdrartaasakQIRLdvgg 255
Cdd:PRK11073 169 KVIIEQADRLRNLVdrllgpqrpgthvtesiHKVAERVVQLVSLELPD------------------------NVRL---- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 256 ERG-------LTVYGDHalLVTAVRNLLDNAV-AYSPEGAHVGIGVRAVDGL----------VEVAVVDQGIGIASDEQD 317
Cdd:PRK11073 221 IRDydpslpeLAHDPDQ--IEQVLLNIVRNALqALGPEGGTITLRTRTAFQLtlhgeryrlaARIDIEDNGPGIPPHLQD 298
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1890773835 318 RVFerfYrvdPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKgSTFTLRLPV 373
Cdd:PRK11073 299 TLF---Y---PMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
249-361 |
4.08e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.41 E-value: 4.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 249 IRLDVGGErgLTVYGDHALLVTAVRNLLDNAVAYSPEgaHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFYRVDP 328
Cdd:PRK10815 362 ITLDISPE--ITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADT 437
|
90 100 110
....*....|....*....|....*....|...
gi 1890773835 329 ARSrdtgGTGLGLSIVKHVAADHGGEVTVWSRP 361
Cdd:PRK10815 438 LRP----GQGLGLSVAREITEQYEGKISAGDSP 466
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
170-375 |
2.29e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.93 E-value: 2.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 170 ALSLLAETVQD-AANDPEAVRRFAGRMRGEAARLSALVHEII------ELSRLQVAGALQDIavvdvdavveesVDRART 242
Cdd:COG4585 71 AIKLQLEAARRlLDADPEAAREELEEIRELAREALAELRRLVrglrppALDDLGLAAALEEL------------AERLLR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 243 AASAkQIRLDVGGERGLTVYGDHALLVTAVRNLLDNAVAYSPeGAHVGIGVRAVDGLVEVAVVDQGIGIASDEqdrvfer 322
Cdd:COG4585 139 AAGI-RVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPEA------- 209
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1890773835 323 fyrvdparsrdTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPVGA 375
Cdd:COG4585 210 -----------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
275-373 |
8.00e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 51.17 E-value: 8.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 275 LLDNAVAY----SPEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRVFERFyrvdparSRDTGGTGLGLSIVKHVAAD 350
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*.
gi 1890773835 351 HGGE---VTVWSRPGKGSTFTLRLPV 373
Cdd:COG2972 417 YYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
333-372 |
6.93e-06 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 46.42 E-value: 6.93e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1890773835 333 DTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16916 139 DVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
270-370 |
1.12e-05 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 44.84 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 270 TAVRNLLDNAVAYS---PEGAHVGIGVRAVDGLVEVAVVDQGIGIASDEQDRvfERFYRVDPARSRdtggTGLGLSIVKH 346
Cdd:cd16942 41 TVVSEAVTNAIIHGynnDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEAR--QPLFTTKPELER----SGMGFTIMEN 114
|
90 100
....*....|....*....|....
gi 1890773835 347 VAadhgGEVTVWSRPGKGSTFTLR 370
Cdd:cd16942 115 FM----DEVIVESEVNKGTTVYLK 134
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
160-372 |
4.71e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 45.83 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 160 VSHELKTPVGALSLLAETVQDAA--NDPEAVRRFAGRMRGEAARLSALVHEIIELSRlQVAGALQDIAVVDVDAVVEESV 237
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALeqENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR-KSDTPLQPVDLRQVIEQAWELV 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 238 DrarTAASAKQIRLDVGGErgLTVYGDHALLVTAVRNLLDNAVAYSPEGAHVGIGVRAVDGLVEVAVVDQGIGIASdeQD 317
Cdd:COG4192 519 E---SRAKPQQITLHIPDD--LMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VD 591
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1890773835 318 RVFERFYrvdparSRDTGGTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:COG4192 592 KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
336-373 |
6.45e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.17 E-value: 6.45e-05
10 20 30
....*....|....*....|....*....|....*...
