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Conserved domains on  [gi|1917113120|ref|WP_192908669|]
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MULTISPECIES: carboxylesterase [Cytobacillus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
10-245 7.05e-87

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 258.33  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  10 GAESFYYEGNEIGILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDRCT 89
Cdd:COG1647     5 GAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  90 SVYAAGQSMGGALTLWLANKYPEIAGIVLINAALRV--------PCYEYLKgktnpRYLDEGAPDIKKEDVEEITYGKVP 161
Cdd:COG1647    85 KVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIddpsapllPLLKYLA-----RSLRGIGSDIEDPEVAEYAYDRTP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120 162 VPSIFELQKIMERTPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKIGSVKKKAISLYNSYHVASMDNDKEKIVNITHQ 241
Cdd:COG1647   160 LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILD 239


                  ....
gi 1917113120 242 YIQQ 245
Cdd:COG1647   240 FLER 243
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
10-245 7.05e-87

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 258.33  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  10 GAESFYYEGNEIGILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDRCT 89
Cdd:COG1647     5 GAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  90 SVYAAGQSMGGALTLWLANKYPEIAGIVLINAALRV--------PCYEYLKgktnpRYLDEGAPDIKKEDVEEITYGKVP 161
Cdd:COG1647    85 KVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIddpsapllPLLKYLA-----RSLRGIGSDIEDPEVAEYAYDRTP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120 162 VPSIFELQKIMERTPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKIGSVKKKAISLYNSYHVASMDNDKEKIVNITHQ 241
Cdd:COG1647   160 LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILD 239


                  ....
gi 1917113120 242 YIQQ 245
Cdd:COG1647   240 FLER 243
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-224 3.59e-13

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 66.85  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTpqSVRF--LGESFAKLGYTVFAPRLKGHG------THYKDMEktsheDWFAEAEKGYQFLKDR--CTSVY 92
Cdd:pfam12146   7 VVLVHGLGEH--SGRYahLADALAAQGFAVYAYDHRGHGrsdgkrGHVPSFD-----DYVDDLDTFVDKIREEhpGLPLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  93 AAGQSMGGALTLWLANKYPE-IAGIVLINAALRVPCYEY---------LKGKTNPRYLDEGAPD----------IKKEDV 152
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDkVDGLILSAPALKIKPYLAppilkllakLLGKLFPRLRVPNNLLpdslsrdpevVAAYAA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917113120 153 EEITYGKVPVPSIFELQKIMERTPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKIGSVKKKAISLYNSYH 224
Cdd:pfam12146 160 DPLVHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 34-118 5.04e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 43.65  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  34 QSVRFLGESFAKLGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDR-CTSVYAAGQSMGGALTLWLANKYP- 111
Cdd:TIGR03101  43 RMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQgHPPVTLWGLRLGALLALDAANPLAa 122


                  ....*..
gi 1917113120 112 EIAGIVL 118
Cdd:TIGR03101 123 KCNRLVL 129
PLN02578 PLN02578
hydrolase
 17-174 2.79e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 38.28  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  17 EGNEIGILITHGFLGTPQSVRFLGESFAKlGYTVFAPRLKGHGTHYKDMEKTSHEDWfaeAEKGYQFLKDRCTS-VYAAG 95
Cdd:PLN02578   83 QGEGLPIVLIHGFGASAFHWRYNIPELAK-KYKVYALDLLGFGWSDKALIEYDAMVW---RDQVADFVKEVVKEpAVLVG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  96 QSMGGALTLWLANKYPE-IAGIVLINAAlrvpcyeylkgktnPRYLDEGAPDIKKEDVEEITYGKvpvPSIFELQKIMER 174
Cdd:PLN02578  159 NSLGGFTALSTAVGYPElVAGVALLNSA--------------GQFGSESREKEEAIVVEETVLTR---FVVKPLKEWFQR 221
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
10-245 7.05e-87

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 258.33  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  10 GAESFYYEGNEIGILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDRCT 89
Cdd:COG1647     5 GAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  90 SVYAAGQSMGGALTLWLANKYPEIAGIVLINAALRV--------PCYEYLKgktnpRYLDEGAPDIKKEDVEEITYGKVP 161
Cdd:COG1647    85 KVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIddpsapllPLLKYLA-----RSLRGIGSDIEDPEVAEYAYDRTP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120 162 VPSIFELQKIMERTPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKIGSVKKKAISLYNSYHVASMDNDKEKIVNITHQ 241
Cdd:COG1647   160 LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILD 239


                  ....
gi 1917113120 242 YIQQ 245
Cdd:COG1647   240 FLER 243
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
23-245 3.20e-17

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 3.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHG-THYKDMEKTSHEDWFAEAEKGYQFLKDR-CTSVYAAGQSMGG 100
Cdd:COG2267    31 VVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGrSDGPRGHVDSFDDYVDDLRAALDALRARpGLPVVLLGHSMGG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120 101 ALTLWLANKYPE-IAGIVLInaalrvpcyeylkgktNPRYLDEgapdikkedveeiTYGKVPVPSIFELqkimeRTPDLL 179
Cdd:COG2267   111 LIALLYAARYPDrVAGLVLL----------------APAYRAD-------------PLLGPSARWLRAL-----RLAEAL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1917113120 180 PSIKTPVLGFKSVEDHVVPAECTDFILEKIGSvKKKAISLYNSYHVASMDNDKEKIVNITHQYIQQ 245
Cdd:COG2267   157 ARIDVPVLVLHGGADRVVPPEAARRLAARLSP-DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-209 1.35e-13

