|
Name |
Accession |
Description |
Interval |
E-value |
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
274-803 |
2.41e-167 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 493.38 E-value: 2.41e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 274 GLLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEA 353
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 354 FANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAAneVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 434 TPVLNNIVIIVTLGLFIWVYGTAETSGMKVTSIPAegerllgigvllglIVQSLAMIPYLRETGFRLRLRFDWRGHGLGK 513
Cdd:TIGR01695 159 SPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGG--------------VAQLLIQLPFLRKAGFLLKPRFNFRDPGLKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 514 AITLAKWTVLFVLANQAGAMIVIqlstaaGKASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGA 593
Cdd:TIGR01695 225 FLKLFLPTTLGSSASQITLLINT------ALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 594 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRT 671
Cdd:TIGR01695 299 LRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGafSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRT 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 672 PFYNTvivaVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDLDGaRVLRTYARLCIASvpaAL 751
Cdd:TIGR01695 379 PFINS----VISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPF-GVLKVLAKLVIAS---AI 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1912958257 752 IGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 803
Cdd:TIGR01695 451 IGGVLYLIVSVSLGGVLVKNLLGLLAIGLIGLLVYFLGLALLKIEELNLLLR 502
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-778 |
1.72e-135 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 409.76 E-value: 1.72e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 300 IVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPL 379
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 380 LIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYGTAETS 459
Cdd:pfam03023 81 LIRLLAPG--FDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 460 GMKVTSIpaegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLs 539
Cdd:pfam03023 159 LAIGVLI--------------GGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFL- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 540 taagkASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:pfam03023 224 -----ASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 620 GIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTvivaVVNAAASGLCYLLLPSR 697
Cdd:pfam03023 299 SIPIVSLLFerGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKIS----LISAVLNILLSLLLLPP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 698 WAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdlDGARVLRTYARLciASVPAALIGGAACYAISRSLGQGVVGSLAALLA 777
Cdd:pfam03023 375 LGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLAS--LVVPTALMAGVILLLSSLTQGPWVVGSLLLILV 450
|
.
gi 1912958257 778 G 778
Cdd:pfam03023 451 G 451
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
276-796 |
4.86e-131 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 399.91 E-value: 4.86e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 276 LKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAF 354
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALeKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNpvASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP--GFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 435 PVLNNIVIIVTLGLFIWVYGTAETS---GMKVTSIpaegerllgigvllgliVQSLAMIPYLRETGFRLRLRFDWRGHGL 511
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYAlawGVLLGGV-----------------LQLLIQLPALRRLGLRLRPRFDLRDPGV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 512 GKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDG 591
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSV------SALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 592 GAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDT 669
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 670 RTPFYNTVIVAVVNAaasgLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdLDGARVLRTYARLCIASVPA 749
Cdd:COG0728 376 RTPVRIAVIAVVVNI----VLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGG-LPLRGILRTLLKLLLASLVM 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1912958257 750 ALIGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIE 796
Cdd:COG0728 451 GAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVR 497
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
283-725 |
6.57e-114 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 352.53 E-value: 6.57e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 283 AAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAFANRLLTL 361
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLeKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 362 VMVALGALTVITVFAAPLLIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPG--FSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 442 IIVTLGLFIWVYGTaetsGMKVTSIpaegerllgiGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd13123 159 IIAGLLLLAPLFDL----GIYALAW----------GVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 522 VLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQG 601
Cdd:cd13123 225 LLGVSVSQINLLVDTILASFLPEGSI------SALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 602 LRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTviv 679
Cdd:cd13123 299 LRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIA--- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1912958257 680 aVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13123 376 -VIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| DUF1373 |
pfam07117 |
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins ... |
203-285 |
2.55e-05 |
|
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.
