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deoxyguanosinetriphosphate triphosphohydrolase [Rhizobium esperanzae]
Protein Classification
deoxyguanosinetriphosphate triphosphohydrolase family protein ( domain architecture ID 11479518 )
deoxyguanosinetriphosphate triphosphohydrolase family protein similar to deoxyguanosinetriphosphate (dGTP) triphosphohydrolase, which catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK01286
PRK01286 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
14-405
4.56e-176
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234934 [Multi-domain]
Cd Length: 336
Bit Score: 493.92
E-value: 4.56e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 14 ER A V YAA DPWT SRGRL YQ E DGS P T R SD FQRDRDRI V H TT AFRRLKHKTQVFI AQD GDHYRTRLTHT I EVAQIAR AL ARAL 93
Cdd:PRK01286 2 TL A P YAA LSAN SRGRL RP E EPC P I R TE FQRDRDRI I H SK AFRRLKHKTQVFI NPE GDHYRTRLTHT L EVAQIAR TI ARAL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 94 RL D EDL A E GV AL V HD F GHTPFGH T GEDAL H E VLLP YGGF D HN A QSLR I V T KLE R RY aef DG I NLTWE SL EG LV KH N GP LL 173
Cdd:PRK01286 82 RL N EDL T E AI AL G HD L GHTPFGH A GEDAL N E LMKE YGGF E HN E QSLR V V D KLE K RY --- DG L NLTWE VR EG IL KH S GP RN 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 174 T P E G vgtrgpvpqpildycelhdlela T Y A S LE A Q VAAI AD D IAYN T HDIDDG L R S G YL T FDM L E E ipflaglmaevrar 253
Cdd:PRK01286 159 A P L G ----------------------- T A A T LE G Q IVRL AD E IAYN N HDIDDG I R A G LI T LED L P E -------------- 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 254 yphl EPS R FTH E IM RR Q I TRM V E D V I AVA Q ER L SLLR pesaadirg A DQVIAT FSE KM AE TDRQIKAM LF KRI YR N P DIM 333
Cdd:PRK01286 202 ---- DVR R LLG E TH RR R I NTL V V D L I KNT Q RN L AEGA --------- A APPLVS FSE EV AE AMKELRRF LF ENV YR H P KVK 268
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1892269101 334 R I R AG A A RIV T DLF AA YM AN P KEMQSH Y W vdhi AGLADAPKA R H V G DY L AGMTD T YA ISAH RRLF DHT P D L R 405
Cdd:PRK01286 269 R E R EK A K RIV Q DLF EY YM ED P ELLPPE Y Q ---- NIAEEEGLE R A V A DY I AGMTD R YA LREY RRLF VPK P W L Y 336
Name
Accession
Description
Interval
E-value
PRK01286
PRK01286 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
14-405
4.56e-176
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234934 [Multi-domain]
Cd Length: 336
Bit Score: 493.92
E-value: 4.56e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 14 ER A V YAA DPWT SRGRL YQ E DGS P T R SD FQRDRDRI V H TT AFRRLKHKTQVFI AQD GDHYRTRLTHT I EVAQIAR AL ARAL 93
Cdd:PRK01286 2 TL A P YAA LSAN SRGRL RP E EPC P I R TE FQRDRDRI I H SK AFRRLKHKTQVFI NPE GDHYRTRLTHT L EVAQIAR TI ARAL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 94 RL D EDL A E GV AL V HD F GHTPFGH T GEDAL H E VLLP YGGF D HN A QSLR I V T KLE R RY aef DG I NLTWE SL EG LV KH N GP LL 173
Cdd:PRK01286 82 RL N EDL T E AI AL G HD L GHTPFGH A GEDAL N E LMKE YGGF E HN E QSLR V V D KLE K RY --- DG L NLTWE VR EG IL KH S GP RN 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 174 T P E G vgtrgpvpqpildycelhdlela T Y A S LE A Q VAAI AD D IAYN T HDIDDG L R S G YL T FDM L E E ipflaglmaevrar 253