gi 1890773835 336 GTGLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLPV 373
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
264-372 |
7.08e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 45.21 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 264 DHALLVTAVRNLLDNAVAYS---PEG---AHVGIGVRAVDGLVEVAvvDQGIGIASDEQDRVFERFYRVdpaRSRDTGGT 337
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASlrsDEGnkiVELFLSDEGDDVVIEVA--DQGCGVPESLRDKIFEQGVST---RADEPGEH 503
|
90 100 110
....*....|....*....|....*....|....*
gi 1890773835 338 GLGLSIVKHVAADHGGEVTVWSRPGKGSTFTLRLP 372
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
236-373 |
4.14e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 236 SVDRARTAASAKQIRLDVGGERGLTVygdhALLVT-AVRNLLDNAVAYSPEGaHVGIGVRAVDGLVEVAVVDQGIGIASD 314
Cdd:COG2172 10 DLGLARRAVRALLRELGLDEDDADDL----VLAVSeAVTNAVRHAYGGDPDG-PVEVELELDPDGLEIEVRDEGPGFDPE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1890773835 315 EqdrvferfyRVDPARSRDTGGtgLGLSIVKHVAAdhggEVTVWSRPGkGSTFTLRLPV 373
Cdd:COG2172 85 D---------LPDPYSTLAEGG--RGLFLIRRLMD----EVEYESDPG-GTTVRLVKRL 127
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-372 |
1.57e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 37.53 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 272 VRNLLDNAVAYSPeGAHVGIGVRAVDGLVEVAVVDQGIGiasdeqdrvferfyRVDPARSrdtGGTGLGLSIVKHVAADH 351
Cdd:cd16917 5 VQEALTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVG--------------FDGPAPP---GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 1890773835 352 GGEVTVWSRPGKGSTFTLRLP 372
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
237-376 |
2.69e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.27 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 237 VDRARTAASAKQIRLDVGGERgLTVYGDHALLVTAVRN-LLDNAVAY---SPEGAHVGIGVRAVDGLVEVAVVDQGIGIA 312
Cdd:COG3920 369 LEPLRDSYGGRGIRIELDGPD-VELPADAAVPLGLILNeLVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLP 447
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1890773835 313 SDeqdrvferfyrVDPARSRdtggtGLGLSIVKHVAADHGGEVTVwsRPGKGSTFTLRLPVGAV 376
Cdd:COG3920 448 ED-----------VDPPARK-----GLGLRLIRALVRQLGGTLEL--DRPEGTRVRITFPLAEL 493
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
291-372 |
5.45e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 39.07 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 291 IGVRAV---DGLVEVAVVDQGIGIAS-DEQDRVFerfyrvdparsrdtggtglGLSIVKHVAADHGGEVTVWSRPGKGST 366
Cdd:PRK10935 492 IAVSCVtnpDGEHTVSIRDDGIGIGElKEPEGHY-------------------GLNIMQERAERLGGTLTISQPPGGGTT 552
|
....*.
gi 1890773835 367 FTLRLP 372
Cdd:PRK10935 553 VSLTFP 558
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
139-373 |
7.20e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 38.89 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 139 LAEDRTQARRLEaiRRDFVVNVSHELKTPVGALSLLAETVQDAANDPEAVRRFagRMRGEAARLSALVHEII----ELSR 214
Cdd:PRK13560 593 HAEEKIKAALTE--KEVLLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAKCAF--AESQDRICAMALAHEKLyqseDLAD 668
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 215 LQVAGALQDIAVVDVDAVveeSVDRARTAAS--AKQIRLDVggERGLTVygdhALLVTavrNLLDNAVAYS-PEGAHVGI 291
Cdd:PRK13560 669 IDFLDYIESLTAHLKNSF---AIDFGRIDCKidADDGCLDI--DKAIPC----GLIIS---ELLSNALKHAfPDGAAGNI 736
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890773835 292 GV---RAVDGLVEVAVVDQGIGIasdeqdrvferfyrvdPARSRDTGGTGLGLSIVKHVAADHGGEVTVWSRpgKGSTFT 368
Cdd:PRK13560 737 KVeirEQGDGMVNLCVADDGIGL----------------PAGFDFRAAETLGLQLVCALVKQLDGEIALDSR--GGARFN 798
|
....*
gi 1890773835 369 LRLPV 373
Cdd:PRK13560 799 IRFPM 803
|
|
| |