Pssm-ID: 462093 [Multi-domain] Cd Length: 212 Bit Score: 46.32 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 203 PDPYGNAQTHGQYG---GSAQYGGSAATPGQHAaPAPGQYAVAPTPEAAEAPLQEPEPAPPASQASPKKGGRAGGLLKSS 279
Cdd:pfam07117 33 PLPPGQEPEPPRPEeeeGQGGGGGTFPFPGSPE-PEPGGGGSGPMPMSASAPEPEPAKAKPQRPAPAQGHGHGGGGDSDS 111
|
....*.
gi 1912958257 280 AVMAAG 285
Cdd:pfam07117 112 SGSGSG 117
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
209-266 |
1.45e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 1.45e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1912958257 209 AQTHGQYGGSAQYGGSAATPGQHAAPAPGQYAVAPTPEAAEAPLQEPEPAPPASQASP 266
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP 442
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
274-803 |
2.41e-167 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 493.38 E-value: 2.41e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 274 GLLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEA 353
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 354 FANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAAneVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 434 TPVLNNIVIIVTLGLFIWVYGTAETSGMKVTSIPAegerllgigvllglIVQSLAMIPYLRETGFRLRLRFDWRGHGLGK 513
Cdd:TIGR01695 159 SPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGG--------------VAQLLIQLPFLRKAGFLLKPRFNFRDPGLKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 514 AITLAKWTVLFVLANQAGAMIVIqlstaaGKASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGA 593
Cdd:TIGR01695 225 FLKLFLPTTLGSSASQITLLINT------ALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 594 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRT 671
Cdd:TIGR01695 299 LRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGafSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRT 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 672 PFYNTvivaVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDLDGaRVLRTYARLCIASvpaAL 751
Cdd:TIGR01695 379 PFINS----VISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPF-GVLKVLAKLVIAS---AI 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1912958257 752 IGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 803
Cdd:TIGR01695 451 IGGVLYLIVSVSLGGVLVKNLLGLLAIGLIGLLVYFLGLALLKIEELNLLLR 502
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-778 |
1.72e-135 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 409.76 E-value: 1.72e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 300 IVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPL 379
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 380 LIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYGTAETS 459
Cdd:pfam03023 81 LIRLLAPG--FDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 460 GMKVTSIpaegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLs 539
Cdd:pfam03023 159 LAIGVLI--------------GGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFL- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 540 taagkASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:pfam03023 224 -----ASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 620 GIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTvivaVVNAAASGLCYLLLPSR 697
Cdd:pfam03023 299 SIPIVSLLFerGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKIS----LISAVLNILLSLLLLPP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 698 WAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdlDGARVLRTYARLciASVPAALIGGAACYAISRSLGQGVVGSLAALLA 777
Cdd:pfam03023 375 LGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLAS--LVVPTALMAGVILLLSSLTQGPWVVGSLLLILV 450
|
.
gi 1912958257 778 G 778
Cdd:pfam03023 451 G 451
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
276-796 |
4.86e-131 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 399.91 E-value: 4.86e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 276 LKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAF 354
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALeKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNpvASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP--GFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 435 PVLNNIVIIVTLGLFIWVYGTAETS---GMKVTSIpaegerllgigvllgliVQSLAMIPYLRETGFRLRLRFDWRGHGL 511
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYAlawGVLLGGV-----------------LQLLIQLPALRRLGLRLRPRFDLRDPGV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 512 GKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDG 591
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSV------SALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 592 GAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDT 669
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 670 RTPFYNTVIVAVVNAaasgLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdLDGARVLRTYARLCIASVPA 749
Cdd:COG0728 376 RTPVRIAVIAVVVNI----VLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGG-LPLRGILRTLLKLLLASLVM 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1912958257 750 ALIGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIE 796
Cdd:COG0728 451 GAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVR 497
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
283-725 |
6.57e-114 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 352.53 E-value: 6.57e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 283 AAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAFANRLLTL 361
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLeKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 362 VMVALGALTVITVFAAPLLIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPG--FSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 442 IIVTLGLFIWVYGTaetsGMKVTSIpaegerllgiGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd13123 159 IIAGLLLLAPLFDL----GIYALAW----------GVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 522 VLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQG 601
Cdd:cd13123 225 LLGVSVSQINLLVDTILASFLPEGSI------SALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 602 LRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTviv 679
Cdd:cd13123 299 LRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIA--- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1912958257 680 aVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13123 376 -VIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
275-719 |
1.34e-18 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 88.47 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 275 LLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGdTFQVAYQLPTMIYILtVGGGLNSVFVPQLVRAmkdDEDGGEAF 354
Cdd:COG2244 4 LLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYG-LFALALSIVALLSVL-ADLGLSTALVRFIAEY---REEELRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVAsdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG2244 79 LSTALLLRLLLSLLLALLLLLLAPFIAALLGEPEL---------ALLLLLLALALLLSALSAVLLALLRGLERFKLLALI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 435 PVLNNIVIIVTLGLFIWVygtaetsGMKVTSIPaegerllgigvllglivqslamipylretgfrlrLRFdwrghglGKA 514
Cdd:COG2244 150 NILSSLLSLLLALLLALL-------GLGLWGLV----------------------------------LKY-------SLP 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 515 ITLAkwTVLFVLANQAGAMIVIQLSTAAGkaspvdgtgFAAYANAQLIWGLPQAIITvSLMAALLPRISRSASEEDGGAV 594
Cdd:COG2244 182 LLLS--GLLGLLLTNLDRLLLGALLGPAA---------VGIYSAAYRLASLLLLLIT-ALSQVLFPRLSRLLAEGDREEL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 595 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFY 674
Cdd:COG2244 250 RRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFG----PEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLI 325
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1912958257 675 NTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAW 719
Cdd:COG2244 326 ISLIGAVLNL---VLNLLLIP-RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
280-727 |
3.61e-16 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 81.75 E-value: 3.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 280 AVMAAGTMVSRLTGFV-RSAL--IVSALGVGLlgdtFQVAYQLPTMIYILTVGGglNSVFVPQLV---RAMKDDEDGGEA 353
Cdd:cd13124 1 LILTIAGLISKILGAIyRIPLqnIIGDEGMGL----YQMAYPIYGIFLTLATAG--IPVAISKLVaeyNALGDYKGARRI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 354 FanRLLTLVMVALGAL-TVITVFAAPLLIRLLSNpvasDPAAnevgITFVRYFLPSIFFMGLHVVMgqvlnaRGRF-GAM 431
Cdd:cd13124 75 F--RVSLILLLILGLVfFLLLFFGAPFLAQLLLG----DPRL----APVIRALAPAILIVPLLSVL------RGYFqGLQ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 432 MWTP-----VLNNIV-IIVTLGLFIWVY---------GTAETSGMKVTSIPAegerllgigvllglivqSLAMIPYlret 496
Cdd:cd13124 139 NMTPtavsqVIEQIVrVIVILVLAYLLLpvggglyyaAAGATFGAVIGALAG-----------------LLVLLYY---- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 497 gFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAG----------------AMIVIQLSTAAGKASPVDGTGFAAYA-NA 559
Cdd:cd13124 198 -YRKKRRELKRLLRKSPRSKISTKEILKELLSYAIpitlsslilpllqlidSFTVPRRLQAAGLSESEATALYGILTgRA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 560 QLIWGLPqAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSSgtseatNM 639
Cdd:cd13124 277 QPLVQLP-TVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS------EG 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 640 GYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIvavvnaaasGLC------YLLLPsRWAVVGMAASYGLAYVI 713
Cdd:cd13124 350 GLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI---------GLLvkivlnYVLIP-IFGIYGAAIATVIGFLV 419
|
490
....*....|....
