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Conserved domains on  [gi|1946570871|ref|WP_198180977|]
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MULTISPECIES: glucose-6-phosphate dehydrogenase [Lactobacillus]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11481539)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-482 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


:

Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 631.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   1 MNNIPVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHET-HNEVDENDLAAFAS 79
Cdd:PRK05722    5 RTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFaRTPFDEEVWERFLS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  80 HFYYQSHDVTNIEHYETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLT-SSGFNRIVVEKPFGRDLATA 158
Cdd:PRK05722   85 RLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNeGGGWRRVVIEKPFGHDLASA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 159 EELNKQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMV 238
Cdd:PRK05722  165 RELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 239 QNHIFQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQY----LGSDVTFGYRQEPNVAEDSNTETF 314
Cdd:PRK05722  245 QNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYtagwIGGKPVPGYREEEGVNPDSTTETF 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 315 VAGEVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSNQ-----YGMAHSNNISIIIDPQMQIFITINGKK-INESG 388
Cdd:PRK05722  325 VALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNlfeesAEELGPNKLVIRIQPDEGISLRFNAKVpGEGME 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 389 IRREDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSA 468
Cdd:PRK05722  405 LRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGP---PPPYPAGTWGPEAA 481

                         490
                  ....*....|....
gi 1946570871 469 AKIFESPTERWIYE 482
Cdd:PRK05722  482 DALLARDGRSWREP 495
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-482 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 631.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   1 MNNIPVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHET-HNEVDENDLAAFAS 79
Cdd:PRK05722    5 RTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFaRTPFDEEVWERFLS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  80 HFYYQSHDVTNIEHYETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLT-SSGFNRIVVEKPFGRDLATA 158
Cdd:PRK05722   85 RLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNeGGGWRRVVIEKPFGHDLASA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 159 EELNKQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMV 238
Cdd:PRK05722  165 RELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 239 QNHIFQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQY----LGSDVTFGYRQEPNVAEDSNTETF 314
Cdd:PRK05722  245 QNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYtagwIGGKPVPGYREEEGVNPDSTTETF 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 315 VAGEVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSNQ-----YGMAHSNNISIIIDPQMQIFITINGKK-INESG 388
Cdd:PRK05722  325 VALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNlfeesAEELGPNKLVIRIQPDEGISLRFNAKVpGEGME 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 389 IRREDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSA 468
Cdd:PRK05722  405 LRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGP---PPPYPAGTWGPEAA 481

                         490
                  ....*....|....
gi 1946570871 469 AKIFESPTERWIYE 482
Cdd:PRK05722  482 DALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 5-479 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 578.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHE-THNEVDENDLAAFASHFYY 83
Cdd:COG0364     9 PCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEfSRKPFDEEVWERFLERLHY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  84 QSHDVTNIEHYETLKNLAQDLDDRYsAQGNRIFYMAMAPKFFGTIAEHINDQHL-TSSGFNRIVVEKPFGRDLATAEELN 162
Cdd:COG0364    89 VSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLaTEGGWRRVVIEKPFGHDLASARELN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 163 KQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHI 242
Cdd:COG0364   168 DELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 243 FQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQYL-----GSDVTfGYRQEPNVAEDSNTETFVAG 317
Cdd:COG0364   248 LQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTagwigGEPVP-GYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 318 EVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHM-----SNQYGMAHSNNISIIIDPQMQIFITINGKKI-NESGIRR 391
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVphslfRETAEELPPNRLVIRIQPDEGISLRFNAKVPgLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 392 EDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSAAKI 471
Cdd:COG0364   407 VSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEP---PPPYPAGSWGPEAADAL 483


                  ....*...
gi 1946570871 472 FESPTERW 479
Cdd:COG0364   484 LARDGRSW 491
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 5-479 6.98e-167

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 479.89  E-value: 6.98e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHETHNEVDENDLAAFASHFYYQ 84
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  85 SHDVTNIEHYETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLTSSG-FNRIVVEKPFGRDLATAEELNK 163
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 164 QITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIF 243
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 244 QIITLLAMPEPKDLTSQSIHQAKQELLDSMViPNEKEiARHFVRGQYLGSDV----TFGYRQEPNVAEDSNTETFVAGEV 319
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALR-PIDPD-DNNTVRGQYGAGEIggvsVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 320 KFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMS------NQYGMAHSNNISIIIDPQMQIFITINGKKINESGIRRE- 392
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPsllfkaNERDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPv 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 393 --DLSYGfsSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENeqGQEPEQYLPYRMGPKSAAK 470
Cdd:TIGR00871 400 klDFSYA--SRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANK--GPSPPNYPAGSWGPKEADE 475


                  ....*....
gi 1946570871 471 IFESPTERW 479
Cdd:TIGR00871 476 LIRKDGRSW 484
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
190-480 3.17e-105

