|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-404 |
5.69e-55 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 186.71 E-value: 5.69e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAmiGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLF 98
Cdd:cd17355 1 GWVVLAVT--FLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGW-FDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGW 177
Cdd:cd17355 79 AAGLVLLALAT-SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 178 RTAFVAIGALPILIGIPMVLWLFRENRKANLAVATPGAEEPVeeyGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLE 257
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASP---GSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 258 NILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAG 337
Cdd:cd17355 235 PYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1891802043 338 FEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGGA 404
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-402 |
1.15e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 162.36 E-value: 1.15e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 26 AMIGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSL 105
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 106 SLSTGSLTLFYgqWVIMSVLGAGTLSATWTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAI 184
Cdd:COG2223 88 ALAVSYWLLLL--LGLLLGIGGGGSFAVGIALVSKWFPPDrRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 185 GALPILIGIPMVLWLFRENRKANLAVATPGAeepveeygmTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRS-F 263
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 264 KFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLL 343
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1891802043 344 AFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITG 402
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-411 |
2.02e-37 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 140.01 E-value: 2.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 9 TPAGSRETRQGWLVVAsAMIGVALGLSPiPFYTIGMFAPELSREFGWSF--ASMMGSIGVqsAVVMVASPLAGFAIDRYG 86
Cdd:COG2807 6 SSARRSRRAGRWLLLL-AIVLVALNLRP-AITSVGPLLPEIRADLGLSAtqAGLLTTLPL--LAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 87 ARPVALISLGLFGLCFMSLSLSTGSLTLFYGQWVIMsvLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKP 166
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIG--AGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 167 FAAWIIADFGWRTAFVAIGALPILIGIPMVLWLFRENRKANLAVATPgaeepveeygmTLGQALRSVKFWILAVSFFLIS 246
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-----------SLRSLWRSPLAWLLTLFFGLQS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 247 FALTAPTPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMI-LLIPAIGSWLLSgdALGSEGA 325
Cdd:COG2807 229 LLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLlGLLGLAGLLGLL--LAPGSLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 326 FAAVLFIGFGAGFEFDLLAFLISRYFG-QRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGGA 404
Cdd:COG2807 307 WLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
....*..
gi 1891802043 405 LLLLLGR 411
Cdd:COG2807 387 AGLLAGR 393
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-404 |
3.50e-36 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 136.59 E-value: 3.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 20 WLVVASAMIGVALGLSPIpfYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFG 99
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQ--YAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 100 LCFMSLSLSTGSLTLFYGQWVIMSvLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRT 179
Cdd:cd17353 80 LGFILSAFAISLPLLFLGYGVLGG-IGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 180 AFVAIGALPILIgIPMVLWLFRENRKANLAVATPGAEEPVEEYG--MTLGQALRSVKFWILAVSFFLISFALTAPTPNLE 257
Cdd:cd17353 159 TFLILGIIFLII-IVIGAFLIRDPPKGWVPPGVDPLANNAENSPrdYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 258 NILRSFKFELAEIGAITAS-FGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGA 336
Cdd:cd17353 238 PIGQEFAGLDAGIAALAVSiLSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCY 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1891802043 337 GFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYaFDMTGSYGTALRLGIGFVITGGA 404
Cdd:cd17353 318 GGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-388 |
5.91e-28 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 113.42 E-value: 5.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASA--MIGVALGLSpipfYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLG 96
Cdd:cd17352 1 GWVVVFASflVNFFTDGIL----NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 97 LFGLCFMSLSLSTGSLTLFYGQWVIMSvLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFG 176
Cdd:cd17352 77 LAALGLLLSSFATSLWQLYLTYGVLGG-LGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 177 WRTAFVAIGALpILIGIPMVLwlfrenrkanlavatpgaeepveeygmtLGQALRSVKFWILAVSFFLISFALTAPTPNL 256
Cdd:cd17352 156 WRGALLILGGL-CLNLCVCGL----------------------------LLRLLKDPTFVLLALGVSFAMLGFFVPFVYL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 257 ENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAV-LFIGFG 335
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFsVLFGFC 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1891802043 336 AGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSY 388
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDY 339
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-414 |
2.98e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.50 E-value: 2.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 13 SRETRQGWLVVASAMIGVALglSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVAL 92
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFL--NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 93 ISLGLFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWII 172
Cdd:COG2271 80 IGLLLWGLATLLFGFAT-SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 173 ADFGWRTAFVAIGALPILIGIpmvlwlfrenrkanlavatpgaeepveeygmtlgqalrsVKFWILAVSFFLISFALTAP 252
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLAL---------------------------------------LRFWLLALAYFLVYFALYGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 253 TPNLENILRSFK-FELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMIL-LIPAIGSWLLSGDALGSEGAFAAVL 330
Cdd:COG2271 200 LTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIgLLLAALALLLLALLPSPALAIALLF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 331 FIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGsYGTALRLGIGFVITGGALLLLLG 410
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
....
gi 1891802043 411 RYPK 414
Cdd:COG2271 359 RETR 362
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
40-404 |
7.77e-24 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 102.10 E-value: 7.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 40 YTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQW 119
Cdd:cd17314 20 LSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 120 VIMSVlGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWL 199
Cdd:cd17314 100 VFIGA-GTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 200 FRENRKANLAVATpgaeepVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAE-IGAITASFG 278
Cdd:cd17314 179 FKEPPDNQARLHV------QKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSfVTKLMSIYG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 279 LAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSW--LLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNY 356
Cdd:cd17314 253 LFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLcaFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESF 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1891802043 357 GVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGGA 404
Cdd:cd17314 333 ATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-375 |
2.15e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.49 E-value: 2.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 39 FYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQ 118
Cdd:pfam07690 13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 119 wvIMSVLGAGTLSATWTRVVNGWF-DKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVL 197
Cdd:pfam07690 93 --VLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 198 WLFRENRKanlavaTPGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASF 277
Cdd:pfam07690 171 PRPPPESK------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 278 GLAVIAGRIIGGWLLDRF--WAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRN 355
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
|
330 340
....*....|....*....|
gi 1891802043 356 YGVIYGCFYTVIAFGGGLGP 375
Cdd:pfam07690 325 RGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-373 |
2.74e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.27 E-value: 2.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 16 TRQGWLVVASAMIGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISL 95
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 96 GLFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADF 175
Cdd:COG2814 83 LLFALGSLLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 176 GWRTAFVaIGALPILIGIPMVLWLFRENRKanlavatpgaeEPVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPN 255
Cdd:COG2814 162 GWRWVFL-VNAVLALLALLLLLRLLPESRP-----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 256 LENILRS-FKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGdALGSEGAFAAVLFIGF 334
Cdd:COG2814 230 LPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-AGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 1891802043 335 GAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGL 373
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-392 |
3.92e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 91.09 E-value: 3.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 41 TIGMFAPELSREFGWSfASMMGSI-GVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLcFMSLSLSTGSLTLFYGQW 119
Cdd:cd17319 21 NISVAAPTIMKDLGLS-PTQYGLIaSAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL-FTALTGFATSLTSLYVLR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 120 VIMSVLGAGTLSATwTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIpMVLW 198
Cdd:cd17319 99 FLLGVAEAGFFPGA-IKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV-LWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 199 LFRenrkanlavatpgaeepveeygmtlgqalrsvKFWILAVSFFLISFALTAPTPNLENILRSFK-FELAEIGAITASF 277
Cdd:cd17319 177 YLR--------------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARgFSLKQVGLLAAIP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 278 GLAVIAGRIIGGWLLDRF--WAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRN 355
Cdd:cd17319 225 FLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEA 304
|
330 340 350
....*....|....*....|....*....|....*..