gi 1912958257 714 GVGIAWRRLRKRLG 727
Cdd:cd13124 420 AALLNLRALKKLLG 433
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
275-723 |
8.51e-10 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 61.79 E-value: 8.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 275 LLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGdtfQVAYQLPTMIYILTV-GGGLNSVFVPQLVRAMKDDEDggEA 353
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFG---ILSLALAFVGLFSIFaDLGLPTALVREIARYRKEKIR--EI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 354 FANrlLTLVMVALGALTVITVFAAPLLIRLLSNPVasdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:cd13128 76 IST--SLVLKLILGILALLLLFLFAFLIAFYDPEL----------VLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 434 TPVLNNIVIIVTLGLFI------WVYGTAETSGMKVTSIpaegerllgigvllglivqsLAMIPYLRETGFRLRLRFD-- 505
Cdd:cd13128 144 ARIIESVLSLILALILVllggglIGFALAYLIASVLSAI--------------------LLLYIYRKKILLPKFFSFDlk 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 506 -WRGHgLGKAITLAKWTVLFVLANQagaMIVIQLSTAAGKASpvdgTGF--AAYANAQLIWGLPQAIITVslmaaLLPRI 582
Cdd:cd13128 204 lAKEL-LRFSIPLALSGIFSLIYTR---IDTIMLGYFLGDAA----VGIynAAYRIAELLLFIPSAISTA-----LFPRI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 583 SRsASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRA 662
Cdd:cd13128 271 SE-LYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFG----EEYLPAALVLQILAWGFLFIFLNGIFGSI 345
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1912958257 663 FYAYEDTRTPFYNTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAWRRLR 723
Cdd:cd13128 346 LQAIGKQKLTLKILLIGALLNV---ILNLLLIP-KYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
272-721 |
1.88e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 60.54 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 272 AGGLLKSSAVMAAGTMVSRLtgfvrSALIVSALGVGLlgdtfqvayqlPTMIYILTVGGGLN---SVFVPQLVRAmKDDE 348
Cdd:COG0534 19 LGNLLQSLYGLVDTIFVGRL-----GTAALAAVGLAF-----------PIFFLLIALGIGLGvggTALVAQALGA-GDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 349 DGGEAFANrLLTLVMVALGALTVITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRF 428
Cdd:COG0534 82 EARRVLGQ-ALLLALLLGLLLTLLGLLFAPPLLRLLG----ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 429 GAMMWTPVLNNIVIIVTLGLFIWVYgtaetsGMKV------TSIpaegerllgigvllGLIVQSLAMIPYL--RETGFRL 500
Cdd:COG0534 157 KTPMIIMLIGNVLNIVLDPLLIFGG------GLGVagaalaTVI--------------SQAVSALLLLYYLfrKRSLLRL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 501 RLR-FDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKaspvdgTGFAAYANAQLIWGLPQAIItVSLMAALL 579
Cdd:COG0534 217 RLRdLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT------AAVAAYGIALRIESLAFMPA-LGLGQAAQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 580 PRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYV 658
Cdd:COG0534 290 PLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLF---TDDPEVIALAaTYLRIAALFQPFDGLQFV 366
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1912958257 659 VLRAFYAYEDTRTPFYNTVIVAVVNAAasGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRR 721
Cdd:COG0534 367 LSGALRGAGDTRFPMIISLLRLWLVRL--PLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
282-718 |
6.72e-08 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 55.79 E-value: 6.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 282 MAAGTMVSRLTGFVRSALIVSALGVGLLGDTFqVAYQLPTMIYILTVGGGLNSVFVPQLVRAmkDDEDGGEAFANRLLTL 361
Cdd:cd12082 4 LLLSMLLQTLYNLVDTFFLGRLLGDALAAVGL-AFPLIALLIALGVGLSVGTSALISQAIGA--GDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 362 VMVALGALTVITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLG----AEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 442 IIVtlGLFIWVYGTAeTSGMKVTSIPAegerlLGIGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd12082 157 NIL--LDPLLIFGLG-PPELGIAGAAL-----ATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 522 VLFVLANQAGAMIVIQLSTAAGKASPVdgtgfAAYANAQLIWGLPQAIItVSLMAALLPRISRSASeedggavRDDISQG 601
Cdd:cd12082 229 AIQNSLLSLGLLIIVAIVAAFGGAAAL-----AAYTVAFRIASLAFMPA-LGLAQAALPVVGQNLG-------AGNFDRA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 602 LRTTAVAIVpvsFGFVALGIPMCTLMFG--------SSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 673
Cdd:cd12082 296 RRITWVALL---IGLLIGAVLGLLILLFpepilslfTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSL 372
