|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
30-392 |
3.73e-59 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 197.47 E-value: 3.73e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 30 IVVKLMVTIIIIFIGMMTLSNFMINICVNNYFQEFDVEIENIFQTANHDDLYLLINEAQVKSTLEFRLYIILIMLFTVLI 109
Cdd:COG5002 12 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 110 GcFFLYFIISHMMKPLKSLAEQVSEIDIHNIEDLNREIVAIKGGYEIEDLAHTFNVTLKKLYLDYESQKK-------FSS 182
Cdd:COG5002 92 L-LLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERleqmrreFVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 183 NVAHELRTPLAVLYSKIDVFGKKSERNIEEYEELITSLKFNIERLADLVSKILLLTK---KSNNIKLINVCLKDIVEEIV 259
Cdd:COG5002 171 NVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRlesGELKLEKEPVDLAELLEEVV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 260 FDLEGTAEEKSVT--ATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHK 337
Cdd:COG5002 251 EELRPLAEEKGIEleLDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1899505873 338 EKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG5002 331 PRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
175-392 |
3.08e-56 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 184.73 E-value: 3.08e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 175 ESQKKFSSNVAHELRTPLAVLYSKIDVFGKKSERNIEEYEELITSLKFNIERLADLVSKILLLTK---KSNNIKLINVCL 251
Cdd:COG2205 14 RLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRlesGKLSLELEPVDL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 252 KDIVEEIVFDLEGTAEEK--SVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTG 329
Cdd:COG2205 94 AELLEEAVEELRPLAEEKgiRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899505873 330 IGITDEHKEKVFDIFYRVEQSRNRalGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG2205 174 PGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
68-392 |
9.63e-56 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 186.65 E-value: 9.63e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 68 IENIFQTANHDDLYLLINEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIDIHNIEDLNREI 147
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 148 VAIKGGYEIEDLAHTFNVTLKKLYLDYESQKKFSSNVAHELRTPLAVLYSKIDVFGKKSErniEEYEELITSLKFNIERL 227
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD---EEQREYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 228 ADLVSKILLLTK---KSNNIKLINVCLKDIVEEIVFDLEGTAEEKSVT--ATITGDNISMCTDDGLIQRVLFNLIENAIK 302
Cdd:COG0642 158 LRLINDLLDLSRleaGKLELEPEPVDLAELLEEVVELFRPLAEEKGIEleLDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 303 YNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRalGGYGIGLALVESIVKVLGGKIFIRDNK 382
Cdd:COG0642 238 YTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|
gi 1899505873 383 PQGTIFVLSF 392
Cdd:COG0642 316 GKGTTFTVTL 325
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
95-392 |
1.83e-49 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 173.34 E-value: 1.83e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 95 FRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIDIHNiedLNREIVAIKGGYEIEDLAHTFNVTLKKLYLDY 174
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPES---LDQRLDPSRAPAELRELAQSFNAMLGRLEDAF 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 175 ESQKKFSSNVAHELRTPLAVLYSKIDVFGKKsERNIEEYEELITSLKFNIERLADLVSKILLLTKKSNN-IKLINVCLkD 253
Cdd:TIGR01386 239 QRLSQFSADLAHELRTPLTNLLGQTQVALSQ-PRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGqLALERVRL-D 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 254 IVEEI--VFDL-EGTAEEKSVTATITGdNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGI 330
Cdd:TIGR01386 317 LAAELakVAEYfEPLAEERGVRIRVEG-EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGP 395
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899505873 331 GITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIrDNKPQGTIFVLSF 392
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
97-391 |
1.06e-36 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 139.52 E-value: 1.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 97 LYIILIMLFTVLIGcfflyfiisHmmKPLKSLAEQVSEIDIHNIE-DLNREIVAIkggyEIEDLAHTFNVTLKKLYLDYE 175
Cdd:PRK09835 196 LLIVFIVLLAVHKG---------H--APIRSVSRQIQNITSKDLDvRLDPQTVPI----ELEQLVLSFNHMIERIEDVFT 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKIDVFGKKSeRNIEEYEELITSlkfNIE---RLADLVSKILLLTKKSNNiKLINVCLK 252
Cdd:PRK09835 261 RQSNFSADIAHEIRTPITNLITQTEIALSQS-RSQKELEDVLYS---NLEeltRMAKMVSDMLFLAQADNN-QLIPEKKM 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 253 -DIVEEI--VFDL-EGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADT 328
Cdd:PRK09835 336 lDLADEVgkVFDFfEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENP 415
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899505873 329 GIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNkPQGTIFVLS 391
Cdd:PRK09835 416 GTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVIS 477
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
25-392 |
1.03e-35 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 134.35 E-value: 1.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 25 KIKNSIVVKLMVTIIIIFIGMmTLSNFMINICVNNYFQEFDveienifqtanhddlylLINEAQVKSTLEFRLYIILIML 104
Cdd:NF012226 1 KNKSGISKQLFIALSIVNLSV-TLFSVFLGYFIYNYAIEVG-----------------WITLSSLQEDWTEFHFVDWIWL 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 105 FTVLIGCFFLYFIIS-----HMMKPLKSLAE---QVSEIDIHNIEDLNREIVAikggyEIEDLAHTFNVTLKKLYLDYES 176
Cdd:NF012226 63 FTVILCGSVISLIIGmklaqRFIVPINFLADaakKISQGDLSARAEDSQIHSA-----EISELMHNFNDMAQKLESSVKN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 177 QKKFSSNVAHELRTPLAVLYSKI-----DVFgkkserniEEYEELITSLKFNIERLADLVSKILLLTKKSNNIKLIN--- 248
Cdd:NF012226 138 AQVWNAAIAHELRTPITILQGRLqgildGVF--------EPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNyes 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 249 VCLKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYnVNNGKVNINLSKNDTDTIIEIADT 328
Cdd:NF012226 210 VDLKDSIEKVLKMFEDRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRY-ANAGKLKISSSVIQDDWILQIEDE 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1899505873 329 GIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIrDNKPQGTIFVLSF 392
Cdd:NF012226 289 GPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEY-SNSQGNSVFTIKL 351
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
38-392 |
2.02e-32 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 127.98 E-value: 2.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 38 IIIIFIGMMTLSNFMINICVNNYFQEFDVEIENIFQTANHDDLYLLINEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFI 117
Cdd:COG4251 149 LLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 118 ISHMMKPLKSLAEQVSEIDIHNIEDLNREIVAIKggyEIEDLAHTFNVTLKKLYLDYESqkkFSSNVAHELRTPLavlyS 197
Cdd:COG4251 229 LLLLLLLVLLLLLILLLLLLILVLELLELRLELE---ELEEELEERTAELERSNEELEQ---FAYVASHDLREPL----R 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 198 KIDVFGKKSERNI-----EEYEELITSLKFNIERLADLVSKILLLTK-KSNNIKLINVCLKDIVEEIVFDLEGTAEEKSV 271
