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Conserved domains on  [gi|1891747489|ref|WP_183968108|]
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phosphoribosyltransferase family protein [Quisquiliibacterium transsilvanicum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PyrR super family cl42780
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 36-183 1.34e-36

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


The actual alignment was detected with superfamily member COG2065:

Pssm-ID: 441668  Cd Length: 178  Bit Score: 125.17  E-value: 1.34e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  36 DAVIVGILRRGAPLAALLRERLERDHGIAgLPSFDVKIQRYSDDLRLLHPETLLTedPAHAGLDLAGRCVLLVDDVLYRG 115
Cdd:COG2065    32 DLVLVGIQTRGVPLAERLAERIEEIEGVK-VPVGSLDITLYRDDLRRRPPRPVVN--ETEIPFDIDGKTVVLVDDVLYTG 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891747489 116 HSLLRALDWAARRG-AAEVRVAVLADRNVNVLPVHADIVGAHLQLAPDDVVECHVPPYESELSVELVRP 183
Cdd:COG2065   109 RTVRAALDALMDFGrPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRSERVEVRLKEIDGEDAVVIVEP 177
 
Name Accession Description Interval E-value
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 36-183 1.34e-36

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 125.17  E-value: 1.34e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  36 DAVIVGILRRGAPLAALLRERLERDHGIAgLPSFDVKIQRYSDDLRLLHPETLLTedPAHAGLDLAGRCVLLVDDVLYRG 115
Cdd:COG2065    32 DLVLVGIQTRGVPLAERLAERIEEIEGVK-VPVGSLDITLYRDDLRRRPPRPVVN--ETEIPFDIDGKTVVLVDDVLYTG 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891747489 116 HSLLRALDWAARRG-AAEVRVAVLADRNVNVLPVHADIVGAHLQLAPDDVVECHVPPYESELSVELVRP 183
Cdd:COG2065   109 RTVRAALDALMDFGrPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRSERVEVRLKEIDGEDAVVIVEP 177
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
35-182 2.18e-18

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 77.86  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  35 RDAVIVGILRRGAPLAALLRERLERDHGIAgLPSFDVKIQRYSDDL--RLLHPETLLTEDPAhaglDLAGRCVLLVDDVL 112
Cdd:PRK05205   31 DNLVLVGIKTRGVWLAERLAERLEQLEGVD-VPVGELDITLYRDDLtkKGLHPQVKPTDIPF----DIEGKRVILVDDVL 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1891747489 113 YRGHSLLRALDWAARRG-AAEVRVAVLADRNVNVLPVHADIVGAHLQLAPDDVVECHVPPYESELSVELVR 182
Cdd:PRK05205  106 YTGRTIRAALDALFDYGrPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERVVVRLAEVDGRDRVVLER 176
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 34-141 1.72e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 69.35  E-value: 1.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  34 GRDAVIVGILRRGAPLAALLRERLerdhgiaGLPSFDVKIQRYSDDLRLLHPETLLTEDPAhaglDLAGRCVLLVDDVLY 113
Cdd:cd06223    14 LEPDVVVGILRGGLPLAAALARAL-------GLPLAFIRKERKGPGRTPSEPYGLELPLGG----DVKGKRVLLVDDVIA 82

                          90       100
                  ....*....|....*....|....*...
gi 1891747489 114 RGHSLLRALDWAARRGAAEVRVAVLADR 141
Cdd:cd06223    83 TGGTLLAAIELLKEAGAKVVGVAVLLDK 110
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 10-153 1.84e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 69.70  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  10 TLYDTAEVGALLDDMARRAAALLAGRDAVIVGILRRGAPLAALLRERLErdhgiagLPSFDVKIQRYSDDLRLLHPetll 89
Cdd:pfam00156   4 EILDNPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLD-------VPLAFVRKVSYNPDTSEVMK---- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1891747489  90 tedPAHAGLDLAGRCVLLVDDVLYRGHSLLRALDWAARRGAAEVRVAVLADRNVNVLPVHADIV 153
Cdd:pfam00156  73 ---TSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDK 133
 
Name Accession Description Interval E-value
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 36-183 1.34e-36

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 125.17  E-value: 1.34e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  36 DAVIVGILRRGAPLAALLRERLERDHGIAgLPSFDVKIQRYSDDLRLLHPETLLTedPAHAGLDLAGRCVLLVDDVLYRG 115
Cdd:COG2065    32 DLVLVGIQTRGVPLAERLAERIEEIEGVK-VPVGSLDITLYRDDLRRRPPRPVVN--ETEIPFDIDGKTVVLVDDVLYTG 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891747489 116 HSLLRALDWAARRG-AAEVRVAVLADRNVNVLPVHADIVGAHLQLAPDDVVECHVPPYESELSVELVRP 183
Cdd:COG2065   109 RTVRAALDALMDFGrPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRSERVEVRLKEIDGEDAVVIVEP 177
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
35-182 2.18e-18