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1912958257 674 YNTVIVAVVNAAasGLCYLLLPSRWAVVGMAASYGLAYVIGVGIA 718
Cdd:cd12082 373 IVSLLSYWVVRL--PLAYVLAYLGLGLYGIWLALVISLILAALVL 415
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
362-730 |
9.07e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 55.18 E-value: 9.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 362 VMVALGA-LTVITVFAAPLLIRLLSNPVASDPaanevgitfVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNI 440
Cdd:cd13127 77 LNLLLGLlLYLLLFLLAPLIAAFYNEPELIPL---------LRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 441 V-IIVTLGLFIWvygtaetsGMKVTSIpaegerllgigVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGH----GLGKAI 515
Cdd:cd13127 148 VsGVVAIVLALL--------GFGVWAL-----------VAQQLVGALVSTVLLWILSRWRPRLSFSLASLkellSFGSKL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 516 TLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVSLMAALLPRISRSASeeDGGAVR 595
Cdd:cd13127 209 LGS--NLLNYFSRNLDNLII-------GKFLGAAALGY--YSRAYRLALLPVQNITGPITRVLFPALSRLQD--DPERLR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 596 DDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYN 675
Cdd:cd13127 276 RAYLKALRLLALITFPLMVGLALLAEPLVLLLLG----EKWLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKL 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1912958257 676 TVIVAVVNAAAsglcyLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDL 730
Cdd:cd13127 352 GLIKAVLTVLA-----LLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISL 401
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
287-456 |
7.13e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 52.49 E-value: 7.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 287 MVSRLTGFVRS----ALIVSALGVGLLGdTFQVAYQLPTMIyILTVGGGLNSVFVPQLVRAMKDDEDGGEAFaNRLLTLV 362
Cdd:cd13127 209 LGSNLLNYFSRnldnLIIGKFLGAAALG-YYSRAYRLALLP-VQNITGPITRVLFPALSRLQDDPERLRRAY-LKALRLL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 363 MVALGALTVITVFAAPLLIRLL--SNPVASdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNI 440
Cdd:cd13127 286 ALITFPLMVGLALLAEPLVLLLlgEKWLPA--------VPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAV 357
|
170
....*....|....*...
gi 1912958257 441 VIIVTL--GLFIWVYGTA 456
Cdd:cd13127 358 LTVLALliGIPYGIIGVA 375
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
283-426 |
9.46e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 49.05 E-value: 9.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 283 AAGTMVSRLTGFVRSALIVSALGVGLLGdTFQVAYQLPTMIYILTVGGGL-NSVFVPQLVRAmkDDEDGGEAFANRLLTL 361
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALA-AYQIGLRIESLAFMPGFGFSMaASTLVGQNLGA--GDPDEARRYGKRALRL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1912958257 362 VMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARG 426
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTP----DPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAG 372
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
642-795 |
1.03e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 46.03 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 642 MLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAWRR 721
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKL---ILNLLLIP-LFGIVGAAIATVISLLVVALLNLYY 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1912958257 722 LRKRLGGDLdgarVLRTYARLCIASVPAALIGGAACYAISRSLGQGVvgslaALLAGGVLLFGVFFVAARRMRI 795
Cdd:pfam14667 77 LRRYLGLRL----LLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLAL-----ALLLAVLVGALVYLLLLLLLKL 141
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
275-450 |
2.35e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 47.50 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 275 LLKSSAVMAAGTMVSRLtgfvrSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKDDEDGGEAF 354
Cdd:cd13134 17 LLQMLLGTIDTFMLSRY-----SDNAVAAVGVAN-----QILFLLILIFSFISTGT---SILIAQYLGA-KDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 355 ANRLLTLVMVALgALTVITVFAAPLLIRLLSNPvasdPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:cd13134 83 GVALLFNLLLGL-VFSLLLLFFGAELLRLMGLP----PELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYV 157
|
170
....*....|....*.
gi 1912958257 435 PVLNNIVIIVTLGLFI 450
Cdd:cd13134 158 SLIMNILNIVGNYLLI 173
|
|
| DUF1373 |
pfam07117 |
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins ... |
203-285 |
2.55e-05 |
|
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.