Cdd:PRK01286 159 A P L G ----------------------- T A A T LE G Q IVRL AD E IAYN N HDIDDG I R A G LI T LED L P E -------------- 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 254 yphl EPS R FTH E IM RR Q I TRM V E D V I AVA Q ER L SLLR pesaadirg A DQVIAT FSE KM AE TDRQIKAM LF KRI YR N P DIM 333
Cdd:PRK01286 202 ---- DVR R LLG E TH RR R I NTL V V D L I KNT Q RN L AEGA --------- A APPLVS FSE EV AE AMKELRRF LF ENV YR H P KVK 268
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1892269101 334 R I R AG A A RIV T DLF AA YM AN P KEMQSH Y W vdhi AGLADAPKA R H V G DY L AGMTD T YA ISAH RRLF DHT P D L R 405
Cdd:PRK01286 269 R E R EK A K RIV Q DLF EY YM ED P ELLPPE Y Q ---- NIAEEEGLE R A V A DY I AGMTD R YA LREY RRLF VPK P W L Y 336
Dgt
COG0232 dGTP triphosphohydrolase [Nucleotide transport and metabolism];
35-398
4.06e-142
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
Pssm-ID: 440002 [Multi-domain]
Cd Length: 345
Bit Score: 408.39
E-value: 4.06e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 35 SPT RS D FQRDRDRI V H TT AFRRL KH KTQVF IAQD GDHYRTRLTH TI EVAQIAR AL ARAL R L D EDL A E GV AL V HD F GH T PF 114
Cdd:COG0232 1 DDI RS P FQRDRDRI I H SA AFRRL QD KTQVF PLPE GDHYRTRLTH SL EVAQIAR SI ARAL G L N EDL V E AA AL A HD L GH P PF 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 115 GH T GEDAL H E VLLPY GGF DH NAQSLRI V T K LE R RYA e F D G I NLT WES L E G LV K HN GP L L TPEGVGTR G PVP -- QPIL D YC 192
Cdd:COG0232 81 GH A GEDAL N E LFRDL GGF EG NAQSLRI L T R LE K RYA - F G G L NLT YAT L D G IL K YP GP S L AAPKPKPK G FYQ se KDVF D WV 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 193 -- EL HD L E L ATYAS LEAQ VAAI ADDIAY NT HD ID D GL R S G Y L TFDM L E E IPFLA G LMA E V R AR yphlepsrft H E IMR R Q 270
Cdd:COG0232 160 re EL GL L A L GRPRT LEAQ IVEL ADDIAY SV HD LE D AI R A G L L SLED L P E LLEYL G PLD E R R RL ---------- G E LRS R L 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 271 I T R M V E DVI AVAQ E R L sllrpesaadirg A D QVIAT FS EKM A ETDRQI K AM LF K R I YR N P DIM R IRAGAA RI VTD LF A A Y 350
Cdd:COG0232 230 I G R L V T DVI EASR E N L ------------- F D GPLIA FS PEV A AALKEL K KF LF E R V YR H P EVL R LELKGR RI IRE LF D A F 296
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1892269101 351 MAN P K E MQSHYWVDHIAGLA D - APKA R H V G DY L AGMTD T YA ISAH RRLF 398
Cdd:COG0232 297 LED P L E LLPEEFRERYEAAD D e YGRL R V V A DY I AGMTD R YA LRLY RRLF 345
dGTP_triPase
TIGR01353 deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
37-398
6.25e-104
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273571 [Multi-domain]
Cd Length: 381
Bit Score: 312.38
E-value: 6.25e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 37 T R SD F Q RD R DRI V H TT AFRRL KH KTQVF IAQDG D HY RTRLTH TI EVAQ I ----------- ARALARA L RLD E D LAE GVA L 105
Cdd:TIGR01353 1 E R TP F E RD Y DRI I H SS AFRRL QD KTQVF PLAEN D FV RTRLTH SL EVAQ V grsianliglr YDLELEE L GPF E R LAE TAC L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 106 V HD F G HT PFGH T GE D AL HEVLLP YG - GF DH NAQ SL RI V T K LE R R YAEFD G I NLTW ES L E G LV K HNG P LLTPEGV G t RGPV 184