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 77.86  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  35 RDAVIVGILRRGAPLAALLRERLERDHGIAgLPSFDVKIQRYSDDL--RLLHPETLLTEDPAhaglDLAGRCVLLVDDVL 112
Cdd:PRK05205   31 DNLVLVGIKTRGVWLAERLAERLEQLEGVD-VPVGELDITLYRDDLtkKGLHPQVKPTDIPF----DIEGKRVILVDDVL 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1891747489 113 YRGHSLLRALDWAARRG-AAEVRVAVLADRNVNVLPVHADIVGAHLQLAPDDVVECHVPPYESELSVELVR 182
Cdd:PRK05205  106 YTGRTIRAALDALFDYGrPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERVVVRLAEVDGRDRVVLER 176
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 34-141 1.72e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 69.35  E-value: 1.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  34 GRDAVIVGILRRGAPLAALLRERLerdhgiaGLPSFDVKIQRYSDDLRLLHPETLLTEDPAhaglDLAGRCVLLVDDVLY 113
Cdd:cd06223    14 LEPDVVVGILRGGLPLAAALARAL-------GLPLAFIRKERKGPGRTPSEPYGLELPLGG----DVKGKRVLLVDDVIA 82

                          90       100
                  ....*....|....*....|....*...
gi 1891747489 114 RGHSLLRALDWAARRGAAEVRVAVLADR 141
Cdd:cd06223    83 TGGTLLAAIELLKEAGAKVVGVAVLLDK 110
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 10-153 1.84e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 69.70  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  10 TLYDTAEVGALLDDMARRAAALLAGRDAVIVGILRRGAPLAALLRERLErdhgiagLPSFDVKIQRYSDDLRLLHPetll 89
Cdd:pfam00156   4 EILDNPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLD-------VPLAFVRKVSYNPDTSEVMK---- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1891747489  90 tedPAHAGLDLAGRCVLLVDDVLYRGHSLLRALDWAARRGAAEVRVAVLADRNVNVLPVHADIV 153
Cdd:pfam00156  73 ---TSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDK 133
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 38-138 1.81e-12

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 61.79  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  38 VIVGILRRGAPLAALLRERLerdhGIAGLPSfdVKIQRYSDDLRLLHPETLLTEDPAhaglDLAGRCVLLVDDVLYRGHS 117
Cdd:COG2236    34 VIVAIARGGLVPARILADAL----GVPDLAS--IRVSSYTGTAKRLEEPVVKGPLDE----DLAGKRVLIVDDVADTGRT 103

                          90       100
                  ....*....|....*....|.
gi 1891747489 118 LLRALDWAARRGAAEVRVAVL 138
Cdd:COG2236   104 LEAVRDLLKEAGPAEVRTAVL 124
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 34-154 2.32e-10

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 56.57  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  34 GRDAVIVGILRRGAPLAA-LLReRLERDHGIaglpSFdVKIQRY------SDDLRLLHpetllteDPahaGLDLAGRCVL 106
Cdd:COG0634    32 GKEPLVVGVLKGAFVFMAdLLR-ALDFPLEI----DF-MHVSSYgggtesSGEVRILK-------DL---DEDIEGRDVL 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1891747489 107 LVDDVLYRGHSLLRALDWAARRGAAEVRVAVLAD----RNVnvlPVHADIVG 154
Cdd:COG0634    96 IVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDkperRKV---DVPADYVG 144
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 11-154 3.54e-08

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 50.63  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  11 LYDTAEVGALLDDMARRAAALLAGRDAVIVGILRRGAPLAALLRERLERDHgiaglpSFD-VKIQRYSDDLR------LL 83
Cdd:PRK09162   16 LVSAAEVEAAIDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRLDFPL------EFDyLHATRYRNETTggelvwKV 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1891747489  84 HPETlltedpahaglDLAGRCVLLVDDVLYRGHSLLRALDWAARRGAAEVRVAVLADRNVN--VLPVHADIVG 154
Cdd:PRK09162   90 KPRE-----------SLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDrkAKPLKADFVG 151
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
98-137 6.17e-03

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 36.20  E-value: 6.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1891747489  98 LDLAGRCVLLVDDVLYRGHSLLRALDWAARRGAAEVRVAV 137
Cdd:COG1926   117 PDLKGRTVILVDDGIATGATMRAALRALRRQGPARIVVAV 156
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 38-150 6.32e-03

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 36.00  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891747489  38 VIVGILRRGAPLAALLRERLERDHGIaglpsfdvkiqrYsddlrllHPETLLTEDPAHAG-------LDLAGRCVLLVDD 110
Cdd:PRK02277   88 VVVGIAKSGVPLATLVADELGKDLAI------------Y-------HPKKWDHGEGEKKTgsfsrnfASVEGKRCVIVDD 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1891747489 111 VLYRGHSLLRALDWAARRGAAEVRVAVLADRN----VNVLPVHA 150
Cdd:PRK02277  149 VITSGTTMKETIEYLKEHGGKPVAVVVLIDKSgideIDGVPVYS 192
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 97-141 8.77e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 35.51  E-value: 8.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1891747489  97 GLDLAGRCVLLVDDVLYRGHSLLRALDWAARRGAAEVRVAVLADR 141
Cdd:COG0461   107 GGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDR 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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