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Conserved domains on  [gi|1892881861|ref|WP_184998566|]
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MarR family winged helix-turn-helix transcriptional regulator [Vibrio crassostreae]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-142 3.23e-32

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 111.22  E-value: 3.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861   1 MSDQDEylKLDNQVCFALYSASNAMSRAYQPLLKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEA 80
Cdd:COG1846     1 MSDEPD--PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1892881861  81 KGYVLRKRSTEDERVRVITLTPVGTELKERAQTVPEEIFC--LSKMNENELKSLKAQCEQLLDN 142
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAelLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-142 3.23e-32

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 111.22  E-value: 3.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861   1 MSDQDEylKLDNQVCFALYSASNAMSRAYQPLLKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEA 80
Cdd:COG1846     1 MSDEPD--PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1892881861  81 KGYVLRKRSTEDERVRVITLTPVGTELKERAQTVPEEIFC--LSKMNENELKSLKAQCEQLLDN 142
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAelLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
33-129 1.04e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.03  E-value: 1.04e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861   33 LKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTPVGTELKERAQ 112
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*....
gi 1892881861  113 TVPEEIF--CLSKMNENEL 129
Cdd:smart00347  83 EARSETLaeLLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-95 3.56e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 60.25  E-value: 3.56e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1892881861  38 LTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERV 95
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
PRK12680 PRK12680
LysR family transcriptional regulator;
36-118 4.23e-04

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 38.84  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861  36 LDLTYLQYIVMMVlweQHEINVKALGAKTHLDSGTLTPLLKRLEAK-GYVL---RKRSTEdervrviTLTPVGTELKERA 111
Cdd:PRK12680    1 MTLTQLRYLVAIA---DAELNITLAAARVHATQPGLSKQLKQLEDElGFLLfvrKGRSLE-------SVTPAGVEVIERA 70


                  ....*..
gi 1892881861 112 QTVPEEI 118
Cdd:PRK12680   71 RAVLSEA 77
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 34-102 3.56e-03

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 34.92  E-value: 3.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1892881861  34 KALDLTYLQYIVMMVLW----EQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTP 102
Cdd:TIGR01889  19 KEFNLSLEELLILYYLGklenNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDDERKVIISINK 91
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-142 3.23e-32

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 111.22  E-value: 3.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861   1 MSDQDEylKLDNQVCFALYSASNAMSRAYQPLLKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEA 80
Cdd:COG1846     1 MSDEPD--PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1892881861  81 KGYVLRKRSTEDERVRVITLTPVGTELKERAQTVPEEIFC--LSKMNENELKSLKAQCEQLLDN 142
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAelLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
33-129 1.04e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.03  E-value: 1.04e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861   33 LKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTPVGTELKERAQ 112
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*....
gi 1892881861  113 TVPEEIF--CLSKMNENEL 129
Cdd:smart00347  83 EARSETLaeLLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-95 3.56e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 60.25  E-value: 3.56e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1892881861  38 LTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERV 95
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-94 1.19e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1892881861  36 LDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDER 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 38-138 7.79e-05

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 39.51  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861  38 LTYLQYIVMMVLWEQHEINVK----ALGAKTHLDSGTLTPLLKRLEAKGYVLRKRsteDERVRVITLTPVGTELKER-AQ 112
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKevveELPEPKDWAYSTVKTLLTRLVKKGLLSREK---DGRAFIYSPLVSREEYKAGqVK 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1892881861 113 TVPEEIFCLS------------KMNENELKSLKAQCEQ 138
Cdd:pfam03965  78 QLLDRFFGGSvpalvanfvereKLSPDDIEELRQLLDQ 115
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
34-89 9.29e-05

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 39.38  E-value: 9.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861  34 KALDLTYLQYIVMMVLWEQHEINVK----ALGAKTHLDSGTLTPLLKRLEAKGYVLRKRS 89
Cdd:COG3682     1 KMKKLTEAELEVMQVLWELGPATVRevleALPEERGWAYTTVLTLLRRLEEKGFLSREKE 60
PRK12680 PRK12680
LysR family transcriptional regulator;
36-118 4.23e-04

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 38.84  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861  36 LDLTYLQYIVMMVlweQHEINVKALGAKTHLDSGTLTPLLKRLEAK-GYVL---RKRSTEdervrviTLTPVGTELKERA 111
Cdd:PRK12680    1 MTLTQLRYLVAIA---DAELNITLAAARVHATQPGLSKQLKQLEDElGFLLfvrKGRSLE-------SVTPAGVEVIERA 70


                  ....*..
gi 1892881861 112 QTVPEEI 118
Cdd:PRK12680   71 RAVLSEA 77
HTH_27 pfam13463
Winged helix DNA-binding domain;
38-104 8.78e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 35.73  E-value: 8.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1892881861  38 LTYLQYIVMMVLWEQHEINVKA-LGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTPVG 104
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLAdICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
33-115 1.14e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 36.80  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1892881861  33 LKALDLTYLQYIVMMVLWEQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTPVGTELKERAQ 112
Cdd:PRK11512   33 LSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCH 112


                  ...
gi 1892881861 113 TVP 115
Cdd:PRK11512  113 QLV 115
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 34-102 3.56e-03

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 34.92  E-value: 3.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1892881861  34 KALDLTYLQYIVMMVLW----EQHEINVKALGAKTHLDSGTLTPLLKRLEAKGYVLRKRSTEDERVRVITLTP 102
Cdd:TIGR01889  19 KEFNLSLEELLILYYLGklenNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDDERKVIISINK 91
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
58-119 4.88e-03

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 34.53  E-value: 4.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1892881861  58 KALGAKTHLDSGTLTPLLKRLEAKGYV--LRKRSTEDERVRVITLTPVGTELKERAQTVPEEIF 119
Cdd:COG1695    34 ERSGGFWKVSEGTLYPALKRLEKEGLVesEWEESEGGPRRKYYRLTEAGREELAEWLEEWEKLA 97
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 69-104 7.43e-03

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 33.37  E-value: 7.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1892881861  69 GTLTPLLKRLEAKGYV--LRKRSTEDERVRVITLTPVG 104
Cdd:pfam03551  32 GTLYPILKRLEKEGLVesEWVDSGGGPPRKYYRLTDAG 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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