Cdd:TIGR01353 81 A HD I G NP PFGH A GE R AL NDWMRE YG p GF EG NAQ TF RI L T T LE K R RRAKG G L NLTW RT L A G IL K YPR P SSEDAFK G - GYLN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 185 PQPILDYC EL ------- HD L E L AT Y A S LE AQ VAAI ADDIAY NT HD ID D GLRS G Y LTFD M L EEIPFLAGLMA E VRARYPH L 257
Cdd:TIGR01353 160 KKKGIYDS EL avfdrva EL L G L TW Y R S PL AQ LMEA ADDIAY TV HD LE D AIKL G L LTFD D L QHLLLIQAGFE E LGSEMTD L 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 258 EP S R f TH E IM R RQITRMVE D V I AVAQERL s LLRPES A AD I RGADQVIAT FS EKM AE TDRQI K AM L F KR I YR N PD IM RI RA 337
Cdd:TIGR01353 240 SI S A - EN E QI R SLRGKLIT D L I ESVAKAE - FSSHLV A IL I GTFHHTLVE FS PRL AE LLEAL K KF L R KR V YR H PD VE RI EY 317
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1892269101 338 GAAR I V T D LF A A Y M ANPKEM qs HYWVDHIAG L AD A P ---- KAR H V G DY L AGMTD T YA ISAH RRLF 398
Cdd:TIGR01353 318 QGEQ I I T G LF D A F M PDLPPR -- LLPPELRSK L RK A E dnyy KAR V V C DY I AGMTD R YA LEEY RRLF 380
antiphage_dGTPase
NF041026 anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
37-398
2.59e-68
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.
Pssm-ID: 468955 [Multi-domain]
Cd Length: 426
Bit Score: 222.00
E-value: 2.59e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 37 T RS D FQRDR D RI V H TT AFRRL KH KTQV FIAQDG D H YRTRLTH TI EVAQI ----------- ARALA RAL RL D ED L A E GVA L 105
Cdd:NF041026 16 H RS P FQRDR A RI I H SA AFRRL QA KTQV LGLGES D F YRTRLTH SL EVAQI gtgivaqlkak QPEPL RAL LP D DS L I E AIC L 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 106 V HD F GH T PFGH T GE D AL HEVLLPY GGF DH N A Q S LRI V TKLE r R Y A E FD G I NLT WES L E G LV K H ------- NG P L L T P EGV 178
Cdd:NF041026 96 A HD I GH P PFGH G GE V AL NYMMRDH GGF EG N G Q T LRI L TKLE - P Y T E HH G M NLT RRT L L G VL K Y palysqv QA P Q L P P KVS 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 179 GT R GPVP ------------- Q PIL D ------------- YCE L HDLELAT ----- YA SL EAQVAAI ADDIAY NT HD ID D GL 227
Cdd:NF041026 175 NF R QLKA sdwkppkgyydcd Q DVV D wvlaplsendral FTS L DEKPGKQ hgktr FK SL DCSIMEL ADDIAY GV HD LE D AI 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 228 RS G YL T FDMLE E I --- PFL A GLMAEVRARYPH L EPSR F TH E IMR R -- Q I TRM V EDV I A ---- VAQERLS -- LLR PE saad 296
Cdd:NF041026 255 VL G LV T REQWQ E A vap KLA A LGDPWLSDNLDE L SDKL F SG E HYE R kd A I GAL V NYF I T siei KEVDAFE ep LLR YN ---- 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 297 irgadqvi A TFSEKM A ETDRQI K AMLFKRIY R N P DIMRIRAGAAR IV TD LF A A YMAN P K ----- EMQSHY wvd HI A GLAD 371
Cdd:NF041026 331 -------- A VLPPEV A ALLEVL K QFVYQYVI R S P EVQQLEYKGQQ IV ME LF E A LASD P E rllpe NTRERW --- QE A EEDG 399
410 420
....*....|....*....|....*..
gi 1892269101 372 APKA R HVG DY L AGMTD T YA ISAHR RLF 398
Cdd:NF041026 400 ENGK R VIC DY I AGMTD E YA LRLYQ RLF 426
HD_assoc
pfam13286 Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
305-396
8.81e-29
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.
