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Conserved domains on  [gi|1913255459|ref|WP_191972167|]
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hypothetical protein, partial [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA super family cl35847
cell envelope integrity inner membrane protein TolA; Provisional
 2-86 1.38e-03

cell envelope integrity inner membrane protein TolA; Provisional


The actual alignment was detected with superfamily member PRK09510:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 35.94  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:PRK09510  147 AKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAA 226


                  ....*
gi 1913255459  82 AEAEA 86
Cdd:PRK09510  227 AAKAA 231
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2-86 1.38e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 35.94  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:PRK09510  147 AKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAA 226


                  ....*
gi 1913255459  82 AEAEA 86
Cdd:PRK09510  227 AAKAA 231
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-86 9.33e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 33.73  E-value: 9.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:NF033609  714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793


                  ....*
gi 1913255459  82 AEAEA 86
Cdd:NF033609  794 SDSDS 798
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2-86 1.38e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 35.94  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:PRK09510  147 AKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAA 226


                  ....*
gi 1913255459  82 AEAEA 86
Cdd:PRK09510  227 AAKAA 231
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2-94 1.62e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 35.55  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:PRK09510  139 AKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKK 218

                          90
                  ....*....|...
gi 1913255459  82 AEAEALVLAEAEA 94
Cdd:PRK09510  219 AAAEAKAAAAKAA 231
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-86 9.33e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 33.73  E-value: 9.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913255459   2 AEAEALVDAEAEALVEADSDAEILAEADALVDAEAEALVDAEAEALVDADSEALVDAEAEALVDAEAEALVLAEAEALVD 81
Cdd:NF033609  714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793


                  ....*
gi 1913255459  82 AEAEA 86
Cdd:NF033609  794 SDSDS 798
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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