gi 1891802043 356 YGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTAL 392
Cdd:cd17319 305 AATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAF 341
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-391 |
1.35e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.83 E-value: 1.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 39 FYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFygQ 118
Cdd:cd17475 12 AQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL--V 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 119 WVIMSVLGAGTLSATWTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVL 197
Cdd:cd17475 90 LLFLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 198 WLfrenRKANLAVATPGAEEPVEeygMTLGQALRSVKFW-ILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITAS 276
Cdd:cd17475 170 FY----REPPAASAATESASTLL---RSLKEVLRNRDVWlIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 277 FGLAVIAGRIIGGWLLDRFWA---PACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFG-AGFEFDLLAF-LISRYF 351
Cdd:cd17475 243 AQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGlFAIGWNGLYLtLVAESA 322
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1891802043 352 GQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTA 391
Cdd:cd17475 323 GPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPA 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-400 |
2.98e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.86 E-value: 2.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 28 IGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSL 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 108 STGSLTLFYGQwvIMSVLGAGTLSATWTRVVNGWFD-KNRGLALGIASSGTGITGFLIKPFAAWIIA--DFGWRTAFVAI 184
Cdd:cd06174 81 APSFWLLLLGR--FLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 185 GALPILIGIPMVLWLFRENRKANLAVATPGAEEPVEEygmtLGQALRSVKFWILAVSFFLISFALTAPTPNLENIL-RSF 263
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL----LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLlDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 264 KFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLL 343
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1891802043 344 AFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVI 400
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-392 |
1.63e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 80.29 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 47 PELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQwVIMSVLG 126
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAR-ALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 127 AGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIpmVLWLFRENRKA 206
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAL--LLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 207 NLAVATPgaeepveeYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAE-IGAITASFGLAVIAGR 285
Cdd:cd17324 180 KKPGSLG--------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSaIIGLLLLFGVAGVVGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 286 IIGGWLLDRFWAPACAFMILLIpAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYfGQRNYGVIYGCFYT 365
Cdd:cd17324 252 PLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLA 329
|
330 340
....*....|....*....|....*..
gi 1891802043 366 VIAFGGGLGPVVYGYAFDMTGSYGTAL 392
Cdd:cd17324 330 AYNLGGALGAALGGLVLDHGGWAGVGW 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-400 |
1.17e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.00 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 28 IGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSL 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 108 STgsltlFYGQWVIMSVLGAGTLSATWTR----VVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVA 183
Cdd:cd17325 81 AT-----SYWQLLLARFLQGLASAAVWPAamalIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 184 IGALPILIGIPMVLWLFRENRKANLAVATPGAEEPveeygmTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRS- 262
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRS------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEl 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 263 FKFELAEIGAITASFGLAVIAGRIIGGWLLDRF--WAPACAFMILLIPAIGSWLLSGDALgseGAFAAVLFIGFGAGFEF 340
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIgrKPLILIGLLLSAVALLLLPLATSFW---LLLLLLALLGLGLGLVF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 341 DLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDmTGSYGTALRLGIGFVI 400
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLL 365
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
79-392 |
6.63e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 75.75 E-value: 6.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 79 GFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYgqwVIMSVLG-AGTLSATWTRVVNGWFDKNR-----GLALGI 152
Cdd:cd17341 55 GFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLL---VLGFLLGfAGANFASGQPWASFWFPKEKiggaaGGIAGA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 153 ASSGTGITGFLIKPFAAWIIAD---FGWRTAFVAIGALPILIGIPMVLWlfrenrkanlAVATPGAEEPVEEYGMTLGQA 229
Cdd:cd17341 132 GNMGVAVSQLLAPLIAGAIVFDggfVGWRNAFFVPGILLAIAAVLVLLF----------GDDLPTGKASALEFLKVQLAV 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 230 LRSVKFWILAVsFFLISF----ALTAPTPNLenILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRF---------W 296
Cdd:cd17341 202 LKNYRTWILSL-LYGVTFgsfvGFSNVLPTY--FKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFggrrrlwwlF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 297 APACAFMILLIpaigsWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFgQRNYGVIYGCFYTVIAFGGGLGPV 376
Cdd:cd17341 279 IVMTIGAALLS-----LSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPL 352
|
330
....*....|....*.
gi 1891802043 377 VYGYAFDMTGSYGTAL 392
Cdd:cd17341 353 LFGSSALMTGSGVGAF 368
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-402 |
9.65e-14 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 72.04 E-value: 9.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIGVALGLSPIpfYTIGMFAPELSREFGWSFA--SMMGSIGVqsAVVMVASPLAGFAIDRYGARPVALISLG 96
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVL--RSFGVFFVEFVEYFEESAQrvSWITSIGL--AVQQLASPVGSALSTRYGARPVVMLGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 97 LFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFG 176
Cdd:cd17423 77 LSSLGFLLASFAT-SLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 177 WRtafvaiGALPILIGIPMVLW----LFRENRKANLAVATPgaEEPVEEYGMTLgqaLRSVKFWILAVSFFLISFALTAP 252
Cdd:cd17423 156 WR------GALLLLSALSLHLVpcgaLLRPLALPGDPPAPP--RSLSAAFGLSL---LTHRAFLRYALATTLINTGYFIP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 253 TPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIG-SWLLSGDALGSEGAFAAVLF 331
Cdd:cd17423 225 YVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGlSLLLLPLAKVYGSLLALAVA 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1891802043 332 IGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITG 402
Cdd:cd17423 305 YGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLG 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
42-380 |
1.41e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.62 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 42 IGMFAPELSREFGWSFAS--MMGSIGVqsAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQW 119
Cdd:TIGR00895 36 MGFAAPAISAEWGLDPVQlgFLFSAGL--IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 120 VIMSVLGAGTLSATwTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWL 199
Cdd:TIGR00895 114 LAGLGLGGLMPNLN-ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 200 ----------------FRENRKANLAVATPGAEEPVEEYGMTLGQALRSVKF--------WILAVSFFLISFALTAPTPN 255
Cdd:TIGR00895 193 pesidflvskrpetvrRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFqgktaritVLLWLLYFMLLVGVYFLTNW 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 256 LENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFwAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFG 335
Cdd:TIGR00895 273 LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL-GPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFF 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1891802043 336 AGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGY 380
Cdd:TIGR00895 352 VNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-386 |
7.22e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.50 E-value: 7.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 26 AMIGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSL 105
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 106 SLSTGSLTLFYGQWVIMsvLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIA---DFGWRTAFV 182
Cdd:COG0738 91 ALAPSYPLLLLALFLLG--LGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 183 AIGALPILIGIPMVLWLFRENRKanlavatpgAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRS 262
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIEE---------EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 263 -FKFELAEIGAITASFGLAVIAGRIIGGWLLDRFwAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFD 341
Cdd:COG0738 240 vLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1891802043 342 LLAFLISRYFGQRNYGVIyGCFYTVIAFGGGLGPVVYGYAFDMTG 386
Cdd:COG0738 319 TIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-386 |
7.41e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.34 E-value: 7.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 47 PELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGsltlFYgqWVIMSVLG 126
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN----YW--LLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 127 AGTLSATW----TRVVNGWFDKNRGLALGIASSGtGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIgipmVLWLFRE 202
Cdd:cd17478 94 AGIGSAAFhpegARLASQAAGGRRGLAMSIFSVG-GNLGFALGPLIAAALVALFGGLGLLILLIIPGLA----VALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 203 NRKANLAVATPGAEEPVEeygmTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASFGLAVI 282
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSA----RSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 283 AGRIIGGWLLDRF--WAPACAFMILLIPAIGSWLLSGDALgsegAFAAVLFIGFGAGFEFDLLAFLISRYFGqRNYGVIY 360
Cdd:cd17478 245 IGTLIGGPLSDRFgrRRVIIASLLLAAPFLLLFLLTPGIW----SYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLAS 319
|
330 340
....*....|....*....|....*.