Pssm-ID: 433087 [Multi-domain]
Cd Length: 91
Bit Score: 107.61
E-value: 8.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 305 AT FS EK MA ETDRQI K AM LF KRI YR N P DIM R IRAG A A RI VTD LF A A Y MA N P KEMQSHYWVDHI A G l A D APK AR H V G DY L AG 384
Cdd:pfam13286 1 VA FS PE MA AELAEL K RF LF EYV YR H P RVQ R EEEK A R RI IRE LF E A L MA D P ELLPPEFRARWE A A - G D DAR AR V V C DY I AG 79
90
....*....|..
gi 1892269101 385 MTD T YA ISA HRR 396
Cdd:pfam13286 80 MTD R YA LRL HRR 91
Name
Accession
Description
Interval
E-value
PRK01286
PRK01286 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
14-405
4.56e-176
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234934 [Multi-domain]
Cd Length: 336
Bit Score: 493.92
E-value: 4.56e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 14 ER A V YAA DPWT SRGRL YQ E DGS P T R SD FQRDRDRI V H TT AFRRLKHKTQVFI AQD GDHYRTRLTHT I EVAQIAR AL ARAL 93
Cdd:PRK01286 2 TL A P YAA LSAN SRGRL RP E EPC P I R TE FQRDRDRI I H SK AFRRLKHKTQVFI NPE GDHYRTRLTHT L EVAQIAR TI ARAL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 94 RL D EDL A E GV AL V HD F GHTPFGH T GEDAL H E VLLP YGGF D HN A QSLR I V T KLE R RY aef DG I NLTWE SL EG LV KH N GP LL 173
Cdd:PRK01286 82 RL N EDL T E AI AL G HD L GHTPFGH A GEDAL N E LMKE YGGF E HN E QSLR V V D KLE K RY --- DG L NLTWE VR EG IL KH S GP RN 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 174 T P E G vgtrgpvpqpildycelhdlela T Y A S LE A Q VAAI AD D IAYN T HDIDDG L R S G YL T FDM L E E ipflaglmaevrar 253
Cdd:PRK01286 159 A P L G ----------------------- T A A T LE G Q IVRL AD E IAYN N HDIDDG I R A G LI T LED L P E -------------- 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 254 yphl EPS R FTH E IM RR Q I TRM V E D V I AVA Q ER L SLLR pesaadirg A DQVIAT FSE KM AE TDRQIKAM LF KRI YR N P DIM 333
Cdd:PRK01286 202 ---- DVR R LLG E TH RR R I NTL V V D L I KNT Q RN L AEGA --------- A APPLVS FSE EV AE AMKELRRF LF ENV YR H P KVK 268
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1892269101 334 R I R AG A A RIV T DLF AA YM AN P KEMQSH Y W vdhi AGLADAPKA R H V G DY L AGMTD T YA ISAH RRLF DHT P D L R 405
Cdd:PRK01286 269 R E R EK A K RIV Q DLF EY YM ED P ELLPPE Y Q ---- NIAEEEGLE R A V A DY I AGMTD R YA LREY RRLF VPK P W L Y 336
Dgt
COG0232 dGTP triphosphohydrolase [Nucleotide transport and metabolism];
35-398
4.06e-142
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
Pssm-ID: 440002 [Multi-domain]
Cd Length: 345
Bit Score: 408.39
E-value: 4.06e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 35 SPT RS D FQRDRDRI V H TT AFRRL KH KTQVF IAQD GDHYRTRLTH TI EVAQIAR AL ARAL R L D EDL A E GV AL V HD F GH T PF 114
Cdd:COG0232 1 DDI RS P FQRDRDRI I H SA AFRRL QD KTQVF PLPE GDHYRTRLTH SL EVAQIAR SI ARAL G L N EDL V E AA AL A HD L GH P PF 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 115 GH T GEDAL H E VLLPY GGF DH NAQSLRI V T K LE R RYA e F D G I NLT WES L E G LV K HN GP L L TPEGVGTR G PVP -- QPIL D YC 192
