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Conserved domains on  [gi|1895999061|ref|WP_186405328|]
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heme o synthase [Candidatus Accumulibacter aalborgensis]

Protein Classification

protoheme IX farnesyltransferase( domain architecture ID 10792362)

protoheme IX farnesyltransferase acts in step 1 of the conversion protoheme IX to heme O in heme O biosynthesis

EC:  2.5.1.141
Gene Ontology:  GO:0016765|GO:0008495|GO:0006783|GO:0016740|GO:0048034
PubMed:  7885224|34428995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 8-298 4.80e-123

protoheme IX farnesyltransferase; Provisional


:

Pssm-ID: 235293  Cd Length: 296  Bit Score: 353.68  E-value: 4.80e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061   8 SRRSAGQRLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRAR 87
Cdd:PRK04375    2 SSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  88 PTARGEVSTAETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAI 167
Cdd:PRK04375   82 PLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 168 TGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYL 247
Cdd:PRK04375  162 TGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLYL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1895999061 248 TAALILDTIFLVYSVVLWRDYSDKLARITFRYSIIYLTLLFAALLADHFLR 298
Cdd:PRK04375  242 VVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLL 292
 
Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 8-298 4.80e-123

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 353.68  E-value: 4.80e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061   8 SRRSAGQRLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRAR 87
Cdd:PRK04375    2 SSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  88 PTARGEVSTAETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAI 167
Cdd:PRK04375   82 PLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 168 TGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYL 247
Cdd:PRK04375  162 TGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLYL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1895999061 248 TAALILDTIFLVYSVVLWRDYSDKLARITFRYSIIYLTLLFAALLADHFLR 298
Cdd:PRK04375  242 VVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLL 292
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 1-298 5.00e-116

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 335.95  E-value: 5.00e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061   1 MAVISTNSRRSAGQRLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDAR 80
Cdd:COG0109     1 MSSASASSAASLRSTLRDYLALTKPRIILLLLFTALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  81 MARTRARPTARGEVSTAETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPP 160
Cdd:COG0109    81 MKRTKNRPLPTGRISPREALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 161 LLGWSAITGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLG 240
Cdd:COG0109   161 LIGWAAVTGSLSLEALLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYLLG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1895999061 241 MSGPWYLTAALILDTIFLVYSVVLWRDYSDKLARITFRYSIIYLTLLFAALLADHFLR 298
Cdd:COG0109   241 MAGLIYLVVALVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLL 298
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 20-283 8.30e-97

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 286.26  E-value: 8.30e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  20 FELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAET 99
Cdd:cd13957     1 LELTKPRITLLVLLTALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 100 LTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLF 179
Cdd:cd13957    81 LIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 180 LIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLV 259
Cdd:cd13957   161 LILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYFLY 240

                         250       260
                  ....*....|....*....|....
gi 1895999061 260 YSVVLWRDYSDKLARITFRYSIIY 283
Cdd:cd13957   241 LAIKLYRSPDDKWARKLFFASLIY 264
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 18-283 1.87e-78

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 239.84  E-value: 1.87e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  18 AFFELCKPRVNSLIVFTAMIGMFLAA-PQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVST 96
Cdd:TIGR01473   2 DYLQLTKPRIISLLLITAFAGMWLAPgGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  97 AETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEAL 176
Cdd:TIGR01473  82 REALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTIWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGAW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 177 VLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTI 256
Cdd:TIGR01473 162 LLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVSLLLAFLGGTGWLYLIVATLLGAL 241

                         250       260
                  ....*....|....*....|....*...
gi 1895999061 257 FLVYSVVLWRDYSD-KLARITFRYSIIY 283
Cdd:TIGR01473 242 FLYLAFKFYRDPTDrKKARKLFKFSLIY 269
UbiA pfam01040
UbiA prenyltransferase family;
31-279 5.82e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 152.77  E-value: 5.82e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  31 IVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAETLTLATLVGGFG 110
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 111 LWVLhAFVNPLTMWLTLATFLGYaVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFIWTPPHF 190
Cdd:pfam01040  81 LLLL-LLLNPLTALLGLAALLLY-VLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 191 WALACYRCADYAKSGLPMLPVTHGIPFTcLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLVYSVVLWRDYSD 270
Cdd:pfam01040 159 LANDLRDREDDRKAGIKTLPVVLGRKAA-RILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*....
gi 1895999061 271 KLARITFRY 279
Cdd:pfam01040 238 KKDAKAFFF 246
 
Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 8-298 4.80e-123

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 353.68  E-value: 4.80e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061   8 SRRSAGQRLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRAR 87
Cdd:PRK04375    2 SSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  88 PTARGEVSTAETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAI 167
Cdd:PRK04375   82 PLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 168 TGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYL 247
Cdd:PRK04375  162 TGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLYL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1895999061 248 TAALILDTIFLVYSVVLWRDYSDKLARITFRYSIIYLTLLFAALLADHFLR 298
Cdd:PRK04375  242 VVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLL 292
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 1-298 5.00e-116

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 335.95  E-value: 5.00e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061   1 MAVISTNSRRSAGQRLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDAR 80
Cdd:COG0109     1 MSSASASSAASLRSTLRDYLALTKPRIILLLLFTALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  81 MARTRARPTARGEVSTAETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPP 160
Cdd:COG0109    81 MKRTKNRPLPTGRISPREALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 161 LLGWSAITGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLG 240
Cdd:COG0109   161 LIGWAAVTGSLSLEALLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYLLG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1895999061 241 MSGPWYLTAALILDTIFLVYSVVLWRDYSDKLARITFRYSIIYLTLLFAALLADHFLR 298
Cdd:COG0109   241 MAGLIYLVVALVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLL 298
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 20-283 8.30e-97

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 286.26  E-value: 8.30e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  20 FELCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAET 99
Cdd:cd13957     1 LELTKPRITLLVLLTALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 100 LTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLF 179
Cdd:cd13957    81 LIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 180 LIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLV 259
Cdd:cd13957   161 LILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYFLY 240

                         250       260
                  ....*....|....*....|....
gi 1895999061 260 YSVVLWRDYSDKLARITFRYSIIY 283
Cdd:cd13957   241 LAIKLYRSPDDKWARKLFFASLIY 264
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 18-283 1.87e-78

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 239.84  E-value: 1.87e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  18 AFFELCKPRVNSLIVFTAMIGMFLAA-PQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVST 96
Cdd:TIGR01473   2 DYLQLTKPRIISLLLITAFAGMWLAPgGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  97 AETLTLATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEAL 176
Cdd:TIGR01473  82 REALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTIWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGAW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 177 VLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTI 256
Cdd:TIGR01473 162 LLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVSLLLAFLGGTGWLYLIVATLLGAL 241

                         250       260
                  ....*....|....*....|....*...
gi 1895999061 257 FLVYSVVLWRDYSD-KLARITFRYSIIY 283
Cdd:TIGR01473 242 FLYLAFKFYRDPTDrKKARKLFKFSLIY 269
UbiA pfam01040
UbiA prenyltransferase family;
31-279 5.82e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 152.77  E-value: 5.82e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  31 IVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAETLTLATLVGGFG 110
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 111 LWVLhAFVNPLTMWLTLATFLGYaVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFIWTPPHF 190
Cdd:pfam01040  81 LLLL-LLLNPLTALLGLAALLLY-VLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 191 WALACYRCADYAKSGLPMLPVTHGIPFTcLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLVYSVVLWRDYSD 270
Cdd:pfam01040 159 LANDLRDREDDRKAGIKTLPVVLGRKAA-RILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*....
gi 1895999061 271 KLARITFRY 279
Cdd:pfam01040 238 KKDAKAFFF 246
PLN02776 PLN02776
prenyltransferase
 22-283 1.77e-37

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 135.64  E-value: 1.77e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  22 LCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAETLT 101
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSGEAIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 102 LATLVGGFGLWVLHAFVNPLTMWLTLATFLGYAVIYTvVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLI 181
Cdd:PLN02776   81 WAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYT-PLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 182 IFIWTPPHFWALAcYRC-ADYAKSGLPMLPVTHGI-PFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLV 259
Cdd:PLN02776  160 LYFWQMPHFMALA-YMCrDDYAAGGYRMLSLADATgRRTALVALRNCLYLAPLGFLAYDWGVTSSPFALEAALLTAYLAA 238

                         250       260
                  ....*....|....*....|....
gi 1895999061 260 YSVVLWRDYSDKLARITFRYSIIY 283
Cdd:PLN02776  239 SAASFYREPTNANARKMFHGSLLY 262
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 22-267 1.71e-15