gi 1891802043 361 GCFYTVIAFGGGLGPVVYGYAFDMTG 386
Cdd:cd17478 320 GLMMGLSFGLGGIGAPVLGALADAFG 345
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-403 |
1.41e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 47 PELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLcFMSLSLSTGSLTLFYGqWVIMSVLG 126
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI-GGLLCGLSDSFALLLA-GRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 127 AGTLSATWTRVVNGWFD-KNRGLALGIASSGTGItGFLIKPFAAWIIADFGWRTAFVAIGALpILIGIPMVLWLFRENRK 205
Cdd:cd17474 101 AAGLGPLALTLIGDLFEgGERAKAMGLYEAALGL-GIAVGPLLGGLLAAISWRYPFFLLAAL-IPVAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 206 anlavatpGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENIL-RSFKFELAEIGAITASFGLAVIAG 284
Cdd:cd17474 179 --------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLeLLYGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 285 RIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFY 364
Cdd:cd17474 251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
|
330 340 350
....*....|....*....|....*....|....*....
gi 1891802043 365 TVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGG 403
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-403 |
1.04e-09 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 59.83 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIGVALGL-SPipfYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISlGL 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYgSP---LAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFS-GF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 98 FGLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGW 177
Cdd:cd17428 77 MVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 178 RTAFVAIGALPILIgipmvlwlfrenrkanLAVATPgaeepveeygMTLgqaLRSVKFWILAVSFFLISFALTAPTPNLE 257
Cdd:cd17428 157 DGCLLIVGALALNL----------------LACGSL----------MRL---FKNRVFSALFIAILLFDIGAFPPSLLME 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 258 NILRSFKF-ELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFI-GFG 335
Cdd:cd17428 208 DVARSENIiEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAIlGFL 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1891802043 336 AGfEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGG 403
Cdd:cd17428 288 SG-NWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGG 354
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-193 |
4.11e-09 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 57.84 E-value: 4.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIGVALGLSPIPfyTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLF 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIK--SFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWR 178
Cdd:cd17422 79 SLGMITASFAS-SIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWR 157
|
170
....*....|....*
gi 1891802043 179 TAFVAIGALPILIGI 193
Cdd:cd17422 158 YCLLVVGALQLNIVV 172
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
19-187 |
1.13e-08 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 56.67 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIgvALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLF 98
Cdd:TIGR00892 17 GWVVLGATFV--SIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTrVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWR 178
Cdd:TIGR00892 95 SLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLT-MLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWR 173
|
....*....
gi 1891802043 179 TAFVAIGAL 187
Cdd:TIGR00892 174 GSFLILGGL 182
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
42-338 |
1.98e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 55.74 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 42 IGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLcfmsLSLSTGSLTLFYGQWVI 121
Cdd:PRK11551 34 AGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGL----FSLATAQAWDFPSLLVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 122 --MSVLGAG----TLSATWTRVVNgwfDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIgIPM 195
Cdd:PRK11551 110 rlLTGVGLGgalpNLIALTSEAVG---PRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLL-VPL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 196 VLWLFRENRKANLAVATPGAEEPVEEYGMTLGQALRSVKFWI-----LAVSFFLISFaltaptpnLENILRSFKFELAEI 270
Cdd:PRK11551 186 LMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATATLLLWIsyfftLIVLYFLLNW--------LPSLLVGQGLSRSQA 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891802043 271 GAITASFGLAVIAGRIIGGWLLDRF-WAPACAFMILLIpaigswLLSGDALGSEGAFAAVLFIGFGAGF 338
Cdd:PRK11551 258 GLVQIAFNIGGALGSLLIGALMDRLrPRRVVLLIYAGI------LASLAALAAAPSFAGMLLAGFAAGL 320
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
39-391 |
4.57e-08 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 54.56 E-value: 4.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 39 FYTIGMFAPELSREFGWSFASMMgSIGVQSAVVMVASPLAGFAIDRYGARPVALIS--LGLFGLCFMSLSLSTGSLTL-F 115
Cdd:cd17354 19 IYLFSLYSPPLKSTLGYSQQQNN-LLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGaiLFFPGYGVLWLVVTGLISDLsF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 116 YGQWVIMSVLGAGTLSATWTRVVNGW--FDKNRGLALGIASSGTGITGFLikpFAAWIIADFGWRTA--FVAIGALPILI 191
Cdd:cd17354 98 WLMCLCFFLIGNSTSSLYTAALVTCAknFPESRGLAIGIPKGCYGLSGAI---GSQLYKALFFHDSArvFLFLAVLPAVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 192 GIpMVLWLFRenrkanlavatpgaeePVEEYGmtlGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFElAEIG 271
Cdd:cd17354 175 GL-LAWFSVR----------------IVSIEE---GEFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQSLTGP-SNTS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 272 AITASFGLAVIAGRIIGGWLLDRF-----WAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFL 346
Cdd:cd17354 234 TLVSLFSIFSFLGRLLSGLLSDLFvrkfrLPRPSRMVLLLLILSLGHLLQAFGLPSGALYVASALIGFGYGGLFSIAPTI 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1891802043 347 ISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTA 391
Cdd:cd17354 314 VSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGGEGAG 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-205 |
9.17e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 9.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 20 WLVVASAMIGVALGLSPIPFYTIGMFAPE-LSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLG-L 97
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGlL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 98 FGLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGW 177
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....*...
gi 1891802043 178 RTAFVAIGALPiLIGIPMVLWLFRENRK 205
Cdd:COG2271 337 QAAFLLLAALA-LLAALLALLLLRETRK 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
68-401 |
2.31e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 68 SAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQwVIMSVLGAGTLSATWTRVVNGWFDKNRG 147
Cdd:cd17473 45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR-ALLGIGVAGIMTLATALIGDYFEGEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 148 LALGIASSGTGITGfLIKPFAAWIIADFGWRTAFvAIGALPILIGIPMVLWLFRenrkanlavaTPGAEEPVEEYGMTLG 227
Cdd:cd17473 124 KMLGLQSAAMSLGG-VVFLLLGGALAEIGWRAPF-LVYLLALPVLILVLLFLPE----------PARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 228 QALRSVKFWILAVSFFLISFALTAPTPNLENILRS-FKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILL 306
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 307 IPAIGSWLLSGdALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTG 386
Cdd:cd17473 272 LMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
330
....*....|....*..