Cdd:COG0232 81 GH A GEDAL N E LFRDL GGF EG NAQSLRI L T R LE K RYA - F G G L NLT YAT L D G IL K YP GP S L AAPKPKPK G FYQ se KDVF D WV 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 193 -- EL HD L E L ATYAS LEAQ VAAI ADDIAY NT HD ID D GL R S G Y L TFDM L E E IPFLA G LMA E V R AR yphlepsrft H E IMR R Q 270
Cdd:COG0232 160 re EL GL L A L GRPRT LEAQ IVEL ADDIAY SV HD LE D AI R A G L L SLED L P E LLEYL G PLD E R R RL ---------- G E LRS R L 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 271 I T R M V E DVI AVAQ E R L sllrpesaadirg A D QVIAT FS EKM A ETDRQI K AM LF K R I YR N P DIM R IRAGAA RI VTD LF A A Y 350
Cdd:COG0232 230 I G R L V T DVI EASR E N L ------------- F D GPLIA FS PEV A AALKEL K KF LF E R V YR H P EVL R LELKGR RI IRE LF D A F 296
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1892269101 351 MAN P K E MQSHYWVDHIAGLA D - APKA R H V G DY L AGMTD T YA ISAH RRLF 398
Cdd:COG0232 297 LED P L E LLPEEFRERYEAAD D e YGRL R V V A DY I AGMTD R YA LRLY RRLF 345
dGTP_triPase
TIGR01353 deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
37-398
6.25e-104
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273571 [Multi-domain]
Cd Length: 381
Bit Score: 312.38
E-value: 6.25e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 37 T R SD F Q RD R DRI V H TT AFRRL KH KTQVF IAQDG D HY RTRLTH TI EVAQ I ----------- ARALARA L RLD E D LAE GVA L 105
Cdd:TIGR01353 1 E R TP F E RD Y DRI I H SS AFRRL QD KTQVF PLAEN D FV RTRLTH SL EVAQ V grsianliglr YDLELEE L GPF E R LAE TAC L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 106 V HD F G HT PFGH T GE D AL HEVLLP YG - GF DH NAQ SL RI V T K LE R R YAEFD G I NLTW ES L E G LV K HNG P LLTPEGV G t RGPV 184
Cdd:TIGR01353 81 A HD I G NP PFGH A GE R AL NDWMRE YG p GF EG NAQ TF RI L T T LE K R RRAKG G L NLTW RT L A G IL K YPR P SSEDAFK G - GYLN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 185 PQPILDYC EL ------- HD L E L AT Y A S LE AQ VAAI ADDIAY NT HD ID D GLRS G Y LTFD M L EEIPFLAGLMA E VRARYPH L 257
Cdd:TIGR01353 160 KKKGIYDS EL avfdrva EL L G L TW Y R S PL AQ LMEA ADDIAY TV HD LE D AIKL G L LTFD D L QHLLLIQAGFE E LGSEMTD L 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 258 EP S R f TH E IM R RQITRMVE D V I AVAQERL s LLRPES A AD I RGADQVIAT FS EKM AE TDRQI K AM L F KR I YR N PD IM RI RA 337
Cdd:TIGR01353 240 SI S A - EN E QI R SLRGKLIT D L I ESVAKAE - FSSHLV A IL I GTFHHTLVE FS PRL AE LLEAL K KF L R KR V YR H PD VE RI EY 317
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1892269101 338 GAAR I V T D LF A A Y M ANPKEM qs HYWVDHIAG L AD A P ---- KAR H V G DY L AGMTD T YA ISAH RRLF 398
Cdd:TIGR01353 318 QGEQ I I T G LF D A F M PDLPPR -- LLPPELRSK L RK A E dnyy KAR V V C DY I AGMTD R YA LEEY RRLF 380
antiphage_dGTPase
NF041026 anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
37-398
2.59e-68
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.