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 67.72  E-value: 1.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120   1 MNERYPVLDGAESFYYEGNEIG--ILITHGFLGTPQSVRFLGESFAKlGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAE 78
Cdd:COG0596     2 STPRFVTVDGVRLHYREAGPDGppVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  79 kgyQFLKDR-CTSVYAAGQSMGGALTLWLANKYPE-IAGIVLINAALRVPCYEYLKGKTNPRYLDEGAPDIKKEDVeeit 156
Cdd:COG0596    81 ---ALLDALgLERVVLVGHSMGGMVALELAARHPErVAGLVLVDEVLAALAEPLRRPGLAPEALAALLRALARTDL---- 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1917113120 157 ygkvpvpsifelqkimertPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKI 209
Cdd:COG0596   154 -------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELL 187
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-224 3.59e-13

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 66.85  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTpqSVRF--LGESFAKLGYTVFAPRLKGHG------THYKDMEktsheDWFAEAEKGYQFLKDR--CTSVY 92
Cdd:pfam12146   7 VVLVHGLGEH--SGRYahLADALAAQGFAVYAYDHRGHGrsdgkrGHVPSFD-----DYVDDLDTFVDKIREEhpGLPLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  93 AAGQSMGGALTLWLANKYPE-IAGIVLINAALRVPCYEY---------LKGKTNPRYLDEGAPD----------IKKEDV 152
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDkVDGLILSAPALKIKPYLAppilkllakLLGKLFPRLRVPNNLLpdslsrdpevVAAYAA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917113120 153 EEITYGKVPVPSIFELQKIMERTPDLLPSIKTPVLGFKSVEDHVVPAECTDFILEKIGSVKKKAISLYNSYH 224
Cdd:pfam12146 160 DPLVHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
22-200 5.29e-12

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 63.45  E-value: 5.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  22 GILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHGTHYKD-------MEKTSHEDWFAEAEKGYQFLKDR---CTS- 90
Cdd:COG0412    31 GVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGDDpdearalMGALDPELLAADLRAALDWLKAQpevDAGr 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  91 VYAAGQSMGGALTLWLANKYPEIAGIVLInaalrvpcyeylkgktnpryldegapdikkedveeitYGKVPVPSifelqk 170
Cdd:COG0412   111 VGVVGFCFGGGLALLAAARGPDLAAAVSF-------------------------------------YGGLPADD------ 147

                         170       180       190
                  ....*....|....*....|....*....|
gi 1917113120 171 imerTPDLLPSIKTPVLGFKSVEDHVVPAE 200
Cdd:COG0412   148 ----LLDLAARIKAPVLLLYGEKDPLVPPE 173
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
23-200 1.11e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 59.65  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFlGTPQSVRFLGES--FAKLGYTVFAPRLKGHGTHYKDMEKTSHEDwfaeAEKGYQFLKDRC----TSVYAAGQ 96
Cdd:COG1506    26 VVYVHGG-PGSRDDSFLPLAqaLASRGYAVLAPDYRGYGESAGDWGGDEVDD----VLAAIDYLAARPyvdpDRIGIYGH 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  97 SMGGALTLWLANKYPE-IAGIVLINAAlrvpcyeylkgkTNPRYLDEGAPDIKKedveeiTYGKVPVPSIFELQkimERT 175
Cdd:COG1506   101 SYGGYMALLAAARHPDrFKAAVALAGV------------SDLRSYYGTTREYTE------RLMGGPWEDPEAYA---ARS 159

                         170       180
                  ....*....|....*....|....*.
gi 1917113120 176 P-DLLPSIKTPVLGFKSVEDHVVPAE 200
Cdd:COG1506   160 PlAYADKLKTPLLLIHGEADDRVPPE 185
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-141 1.42e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 59.83  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHG-----THYKDMEKTSHEDWFAEAEKGYQFlkdrcTSVYAAGQS 97
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGkssrpKAQDDYRTDDLAEDLEYILEALGL-----EKVNLVGHS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1917113120  98 MGGALTLWLANKYPE-IAGIVLINAALRVPCYEYLKGKTNPRYLD 141
Cdd:pfam00561  78 MGGLIALAYAAKYPDrVKALVLLGALDPPHELDEADRFILALFPG 122
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 23-246 9.05e-09