Cdd:COG4251 299 KISGFSQLLEEDYgdkldEEGREYLERIRDAAERMQALIDDLLAYSRvGRQELEFEPVDLNELLEEVLEDLEPRIEERGA 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 272 TATItGDNISMCTDDGLIQRVLFNLIENAIKYN--VNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQ 349
Cdd:COG4251 379 EIEV-GPLPTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS 457
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1899505873 350 SRNRalGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG4251 458 RDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
96-376 |
4.44e-31 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 123.40 E-value: 4.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 96 RLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIDIHNIEDLnreiVAIKGGYEIEDLAHTFNVTLKKLYLDYE 175
Cdd:NF012163 163 KRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTR----VTPTSNDELGKLAQDFNQLASTLEKNEQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKI----DVFGKKSERNIEEYEELITSLKFNIERLADLV---SKILLLTKKS-NNIKLI 247
Cdd:NF012163 239 MRRDFMADISHELRTPLAVLRAELeaiqDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSmsdEGALAYQKASvDLVPLL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 248 NVCLKDIVE-------EIVFDLEGtaeeksvTATITGDnismctDDGLIQrVLFNLIENAIKYNVNNGKVNINLSKNDTD 320
Cdd:NF012163 319 EVEGGAFRErfasaglELEVSLPD-------SSLVFGD------RDRLMQ-LFNNLLENSLRYTDSGGSLHISASQRPKE 384
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1899505873 321 TIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKI 376
Cdd:NF012163 385 VTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTL 440
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
181-392 |
2.95e-30 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 119.52 E-value: 2.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 181 SSNVAHELRTPLAVLYSKIDVFGKKSERNI--EEYEELITSLKFNIERLADLVSKILLLTKKSNnIKLINVCLKDIVEEI 258
Cdd:COG4191 146 AAGIAHEINNPLAAILGNAELLRRRLEDEPdpEELREALERILEGAERAAEIVRSLRAFSRRDE-EEREPVDLNELIDEA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 259 VFDLEGTAEEKSVTAT--ITGDNISMCTDDGLIQRVLFNLIENAIK--YNVNNGKVNINLSKNDTDTIIEIADTGIGITD 334
Cdd:COG4191 225 LELLRPRLKARGIEVEldLPPDLPPVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPP 304
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899505873 335 EHKEKVFDIFY---RVEQsrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG4191 305 EVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
289-392 |
8.22e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 110.77 E-value: 8.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRalGGYGIGLALVESI 368
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1899505873 369 VKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
284-392 |
2.98e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.66 E-value: 2.98e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 284 TDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQsRNRALGGYGIGLA 363
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100
....*....|....*....|....*....
gi 1899505873 364 LVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
184-392 |
5.72e-29 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 116.99 E-value: 5.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 184 VAHELRTPLAVLYSKIDV----FGKKSERNIEEYEELITSLKFNIERLADLVSKILLLTKKSNnIKLINVCLKDIVEEIV 259
Cdd:COG5000 208 IAHEIKNPLTPIQLSAERlrrkLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE-PQLEPVDLNELLREVL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 260 FDLEGTAEEKSVT--ATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHK 337
Cdd:COG5000 287 ALYEPALKEKDIRleLDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVL 366
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1899505873 338 EKVFDIFY--RVEqsrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG5000 367 ERIFEPFFttKPK--------GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
178-388 |
1.02e-27 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 111.92 E-value: 1.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 178 KKFSSNVAHELRTPLAVL--YSKI-----DVFGKKSERNIEEYEElitslkfNIERLADLVSKILLLTK---KSNNIKLI 247
Cdd:TIGR02966 115 RDFVANVSHELRTPLTVLrgYLETladgpDEDPEEWNRALEIMLE-------QSQRMQSLVEDLLTLSRlesAASPLEDE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 248 NVCLKDIVEEIVFDLEGTAEEKSVTATITGD-NISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIA 326
Cdd:TIGR02966 188 PVDMPALLDHLRDEAEALSQGKNHQITFEIDgGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVT 267
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899505873 327 DTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIF 388
Cdd:TIGR02966 268 DTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTF 329
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
148-376 |
1.88e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 113.19 E-value: 1.88e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 148 VAIKGGYEIEDLAHTFN---VTLKKlylDYESQKKFSSNVAHELRTPLAVLYSkidvfgkksernieEYEELITSL-KFN 223
Cdd:PRK10549 211 VTPTSRDELGRLAQDFNqlaSTLEK---NEQMRRDFMADISHELRTPLAVLRG--------------ELEAIQDGVrKFT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 224 IERLADLVSKILLLTKKSNNIKLINVC-------------LKDIVEEIVFDLEGTAEEKSVTATIT-GDNISMCTD-DGL 288
Cdd:PRK10549 274 PESVASLQAEVGTLTKLVDDLHQLSLSdegalayrktpvdLVPLLEVAGGAFRERFASRGLTLQLSlPDSATVFGDpDRL 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQrvLF-NLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVES 367
Cdd:PRK10549 354 MQ--LFnNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLN 431
|
....*....
gi 1899505873 368 IVKVLGGKI 376
Cdd:PRK10549 432 IVEAHNGRI 440
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
176-391 |
2.49e-27 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 112.39 E-value: 2.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKIDVfgkkSErNIEEYEELitSLKFNIERLADLVSKILL---LTKKSNNIKLINVCLK 252
Cdd:PRK10604 211 SKKQLIDGIAHELRTPLVRLRYRLEM----SD-NLSAAESQ--ALNRDIGQLEALIEELLTyarLDRPQNELHLSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 253 DIVEEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGI 332
Cdd:PRK10604 284 AWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGI 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1899505873 333 TDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:PRK10604 362 PPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFS 420
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
284-392 |
3.26e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 95.90 E-value: 3.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 284 TDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDtDTIIEIADTGIGITDEHKEKVFDIFYRveqSRNRALGGYGIGLA 363
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFST---ADKRGGGGTGLGLS 76
|
90 100
....*....|....*....|....*....