Pssm-ID: 462093 [Multi-domain] Cd Length: 212 Bit Score: 46.32 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 203 PDPYGNAQTHGQYG---GSAQYGGSAATPGQHAaPAPGQYAVAPTPEAAEAPLQEPEPAPPASQASPKKGGRAGGLLKSS 279
Cdd:pfam07117 33 PLPPGQEPEPPRPEeeeGQGGGGGTFPFPGSPE-PEPGGGGSGPMPMSASAPEPEPAKAKPQRPAPAQGHGHGGGGDSDS 111
|
....*.
gi 1912958257 280 AVMAAG 285
Cdd:pfam07117 112 SGSGSG 117
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
287-725 |
1.19e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.20 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 287 MVSRLtgfvrSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKDDEDGGEAFANRLLTLVMVAL 366
Cdd:cd13137 27 MVGRL-----GAEAIAAVGLAT-----QVLWLLLVLNMALGTGT---VALVSQSYGA-GDYERARRALGQSLLLALLLSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 367 gALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTL 446
Cdd:cd13137 93 -PLALLGLLFAEPLLRLLGA----DPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 447 GLFIwvYGTAETSGMKV------TSIpaegerllgigvllgliVQSLAMIPYL-----RETGFRLRL-RFDWRGHGLGKA 514
Cdd:cd13137 168 YVLI--FGLWGFPGLGVagaalaTVI-----------------SRVVGALLLLflllrGRLPIKISFkGFRLDRKIIKKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 515 ITLAKWTVLFVLANQAGAMIVIQLSTAAGKASpvdgtgFAAYANAQLIWGLPqAIITVSLMAALLPRISRSASEEDGGAV 594
Cdd:cd13137 229 LRIGLPAGLEQLLRSLGFLVLLAIVASYGTAA------LAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDEA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 595 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 673
Cdd:cd13137 302 RRYGKRALRLGVLFMGLLGLLLFIFAPPLASLF---TPDPEVIELGvLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1912958257 674 YNTVIVAVVNAAasGLCYLL-LPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13137 379 IINLISMWLVRL--PLAYLLgFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
359-466 |
2.44e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 44.37 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 359 LTLVMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNArgrFGAMMWTPVLN 438
Cdd:cd13138 308 IIISLIIGLIIILLVFFFAPQLLGLFTS----DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG---LGKTKFPMIIS 380
|
90 100
....*....|....*....|....*...
gi 1912958257 439 NIVIIVTLGLFIWVygTAETSGMKVTSI 466
Cdd:cd13138 381 ILRLWLVRIPLAYL--LSRLTGLGLFGI 406
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
282-455 |
4.09e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 43.72 E-value: 4.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 282 MAAGTMVSRLTGFVRSalIVSALGVGLLGDTFQVAYQLPTMIYILT---VGGGLNSvfvpqlvrAMkdDEDGGEAFANRL 358
Cdd:cd13132 8 LAAPLVLTSLLQYSLS--VVSVVFVGHLGKLELAAASLASSFANVTgfsILLGLAS--------AL--DTLCGQAFGAKN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 359 LTLV-MVALGALTVITVFAAPL-LIRLLSNPVAS----DPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMM 432
Cdd:cd13132 76 YKLVgVYLQRALVILLLCCVPIsLLWLNTEPILLllgqDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLV 155
|
170 180
....*....|....*....|...