gi 1891802043 387 SYGTALRL--GIGFVIT 401
Cdd:cd17473 351 GLSGAFLIlgVLALVLA 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
42-336 |
2.33e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 42 IGMFAPELSREFGWSfASMMGSIGVQSAV-VMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLfyGQWV 120
Cdd:cd17365 18 MGFVAPALAQDWGLS-PAQLGPVGSAALFgMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL--ALLR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 121 IMSVLGAGTLSATWTRVVNGWF-DKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVaIGALPILIGIPMVLwl 199
Cdd:cd17365 95 FLTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL-LGGVPPLILLPLLR-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 200 frenrkanlavatpgaeepveeygmtlgqalRSVKFWILAVSFFLISFALTAPTPNLeniLRSFKFELAEIGAITASFGL 279
Cdd:cd17365 172 -------------------------------GTLLLWVTFFMGLLLVYLLNSWLPKL---MVEAGYSLSQALTITLLLNI 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1891802043 280 AVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGA 336
Cdd:cd17365 218 GGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV 274
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
72-386 |
2.58e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 72 MVASPLAGFAIDRYGAR-----PVALISLGLFGLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWF---- 142
Cdd:COG2211 60 AITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGaelt 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 143 --DKNRGLALGIASSGTGITGFLIKPFAAWIIADFG--WRTAFVAIGALPILIGIPMVLWLFRENRKAnlavatPGAEEP 218
Cdd:COG2211 140 pdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKER------PVPEEE 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 219 VEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRS-FKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWA 297
Cdd:COG2211 214 KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 298 PACAFMILLIPAIGS---WLLSGDALGSEGAFAAVLFIGFGAGF--EFDLLAFLI---SRYFGQRNYGVIYGCFYTVIAF 369
Cdd:COG2211 294 KKAFIIGLLLAALGLlllFFLGPGNLWLLLVLAALAGIGLGAILvlPWAMLADVVdydEWKTGRRREGLYFGIFTFAIKL 373
|
330
....*....|....*..
gi 1891802043 370 GGGLGPVVYGYAFDMTG 386
Cdd:COG2211 374 GQALAGALAGLLLALFG 390
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-400 |
2.74e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.21 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 64 IGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFD 143
Cdd:cd17489 37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-SVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 144 KNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALpILIGIPMVLWLFRENRKAnlavatpgaeEPVEEYG 223
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL-ALLALLLVFLVKDPPPVA----------AEEAEAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 224 MTLGQALRSVKFWILAVSFFLISFALTAptpnLENILRSFKFEL--AEIGAITASFGLAVIAGRIIGGWLLDRfWAPACA 301
Cdd:cd17489 185 TRAFRRLVEKKVLPPALILFLASIAYGA----ISTFLPLYAAERgiSNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 302 FMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYA 381
Cdd:cd17489 260 IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
330
....*....|....*....
gi 1891802043 382 FDMTGsYGTALRLGIGFVI 400
Cdd:cd17489 340 AELFG-YRAMFLLAAVVVL 357
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-400 |
3.18e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.81 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 30 VALGLSPIPFYTIGMFAPELSREFGW-----SFASMMGSIGvqSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMS 104
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKlgasgYYVGLLQSSY--SLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 105 LSLStGSLTLFYGQWVIMSVLGAG--TLSATWTRVVNgwfDKNRGLALGIASSGTGItGFLIKP-FAAWIIADFGWRTAF 181
Cdd:cd17330 81 LGLS-RNLWLLFLARFLDGLTGGNvsVAQAYIADITD---EEERAKAFGIISAAFGL-GFILGPaLGGFLSTPYGYALPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 182 VAIGALPILIGIPMVLWLFRenrkanlavatpgaeepveeygmtlgqalrsvkFWILAVSFFLISFALTAPTPNLENILR 261
Cdd:cd17330 156 LVAAALALLNLVLVLFFLPP---------------------------------LRRLLLVYFLIALAFAGLESVFSLFLK 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 262 -SFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEF 340
Cdd:cd17330 203 dRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 341 DLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVI 400
Cdd:cd17330 283 PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLI 342
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-306 |
3.72e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 3.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 9 TPAGSRETRQGWLVVASAMIGVALglSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGAR 88
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFL--EGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 89 PVALISLGLFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFA 168
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAP-SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 169 AWIIADFGWRTAFVaIGALPILIGIPMVLWLFRENRKANLAVATPGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFA 248
Cdd:COG0477 159 GLLVAALGWRWIFL-INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1891802043 249 LTAPTPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILL 306
Cdd:COG0477 238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-187 |
4.16e-07 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 51.74 E-value: 4.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIgvALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLF 98
Cdd:cd17427 1 GWAVVFGAFI--SIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTrVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWR 178
Cdd:cd17427 79 SLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALT-IIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWR 157
|
....*....
gi 1891802043 179 TAFVAIGAL 187
Cdd:cd17427 158 GSFLILGGL 166
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-386 |
6.02e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 51.22 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 46 APELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgSLTLFYGQWVImSVL 125
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-SLWVMAALWAL-NGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 126 GAGTLSATWTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWIIADF-GWRTAFVAIGALPILIGIpMVLWLFREN 203
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSeRGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSL-ICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 204 rkaNLAVATPGAEE----------PVEEYGMTLGQA-----LRSVKFWILAVSFFLISFALTAPTPNLENIL-RSFKFEL 267
Cdd:TIGR00881 175 ---PQSCGLPPAEEmpneepdgdaEKKEEELTKKQIflqyvLLNKVLWYISLGYVFVYVVRTGILDWSPLYLtQEKGFSK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 268 AEIGAITASFGLAVIAGRIIGGWLLDRFW-----APACAFMIL-LIPAIGSWLLSGDALGSEGAFAAVL-FIGFGAGFEF 340
Cdd:TIGR00881 252 EKASWAFTLYELGGLVGTLLAGWLSDKLFngrrgPLAVFFMALiIVSLLVYWLNPAANPLMDLICLFALgFLVYGPQMLI 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1891802043 341 DLLAFLISRYFGQRNYGVIYGCFYTViafGGGLGPVVYGYAFDMTG 386
Cdd:TIGR00881 332 GVIASELAPKKAAGTAAGFVGFFAYL---GGILAGLPLGYLADGFG 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
40-315 |
6.62e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.08 E-value: 6.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 40 YTIGMFAPELSREFG--WSFASMMGSigVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgsltlFYG 117
Cdd:cd17328 16 FTIAGVLPDIQSDFLidDSLAGLLQT--VFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP-----NFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 118 QWVIMSVL---GAGTLSATWTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWII-ADFGWRTAFVAIGALPILIG 192
Cdd:cd17328 89 QLLLFRALvgiGEASYSPIAPTIIADLFPKEkRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 193 IpmVLWLFRENRKANLAVATPGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISF---ALTAPTPNLenILRSFKFELAE 269
Cdd:cd17328 169 I--LLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFvtgALAFWAPTF--FLRAFGVGDLS 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1891802043 270 IGAITASFGLAVIAGRIIGGWL---LDRFWAPACAFMILLIPAIGSWLL 315
Cdd:cd17328 245 SADVGLIFGAITCIAGVLGVLLggiLADRLRRKTPRADPLVCAVGLLAA 293
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-379 |
7.80e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 7.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 28 IGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSL 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 108 STGSLTLFYGQwVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVaigaL 187
Cdd:cd17321 81 APSLAFLIAAR-ALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL----I 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 188 PILIGIpMVLWLFRENRKANLAVATPGAeepveeygmtlgqalrsvkfwILAVSFFLISFALTaptpnlenilRSFKFEL 267
Cdd:cd17321 156 NVPIGL-VALLLARTFSGAVLAAFLLGA---------------------ALGGLLFLLPLYLQ----------GVLGYSP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 268 AEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLS--GDALGSEGAFAAVLFIGFGAGFEFDLLAF 345
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllGADSSVWLLLPGLVLLGLGLGLFATPLTN 283
|
330 340 350
....*....|....*....|....*....|....