gi 1899505873 364 LVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
73-391 |
2.98e-23 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 101.26 E-value: 2.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 73 QTANHDDLYLLINEAQVKSTLEF--RLYIILIMLFTVLIGcfFLYFIISH-MMKPLKS---LAEQVSEIDIhniedlnRE 146
Cdd:NF040691 163 PVAGNYELYLLFPLEDEQSTLALvrGTLLLGGLALVVLLG--LIAWLVTRqVVAPVRSaarTAERFAAGDL-------SE 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 147 IVAIKGGYEIEDLAHTFN---VTLKKLYLDYES----QKKFSSNVAHELRTPLA-------VLYSKIDVFGKKSERN--- 209
Cdd:NF040691 234 RMPVKGEDDLARLARSFNqmaDSLQRQIRQLEElsrlQQRFVSDVSHELRTPLTtirmaadVIHDSRDDFDPATARSael 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 210 ----IEEYEELITSLkFNIERL-ADLVskilLLTKKSNNiklinvcLKDIVEEIVFDLEGTAEEK----SVTATITGDNI 280
Cdd:NF040691 314 lhteLDRFESLLSDL-LEISRFdAGAA----ELDVEPVD-------LRPLVRRVVDALRQLAERAgvelRVDAPGTPVVA 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 281 SMctDDGLIQRVLFNLIENAIKYnvNNGK-VNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYG 359
Cdd:NF040691 382 EV--DPRRVERVLRNLVVNAIEH--GEGKpVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTG 457
|
330 340 350
....*....|....*....|....*....|..
gi 1899505873 360 IGLALVESIVKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:NF040691 458 LGLAIALEDARLHGGWLEAWGRPGQGSQFRLT 489
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
285-385 |
6.85e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 89.83 E-value: 6.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 285 DDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLAL 364
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|.
gi 1899505873 365 VESIVKVLGGKIfIRDNKPQG 385
Cdd:cd16946 81 CHNIALAHGGTI-SAEHSPLG 100
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
184-388 |
8.61e-22 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 95.79 E-value: 8.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 184 VAHELRTPL--AVL------YSKIDVFGKKSERNIEEYEELITSLKFNIERLadlvSKILLLTKKSNNIKL-IN---VCL 251
Cdd:PRK09303 158 LAHDLRTPLtaASLaletleLGQIDEDTELKPALIEQLQDQARRQLEEIERL----ITDLLEVGRTRWEALrFNpqkLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 252 KDIVEEIVFDLEGTAEEKSVTAT--ITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTI-IEIADT 328
Cdd:PRK09303 234 GSLCQEVILELEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVqVSICDT 313
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899505873 329 GIGITDEHKEKVFDIFYRVEQSRNRAlgGYGIGLALVESIVKVLGGKIFIrDNKP-QGTIF 388
Cdd:PRK09303 314 GPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWV-DSEPgQGSCF 371
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-385 |
4.11e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 87.38 E-value: 4.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESI 368
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90
....*....|....*..
gi 1899505873 369 VKVLGGKIFIRDNKPQG 385
Cdd:cd16949 79 IEQHGGKIKASNRKPGG 95
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
104-387 |
7.78e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 92.72 E-value: 7.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 104 LFTVLIGCFFLYFIISHMMKPLKSL--------AEQVSEIDIHniEDLnREIVAIkggyeiedlAHTFNVTLKKLYLDYE 175
Cdd:PRK10755 68 LVMVSLTLLICFQAVRWITRPLAELqkeleartADNLTPIAIH--SST-LEIEAV---------TSALNQLVSRLTSTLD 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKIDVFGKKSerNIEeyeelITSLKFNIERLADLVSKILLLTKKSNNIKLINVCLKDIV 255
Cdd:PRK10755 136 QERLFTADVAHELRTPLAGIRLHLELLEKQH--HID-----VAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 256 EEIV------FDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTG 329
Cdd:PRK10755 209 EDVIlpsqdeLSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEG 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1899505873 330 IGITDEHKEKVFDIFYRVEQSrnraLGGYGIGLALVESIVKVLGGKIFIRDNKPQ-GTI 387
Cdd:PRK10755 289 PGIDESKCGELSKAFVRMDSR----YGGIGLGLSIVSRITQLHHGQFFLQNRQERsGTR 343
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
175-392 |
3.72e-20 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 91.06 E-value: 3.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 175 ESQKKFSSNVAHELRTPLAVLYSKIDVFGKK-SERNIEEYEELITSlkfNIERLADLVSKILLLTKKS-NNIKLINvcLK 252
Cdd:COG3852 133 AAVGELAAGLAHEIRNPLTGIRGAAQLLERElPDDELREYTQLIIE---EADRLNNLVDRLLSFSRPRpPEREPVN--LH 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 253 DIVEEIVFDLE-GTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTI--------- 322
Cdd:COG3852 208 EVLERVLELLRaEAPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyv 287
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899505873 323 -IEIADTGIGITDEHKEKVFDIFYRveqsrNRAlGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG3852 288 rIEVIDNGPGIPEEILDRIFEPFFT-----TKE-KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-393 |
8.10e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 84.49 E-value: 8.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESI 368
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRL 100
|
90 100
....*....|....*....|....*
gi 1899505873 369 VKVLGGKIFIRDNKPQGTIFVLSFQ 393
Cdd:cd16947 101 AESMGGSIYVNSKPYEKTVFTVTLK 125
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
289-388 |
1.29e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 83.31 E-value: 1.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNvNNGKVNINLSKNDTDT-----IIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLA 363
Cdd:cd16922 1 LRQILLNLLGNAIKFT-EEGEVTLRVSLEEEEEdgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100
....*....|....*....|....*
gi 1899505873 364 LVESIVKVLGGKIFIRDNKPQGTIF 388
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTF 104
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
77-370 |
4.49e-19 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 88.84 E-value: 4.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 77 HDDLYLL-----INEAQvkstLEFRLYI----ILIMLFTVLIGCFFLYFI---ISHMMKPLKSLAEQVS--EIDIH-NIE 141
Cdd:PRK09470 141 GEDNYQLylirpANSPQ----SDFINLLfdrpLLLLLVTMLVSTPLLLWLawsLAKPARKLKNAADEVAqgNLRQHpELE 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 142 dlnreivaiKGGYEIEDLAHTFNVTLKKLYLDYESQKKFSSNVAHELRTPL-------AVLyskidvfgkksERNIEEYE 214
Cdd:PRK09470 217 ---------TGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLtrlqlatALL-----------RRRQGESK 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 215 ELiTSLKFNIERLADLVSKILLLTKKSNNIKLI--NVCLKDIVEEIVFDLEGTAEEKSVTATITGD--NISMCTDDGLIQ 290
Cdd:PRK09470 277 EL-ERIETEAQRLDSMINDLLVLSRNQQKNHLEreTFKANSLWSEVLEDAKFEAEQMGKSLTVSAPpgPWPINGNPNALA 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 291 RVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVK 370
Cdd:PRK09470 356 SALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQ 433
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
285-386 |
4.52e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 79.37 E-value: 4.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 285 DDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIeIADTGIGITDEHKEKVFDIFYRveqSRNRALGGYGIGLAL 364
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGLSI 85
|
90 100
....*....|....*....|..