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 74.88  E-value: 1.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  22 LCKPRVNSLIVFTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAETLT 101
Cdd:COG0382     9 LDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 102 LATLVGGFGLWVLhAFVNPLTMWLTLATFLGyAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLI 181
Cdd:COG0382    89 LAIVLLLLALALA-LLLNPLTFLLALAALAL-AWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWLLALA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 182 IFIWTpphfWAL----ACYRCADYAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIF 257
Cdd:COG0382   167 AFLWT----LAYdtiyDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLL 242

                         250
                  ....*....|
gi 1895999061 258 LVYSVVLWRD 267
Cdd:COG0382   243 YLSQLWLLRP 252
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 30-273 1.30e-14

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 72.11  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  30 LIVFTAMIGMFLAAPQFPP-----FALFVAASIGIALVAGAAaaiNCLIEQQIDARMARTRARPTARGEVSTAETLTLAT 104
Cdd:cd13959    11 LLLPPALWGLLLAAGGLPLpllklLLLFLLGAFLMRSAGCTI---NDIADRDIDAKVPRTKNRPLASGAISVKEALLFLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 105 LVGGFGLWVLhAFVNPLTMWLTLATFLGyAVIYTvVLKPATPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFI 184
Cdd:cd13959    88 VQLLLGLALL-LQLNPLTILLSPIALLL-VLIYP-LMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYLAVIF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 185 WTpphfwaLA---CYRCADY---AKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFL 258
Cdd:cd13959   165 WT------AGydtIYAHQDReddRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQ 238

                         250
                  ....*....|....*
gi 1895999061 259 VYSVVLWRDYSDKLA 273
Cdd:cd13959   239 EHRLDLPDPLRSCLA 253
ubiA PRK12886
prenyltransferase; Reviewed
 70-268 2.25e-07

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 51.23  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  70 NCLIEQQIDARMARTRARPTARGEVSTAETLtLATLVGGFGLWVLHAFVNPLTMWLTLATfLGYAVIYTVVlKPATPMNI 149
Cdd:PRK12886   62 NRLIDAEIDARNPRTAGRAIPAGLISKGSAI-LFIVLSSLLMLFAAWFLNPLCLYLSPPA-LFFLLLYSYC-KRFTALAH 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 150 VIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFIWTPPhFWALACYRCADY-AKSGLPMLPVTHGIPFTCLHSLLYVVM 228
Cdd:PRK12886  139 VVLGFCLALAPLGAWIAIRGTIELPAILLGLAVLFWVAG-FDILYALQDLEFdRKEGLHSIPAKLGVNGSLWIARVFHLL 217

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1895999061 229 LTGATILPYTLGMSGPWYLtAALILDTIFLVYSVVLWRDY 268
Cdd:PRK12886  218 MIGFLFALGISAGLGPWFL-AGLAVTGILLLYEHWLLRGG 256
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 20-263 3.00e-07

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 50.81  E-value: 3.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  20 FELCKPRVNSLIVFTAMIGMFLA-APQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDARMARTRARPTARGEVSTAE 98
Cdd:cd13956     1 LRLMRPYTLLYVLAPALAGAALAgAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKPDRPLPSGRLSPRQAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  99 TLTLATLVGGFGLWVLhafVNPLTMWLTLATFLGyAVIYTVVLKPATPMNIVIGGASGAMPPLLGWSAI-TGQVGPEALV 177
Cdd:cd13956    81 AFAAALLLVGLALALA---LGPLALLLLLAGLLL-GLAYSLGLKRLKLGGWGVLGYATGLALLPGLGAVaAGGLVPLALL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 178 LFLIIFIW-TPPHFWALACYRCADyAKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTI 256
Cdd:cd13956   157 LALVFLLLgLGINLYNDLPDVEGD-RAAGIRTLPVRLGPRRARRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVALL 235


                  ....*..
gi 1895999061 257 FLVYSVV 263
Cdd:cd13956   236 ALRARFA 242
ubiA PRK12882
prenyltransferase; Reviewed
 13-259 8.44e-06

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 46.50  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  13 GQRLSAFFELCKPrVNSLIV-FTAMIGMFLAAPQFPPFALFVAASIGIALVAGAAAAINCLIEQQIDArmARTRARPTAR 91
Cdd:PRK12882    1 GMTVRGYLELTRP-VNAVVAgVAAFIGAFIAGGILSSPSLTGLAFAAVFLATGAGNAINDYFDREIDR--INRPDRPIPS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  92 GEVSTAETLTLATLVGGFGLwVLHAFVNPLTMWLTLATFLGYaVIYTVVLKpATPM--NIVIGGASGAMppLLGWSAITG 169
Cdd:PRK12882   78 GAVSPRGALAFSILLFAAGV-ALAFLLPPLCLAIALFNSLLL-VLYAETLK-GTPGlgNASVAYLTGST--FLFGGAAVG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 170 QVGPEAL-VLFLIIFIWTpphfwaLACYRCADY------AKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMS 242
Cdd:PRK12882  153 TEGLLALlVLFALAALAT------LAREIIKDVediegdRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLLSTF 226