gi 1891802043 346 LISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYG 379
Cdd:cd17321 284 AALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-199 |
1.03e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 48.03 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 69 AVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLStGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGL 148
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALS-SNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGV 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1891802043 149 ALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWL 199
Cdd:TIGR00880 88 ALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-199 |
1.24e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 64 IGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFD 143
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1891802043 144 KNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWL 199
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
224-386 |
1.61e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 224 MTLGQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPAcAFM 303
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-VLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 304 ILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFD 383
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
...
gi 1891802043 384 MTG 386
Cdd:COG2814 160 LFG 162
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-403 |
1.67e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 20 WLVVASAMIGVALGLSpIPFYTIgmfapELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFG 99
Cdd:cd17329 3 VLLIGSFLNRLGFFMV-WPFMAI-----YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 100 LCFMSLSLStGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGItGFLIKPFAAWIIADFGWRT 179
Cdd:cd17329 77 LGFALLGFA-HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINL-GVAIGPLLGGLLLLYSFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 180 AFVAIGALPILIGIpMVLWLFRENRkanlavaTPGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLE-N 258
Cdd:cd17329 155 LFLAAAVLFLLAAL-VLLFLLPETR-------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPvY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 259 ILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRfWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGF 338
Cdd:cd17329 227 VVEILGLGESLLGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEML 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1891802043 339 EFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGG 403
Cdd:cd17329 306 VFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-187 |
2.02e-06 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIgvALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLF 98
Cdd:cd17426 1 GWAVVLGAFI--SIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTrVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWR 178
Cdd:cd17426 79 GAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALT-MIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWR 157
|
....*....
gi 1891802043 179 TAFVAIGAL 187
Cdd:cd17426 158 GSFLILGGL 166
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-394 |
2.15e-06 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 49.42 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIgVALGLSPIPfYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARpVALISLGLF 98
Cdd:cd17424 1 GWMIVAGCFL-VTVCTRAVT-RCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQ-VGIILGGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 99 GLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWR 178
Cdd:cd17424 78 ASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 179 tafvaiGALPILIGIPMvlwlfrenrkaNLAVAtpGAeepveeygmtLGQALRSVKFWILAVSFFLISFALTAPTPNLEN 258
Cdd:cd17424 158 ------GALLILGGFVL-----------NLCVC--GA----------LMRFLLMPDFLVLAVSVLFLAYGCSPPFVYLVP 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 259 ILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIpAIGSWLLSGDALGSEGAFAAVLFIGFGAGF 338
Cdd:cd17424 209 YALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLF-AVGMDGLCCLFLPILKTFPLLVPFSFTFGY 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1891802043 339 eFD-----LLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRL 394
Cdd:cd17424 288 -FDgayvaLIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLL 347
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
41-307 |
6.29e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.04 E-value: 6.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 41 TIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARpvALISLGLFGLCFMSLSLSTGSLTLFYGQWV 120
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIR--RFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 121 IMSVLGAGTLSATWTRVVNGWF-DKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIpmVLWL 199
Cdd:cd17312 99 GLNGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAI--ILFF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 200 FRENRKANLavatpgaeepveeygmtlgqalrsvkfWILAVSFFLISFALTAPTPNLENILRSFK-FELAEIGAITASFG 278
Cdd:cd17312 177 FLRDSPPYV---------------------------WVLSLAYAFVYIVRYACLDWGPLYLYEVKgYSLIDAGWFSSLYE 229
|
250 260 270
....*....|....*....|....*....|...
gi 1891802043 279 LAVIAGRIIGGWLLDRFW----APACAFMILLI 307
Cdd:cd17312 230 VGGIAGTILAGLLSDKLFggrrAPIAVIYMLLM 262
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-187 |
1.26e-05 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 47.07 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 19 GWLVVASAMIGVALGLspiPFYT-IGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGL 97
Cdd:cd17425 1 AWVVLLATMIVQGLTL---GFPScIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 98 FGLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTrVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGW 177
Cdd:cd17425 78 SGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVT-VLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGW 156
|
170
....*....|
gi 1891802043 178 RTAFVAIGAL 187
Cdd:cd17425 157 RGSFLVFGGV 166
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-404 |
1.33e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 39 FYTIGMFAPELSREFGWSFASMM--GSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLcFMSLSLSTGSLTLFY 116
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGL-ATLLIGLLPTPILLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 117 GQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGItGFLIKPFAAWII-----ADFGWRTAFvAIGALPILI 191
Cdd:cd17316 94 VLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAL-GALLAALVASLLipllsGDWGWRILF-LIGALPALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 192 GIPMvlwlfrenrkanlavatpgaeepveeygmtlgqALRSVKFWILAVSFFLISFALTAPTPNLenILRSFKFELAEIG 271
Cdd:cd17316 172 ALLL---------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 272 AITASFGLAVIAGRIIGGWLLDRF---WAPACAFMILLIPAIGSWLLsGDALGSEGAFAAVLFIGFGAGFeFDLLAFLIS 348
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIgrkKTLVIGLILSGILALPLFYL-LSGSPTLLLLLLFILSFFVGGV-WGALYAYLA 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1891802043 349 RYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVITGGA 404
Cdd:cd17316 295 ELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
72-399 |
1.70e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.55 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 72 MVASPLAGFAIDRYGARPVALISLGLFgLCFMSLSLSTGSLTLFYGQwVIMSVLGAGTLSATWTRVVNGWFDKNRGLALG 151
Cdd:cd17333 45 LIGSLLAGFLMKRLGRRRTLILGLLLI-SLALALIFATPSIYLFVVL-MFLAGLGAGILDTGANTFVGALFEESSATRLN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 152 IASSGTGITGFLIKPFAAWIIA-DFGWRTAFVAIGALPILIGIPMVLWLFRENRKANLAVATPGAEEPveeygmTLGQAL 230
Cdd:cd17333 123 VLHGFFGLGALIGPLIATSLLTsELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSA------SASRLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 231 RSVKFWILAVSFFL-----ISFALTAPTPNLENILRSFKFelaeIGAITASFGLAVIAGRIIGGWLLDRFwAPACAFMIL 305
Cdd:cd17333 197 RNPSIILGALALFLyvgaeTAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGGPISRRI-KPHTLLVLS 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 306 LIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNyGVIYGCFYTVIAFGGGLGPVVYGYaFDMT 385
Cdd:cd17333 272 GSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGF-IAEA 349
|
330
....*....|....