Pssm-ID: 468955 [Multi-domain]
Cd Length: 426
Bit Score: 222.00
E-value: 2.59e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 37 T RS D FQRDR D RI V H TT AFRRL KH KTQV FIAQDG D H YRTRLTH TI EVAQI ----------- ARALA RAL RL D ED L A E GVA L 105
Cdd:NF041026 16 H RS P FQRDR A RI I H SA AFRRL QA KTQV LGLGES D F YRTRLTH SL EVAQI gtgivaqlkak QPEPL RAL LP D DS L I E AIC L 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 106 V HD F GH T PFGH T GE D AL HEVLLPY GGF DH N A Q S LRI V TKLE r R Y A E FD G I NLT WES L E G LV K H ------- NG P L L T P EGV 178
Cdd:NF041026 96 A HD I GH P PFGH G GE V AL NYMMRDH GGF EG N G Q T LRI L TKLE - P Y T E HH G M NLT RRT L L G VL K Y palysqv QA P Q L P P KVS 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 179 GT R GPVP ------------- Q PIL D ------------- YCE L HDLELAT ----- YA SL EAQVAAI ADDIAY NT HD ID D GL 227
Cdd:NF041026 175 NF R QLKA sdwkppkgyydcd Q DVV D wvlaplsendral FTS L DEKPGKQ hgktr FK SL DCSIMEL ADDIAY GV HD LE D AI 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 228 RS G YL T FDMLE E I --- PFL A GLMAEVRARYPH L EPSR F TH E IMR R -- Q I TRM V EDV I A ---- VAQERLS -- LLR PE saad 296
Cdd:NF041026 255 VL G LV T REQWQ E A vap KLA A LGDPWLSDNLDE L SDKL F SG E HYE R kd A I GAL V NYF I T siei KEVDAFE ep LLR YN ---- 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 297 irgadqvi A TFSEKM A ETDRQI K AMLFKRIY R N P DIMRIRAGAAR IV TD LF A A YMAN P K ----- EMQSHY wvd HI A GLAD 371
Cdd:NF041026 331 -------- A VLPPEV A ALLEVL K QFVYQYVI R S P EVQQLEYKGQQ IV ME LF E A LASD P E rllpe NTRERW --- QE A EEDG 399
410 420
....*....|....*....|....*..
gi 1892269101 372 APKA R HVG DY L AGMTD T YA ISAHR RLF 398
Cdd:NF041026 400 ENGK R VIC DY I AGMTD E YA LRLYQ RLF 426
PRK05318
PRK05318 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
21-398
2.23e-56
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 235403 [Multi-domain]
Cd Length: 432
Bit Score: 191.24
E-value: 2.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 21 DP W TS R g RL YQEDGSP -- T RS DF QRDR D RI V H TT AFRRL KH KTQV FIAQDG D H YRTRLTH TI EVAQI ----------- AR 87
Cdd:PRK05318 4 SV W QE R - RL GEDKQRR nd H RS PY QRDR A RI L H SA AFRRL QA KTQV LGVGEN D F YRTRLTH SL EVAQI gtgivaqlkke KQ 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 88 ALARA L RLDED L A E GVA L V HD F GH T PFGH T GE D AL HEVLLPY GGF DH N A Q SL RI V TKLE r R Y A E FD G I NLT WES L E G LV K 167
Cdd:PRK05318 83 PELKP L LPSDS L I E SLC L A HD I GH P PFGH G GE V AL NYMMRDH GGF EG N G Q TF RI L TKLE - P Y T E HF G M NLT RRT L L G IL K 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 168 H ng P L L TP E G V GTRG P VP ---------------------- Q P I L D Y ----- C E l H D LE L ---------------- AT Y A S 204
Cdd:PRK05318 162 Y -- P A L YS E L V AQYP P PD vanhrqlkasdwkppkgifddd Q D I F D W vlepl S E - N D RA L fqslrpepdspkehlk TR Y K S 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 205 L EAQVAAI ADDIAY NT HD ID D GLRS G YL T FDMLE E -- I P F LA GLMAE - VRARYPHLEPSR F TH E IMR R Q -- I TRM V - EDV 278
Cdd:PRK05318 239 L DCSIMEL ADDIAY GV HD LE D AIVL G LV T RSQWQ E dv A P Q LA QCGDP w LEEEIETIGEKL F SG E HHL R K da I GTL V n YFI 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 279 IAVAQERLS ----- LLR PE saadirgadqvi A TFSEKM A ETDRQI K AMLF K RIY R N P DIM R IRAGAAR IV TD LF A A YMAN 353
Cdd:PRK05318 319 TSIRIKENE efeep LLR YN ------------ A ALEPEF A AALEVL K QFVY K YVI R K P EVQ R LEYKGQQ IV ME LF E A LSSD 386
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1892269101 354 P KEM -- QSHY -- W VDHIAGLA dap KA R HVG DY LA GMTD T YA ISAHRR LF 398
Cdd:PRK05318 387 P ERL lp RNTQ er W RKAEDEEN --- SM R VIC DY IS GMTD E YA YRLYQQ LF 432
PRK03007
PRK03007 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
15-400
2.85e-52