gi 1899505873 365 VESIVKVLGGKIFIRDNKPQGT 386
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGL 107
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
223-394 |
8.68e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 84.90 E-value: 8.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 223 NIE----RLADLVSKILLLTKKSNN---IKLINVCLKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFN 295
Cdd:PRK11100 296 NILtqsaRLQQLIDRLLELARLEQRqelEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGN 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 296 LIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFY---RVEQSRNralgGYGIGLALVESIVKVL 372
Cdd:PRK11100 376 LLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLH 451
|
170 180
....*....|....*....|..
gi 1899505873 373 GGKIFIRDNKPQGTIFVLSFQN 394
Cdd:PRK11100 452 GGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
289-390 |
2.44e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 77.15 E-value: 2.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTI-IEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVES 367
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFlLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|...
gi 1899505873 368 IVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQV 107
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
179-390 |
3.58e-17 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 83.48 E-value: 3.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 179 KFSSNVAHELRTPLAVLYSKIDvFGKKSERNIEEYEELITSLKfNIERLADLVSKILLLTKKSNnIKLINVCLKDIVEEI 258
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQ-IWRQQTSDPPSQEYLSVVLR-EVDRLNKVIDQLLEFSRPRE-SQWQPVSLNALVEEV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 259 VFdLEGTAEEKSvtatitGDNISMCTD--------DG-LIQRVLFNLIENAIKYNVNNGKVNINLSK-NDTDTIIEIADT 328
Cdd:PRK11360 469 LQ-LFQTAGVQA------RVDFETELDnelppiwaDPeLLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDN 541
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899505873 329 GIGITDEHKEKVFDIFYRVEQSrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK11360 542 GCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
184-393 |
4.56e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 82.86 E-value: 4.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 184 VAHELRTPLAVLYSKIDVFGKKSERNiEEYEELITSlkfNIERLADLVSKILLLTK-KSNNIKLINvcLKDIVEEIVFDL 262
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQLLQPGIEDK-EEYFDIMLS---ELDRIESIISEFLALAKpQAVNKEKEN--INELIQDVVTLL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 263 EGTA--EEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKV 340
Cdd:COG5805 368 ETEAilHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1899505873 341 FDIFYRVEQSrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSFQ 393
Cdd:COG5805 448 GEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
78-385 |
5.40e-17 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 82.39 E-value: 5.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 78 DDLYLLINEAQVKSTLeFRLYIILIMLFtvligcfflyFIISHMMKPLKSLAEQVSEIDIHNIEDLNREIVAIKGGYEIE 157
Cdd:PRK10337 153 EDMALAIVAGQLIPWL-VALPIMLIILM----------VLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVE 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 158 DLAHTFNVTLKKLYldyeSQKKFSSNVAHELRTPLAVLYSKIDVfGKKSERNIEEYEELITSLKFNIERLADLVSKILLL 237
Cdd:PRK10337 222 ALNQLFARTHAMMV----RERRFTSDAAHELRSPLAALKVQTEV-AQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 238 TK---KSNNIKLINVCLKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDdglIQRVLF-----NLIENAIKYNVNNGK 309
Cdd:PRK10337 297 SRldsLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRT---GQPLLLsllvrNLLDNAIRYSPQGSV 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 310 VNINLSKNDtdtiIEIADTGIGITDEHKEKVFDIFYR---VEQSrnralgGYGIGLALVESIVKVLGGKI-FirDNKPQG 385
Cdd:PRK10337 374 VDVTLNARN----FTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHGMNVsF--GNAPEG 441
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
180-392 |
6.24e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 82.33 E-value: 6.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 180 FSSNVAHELRTPLAVLYSKIDVFGKKSERNIEEYEELITSlkfNIERLADLVSKILLLTK-KSNNIKLINvcLKDIVEEI 258
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLS---ELDRIESIISEFLVLAKpQAIKYEPKD--LNTLIEEV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 259 VFDLEGTAEEKSV--TATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLS-KNDTDTIIEIADTGIGITDE 335
Cdd:COG5809 348 IPLLQPQALLKNVqiELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEE 427
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1899505873 336 HKEKVFDIFYrveqsrNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG5809 428 RLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-391 |
8.52e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 75.54 E-value: 8.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESI 368
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|...
