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Conserved domains on  [gi|1926927208|ref|WP_193665445|]
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class I SAM-dependent methyltransferase [Bacillus mycoides]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 58-171 2.87e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 86.59  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDLsDFEDEYFDIIVNPVSNLFV 137
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDL-PFPDGSFDLVISSFVLHHL 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1926927208 138 KDVHLVWNEISRVLKNKGIL-ISGFTNPLLWIFDD 171
Cdd:COG2226   101 PDPERALAEIARVLKPGGRLvVVDFSPPDLAELEE 135
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 58-171 2.87e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 86.59  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDLsDFEDEYFDIIVNPVSNLFV 137
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDL-PFPDGSFDLVISSFVLHHL 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1926927208 138 KDVHLVWNEISRVLKNKGIL-ISGFTNPLLWIFDD 171
Cdd:COG2226   101 PDPERALAEIARVLKPGGRLvVVDFSPPDLAELEE 135
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-158 5.10e-21

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 84.64  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  63 LCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLktVQGDMSDLsDFEDEYFDIIVNPVSNLFVKDVHL 142
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTF--VVGDAEDL-PFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*.
gi 1926927208 143 VWNEISRVLKNKGILI 158
Cdd:pfam08241  78 ALREIARVLKPGGILI 93
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 61-161 1.13e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  61 KILCLASGGGQQAPVLAAA-GADVTVTDISKKQLEQDEMVAERDGL-TLKTVQGDMSDLSDFEDEYFD-IIVNPVSNLFV 137
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLAdNVEVLKGDAEELPPEADESFDvIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|....
gi 1926927208 138 KDVHLVWNEISRVLKNKGILISGF 161
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTL 104
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 59-164 2.32e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 47.46  E-value: 2.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  59 GLKILCLASGGGQQAPVLAAAG---ADVTVTDISKKQLE--QDEMVAERDGLTLKTVQGDMSDLSdFEDEYFDIIV---- 129
Cdd:PRK00216   52 GDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAvgREKLRDLGLSGNVEFVQGDAEALP-FPDNSFDAVTiafg 130

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1926927208 130 --NpvsnlfVKDVHLVWNEISRVLKNKGIL-ISGFTNP 164
Cdd:PRK00216  131 lrN------VPDIDKALREMYRVLKPGGRLvILEFSKP 162
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 58-171 2.87e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 86.59  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDLsDFEDEYFDIIVNPVSNLFV 137
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDL-PFPDGSFDLVISSFVLHHL 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1926927208 138 KDVHLVWNEISRVLKNKGIL-ISGFTNPLLWIFDD 171
Cdd:COG2226   101 PDPERALAEIARVLKPGGRLvVVDFSPPDLAELEE 135
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-158 5.10e-21

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 84.64  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  63 LCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLktVQGDMSDLsDFEDEYFDIIVNPVSNLFVKDVHL 142
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTF--VVGDAEDL-PFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*.
gi 1926927208 143 VWNEISRVLKNKGILI 158
Cdd:pfam08241  78 ALREIARVLKPGGILI 93
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 57-158 6.09e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 71.97  E-value: 6.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  57 LEGLKILCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLktVQGDMSDLsDFEDEYFDIIVNpvSNLF 136
Cdd:COG2227    23 PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDF--VQGDLEDL-PLEDGSFDLVIC--SEVL 97

                          90       100
                  ....*....|....*....|....
gi 1926927208 137 --VKDVHLVWNEISRVLKNKGILI 158
Cdd:COG2227    98 ehLPDPAALLRELARLLKPGGLLL 121
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-155 4.02e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.13  E-value: 4.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  62 ILCLASGGGQQAPVLAAA-GADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDLsDFEDEYFDIIV--NPVSNLFVK 138
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDL-PFPDGSFDLVVssGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 1926927208 139 DVHLVWNEISRVLKNKG 155
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 61-161 1.13e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  61 KILCLASGGGQQAPVLAAA-GADVTVTDISKKQLEQDEMVAERDGL-TLKTVQGDMSDLSDFEDEYFD-IIVNPVSNLFV 137
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLAdNVEVLKGDAEELPPEADESFDvIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|....
gi 1926927208 138 KDVHLVWNEISRVLKNKGILISGF 161
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTL 104
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 58-158 3.41e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 52.23  E-value: 3.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAA-GADVTVTDISKKQLEQDEMVAERDGLTLKTV-QGDMSDLSDFEDEYFDIIV------ 129
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGNVEFlVADLAELDPLPAESFDLVVafgvlh 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1926927208 130 --NPVSNLFvkdvhlVWNEISRVLKNKGILI 158
Cdd:COG0500   106 hlPPEEREA------LLRELARALKPGGVLL 130
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 59-164 2.32e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 47.46  E-value: 2.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  59 GLKILCLASGGGQQAPVLAAAG---ADVTVTDISKKQLE--QDEMVAERDGLTLKTVQGDMSDLSdFEDEYFDIIV---- 129
Cdd:PRK00216   52 GDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAvgREKLRDLGLSGNVEFVQGDAEALP-FPDNSFDAVTiafg 130