gi 1912958257 433 WTPVLNNIVIIVTLGLFIWVYGT 455
Cdd:cd13132 156 YISLVALLLNILLNYLLVFVLGL 178
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
277-619 |
4.89e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 43.30 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 277 KSSAVMAAGTMVSRLTGFVRS---ALIVSALGVGLLGdTFQVAYQLPTMIyiltVGGGLNSVFVPQLVRAmKDDEDggea 353
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINkvvAVYLGPSGVALLG-QLQNFVTILQTI----AGGGINNGVVKYTAEY-KDDEE---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 354 fanRLLTLVMVALGALTVITVFAAPLLIrLLSNPVASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:cd13125 71 ---KLARVWSTAFRITLILSILGGLLLL-LFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 434 TPVLNNIVIIVTLGLFIWVYGT--AETSGMKVTSIPAegerllgigvllglivqsLAMIPYLRETGFRLRLRFDWRGHgL 511
Cdd:cd13125 147 INIISSLIGLLVSVLLVYFYGLkgALLALVLNQSLIF------------------LVTLIYSRKQPWFKLKYLWGRLD-K 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 512 GKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPVDGTGFAayanaQLIWGLPQA---IITVSLMAALLPRISrSASE 588
Cdd:cd13125 208 DIIKKLLKFSLMALVSALSLPLSQIIVRNILIRQLGWEAAGYW-----QAVWKISDVylgFITTALSTYYLPRLS-AIKD 281
|
330 340 350
....*....|....*....|....*....|.
gi 1912958257 589 EDggAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:cd13125 282 NK--ELKREVNKQLKVILPLVAIGALLIYLL 310
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
209-266 |
1.45e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 1.45e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1912958257 209 AQTHGQYGGSAQYGGSAATPGQHAAPAPGQYAVAPTPEAAEAPLQEPEPAPPASQASP 266
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP 442
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
361-427 |
1.67e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 41.79 E-value: 1.67e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1912958257 361 LVMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGR 427
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFIN----DPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGH 384
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
326-454 |
6.30e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 39.80 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 326 LTVGGGLNSVFVPQLvrAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAanevgITFVRYF 405
Cdd:cd13143 58 LMIGVGGASLISRRL--GAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYA-----VDYLRII 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1912958257 406 LPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYG 454
Cdd:cd13143 131 LLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLG 179
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
498-630 |
9.40e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 38.73 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 498 FRLRLRFDWRG----HGLGKAITLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVS 573
Cdd:pfam13440 163 WRPRLTFSLKVikelFSFGSWLLLS--NLLNYLARNLDNLII-------GKVLGTAALGL--YSVAYRLALLPTANITSV 231
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1912958257 574 LMAALLPRISRSasEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGS 630
Cdd:pfam13440 232 ITKVLFPALSRI--QDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGS 286
|
|
| DUF3438 |
pfam11920 |
Protein of unknown function (DUF3438); This family of proteins are functionally ... |
206-344 |
9.92e-03 |
|
Protein of unknown function (DUF3438); This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 276 to 307 amino acids in length.
Pssm-ID: 432189 Cd Length: 288 Bit Score: 38.92 E-value: 9.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 206 YGNAQTHGQYGGSAQYGGSAATPGQHAAPAPGQY----AVAPTPEAAE---APLQEPEPAPPASQASPKKGGRAGGLLKS 278
Cdd:pfam11920 122 YGDNKDSGAKAGAKSSASESDPQAPAAAAARPRRetpvPVVLTRYAAQslyAPLRTVEPVPGVRRVNLRRSLKLDTLLPT 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912958257 279 SAVMAAGTMVSRLTGFVRSALIV---SALGVG-----LLGD----TFQVAYQLP-------TMIYILTVGGGLNSVFVPQ 339
Cdd:pfam11920 202 LPVRATPLAAWRLEDQWVTAVRLtntSARWIDldpraLQGDfvtaTFQHPWLGPagtpedtTTLYLVTRGRGLAQALLPA 281
|
....*
gi 1912958257 340 LVRAM 344
Cdd:pfam11920 282 ISPID 286
|
|
| |