gi 1899505873 369 VKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLT 101
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
98-391 |
2.36e-16 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 80.94 E-value: 2.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 98 YIILIMLFTVLIgcFFLYFI-ISHMMKPLKSLAEQVseIDIHNieDLNREIVAIKGGYEIEDLAHTFNVTLKKL--YLDY 174
Cdd:TIGR03785 411 VILAIMSIGTLA--LFGFASwISWRIRRLSDDAEAA--IDSQG--RISGAIPASRSRDEIGDLSRSFAQMVARLrqYTHY 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 175 -ESqkkFSSNVAHELRTPLAVLYSKIDVFgkKSERNIEEYEELITSLKFNIERLADLVSKI-----LLLTKKSNNI---- 244
Cdd:TIGR03785 485 lEN---MSSRLSHELRTPVAVVRSSLENL--ELQALEQEKQKYLERAREGTERLSMILNNMseatrLEQAIQSAEVedfd 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 245 --KLINVCL---KDIVEEIVFDLEGtaEEKSVTATITGDnismctddgLIQRVLFNLIENAIKYNVNNGKVNINLSKNDT 319
Cdd:TIGR03785 560 lsEVLSGCMqgyQMTYPPQRFELNI--PETPLVMRGSPE---------LIAQMLDKLVDNAREFSPEDGLIEVGLSQNKS 628
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899505873 320 DTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDN-KPQGTIFVLS 391
Cdd:TIGR03785 629 HALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRIS 701
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
186-385 |
2.93e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 80.85 E-value: 2.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 186 HELRTPLAVLYSKIDVF-------GKKSERNIEEYEELI---TSLKFNIERLADLVSKILLLTKKSNNiklinvcLKDIV 255
Cdd:PRK10490 673 HDLRTPLTVLFGQAEILtldlaseGSPHARQASEIRQQVlntTRLVNNLLDMARIQSGGFNLRKEWLT-------LEEVV 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 256 EEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDE 335
Cdd:PRK10490 746 GSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPG 825
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1899505873 336 HKEKVFDIFYRVEqsRNRALGGYGIGLALVESIVKVLGGKIFIRdNKPQG 385
Cdd:PRK10490 826 QEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAE-NRPEG 872
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
184-390 |
3.23e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 80.22 E-value: 3.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 184 VAHELRTPLAVLYSKIDVFGKKSERNIEEYEeLITSLKFNIERLADLVSKILLLTKKSNnIKLINVCLKDIVEEIVFDLE 263
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEAHQ-LAQVMAKEADRLNRVVSELLELVKPTH-LALQAVDLNDLINHSLQLVS 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 264 GTAEEKSVTATIT---GDNISMCTDDGLIQrVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKV 340
Cdd:PRK10364 322 QDANSREIQLRFTandTLPEIQADPDRLTQ-VLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 400
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1899505873 341 FDIFYRVEQSrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK10364 401 FTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-393 |
3.98e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 73.52 E-value: 3.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYN--VNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVeQSRNrALGGYGIGLALVE 366
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRL-HSRE-EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1899505873 367 SIVKVLGGKIFIRDNKPQGTIFVLSFQ 393
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
295-390 |
8.85e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 72.71 E-value: 8.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 295 NLIENAI----KYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRalggyGIGLALVESIVK 370
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|
gi 1899505873 371 VLGGKIFIRDNKPQGTIFVL 390
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSI 101
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
266-392 |
4.12e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.43 E-value: 4.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 266 AEEKSVTATITGDN--ISMCTDDGLIQRVLFNLIENAI----KYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEK 339
Cdd:COG3290 257 ARERGIDLTIDIDSdlPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEK 336
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1899505873 340 VFDIFYRVEQSRNRalggyGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG3290 337 IFERGFSTKLGEGR-----GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
290-379 |
1.59e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 68.95 E-value: 1.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 290 QRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRalGGYGIGLALVESIV 369
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAII 79
|
90
....*....|
gi 1899505873 370 KVLGGKIFIR 379
Cdd:cd16923 80 ELHGGSASAE 89
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-376 |
1.71e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.01 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNraLGGYGIGLALVESI 368
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
....*...
gi 1899505873 369 VKVLGGKI 376
Cdd:cd16950 77 SDAHGGSL 84
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-388 |
1.95e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.96 E-value: 1.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIK----YNVNNGKVNINLSKNDTDT-IIEIADTGIGITDEHKEKVFDIFYRVEQSrnralgGYGIGLA 363
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100
....*....|....*....|....*
gi 1899505873 364 LVESIVKVLGGKIFIRDNKPQGTIF 388
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATF 99
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
57-393 |
2.76e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 74.72 E-value: 2.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 57 VNNYFQEFDVEIENIFQTANHDdLYLLINEAQvKSTLEFRLYIILIMLFTVL-IGCFFLYFIISHMMKPLKSLAEQVSEI 135
Cdd:COG4192 288 NNSILEQLRTQISGLVGNSREQ-LVALNQETA-QLVQQSGILLLAIALLSLLlAVLINYFYVRRRLVKRLNALSDAMAAI 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 136 dIHNIEDLNreiVAIKGGYEIEDLA-----HTFNVTLKKLYLDYE-SQKKFSSN------------------------VA 185
Cdd:COG4192 366 -AAGDLDVP---IPVDGNDEIGRIArllrvFRDQAIEKTQELETEiEERKRIEKnlrqtqdeliqaakmavvgqtmtsLA 441
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 186 HELRTPL----AVLYSKIDVFGKKSERNIEEYEELITSLkfnIERLADLVSKILLLTKKSNNiKLINVCLKDIVEEIVFD 261
Cdd:COG4192 442 HELNQPLnamsMYLFSAKKALEQENYAQLPTSLDKIEGL---IERMDKIIKSLRQFSRKSDT-PLQPVDLRQVIEQAWEL 517
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 262 LEGTAEEKSVTATITGDNIsMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDehKEKVF 341
Cdd:COG4192 518 VESRAKPQQITLHIPDDLM-VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLF 594
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1899505873 342 DIFYRVEQSrnralgGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSFQ 393
Cdd:COG4192 595 TPFTTTKEV------GLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
283-391 |
4.63e-14 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 73.82 E-value: 4.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 283 CTDDGLIQRVLFNLIENAIKYNvNNGKVNINLSKNDTDTI-IEIADTGIGITDEHKEKVFDIFYRVEQSR-NRALGGYGI 360
Cdd:PRK11091 393 ITDGTRLRQILWNLISNAVKFT-QQGGVTVRVRYEEGDMLtFEVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGI 471
|
90 100 110
....*....|....*....|....*....|.
gi 1899505873 361 GLALVESIVKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:PRK11091 472 GLAVSKRLAQAMGGDITVTSEEGKGSCFTLT 502
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
295-392 |
5.36e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 67.61 E-value: 5.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 295 NLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGG 374
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*...
gi 1899505873 375 KIFIRDNKPQGTIFVLSF 392
Cdd:cd16952 87 RLLIASELGKGSRFTCLF 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
292-392 |
1.28e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.54 E-value: 1.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 292 VLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNrALGGYGIGLALVESIVKV 371
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|.