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1926927208 130 --NpvsnlfVKDVHLVWNEISRVLKNKGIL-ISGFTNP 164
Cdd:PRK00216  131 lrN------VPDIDKALREMYRVLKPGGRLvILEFSKP 162
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-159 7.42e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 44.72  E-value: 7.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLA---AAGADVTVTDISKKQLEQDEMVAERDGLT-LKTVQGDMSDL-SDFEDEYFDIIV-NP 131
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAeelGPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELpELLEDDKFDVVIsNC 82

                          90       100
                  ....*....|....*....|....*...
gi 1926927208 132 VSNLfVKDVHLVWNEISRVLKNKGILIS 159
Cdd:pfam13847  83 VLNH-IPDPDKVLQEILRVLKPGGRLII 109
PRK08317 PRK08317
hypothetical protein; Provisional
 58-155 7.48e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 45.70  E-value: 7.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAA---GADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDLsDFEDEYFDIIVnpVSN 134
Cdd:PRK08317   19 PGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGL-PFPDGSFDAVR--SDR 95

                          90       100
                  ....*....|....*....|...
gi 1926927208 135 LF--VKDVHLVWNEISRVLKNKG 155
Cdd:PRK08317   96 VLqhLEDPARALAEIARVLRPGG 118
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 59-158 1.45e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.15  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  59 GLKILCLASGGGQQAPVLAAA-GADVTVTDISKKQLEQDEMVAERDGLT--LKTVQGDMSDLsdFEDEYFDIIVNP---- 131
Cdd:COG2230    52 GMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAGLAdrVEVRLADYRDL--PADGQFDAIVSIgmfe 129

                          90       100
                  ....*....|....*....|....*...
gi 1926927208 132 -VSNLFVKDVHlvwNEISRVLKNKGILI 158
Cdd:COG2230   130 hVGPENYPAYF---AKVARLLKPGGRLL 154
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 65-157 4.06e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.58  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926927208  65 LASGGGQQAPVLAAA--GADVTVTDISKKQLEQ-DEMVAERDGLTLKTVQGDMSDLSDFEDEYFDIIVnpVSNLF--VKD 139
Cdd:pfam08242   3 IGCGTGTLLRALLEAlpGLEYTGLDISPAALEAaRERLAALGLLNAVRVELFQLDLGELDPGSFDVVV--ASNVLhhLAD 80

                          90
                  ....*....|....*...
gi 1926927208 140 VHLVWNEISRVLKNKGIL 157
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
FabG-like PRK07231
SDR family oxidoreductase;
66-130 2.30e-03

SDR family oxidoreductase;


Pssm-ID: 235975 [Multi-domain]  Cd Length: 251  Bit Score: 38.27  E-value: 2.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926927208  66 ASGGGQQ-APVLAAAGADVTVTDISKKQLEqdEMVAE-RDGLTLKTVQGDMSDLSDFED------EYF---DIIVN 130
Cdd:PRK07231   14 SSGIGEGiARRFAAEGARVVVTDRNEEAAE--RVAAEiLAGGRAIAVAADVSDEADVEAavaaalERFgsvDILVN 87
FabG COG1028
NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and ...
 76-130 2.98e-03

NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism]; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440651 [Multi-domain]  Cd Length: 249  Bit Score: 38.23  E-value: 2.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926927208  76 LAAAGADVTVTDISKKQLEqdEMVAE--RDGLTLKTVQGDMSDLSDFE-------DEY--FDIIVN 130
Cdd:COG1028    26 LAAEGARVVITDRDAEALE--AAAAElrAAGGRALAVAADVTDEAAVEalvaaavAAFgrLDILVN 89
PRK14968 PRK14968
putative methyltransferase; Provisional
 58-131 4.02e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.19  E-value: 4.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926927208  58 EGLKILCLASGGGQQAPVLAAAGADVTVTDISKKQLEQDEMVAERDGLTLKTVQGDMSDL-SDFEDEYFDIIV-NP 131
Cdd:PRK14968   23 KGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSDLfEPFRGDKFDVILfNP 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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