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 315.15  E-value: 3.17e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 190 LPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIFQIITLLAMPEPKDLTSQSIHQAKQEL 269
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 270 LDSMVIPNEKEIARHFVRGQYL-----GSDVTfGYRQEPNVAEDSNTETFVAGEVKFKKGPLADLPIYFRTGKEMREKKN 344
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGagwigGEPVP-GYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 345 RIDIVLKHMS----NQYGMAHSNNISIIIDPQMQIFITINGKKI-NESGIRREDLSYGFSSDEQKQVPDGYERLLHDVFV 419
Cdd:pfam02781 160 EIRIQFKDVPhnlfRDPGTLPPNELVIRIQPDEGIYLKFNAKVPgLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1946570871 420 NDSTNFTHWSELKNYWKFIDNVEEAWQKEneqgqEPEQYLPYRMGPKSAAKIFESPTERWI 480
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEE-----KPPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-482 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 631.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   1 MNNIPVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHET-HNEVDENDLAAFAS 79
Cdd:PRK05722    5 RTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFaRTPFDEEVWERFLS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  80 HFYYQSHDVTNIEHYETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLT-SSGFNRIVVEKPFGRDLATA 158
Cdd:PRK05722   85 RLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNeGGGWRRVVIEKPFGHDLASA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 159 EELNKQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMV 238
Cdd:PRK05722  165 RELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 239 QNHIFQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQY----LGSDVTFGYRQEPNVAEDSNTETF 314
Cdd:PRK05722  245 QNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYtagwIGGKPVPGYREEEGVNPDSTTETF 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 315 VAGEVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSNQ-----YGMAHSNNISIIIDPQMQIFITINGKK-INESG 388
Cdd:PRK05722  325 VALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNlfeesAEELGPNKLVIRIQPDEGISLRFNAKVpGEGME 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 389 IRREDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSA 468
Cdd:PRK05722  405 LRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGP---PPPYPAGTWGPEAA 481

                         490
                  ....*....|....
gi 1946570871 469 AKIFESPTERWIYE 482
Cdd:PRK05722  482 DALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 5-479 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 578.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHE-THNEVDENDLAAFASHFYY 83
Cdd:COG0364     9 PCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEfSRKPFDEEVWERFLERLHY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  84 QSHDVTNIEHYETLKNLAQDLDDRYsAQGNRIFYMAMAPKFFGTIAEHINDQHL-TSSGFNRIVVEKPFGRDLATAEELN 162
Cdd:COG0364    89 VSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLaTEGGWRRVVIEKPFGHDLASARELN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 163 KQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHI 242
Cdd:COG0364   168 DELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 243 FQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQYL-----GSDVTfGYRQEPNVAEDSNTETFVAG 317
Cdd:COG0364   248 LQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTagwigGEPVP-GYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 318 EVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHM-----SNQYGMAHSNNISIIIDPQMQIFITINGKKI-NESGIRR 391
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVphslfRETAEELPPNRLVIRIQPDEGISLRFNAKVPgLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 392 EDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSAAKI 471
Cdd:COG0364   407 VSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEP---PPPYPAGSWGPEAADAL 483


                  ....*...
gi 1946570871 472 FESPTERW 479
Cdd:COG0364   484 LARDGRSW 491
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 5-479 6.98e-167

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 479.89  E-value: 6.98e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHETHNEVDENDLAAFASHFYYQ 84
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  85 SHDVTNIEHYETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLTSSG-FNRIVVEKPFGRDLATAEELNK 163
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 164 QITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIF 243
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 244 QIITLLAMPEPKDLTSQSIHQAKQELLDSMViPNEKEiARHFVRGQYLGSDV----TFGYRQEPNVAEDSNTETFVAGEV 319
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALR-PIDPD-DNNTVRGQYGAGEIggvsVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 320 KFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMS------NQYGMAHSNNISIIIDPQMQIFITINGKKINESGIRRE- 392
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPsllfkaNERDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPv 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 393 --DLSYGfsSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENeqGQEPEQYLPYRMGPKSAAK 470
Cdd:TIGR00871 400 klDFSYA--SRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANK--GPSPPNYPAGSWGPKEADE 475


                  ....*....
gi 1946570871 471 IFESPTERW 479
Cdd:TIGR00871 476 LIRKDGRSW 484
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
5-482 1.88e-146

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 427.39  E-value: 1.88e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAV-HETHNEVDENDLAAFASHFYY 83
Cdd:PRK12853    8 PCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLrAFGADGFDDAVWDRLAARLSY 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  84 QSHDVTNIEHYETLKnlaqdldDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLTSsGFNRIVVEKPFGRDLATAEELNK 163
Cdd:PRK12853   88 VQGDVTDPADYARLA-------EALGPGGNPVFYLAVPPSLFAPVVENLGAAGLLP-EGRRVVLEKPFGHDLASARALNA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 164 QITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIF 243
Cdd:PRK12853  160 TLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 244 QIITLLAMPEPKDLTSQSIHQAKQELLDSM-VIPNEkeiARHFVRGQY-----LGSDVTfGYRQEPNVAEDSNTETFVAG 317
Cdd:PRK12853  240 QLLALVAMEPPASFDADAVRDEKAKVLRAIrPLDPD---DVHTVRGQYtagtvGGEPVP-GYREEPGVDPDSRTETFVAL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 318 EVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSNQY----GMAHSNNISIIIDPQMQIFITINGkKINESGIRRED 393
Cdd:PRK12853  316 KLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALfrgtGVEPPNRLVIRLQPDEGISLELNV-KRPGPGMRLRP 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 394 LSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKeneQGQEPEQYLPYRMGPKSAAKIFE 473
Cdd:PRK12853  395 VELDADYADDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAA---DPVPPHEYPAGSWGPAAADALLA 471