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 54.54  E-value: 9.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLKGHG------THYKDMEKTSHEDWFAEAEKGYQFLKDRctsVYAAGQ 96
Cdd:COG1073    40 VVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGesegepREEGSPERRDARAAVDYLRTLPGVDPER---IGLLGI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  97 SMGGALTLWLANKYPEIAGIVLINAALRVPcyeylkgktnprylDEGApdIKKEDVEEITYGKVPVPSIFELQKIMERTP 176
Cdd:COG1073   117 SLGGGYALNAAATDPRVKAVILDSPFTSLE--------------DLAA--QRAKEARGAYLPGVPYLPNVRLASLLNDEF 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1917113120 177 DLL---PSIKTPVLGFKSVEDHVVPAECTDFILEKIGSvKKKAISLYNSYHVASMDNDKEKIVNITHQYIQQN 246
Cdd:COG1073   181 DPLakiEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAE-PKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKN 252
COG4099 COG4099
Predicted peptidase [General function prediction only];
2-119 1.61e-07

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 50.74  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120   2 NERYPVL----DGAESfyyeGNEIGILITHGflgtpqSVRFLG-ESFAKLGYTVFAPRLKgHGTHYkdMEKTSHEDWFA- 75
Cdd:COG4099    46 GKKYPLVlflhGAGER----GTDNEKQLTHG------APKFINpENQAKFPAIVLAPQCP-EDDYW--SDTKALDAVLAl 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1917113120  76 --EAEKGYQFLKDRctsVYAAGQSMGGALTLWLANKYPE-IAGIVLI 119
Cdd:COG4099   113 ldDLIAEYRIDPDR---IYLTGLSMGGYGTWDLAARYPDlFAAAVPI 156
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 34-118 5.04e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 43.65  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  34 QSVRFLGESFAKLGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDR-CTSVYAAGQSMGGALTLWLANKYP- 111
Cdd:TIGR03101  43 RMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQgHPPVTLWGLRLGALLALDAANPLAa 122


                  ....*..
gi 1917113120 112 EIAGIVL 118
Cdd:TIGR03101 123 KCNRLVL 129
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
70-118 1.39e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 39.45  E-value: 1.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1917113120  70 HEDWFAE-----AEKGYQFLKDRcTSVYAAGQSMGGALTLWLANKYPEIAGIVL 118
Cdd:COG2382   173 FERFLAEelipfVEKNYRVSADP-EHRAIAGLSMGGLAALYAALRHPDLFGYVG 225
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 23-118 1.67e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 38.61  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFlgtPQSVRFLGESFAKlGYTVFAPRLKGHGTHYKDMEKTSHEDWFAEAEKGYQFLKDrctsVYAAGQSMGGAL 102
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARP----VVLVGHSLGGAV 72

                          90
                  ....*....|....*.
gi 1917113120 103 TLwLANKYPEIAGIVL 118
Cdd:pfam12697  73 AL-AAAAAALVVGVLV 87
PLN02578 PLN02578
hydrolase
 17-174 2.79e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 38.28  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  17 EGNEIGILITHGFLGTPQSVRFLGESFAKlGYTVFAPRLKGHGTHYKDMEKTSHEDWfaeAEKGYQFLKDRCTS-VYAAG 95
Cdd:PLN02578   83 QGEGLPIVLIHGFGASAFHWRYNIPELAK-KYKVYALDLLGFGWSDKALIEYDAMVW---RDQVADFVKEVVKEpAVLVG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  96 QSMGGALTLWLANKYPE-IAGIVLINAAlrvpcyeylkgktnPRYLDEGAPDIKKEDVEEITYGKvpvPSIFELQKIMER 174
Cdd:PLN02578  159 NSLGGFTALSTAVGYPElVAGVALLNSA--------------GQFGSESREKEEAIVVEETVLTR---FVVKPLKEWFQR 221
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
23-194 3.39e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 38.20  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTPQS--VRFLGESFAKLGYTVFAPRLKGHGthykdmeKTSH-----------ED--WFAeaekgyQFLKDR 87
Cdd:COG0429    64 VVLLHGLEGSSDShyARGLARALYARGWDVVRLNFRGCG-------GEPNllprlyhsgdtEDlvWVL------AHLRAR 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  88 C--TSVYAAGQSMGGALTLWLA----NKYPEIAGIVLINAALR-VPCYEYLKGKTNPRY----LDEgapdIKKedveeit 156
Cdd:COG0429   131 YpyAPLYAVGFSLGGNLLLKYLgeqgDDAPPLKAAVAVSPPLDlAASADRLERGFNRLYqryfLRS----LKR------- 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1917113120 157 ygkvpvpsifELQKIMERTPDL-----LPSIKT----------PVLGFKSVED 194
Cdd:COG0429   200 ----------KLRRKLALFPGLidleaLKRIRTlrefddaytaPLHGFKDAED 242
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 23-119 6.84e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.19  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917113120  23 ILITHGFLGTPQSVRFLGESFAKLGYTVFAPRLkghGTHYKDMEKTshedwfaeAEKGYQFLkDRCTSVYAAGQ------ 96
Cdd:COG1075     8 VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNY---PSTNGSIEDS--------AEQLAAFV-DAVLAATGAEKvdlvgh 75

                          90       100
                  ....*....|....*....|....*.
gi 1917113120  97 SMGGALTLWLANKY---PEIAGIVLI 119
Cdd:COG1075    76 SMGGLVARYYLKRLggaAKVARVVTL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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