                         250
                  ....*....|....*..
gi 1895999061 243 GPWYLTAALILDTIFLV 259
Cdd:PRK12882  227 GLWYLVLVAPADLVMLA 243
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
70-260 3.56e-04

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 41.24  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  70 NCLIEQQIDARMARTRARPTARGEVS--TAETLTLATLVggfGLWVLHAFVNPLTMWLTlatflGYAVIYTVVL---KPA 144
Cdd:PRK12888   59 NRIIDREIDARNPRTAGRELVTGAVSvrTAWTGALVALA---VFLGAAALLNPLCLALA-----PLAVAPLVVYpyaKRF 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 145 TPMNIVIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFIWTPPHFWALACYRCADYAKSGLPMLPVTHGIPFTcLHSLL 224
Cdd:PRK12888  131 TNFPHAILGLAQAVGPVGAWIAVTGTWSWPAVLLGLAVGLWIGGFDLIYACQDAEVDRRIGVRSVPARFGVRAA-LWASR 209

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1895999061 225 YVVMLTGATILPYTLGMSGPWYLTAALILDTIFLVY 260
Cdd:PRK12888  210 VAHVVTFALFVWFGLAVGFGALWWIGLAITAGAFAY 245
ubiA PRK12884
prenyltransferase; Reviewed
 15-274 6.21e-04

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 40.71  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  15 RLSAFFELCKPRVNSLIVFTAMIGMFLAAPQFPPFALfVAASIGIALVAGAAAAINCLIEQQIDARMARTraRPTARGEV 94
Cdd:PRK12884    3 KMKAYLELLRPEHGLMAGIAVVLGAIIALGGLPLDEA-LLGFLTAFFASGSANALNDYFDYEVDRINRPD--RPIPSGRI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  95 STAETLTLATLVGGFGLwVLHAFVNPLTMwLTLATFLGYAVIYTVVLKPA-TPMNIVIGGASGaMPPLLGwSAITGQVGP 173
Cdd:PRK12884   80 SRREALLLAILLFILGL-IAAYLISPLAF-LVVILVSVLGILYNWKLKEYgLIGNLYVAFLTG-MTFIFG-GIAVGELNE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 174 EALVLFLIIFIWTpphfwaLACYRCADY------AKSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYL 247
Cdd:PRK12884  156 AVILLAAMAFLMT------LGREIMKDIedvegdRLRGARTLAILYGEKIAGRIAAALFILAVLLSPLPYLFGIFNILYL 229

                         250       260
                  ....*....|....*....|....*..
gi 1895999061 248 TAALILDTIFLVYSVVLWRDYSDKLAR 274
Cdd:PRK12884  230 APVLVADLIFLYSAYSLLRSQDRETIR 256
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 203-283 2.22e-03

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 38.79  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061 203 KSGLPMLPVTHGIPFTCLHSLLYVVMLTGATILPYTLGMSGPWYLTAALILDTIFLVYSVVLWRDYSDKLARITFRYSII 282
Cdd:PRK09573  184 KENVITLPIKYGIKKSWYIAKILLILAIVLSPLPYFLGIFGIYYLIVVIICDILFIIAMLILLKNPSIEGASKASKYLKI 263


                  .
gi 1895999061 283 Y 283
Cdd:PRK09573  264 I 264
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
70-186 5.91e-03

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 37.68  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895999061  70 NCLIEQQIDARMARTRARPTARGEVStAETLTLATLVGGFGLWVLHAFVNPLTMWLTLAtFLGYAVIYTvVLKPATPMNI 149
Cdd:PRK12874   67 NRLVDRDIDKDNPRTANRPSVDGRIS-VKSMVLFIVLNALIFIGVSYFINPLAFKLSFP-FLIVLGGYS-YFKRFSSLAH 143

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1895999061 150 VIGGASGAMPPLLGWSAITGQVGPEALVLFLIIFIWT 186
Cdd:PRK12874  144 LVLGLSLGLAPIAGVVAVLGEIPLWSVFLALGVMFWV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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