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 235098 [Multi-domain]
Cd Length: 428
Bit Score: 180.14
E-value: 2.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 15 R AVYAAD P WT S R G RLYQEDG spt R S DF Q RDR D R IV H TT A F RRL KH KTQV FIAQD GD HY RTRLTH TI EVAQI A R AL A RA L R 94
Cdd:PRK03007 14 R ERRVPE P PK S A G LPTEGQH --- R T DF A RDR A R VL H SA A L RRL AD KTQV VGPRE GD TP RTRLTH SL EVAQI G R GI A AG L G 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 95 L D E DL AEGVA L V HD F GH T P F GH T GE D AL H EV LLPY GGF DH NAQ S LRI V T K LE - RRYAEFD --- G I NLT WE SL EGLV K H ng 170
Cdd:PRK03007 91 C D P DL VDLAG L A HD I GH P P Y GH N GE R AL D EV AADC GGF EG NAQ T LRI L T R LE p KVLDPDG rsa G L NLT RA SL DAAC K Y -- 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 171 P LLTP E GV G TRG ------ PVPQPILDY ce LHDLEL A TYAS LEAQV AAI ADD I AY NT HD ID DG LR SG YLTFDM L EEIPF LA 244
Cdd:PRK03007 169 P WTRG E AD G SPR rkfgfy DDDREVFAW -- VRQGAP A GRPC LEAQV MDW ADD V AY SV HD VE DG VV SG RIDLRV L ADPVE LA 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 245 G L MAEVR A RYPHLEPSRFTHEIM R rqi TRMVED V I AV AQERL SL lr PE SAA DIRGADQVIAT F SEKMAETD R Q ------- 317
Cdd:PRK03007 247 A L AELGA A WFSGVDADELLAAAD R --- LSELPV V A AV GKFDG SL -- RS SAA LKNLTSELVGR F ASAAITAT R A aagpgpl 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 318 ------------------- I K AMLFKRIYRN P DIMRIR A GAARIVTDLFA A YM A N - P KEMQSHYWVDHIAGLA DA PKA R H 377
Cdd:PRK03007 322 trydadlvvpelvraeval L K TLALQFVMSD P RHLARQ A RQRERIHRVAD A LW A G a P GALDPQFRAAFNEAAD DA ARL R V 401
410 420
....*....|....*....|...
gi 1892269101 378 V G D YL A GM T DTYAISA H R RL FDH 400
Cdd:PRK03007 402 V V D QI A SL T ESRLERL H A RL CGR 424
PRK01096
PRK01096 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
25-398
3.38e-38
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234897 [Multi-domain]
Cd Length: 440
Bit Score: 142.75
E-value: 3.38e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 25 SR G RL YQEDGSPT ---- RS D F QR D R DRI VHTTA FRRL KH KTQV FIAQDG DH YR TRLTH TI EV A ------------ QIARA 88
Cdd:PRK01096 8 SR E RL GKKGKTSK delg RS P F HK D Y DRI IFSGS FRRL QR KTQV HPLAKN DH IH TRLTH SL EV S cvgrslgmrvge TLKEE 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 89 LARALRLDE D LAEG V --- A L V HD F G HT PFGH T GEDA LH E VLLPYG G ----------------- F DH NAQ SL R IV TKLE rr 148
Cdd:PRK01096 88 KLPDWISPA D IGAI V qsa C L A HD I G NP PFGH F GEDA IR E WFQDAA G rgflddlspqeradfln F EG NAQ GF R VL TKLE -- 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 149 Y AEF D - G IN LT WES L EGLV K HNGPLLTPEGVGTRG ---------- P VPQP I LDYCE L HD L ELATYAS ------ LEA qvaa 211
Cdd:PRK01096 166 Y HQD D g G MR LT YAT L GTYI K YPWSSRHANKQQIKK kkfgcyqsel P LFEQ I AEALG L PQ L GEQRWCR hpltyl LEA ---- 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 212 i ADDI A Y NTH D ID DGL RS G Y L TFDML E EI pf LAG L MAE v RAR Y PH L E P -------- S R FTHEIMR R QITRMV E dvi A VAQ 283
Cdd:PRK01096 242 - ADDI C Y ALI D LE DGL EM G L L NYQEV E AL -- FLE L IGD - KEK Y RQ L G P qdsrrqkl A R LRGKAIG R LVNAVA E --- A FVE 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 284 ERLSL L RPESAA D I rgadqv I ATFSEKMAETDR Q I K AMLFKR I YRNPDIMRIRA GA AR I VTD L F ----- AA YMANPKEMQ 358
Cdd:PRK01096 315 NYDAI L AGTLPG D L ------ I EHCDPDAKRCVQ Q A K DLAREK I FQHKRKVELEI GA YT I LEI L L dafvp AA LYYDSGTTP 388
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1892269101 359 S -- HYWVDHIA G L a D AP KA -------- RH V G D YLA GMTD T YA ISAHRR L F 398
Cdd:PRK01096 389 S fk DKRLLDLL G D - N AP DP tmklylrl LR V L D FIS GMTD S YA KELAQE L T 437
HD_assoc
pfam13286 Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
305-396
8.81e-29
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.
