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Conserved domains on  [gi|1933754602|ref|WP_195196436|]
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HPr family phosphocarrier protein, partial [Coprococcus comes]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 2738)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0009401|GO:0008982
PubMed:  12405346
SCOP:  4001693

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTS-HPr_like super family cl00206
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
1-25 9.80e-06

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


The actual alignment was detected with superfamily member TIGR01003:

Pssm-ID: 469657 [Multi-domain]  Cd Length: 82  Bit Score: 36.86  E-value: 9.80e-06
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKL 25
 
Name Accession Description Interval E-value
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
1-25 9.80e-06

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 36.86  E-value: 9.80e-06
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKL 25
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-25 1.34e-05

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 36.59  E-value: 1.34e-05
                         10        20
                 ....*....|....*....|..
gi 1933754602  4 FKYVVTDAQGIHARPAGILVKA 25
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQL 22
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
1-25 3.76e-05

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 35.47  E-value: 3.76e-05
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQL 25
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
1-25 2.31e-04

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 33.52  E-value: 2.31e-04
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:PRK13780   1 MASKDFHITAETGIHARPATLLVQT 25
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
7-25 7.20e-03

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 29.40  E-value: 7.20e-03
                         10
                 ....*....|....*....
gi 1933754602  7 VVTDAQGIHARPAGILVKA 25
Cdd:cd00367    3 TITNPLGLHARPAALLVQL 21
 
Name Accession Description Interval E-value
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
1-25 9.80e-06

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 36.86  E-value: 9.80e-06
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKL 25
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-25 1.34e-05

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 36.59  E-value: 1.34e-05
                         10        20
                 ....*....|....*....|..
gi 1933754602  4 FKYVVTDAQGIHARPAGILVKA 25
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQL 22
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
1-25 3.76e-05

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 35.47  E-value: 3.76e-05
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQL 25
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
1-25 2.31e-04

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 33.52  E-value: 2.31e-04
                         10        20
                 ....*....|....*....|....*
gi 1933754602  1 MKEFKYVVTDAQGIHARPAGILVKA 25
Cdd:PRK13780   1 MASKDFHITAETGIHARPATLLVQT 25
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
7-25 7.20e-03

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 29.40  E-value: 7.20e-03
                         10
                 ....*....|....*....
gi 1933754602  7 VVTDAQGIHARPAGILVKA 25
Cdd:cd00367    3 TITNPLGLHARPAALLVQL 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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