gi 1891802043 386 GSYGTALRLGIGFV 399
Cdd:cd17333 350 VGIQTAMLLITILY 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
41-296 |
1.79e-05 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 46.35 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 41 TIGMFAPELSREFGWSFA--SMMGSIgvQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgSLTLFYGQ 118
Cdd:cd17421 21 TFGIFFVAFQEEFGGSSEqiSWIGSI--MSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFAT-SVPFLYVS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 119 WVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITgFLIKPFAAWIIADFGWRtafvaiGALPILIGIPMVLw 198
Cdd:cd17421 98 MGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLT-FALAPFTQLLLDEYDWQ------GALLIFGGIMLNL- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 199 lfrenrkanlaVATPGAEEPVEEygmtlgQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASFG 278
Cdd:cd17421 170 -----------VASGMLLRPIDF------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAG 232
|
250
....*....|....*...
gi 1891802043 279 LAVIAGRIIGGWLLDRFW 296
Cdd:cd17421 233 ITETVAQLASGWIADQNW 250
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
70-388 |
1.80e-05 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 46.36 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 70 VVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQWVIMSVlGAGTLSATWTRVVNGWFDKNRGLA 149
Cdd:cd17429 50 ITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGI-GSGMAYLPAVVMVGQYFQKRRALA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 150 LGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWLFRENRkanlavatpgaeepveeygmtlgqA 229
Cdd:cd17429 129 QGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMRLFTNK------------------------V 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 230 LRSVKFW-ILAVSFFLISFALTAPTPNLENIL-RSFKFELAEIGAITASFGlAVIAGRI-----IGGW---LLDRFWAPA 299
Cdd:cd17429 185 FVAFIFWaLFAYCSFVIPFIHLPEIVKLYGLSeQNDKFPLTSIIAIVHIFG-KVILGIIcdlpcISVWnvfILANFTLGV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 300 CafmILLIPAIGSWLlsgdalgseGAFAAVLFIGFGAGFeFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYG 379
Cdd:cd17429 264 C---ILILPLMHTYT---------GLAIVCALIGFSSGY-FSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAG 330
|
....*....
gi 1891802043 380 YAFDMTGSY 388
Cdd:cd17429 331 WIYDITQKY 339
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
66-404 |
2.35e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 66 VQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQWVIMSVLgAGTLSATWTRVVNGWF--- 142
Cdd:cd06173 42 AFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFL-LGIASAFFGPARQALLpel 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 143 --DKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIpmVLWLFRENRKANLAVATPGAEEPVE 220
Cdd:cd06173 121 vpKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL--LLLFIRRPPPAAPGESSSLLLRDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 221 EYGMTLGQALRSVKFWILAVSFFLISFALTAPTPNLenILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFwAPAC 300
Cdd:cd06173 199 EGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL--AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR-RRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 301 AFMILLIPAIGSWLLSGDALGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGY 380
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
330 340
....*....|....*....|....
gi 1891802043 381 AFDMTGSYGTALRLGIGFVITGGA 404
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
42-187 |
2.36e-05 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 46.26 E-value: 2.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 42 IGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISlGLFGLCFMSLSLSTGSLTLFYGQWVI 121
Cdd:cd17430 22 VSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVG-GLLASLGMILASFCTSIIQLYLTAGV 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1891802043 122 MSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGAL 187
Cdd:cd17430 101 ITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGL 166
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
79-337 |
3.54e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 45.37 E-value: 3.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 79 GFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATwtRVVNGWFDKN-RGLALGIAS--- 154
Cdd:TIGR00886 58 GFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFIGIAGGSFASCM--PWISFFFPKKiQGTALGLAAgwg 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 155 -SGTGITGFLIKPFAAWIIADFG------WRTAFVAIGALPILIGIPMVLWLFRENRKANLAVATPGAEEPVeeygmtlg 227
Cdd:TIGR00886 136 nMGGGVAQFVMPPIIGSLIFGGGqpahlaWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEAL-------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 228 QALRSVKFWILAVsFFLISF----ALTAPTPNLenILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFM 303
Cdd:TIGR00886 208 KVFGNRHTWILAL-LYSVTFgsflGVSSIFAML--FKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLM 284
|
250 260 270
....*....|....*....|....*....|....*....
gi 1891802043 304 ILLIPAIGSWLLSGDALGSEGAFAAV-----LFIGFGAG 337
Cdd:TIGR00886 285 NFLGVAMGAFLVVLGLVSDGSLAAFIvlfvaLFFFAGAG 323
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
16-201 |
5.39e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 45.46 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 16 TRQGWLVVASAMIGVALglSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISL 95
Cdd:PRK03893 15 NRAQWKAFSAAWLGYLL--DGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 96 GLFGLCFMSLSLSTGSLTLFYGQWVIMSVLgAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADF 175
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWTLFIARLVIGMGM-AGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVW 171
|
170 180
....*....|....*....|....*.
gi 1891802043 176 GWRTAFvAIGALPILIGipmvLWLFR 201
Cdd:PRK03893 172 GWRALF-FIGILPIIFA----LWLRK 192
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
170-386 |
1.02e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.14 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 170 WIIADFGWRTAFVAIGALPILIGIPmvLWLFRENRkanlAVATPGAEEPVEEYGMTLGQALRSVKFWILAVSFFLISFAL 249
Cdd:cd17485 150 WLYDLIGWQSLLLSLAALYLLLLLP--VLFLRELE----LPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 250 TAPTPNLENILRSFKFELAEIGAITASFGLAV-IAGRIIGGWLLDRFWAPAC---AFMILLIPAIGSWLLS--GDALGSE 323
Cdd:cd17485 224 QGALAMLPPFLVDRGFSLSQIGLLSGVGGSLVsIAGSLLGGYLLKRRGRRRLlllGGLLRLLLLGLYTLLAlgGSGLNWV 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1891802043 324 GAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTG 386
Cdd:cd17485 304 LLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLG 366
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
142-399 |
1.94e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 43.36 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 142 FDKNRGLALGIASSGTGItGFLIKP-FAAWIIADFGWRTAFVAIGALpILIGIPMVLWLFrenrkanlavATPGAEEPVE 220
Cdd:cd17385 123 FPNNIATVLGTLETFSGL-GLMLGPpLGGFLYQAGGYELPFLVLGCL-LLLTVPLNMFIL----------PRYDDDPSPK 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 221 EYGMTlgQALRSVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPAC 300
Cdd:cd17385 191 SGSML--KLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKW 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 301 AFMILLIPAIGSWLLSGDA----LGSEGAFAAVLFI--GFGAGFEF-----DLLAFLISRYF--GQRNYGVIYGCFYTVI 367
Cdd:cd17385 269 LMVIGSIITGVGFLLLGPApllpIKSELWMVIIGLVllGLSLGAALvptfpELLNCAREYGFpdNLSTYGLVSGLFNAAF 348
|
250 260 270
....*....|....*....|....*....|...
