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Conserved domains on  [gi|1942127227|ref|WP_197282373|]
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TatD family hydrolase, partial [Pseudomonas lini]

Protein Classification

TatD family hydrolase( domain architecture ID 1903735)

TatD family hydrolase is a metal-dependent hydrolase similar to Homo sapiens deoxyribonuclease TATDN3

CATH:  3.20.20.140
EC:  3.1.-.-
Gene Ontology:  GO:0046872|GO:0016788|GO:0004536
SCOP:  4002861

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TatD super family cl43021
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
1-70 9.62e-31

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


The actual alignment was detected with superfamily member COG0084:

Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 107.45  E-value: 9.62e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:COG0084    57 AAVGLHPHDAKEHDEEDLAELEELAAHPKVVAIGEIGLDYYRDKSPREVQEEAFRAQLALAKELGLPVII 126
 
Name Accession Description Interval E-value
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
1-70 9.62e-31

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 107.45  E-value: 9.62e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:COG0084    57 AAVGLHPHDAKEHDEEDLAELEELAAHPKVVAIGEIGLDYYRDKSPREVQEEAFRAQLALAKELGLPVII 126
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
1-70 1.89e-30

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 106.68  E-value: 1.89e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:PRK10425   57 STAGVHPHDSSQWQAATEEAIIELAAQPEVVAIGECGLDFNRNFSTPEEQERAFVAQLAIAAELNMPVFM 126
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
 1-70 2.80e-26

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 95.72  E-value: 2.80e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:cd01310    57 AAVGLHPHDADEHVDEDLDLLELLAANPKVVAIGEIGLDYYRDKSPREVQKEVFRAQLELAKELNLPVVI 126
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
 1-70 9.41e-24

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 89.24  E-value: 9.41e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDF-NRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:pfam01026  57 AAVGVHPHEADEASEDDLEALEKLAEHPKVVAIGEIGLDYyYVDESPKEAQEEVFRRQLELAKELGLPVVI 127
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
 1-68 5.28e-17

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 71.52  E-value: 5.28e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPV 68
Cdd:TIGR00010  57 AAVGVHPLDVDDDTKEDIKELERLAAHPKVVAIGETGLDYYKADEYKRRQEEVFRAQLQLAEELNLPV 124
 
Name Accession Description Interval E-value
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
1-70 9.62e-31

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 107.45  E-value: 9.62e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:COG0084    57 AAVGLHPHDAKEHDEEDLAELEELAAHPKVVAIGEIGLDYYRDKSPREVQEEAFRAQLALAKELGLPVII 126
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
1-70 1.89e-30

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 106.68  E-value: 1.89e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:PRK10425   57 STAGVHPHDSSQWQAATEEAIIELAAQPEVVAIGECGLDFNRNFSTPEEQERAFVAQLAIAAELNMPVFM 126
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
 1-70 2.80e-26

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 95.72  E-value: 2.80e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:cd01310    57 AAVGLHPHDADEHVDEDLDLLELLAANPKVVAIGEIGLDYYRDKSPREVQKEVFRAQLELAKELNLPVVI 126
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
 1-70 9.41e-24

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 89.24  E-value: 9.41e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDF-NRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:pfam01026  57 AAVGVHPHEADEASEDDLEALEKLAEHPKVVAIGEIGLDYyYVDESPKEAQEEVFRRQLELAKELGLPVVI 127
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
 1-68 5.28e-17

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 71.52  E-value: 5.28e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPV 68
Cdd:TIGR00010  57 AAVGVHPLDVDDDTKEDIKELERLAAHPKVVAIGETGLDYYKADEYKRRQEEVFRAQLQLAEELNLPV 124
COG1099 COG1099
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
1-68 1.03e-09

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 440716 [Multi-domain]  Cd Length: 260  Bit Score: 51.76  E-value: 1.03e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1942127227   1 ATAGIHPHSASDwNADSDQ---RLRRLLKEPNVVAVGECGLDfnrdfSPRPQQEKVLEEHLAMAVELQLPV 68
Cdd:COG1099    70 CTLGLNPKEANN-RRLAEEvleLLPRYLDKEGVVAIGEIGLD-----DQTPEEEEVFREQLELARELDLPV 134
PRK11449 PRK11449
metal-dependent hydrolase;
1-70 8.50e-09

metal-dependent hydrolase;


Pssm-ID: 171118 [Multi-domain]  Cd Length: 258  Bit Score: 49.58  E-value: 8.50e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1942127227   1 ATAGIHPHSASDWNADSDQRLRRLL--KEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPVFL 70
Cdd:PRK11449   61 AALGLHPGMLEKHSDVSLDQLQQALerRPAKVVAVGEIGLDLFGDDPQFERQQWLLDEQLKLAKRYDLPVIL 132
PRK10812 PRK10812
putative DNAse; Provisional
 4-68 2.80e-06

putative DNAse; Provisional


Pssm-ID: 236767 [Multi-domain]  Cd Length: 265  Bit Score: 42.44  E-value: 2.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1942127227   4 GIHPHSaSDWNADSDQrLRRLLKEPNVVAVGECGLDFNRDFSPRPQQEKVLEEHLAMAVELQLPV 68
Cdd:PRK10812   65 GVHPLN-QDEPYDVEE-LRRLAAEEGVVAMGETGLDYYYTPETKVRQQESFRHHIQIGRELNKPV 127
PTZ00132 PTZ00132
GTP-binding nuclear protein Ran; Provisional
 21-67 9.65e-03

GTP-binding nuclear protein Ran; Provisional


Pssm-ID: 240284 [Multi-domain]  Cd Length: 215  Bit Score: 32.36  E-value: 9.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1942127227  21 LRRLLKEPNVVAVGECGLDFNrDFSPRPQQEKVLEEHLAMAVELQLP 67
Cdd:PTZ00132  164 ARRLTNDPNLVFVGAPALAPE-EIQIDPELVAQAEKELQAAANVPLP 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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