gi 1899505873 372 LGGKIFIRDNKPQGTIFVLSF 392
Cdd:cd16948 88 LGHKIDVESEVGEGTTFTITF 108
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
180-365 |
5.83e-13 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.04 E-value: 5.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 180 FSSNVAHELRTPLAVLYSKIDVFgKKSERNIEEYEELITSLKFNIERLADLVSKILLLTK--KSNNIKL---INV-CLKD 253
Cdd:PRK11006 207 FFANVSHELRTPLTVLQGYLEMM-QDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKieAAPTIDLnekVDVpMMLR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 254 IVE-----------EIVFDLEgtaeeksvtatitgDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTI 322
Cdd:PRK11006 286 VLEreaqtlsqgkhTITFEVD--------------NSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAE 351
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1899505873 323 IEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALV 365
Cdd:PRK11006 352 FSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIV 394
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
288-391 |
7.68e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 64.37 E-value: 7.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 288 LIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYrveqsRNRALG-GYGIGLALVE 366
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSY 77
|
90 100
....*....|....*....|....*
gi 1899505873 367 SIVKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTII 102
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
97-385 |
1.53e-12 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 68.78 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 97 LYIILIMLFTVLIGCFFlyfiISHMMKPLKSL---AEQVSEIDIhniedlnREIVAIKGGYEIEDLAHTFNVTLKKLYLD 173
Cdd:PRK09467 157 RYTLAIGLLSVAGGWLF----IRIQNRPLVALehaALQVGKGEI-------PPPLREYGASEVRSVTRAFNQMAAGIKQL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 174 YESQKKFSSNVAHELRTPLavlySKIDVfgkKSERNIEEYEELITSLKFNIERLADLVSKILLLTKKSNNIKLINVCLKD 253
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPL----TRIRL---ATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 254 IVEEIV---------FDLEGTAEEKsvtaTITGDNISmctddglIQRVLFNLIENAIKYnvNNGKVNINLSKNDTDTIIE 324
Cdd:PRK09467 299 LLGEVIaaesgyereIETALQPGPI----EVPMNPIA-------IKRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQ 365
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899505873 325 IADTGIGITDEHKEKVFDIFYRVEQSRNRAlgGYGIGLALVESIVKVLGGKIFIRdNKPQG 385
Cdd:PRK09467 366 VEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELG-NSEEG 423
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
251-392 |
1.97e-12 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 68.39 E-value: 1.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 251 LKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDD----GLIqrvlFN-LIENAIKY---NVNNGKVNINLSKNDTDTI 322
Cdd:COG3920 361 LRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAavplGLI----LNeLVTNALKHaflSGEGGRIRVSWRREDGRLR 436
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 323 IEIADTGIGITDEhkekvfdifyrVEQSRNRalggyGIGLALVESIVKVLGGKIFIRDnkPQGTIFVLSF 392
Cdd:COG3920 437 LTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELDR--PEGTRVRITF 488
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
180-388 |
3.87e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 67.95 E-value: 3.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 180 FSSNVAHELRTPLAvlyskiDVFG-----KKSERNIEEYEELITslkfnIERLA-DLVSKIllltkksNNI----KL--- 246
Cdd:PRK11107 296 FLANMSHELRTPLN------GVIGftrqtLKTPLTPTQRDYLQT-----IERSAnNLLAII-------NDIldfsKLeag 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 247 ------INVCLKDIVEEIVFDLEGTAEEKSVTATItgdNISMCTDDGLI------QRVLFNLIENAIKYNvNNGKVNI-- 312
Cdd:PRK11107 358 klvlenIPFSLRETLDEVVTLLAHSAHEKGLELTL---NIDPDVPDNVIgdplrlQQIITNLVGNAIKFT-ESGNIDIlv 433
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899505873 313 ---NLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIF 388
Cdd:PRK11107 434 elrALSNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
292-390 |
1.42e-11 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 66.01 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 292 VLFNLIENA----IKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDifyRVEQSRNRALGGYGIGLALVES 367
Cdd:PRK15053 436 IVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEHGIGLYLIAS 512
|
90 100
....*....|....*....|...
gi 1899505873 368 IVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCGTLFSI 535
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-390 |
3.88e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIK--YNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYrveqsRNRALG-GYGIGLALV 365
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*
gi 1899505873 366 ESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTF 100
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
155-391 |
4.09e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 65.14 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 155 EIEDLAHTFNVTLKKLYLDYESQKKFSSNVAHELRTPLAVLYSKIDVFgKKSERNIEEYEELITSLKFNIERLADLVSKI 234
Cdd:PRK09959 690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELL-SGSGLSKEQRVEAISLAYATGQSLLGLIGEI 768
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 235 LLLTK-KSNNIKLIN--VCLKDIVEEIVFDLEGTAEEKSVTATITG---DNISMCTDDGLIQRVLFNLIENAIKYnVNNG 308
Cdd:PRK09959 769 LDVDKiESGNYQLQPqwVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALKF-TTEG 847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 309 KVNINLSK---NDTDTIIE--IADTGIGITDEHKEKVFDIFYRVEQSRNRAlgGYGIGLALVESIVKVLGGKIFIRDNKP 383
Cdd:PRK09959 848 AVKITTSLghiDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPG 925
|
....*...
gi 1899505873 384 QGTIFVLS 391
Cdd:PRK09959 926 IGTTFTIT 933
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
285-385 |
8.63e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.63 E-value: 8.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 285 DDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYrveqSRNRALGGY---GIG 361
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGQkstGLG 76
|
90 100
....*....|....*....|....