gi 1891802043 368 AFGGGLGPVVYGYAFDMTG-SYGTALRLGIGFV 399
Cdd:cd17385 349 SLGAFIGPTLGGFLLERLGfEWAATIQAGLAFV 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-200 |
2.81e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 27 MIGVALGLSPIPFYTIGMFAPELSREFGWSFASMmgSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLS 106
Cdd:cd17489 198 PPALILFLASIAYGAISTFLPLYAAERGISNAGL--FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 107 LSTGSLTLFYGqwVIMSVLGAGTL-SATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFvAIG 185
Cdd:cd17489 276 FAGSPWMLLLA--AVLYGLGFGLLfPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF-LLA 352
|
170
....*....|....*
gi 1891802043 186 ALPILIGIPMVLWLF 200
Cdd:cd17489 353 AVVVLLALVLYIFLL 367
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
67-253 |
4.59e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 42.32 E-value: 4.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 67 QSAVVMVASPLAGFAIDRYGARpvALISLGLFGLCFMSLSLS-TGSLTLFYGQWVIMSVL-GAGtlsatWT---RVVNGW 141
Cdd:cd17343 47 QSLAYAISKFIGGVLSDQISAR--WLFSSGLVLSGLTTVAFSgSSSVWVFSILWFLNGLAqGLG-----WPpcaKILRKW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 142 FD-KNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGIPMVLWLFRENRKANLAVATPGAEEP-- 218
Cdd:cd17343 120 FSpSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGkk 199
|
170 180 190
....*....|....*....|....*....|....*..
gi 1891802043 219 --VEEYGMTLGQALRSVKFWILAVSFFLISFALTAPT 253
Cdd:cd17343 200 kkSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVT 236
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
73-404 |
9.49e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.14 E-value: 9.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 73 VASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQwVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGI 152
Cdd:cd06180 49 VGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR-FLAGAASAFVFVFGSNLVLHHATAAGRGHLIGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 153 ASSGTGITGFLIKPFAAWIIA-DFGWRTAFVAIGALPILIGIPmVLWLFRENRKANLAVATPGAEEPveeygmtlgqalR 231
Cdd:cd06180 128 LFAGVGLGIALSGLLVPAGLGgGLSWRAGWLALALLSAVLLLL-SFLLLRRGPSAPTEASAAESAPG------------L 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 232 SVKFWILAVSFFLISFALTAPTPNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIG 311
Cdd:cd06180 195 NRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 312 SwLLSGdaLGSEGAFAAVLFIGFGAGF-EFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGT 390
Cdd:cd06180 275 V-LLPL--LSPGPAGLVLSAVLFGGTFmAITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAP 351
|
330
....*....|....
gi 1891802043 391 ALRLGIGFVITGGA 404
Cdd:cd06180 352 ALILAAAALVVAAL 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-193 |
1.08e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 37 IPFYTIGMFAPE-LSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLC--FMSLSLSTGSLT 113
Cdd:cd17316 191 FGYYGLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILalPLFYLLSGSPTL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 114 LFYGqWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGI 193
Cdd:cd17316 271 LLLL-LFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
20-197 |
1.21e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 20 WLVVASAMIgVALGLSPIPFYTIgmfapeLSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFG 99
Cdd:cd17370 203 WLYLLAVAL-FALGNFSFAFLIL------RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 100 LCFMSLSLSTGSLTLfygqWVIMSVLGAG---TLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFG 176
Cdd:cd17370 276 LAYLGFALGSSLWLL----LLGFILWGLYmgaQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
|
170 180
....*....|....*....|.
gi 1891802043 177 WRTAFVaIGALPILIGIPMVL 197
Cdd:cd17370 352 PSAAFL-FSAVLALIALLLLL 371
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
26-400 |
1.63e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 26 AMIGVALGLSPiPFYTIGMFAPELSREFGWSfASMMGSIGVQSAVVM-VASPLAGFAIDRYGARPVALISLGLfgLCFMS 104
Cdd:cd17339 3 GIVLIAFNLRP-AITSVGPLLPEIRDDLGLS-ASQAGLLTTLPLLCFaVFSPLAPRLARRFGLERTLLLALLL--LAAGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 105 LSLSTGSLTLFYGQWVIMSVlGAGTLSATWTRVVNGWFDKNRGLALGIASS----GTGITGFLIKPFAAWiiADFGWRTA 180
Cdd:cd17339 79 LLRSLGGIALLFLGTALAGA-GIAVGNVLLPSLIKRDFPRRVGLMTGLYTTsmnlGAALASGLSVPLAQA--LGGGWRGA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 181 fVAIGALPILIGIPMVLWLFRENRKANlAVATPGAEEPVeeygmtlgqaLRSVKFWILAVSFFLISFALTAPTPNLENIL 260
Cdd:cd17339 156 -LAIWALPALLALLIWLPQLRRRKRAA-AAAAPLTKISV----------WRSPLAWQVTLFMGLQSLLFYTLMAWLPTIL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 261 RSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRF----WAPACAFMILLIPAIGSWLLsgdalGSEGAFAAVLFIGFGA 336
Cdd:cd17339 224 IDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLknqrPIVVLLAVLFIIGVLGLLFA-----PTALALLWAVLLGLGG 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891802043 337 GFEFDLLAFLISRYFGQ-----RNYGVIYGCFYTVIAFGgglgPVVYGYAFDMTGSYGTALRLGIGFVI 400
Cdd:cd17339 299 GAAFSLALTLISLRSSDpaeaaALSGMAQSVGYLLAALG----PLLFGVLHDLTGSWTAPLVLLLALTV 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
238-402 |
1.81e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 238 LAVSFFLISFALTAPTPNLENIL-RSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLS 316
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 317 GDAlGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGI 396
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
....*.
gi 1891802043 397 GFVITG 402
Cdd:pfam07690 160 LSLLAA 165
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-372 |
1.87e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.25 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 30 VALGLSPIPFYTIGMfaPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLST 109
Cdd:cd17320 8 VALGPLAIDMYLPAL--PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 110 GSLTLFYGQWVimSVLGAGTLSATWTRVVNGWFD-KNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAFVAIGALP 188
Cdd:cd17320 86 SIEQLLIARFL--QGLGAAAGSVVARAIVRDLYSgAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 189 ILIGIPMVLWLfRENRKANlaVATPGAEEPVEEYgmtlGQALRSVKFW---ILAVSFFLISFALTAPTPNLenILRSFKF 265
Cdd:cd17320 164 LLLLLLVLLFL-PETLPEE--KRKPLLSSLLRAY----KRVLKNRRFLgyaLALGLSFAGLFAYLAAAPFI--YIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 266 ELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGA----FAAVLFIGFGAGFEFD 341
Cdd:cd17320 235 SPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSlwplVAPLFLIFFGFGLIFP 314
|
330 340 350
....*....|....*....|....*....|...
gi 1891802043 342 LLAFLISRYFGQR--NYGVIYGCFYTVIAFGGG 372
Cdd:cd17320 315 NATSLALEPFPHVagTASALLGFLQFLIGALAG 347
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
77-193 |
3.97e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 39.31 E-value: 3.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 77 LAGFAIDRYGARPVALISLGLFGLCFMSLSLSTgSLTLFYGQWVIMSVLgAGTLSATWTRVVNGWFDKN-RGLALGIASS 155
Cdd:cd17488 57 VSGLMSDRSNPRYFMGIGLIATGIINILFGFSS-SLWAFAVLWTLNAFF-QGWGWPPCARLLTHWYSRNeRGFWWSIWNT 134
|
90 100 110
....*....|....*....|....*....|....*...