Pssm-ID: 433087 [Multi-domain]
Cd Length: 91
Bit Score: 107.61
E-value: 8.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 305 AT FS EK MA ETDRQI K AM LF KRI YR N P DIM R IRAG A A RI VTD LF A A Y MA N P KEMQSHYWVDHI A G l A D APK AR H V G DY L AG 384
Cdd:pfam13286 1 VA FS PE MA AELAEL K RF LF EYV YR H P RVQ R EEEK A R RI IRE LF E A L MA D P ELLPPEFRARWE A A - G D DAR AR V V C DY I AG 79
90
....*....|..
gi 1892269101 385 MTD T YA ISA HRR 396
Cdd:pfam13286 80 MTD R YA LRL HRR 91
dgt
PRK04926 deoxyguanosinetriphosphate triphosphohydrolase; Provisional
41-237
6.18e-17
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
Pssm-ID: 235320 [Multi-domain]
Cd Length: 503
Bit Score: 82.28
E-value: 6.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 41 F QR DR D RI VHTT A F RRL KH KTQVF IAQDGDHY R T RLTH TI EV A Q I ------------- ARA L AR A LR LD ------ E DLA E 101
Cdd:PRK04926 32 F ES DR G RI INSA A I RRL QQ KTQVF PLERNAAV R S RLTH SL EV Q Q V gryiakeilsrlk EQK L LE A YG LD eltgpf E SIV E 111
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 102 GVA L V HD F G HT PFGH T GE D A ---- LHEV L L P YGG ------------------------------------ F DH NAQ SL R I 141
Cdd:PRK04926 112 MAC L M HD I G NP PFGH F GE A A indw FRQR L D P DAE sqpltddrcsvaalrlrdgeeplnelrrkirqdlch F EG NAQ GI R L 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 142 V TK L E R ryaefdg I NLT WESLEGLV K HNG P lltpeg VGT RGP V P QP i LD Y --------------- CE L HD - L E LA T Y AS - 204
Cdd:PRK04926 192 V HT L L R ------- L NLT YAQVACIL K YTR P ------ AWW RGP T P AS - HH Y lmkkpgyylseeayv AR L RK e L N LA P Y SR f 257
250 260 270
....*....|....*....|....*....|....*...
gi 1892269101 205 ----- L EA qvaai ADDI A Y NTH D ID D GLRSGYLTFDM L 237
Cdd:PRK04926 258 pltyi M EA ----- ADDI S Y CIA D LE D AVEKRIFSVEQ L 290
HD
pfam01966 HD domain; HD domains are metal dependent phosphohydrolases.
75-157
7.42e-03
HD domain; HD domains are metal dependent phosphohydrolases.
Pssm-ID: 460398 [Multi-domain]
Cd Length: 110
Bit Score: 36.06
E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892269101 75 RL T H TIE VA QI AR A - LARALR LD ED L AEGV AL V HD F G HT PFG HTGEDALHEV llpyggf D H NAQSLR I VTK LE R R YAEF D 153
Cdd:pfam01966 1 RL E H SLR VA LL AR E l AEELGE LD RE L LLLA AL L HD I G KG PFG DEKPEFEIFL ------- G H AVVGAE I LRE LE K R LGLE D 73
....
gi 1892269101 154 GIN L 157
Cdd:pfam01966 74 VLK L 77
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