gi 1899505873 362 LALVESIVKVLGGKIFIRdNKPQG 385
Cdd:cd16945 77 LAFVQEVAQLHGGRITLR-NRPDG 99
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
122-385 |
1.26e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 62.73 E-value: 1.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 122 MKPLKSLAEQVSEIDIHNIEDLNREIVAikggyEIEDLAHTFNVTLKKLYLDYESQKKFSSNVAHELRTPLAVLYSKIDV 201
Cdd:PRK10815 216 LRPIEALAKQVRELEEGEREQLDPNPPR-----ELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRS 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 202 FGKKSERNIEEYEELITSlkfNIERL----------ADLVSKILLLTKKSNNI-----------------KLINVCLkDI 254
Cdd:PRK10815 291 LRSGKQMSVEQAEPIMLE---QISRIsqqigyylhrASMRSEHNLLSRELHSVaplldnltsalnkvyqrKGVNITL-DI 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 255 VEEIVFdlegtAEEKsvtatitgdNISMctddgliqRVLFNLIENAIKYNVNNgkVNINLSKNDTDTIIEIADTGIGITD 334
Cdd:PRK10815 367 SPEITF-----VGEK---------NDFM--------EVMGNVLDNACKYCLEF--VEISARQTDEHLHIVVEDDGPGIPE 422
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1899505873 335 EHKEKVFDIFYRVEQSRNralgGYGIGLALVESIVKVLGGKIFIRDNKPQG 385
Cdd:PRK10815 423 SKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGG 469
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
183-390 |
1.32e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 63.12 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 183 NVAHELRTPLAVLYSKIDVFgKKSERNIEEYEELIT------SLKFNIERLADLvSKIllltkKSNNIKLI--NVCLKDI 254
Cdd:PRK15347 404 TISHEIRTPLNGVLGALELL-QNTPLTAEQMDLADTarqctlSLLAIINNLLDF-SRI-----ESGQMTLSleETALLPL 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 255 VEEIVFDLEGTAEEKSVT-ATITGDNI--SMCTDDGLIQRVLFNLIENAIKYNvNNGKVNINLSKNDTDTIIEIADTGIG 331
Cdd:PRK15347 477 LDQAMLTIQGPAQSKSLTlRTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCG 555
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1899505873 332 ITDEHKEKVFDIFYRVEQSRnralGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK15347 556 IDIQQQQQIFTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
180-390 |
2.68e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 62.39 E-value: 2.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 180 FSSNVAHELRTPL-AVL-YSKIDVFGKKSERNIEEYEELITSlkfNIERLADLVSKILLLTKKSNNIkLINVCLKDIVEE 257
Cdd:PRK13837 453 LASGIAHNFNNILgAILgYAEMALNKLARHSRAARYIDEIIS---AGARARLIIDQILAFGRKGERN-TKPFDLSELVTE 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 258 IV------------FDLEGTAEEksvtATITGDNISmctddglIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDT---- 321
Cdd:PRK13837 529 IApllrvslppgveLDFDQDQEP----AVVEGNPAE-------LQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRApkvl 597
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 322 -----------IIEIADTGIGITDEHKEKVFDIFYRVeqsrnRAlGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK13837 598 shgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFFTT-----RA-GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDV 671
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-392 |
4.80e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 57.26 E-value: 4.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 278 DNISMCTDDGLIQRVLFNLIENAIKYNvnNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNralgG 357
Cdd:cd16954 27 PELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----G 100
|
90 100 110
....*....|....*....|....*....|....*
gi 1899505873 358 YGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:cd16954 101 QGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
285-385 |
8.47e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 55.93 E-value: 8.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 285 DDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRAlGGYGIGLAL 364
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90 100
....*....|....*....|.
gi 1899505873 365 VESIVKVLGGKIFIRDNKPQG 385
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGG 100
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
235-388 |
6.07e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 57.62 E-value: 6.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 235 LLLTKKS----NNIKLInvclkdIVEEIVfdLEGTAEEKSVTATITgdnismctddgliqrVLFNLIENAIKY--NVNNG 308
Cdd:PRK11086 399 FLLGKISrareLGITLI------ISEDSQ--LPDSGDEDQVHELIT---------------ILGNLIENALEAvgGEEGG 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 309 KVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVeQSRNRalggyGIGLALVESIVKVLGGKIFIRDNKPQGTIF 388
Cdd:PRK11086 456 EISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST-KGSNR-----GVGLYLVKQSVENLGGSIAVESEPGVGTQF 529
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
175-239 |
1.74e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 50.67 E-value: 1.74e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899505873 175 ESQKKFSSNVAHELRTPLAVLYSKIDVFgKKSERNIEEYEELITSLKFNIERLADLVSKILLLTK 239
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELL-EEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
291-385 |
2.15e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 2.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 291 RVLFNLIENAIKYNV-NNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYrVEQSRNRALGGY-GIGLALVESI 368
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGQHsGLGLSISRQI 81
|
90
....*....|....*..
gi 1899505873 369 VKVLGGKIFIRDNKPQG 385
Cdd:cd16953 82 IEAHGGISVAENHNQPG 98
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
3-392 |
9.46e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 53.87 E-value: 9.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 3 RDISLMNKNNYENKSYDGSFSKKIKNSIVVKLMVTIIIIFIGMMTLSNFMINICVNNYFQEFDVEIENIFQTANHDDLYL 82
Cdd:COG2972 60 LLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 83 LI---NEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQvseidIHNIEDLNREIVAIKGGYEIEDL 159
Cdd:COG2972 140 VSlipKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKA-----MKKVEKGDLVRLEVSGNDEIGIL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 160 AHTFNVTLKKLYLDYESQKKFSSNVAH-ELRT------P------LAVLYSKIDvfgKKSERNIEEY-EELITSLKFNIE 225
Cdd:COG2972 215 ARSFNEMVERIKELIEEVYELELEKKEaELKAlqaqinPhflfntLNSIRWLAE---LEDPEEAEEMlEALSKLLRYSLS 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 226 RLADLVSkillLTKKSNNIK----LINVCLKDIVEeIVFDLEGTAEEKSVtatitgdnismctddglIQRVLFNLIENAI 301
Cdd:COG2972 292 KGDELVT----LEEELELIKsyleIQKLRFGDRLE-VEIEIDEELLDLLI-----------------PKLILQPLVENAI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 302 KYNVNN----GKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRnralggyGIGLALVESIVKVLGGK-- 375
Cdd:COG2972 350 EHGIEPkeggGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-------GIGLRNVRERLKLYYGEey 422
|
410
....*....|....*...