gi 1891802043 156 GTGITGFLIKPFAAWIIADFGWRTAFVAIGALPILIGI 193
Cdd:cd17488 135 SHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGI 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-400 |
4.31e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 21 LVVASAMIGVALGLSpIPFYTIGMFAPELSrefgwsfASMMGSIG-VQSAVVMVASPLAGFAIDRYGARPVALISLGLFG 99
Cdd:cd17477 1 LLLSVALLGLGSGLL-LPLLSLRLEREGVS-------TALIGLVAsAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 100 LCFMSLSLSTGSLTLFygqwVIMSVLGAG-----TLSATWtrvVNGWF-DKNRGLALGIASSGTGItGFLIKPFAAWIIA 173
Cdd:cd17477 73 VSVLLLALTDSPWVWF----LLRFVMGIGlaglfVVSESW---LNALAtNENRGRVLGLYSTVLGL-GFALGPLLLALVG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 174 DFGWrTAFVAIGALPILIGIPMVLwlfrenrkanlavATPGAEEPVEEYGMTLGQALRSVKFWILAVsfFLISFALTAPT 253
Cdd:cd17477 145 TAGA-LPFLIAAVLLLLALVPLLL-------------TRRAAPEIEEAESISLRRLLRIAPLALLGA--FVAGFLEGAFY 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 254 PNLENILRSFKFELAEIGAITASFGLAVIAGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSGDALGSEGAFAAVLFIG 333
Cdd:cd17477 209 SLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1891802043 334 FGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFVI 400
Cdd:cd17477 289 GAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
47-340 |
4.44e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 47 PELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGLCFMSLSLSTGSLTLFYGQwVIMSVLG 126
Cdd:cd17503 20 PTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR-ILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 127 AGTLSATWTRVVNGWFDKNRGLALGIASSGTGITGFLIKPFAAWIIADFGWRTAF---VAIGALpILIGIPMV-LWLFRE 202
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyinLPIGIL-ALLLAPLLdLRLFKD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 203 nrkANLAVATpgaeepveeygmtlgqalrsvkFWILAVSFFLISFALTAPtPNLENILrsfKFELAEIGAITASFGLAVI 282
Cdd:cd17503 178 ---RNFTLGL----------------------LLSFLLGLGLFGAMFLLP-LYLQNVL---GYSAFESGLVLAPGGLASA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 283 AGRIIGGWLLDRFWAPACAFMILLIPAIGSWLLSG-DALGSEGAFAAVLFI-GFGAGFEF 340
Cdd:cd17503 229 ILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFlTPDTSLWLIILPLFIrGLGMGLVF 288
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
147-293 |
4.84e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 39.14 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 147 GLALGIASSGTGITGfLIKPFAAWIIADFG------WRTAFVAIGALPILIGIpMVLWLFRENRKANLAVATPGAEEPVE 220
Cdd:PLN00028 162 GIAAGWGNLGGGVTQ-LLMPLVFPLIKDAGapsftaWRIAFFVPGLLHIIMGI-LVLTLGQDLPDGNYRELKKSGTMPKD 239
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1891802043 221 EYGMTLGQALRSVKFWILAVSF-FLISFALTaptpnLENILRS-----FKFELAEIGAITASFGLAVIAGRIIGGWLLD 293
Cdd:PLN00028 240 SFSKVLRYGVTNYRTWILALTYgYSFGVELT-----MDNIIAEyfydrFGLSLETAGAIAASFGLMNLFARPAGGYLSD 313
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-404 |
4.96e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 30 VALGLSPIPFYTIGMFAPELSREFGWSFASMmGSIGVQSAVVMVASP-LAGFAIDRYGARPVALISLGLFGLCFMSLSLS 108
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEA-GLLGTVTLAGGAIGGiLGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 109 TGSLTL----------FYGQWVIMSVLGAGTLSAtwtrvvngwfdKNRGLALGIASSGTGITGFLIKPFAAWIIADF--- 175
Cdd:cd17371 85 QNYWQLlilralaglgFGGEWAAGAALMAEYVPA-----------RHRGKALGYVQSGWAVGWLLATLLAALLFPLLppe 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 176 -GWRTAFVaIGALPILIGIPMVLWL-----FRENRKANLAVATPGAEEPVEEYGMtlgqaLRSVKFWILAVSFFLIS-FA 248
Cdd:cd17371 154 iAWRVLFL-LGALPALLVLFIRRFVkeppqWQAARAARRHFADRPSLRELFSPPL-----LRTTLLASLLATGALGGyYG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 249 LTAPTPNLENILRSFKFElaEIGAITASFGLAVIAGRIIGGWLLDR---------FWAPACAFMILLIPAigswllsgdA 319
Cdd:cd17371 228 ITTWLPSYLTGERGLSFE--GSAGYLVVTILGGFLGYLAGGFLADRigrrnnfalFALGSAISILLYFFL---------P 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 320 LGSEGAFAAVLFIGFGAGFEFDLLAFLISRYFGQRNYGVIYGCFYTVIAFGGGLGPVVYGYAFDMTGSYGTALRLGIGFV 399
Cdd:cd17371 297 LSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYY 376
|
....*
gi 1891802043 400 ITGGA 404
Cdd:cd17371 377 IAGLV 381
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
46-310 |
8.46e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 8.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 46 APELSREFGWSfasmMGSIGVQSAVVMVASPLAGFAI----DRYGARPVALISLGLFGLC--FMSLSLS-TGSLTLFYGQ 118
Cdd:cd17345 26 QPYLIEQYGLS----KTEIGLIGSALSIAYGLSKFVMgnlsDRSNPKRFLAIGLILSAIIniLIGFVPSaTSSVGLMFIL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 119 WVIMSVLgAGTLSATWTRVVNGWFDKN-RGLALGIASSGTGITGFLIKPFAAWIIADFG---WRTAFVAIGALPILIGIP 194
Cdd:cd17345 102 LFLNGWF-QGMGWPPSGRTMVHWFSKKeRGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 195 mVLWLFRENRKAnlaVATPGAEEPVEEYG-----------MTLGQ-----ALRSVKFWILA---VSFFLISFALTAPTPN 255
Cdd:cd17345 181 -VLFLGKDTPES---EGLPPIEEYKGDYPeeadgeeeeqeLSAWEifvkyVLKNKLLWYIAianVFVYLVRYGILDWAPT 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1891802043 256 -LENILrsfKFELAEIGAITASFGLAVIAGRIIGGWLLDRFW-----APACAFMILLIPAI 310
Cdd:cd17345 257 yLSEVK---GFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgrraPTGIIFMILVIVAL 314
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-197 |
9.12e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 37.95 E-value: 9.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 21 LVVASAMIGVALGLSPIPFYTIGMFAPELSREFGWSFASMMGSIGVQSAVVMVASPLAGFAIDRYGARPVALISLGLFGL 100
Cdd:cd17365 169 LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1891802043 101 CFMSLSLSTGSLTLFYGQWVIMSVLGAGTLSATWTRVVNGWFDKNRGLALGiASSGTGITGFLIKPFAAWIIADFGWRTA 180
Cdd:cd17365 249 SLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVG-WALGVGRLGAILGPLLGGLLLAAGLGPE 327
|
170
....*....|....*...
gi 1891802043 181 FV-AIGALPILIGIPMVL 197
Cdd:cd17365 328 SVfLALAIPAALGALAVL 345
|
|
| |