gi 1899505873 376 -IFIRDNKPQGTIFVLSF 392
Cdd:COG2972 423 gLEIESEPGEGTTVTIRI 440
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
281-390 |
1.06e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 54.21 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 281 SMCTDDGLIQRVLFNLIENAIKYNvNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGI 360
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGL 633
|
90 100 110
....*....|....*....|....*....|
gi 1899505873 361 GLALVESIVKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK10841 634 GLAICEKLINMMDGDISVDSEPGMGSQFTI 663
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
176-239 |
1.13e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 48.36 E-value: 1.13e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKIDVFgkKSERNIEEYEELITSLKFNIERLADLVSKILLLTK 239
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
290-392 |
7.55e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 47.76 E-value: 7.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 290 QRVLFNLIENAIKYNVNNGKVNINLSK----NDTDT-----------IIEIADTGIGITDEHKEKVFDIFYrveqsRNRA 354
Cdd:cd16919 2 ELAILNLAVNARDAMPEGGRLTIETSNqrvdADYALnyrdlipgnyvCLEVSDTGSGMPAEVLRRAFEPFF-----TTKE 76
|
90 100 110
....*....|....*....|....*....|....*....
gi 1899505873 355 LG-GYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:cd16919 77 VGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
176-243 |
1.15e-06 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 45.63 E-value: 1.15e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1899505873 176 SQKKFSSNVAHELRTPLAVLYSKIDVFgKKSERNIEEyEELITSLKFNIERLADLVSKILLLTKKSNN 243
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELL-LDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
289-390 |
2.25e-06 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 49.90 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 289 IQRVLFNLIENAIKYNvNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRnralGGYGIGLALVESI 368
Cdd:PRK11466 562 IRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRL 636
|
90 100
....*....|....*....|..
gi 1899505873 369 VKVLGGKIFIRDNKPQGTIFVL 390
Cdd:PRK11466 637 AQAMGGELSATSTPEVGSCFCL 658
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
292-378 |
2.31e-06 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 47.34 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 292 VLFNLIENAIKYNVNNGK--------VNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFY-------------RVEQS 350
Cdd:cd16929 47 ILFELLKNAMRATVESHGddsddlppIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGT 126
|
90 100
....*....|....*....|....*...
gi 1899505873 351 RNRALGGYGIGLALVESIVKVLGGKIFI 378
Cdd:cd16929 127 QPSPLAGFGYGLPMSRLYAEYFGGDLDL 154
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
293-392 |
2.09e-05 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 46.02 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 293 LFNLIENAIKYNV----NNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKvfdifyrveqsrnralgGYGIGLALVESI 368
Cdd:COG3275 258 LQPLVENAIKHGIsskeGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK-----------------GSGIGLKNVRER 320
|
90 100
....*....|....*....|....*..
gi 1899505873 369 VKVLGGK---IFIRDNKPQGTIFVLSF 392
Cdd:COG3275 321 LELLYGDkysLEIESTDGGGTKVTLKI 347
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-391 |
3.26e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 39.69 E-value: 3.26e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899505873 323 IEIADTGIGITDEHKEKvfdIFYRVEQSRNralGGYGIGLALVESIVKVLGGKIFIrDNKPQGTIFVLS 391
Cdd:cd16918 46 VSVIDNGPGIPPDLQDT---IFYPMVSGRE---NGTGLGLAIAQNIVSQHGGVIEC-DSQPGHTVFSVS 107
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
62-379 |
5.50e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 42.02 E-value: 5.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 62 QEFDVEIENIFQTANHDDLYLLINEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIdihNIE 141
Cdd:COG2770 177 ADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRI---AAG 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 142 DLNREIvAIKGGYEIEDLAHTFNV---TLKKLYLDYESQKKFSSNVAHELRTPLAVLYSKIDVFGKKSERNIEEYEELIT 218
Cdd:COG2770 254 DLDVRI-PVSRKDEIGELARAFNRmadSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLEL 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 219 SLKFNIERLADLVSKILLLTKKSNNIKLINVCLKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIE 298
Cdd:COG2770 333 LLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEEL 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 299 NAIKYNVNNGKVNINLSKNDTDTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFI 378
Cdd:COG2770 413 VLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492
|
.
gi 1899505873 379 R 379
Cdd:COG2770 493 E 493
|
|
| HAMP |
pfam00672 |
HAMP domain; |
116-170 |
8.53e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 37.22 E-value: 8.53e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1899505873 116 FIISHMMKPLKSLAEQVSEIDIHnieDLNREIvAIKGGYEIEDLAHTFNVTLKKL 170
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASG---DLDVRL-PVSGRDEIGELARAFNQMAERL 51
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
271-392 |
2.47e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.22 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 271 VTATITGDNISMctdDGLIQRVLF----NLIENAIKYnVNNGKVNINLSKNDTDTIIEIADTGIGITDEhkekvfdifyr 346
Cdd:COG4585 144 VELDVDGDPDRL---PPEVELALYrivqEALTNALKH-AGATRVTVTLEVDDGELTLTVRDDGVGFDPE----------- 208
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1899505873 347 veqsrnrALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLSF 392
Cdd:COG4585 209 -------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
80-391 |
7.04e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 38.33 E-value: 7.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 80 LYLLINEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIDIHNIEdlnrEIVAIKGGYEIEDL 159
Cdd:COG3850 101 LLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFD----ARVPVSGRDELGTL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 160 AHTFNVTLKKLYLDYESQKKFSSNVAHELRTPLAVLYSKIDVFGKKSERNIEEYEELITSLKFNIERLADLVSKILLLTK 239
Cdd:COG3850 177 ARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLAL 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 240 KSNNIKLINVCLKDIVEEIVFDLEGTAEEKSVTATITGDNISMCTDDGLIQRVLFNLIENAIKYNVNNGKVNINLSKNDT 319
Cdd:COG3850 257 NILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASV 336
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899505873 320 DTIIEIADTGIGITDEHKEKVFDIFYRVEQSRNRALGGYGIGLALVESIVKVLGGKIFIRDNKPQGTIFVLS 391
Cdd:COG3850 337 VAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEG 408
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
4-170 |
8.92e-03 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 38.08 E-value: 8.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 4 DISLMNKNNYENKSYDGSFSKKIKNSIVVKLMVTIIIIFIGMMTLSNFMINICVNNYFQEFDVEIENIFQTANHDDLYLL 83
Cdd:COG0840 89 LLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLE 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899505873 84 INEAQVKSTLEFRLYIILIMLFTVLIGCFFLYFIISHMMKPLKSLAEQVSEIDIHnieDLNREIvAIKGGYEIEDLAHTF 163
Cdd:COG0840 169 AAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG---DLTVRI-DVDSKDEIGQLADAF 244
|
....*..
gi 1899505873 164 NVTLKKL 170
Cdd:COG0840 245 NRMIENL 251
|
|
| |