                  ....*....
gi 1946570871 474 SPTERWIYE 482
Cdd:PRK12853  472 RDGRGWREP 480
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 5-471 9.96e-116

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 348.95  E-value: 9.96e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   5 PVIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHE--THNeVDENDLAAFASHFY 82
Cdd:PRK12854   11 PTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEfgARK-LDDGEWARFAKRLR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  83 YQSHDVTNIEHyETLKNLAQDLDDRYSAQGNRIFYMAMAPKFFGTIAEHINDQHLTSSgfNRIVVEKPFGRDLATAEELN 162
Cdd:PRK12854   90 YVPGGFLSAGP-GALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEG--SRVVMEKPFGTDLASAEALN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 163 KQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHI 242
Cdd:PRK12854  167 AAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 243 FQIITLLAMPEPKDLTSQSIHQAKQELLDSMvipneKEI-ARHFVRGQYLgsdvtfGYRQEPNVAEDSNTETFVAGEVKF 321
Cdd:PRK12854  247 FQVLAFVAMEPPTALEPDAISEEKNKVFRSM-----RPLdPAEVVRGQYS------GYRDEPGVAPDSTTETFVALKVWI 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 322 KKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSN------QYGMAHSNNISIIIDPQMQIFITINGKKINeSGIRREDLS 395
Cdd:PRK12854  316 DNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYsmfpagSVGAQGPDHLTFDLADNSKVSLSFYGKRPG-PGMRLDKLS 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 396 YGFSSDEQKQVPD---GYERLLHDVFVNDSTNFTHwselknywkfIDNVEEAWQKEN---EQGQEPEQYLPYRMGPKSAA 469
Cdd:PRK12854  395 LQFSLKDTGPKGDvleAYERLILDALRGDHTLFTT----------ADGIESLWEVSQpllEDPPPVKPYAPGSWGPNAIH 464


                  ..
gi 1946570871 470 KI 471
Cdd:PRK12854  465 QL 466
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
190-480 3.17e-105

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 315.15  E-value: 3.17e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 190 LPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIFQIITLLAMPEPKDLTSQSIHQAKQEL 269
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 270 LDSMVIPNEKEIARHFVRGQYL-----GSDVTfGYRQEPNVAEDSNTETFVAGEVKFKKGPLADLPIYFRTGKEMREKKN 344
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGagwigGEPVP-GYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 345 RIDIVLKHMS----NQYGMAHSNNISIIIDPQMQIFITINGKKI-NESGIRREDLSYGFSSDEQKQVPDGYERLLHDVFV 419
Cdd:pfam02781 160 EIRIQFKDVPhnlfRDPGTLPPNELVIRIQPDEGIYLKFNAKVPgLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1946570871 420 NDSTNFTHWSELKNYWKFIDNVEEAWQKEneqgqEPEQYLPYRMGPKSAAKIFESPTERWI 480
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEE-----KPPPYPAGSWGPKAADELLARDGRKWR 295
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 6-468 2.49e-103

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 319.00  E-value: 2.49e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   6 VIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVHETHNEVDENDLAAFASHFYYQS 85
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLARFFKRLDDRECHLEQFLKHISYIS 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  86 HDVTNIEHYETLKNLAQDLDDRYSAQ---GNRIFYMAMAPKFFGTIAEHINDQHLTSSGFNRIVVEKPFGRDLATAEELN 162
Cdd:PTZ00309  135 GSYDEDEDFKRLNKLIERMEEAFQGPekgGNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEELS 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 163 KQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHI 242
Cdd:PTZ00309  215 NQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 243 FQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIarhfVRGQYLGSD--VTFGYRQEPNVAEDSNTETFVAGEVK 320
Cdd:PTZ00309  295 LQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEEC----VLGQYTASAdgSIPGYLEDEGVPKDSTTPTFAAAVLH 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 321 FKKGPLADLPIYFRTGKEMREKKNRIDIVLKHMSN--QYGMAHSNNISII-IDPQMQIFITINGKKIN-ESGIRREDLSY 396
Cdd:PTZ00309  371 INNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEfrPSGDDTQRNELVIrAQPSEAMYLKITAKVPGlSNDLHQTELDL 450

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1946570871 397 GFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVEEAWQKENEQgqePEQYLPYRMGPKSA 468
Cdd:PTZ00309  451 TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVK---PEPYPFGSRGPKEA 519
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
9-188 1.37e-91

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 275.84  E-value: 1.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   9 IIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVhETHNEVDENDLAAFASHFYYQSHDV 88
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREAL-KEFKELDEEKWDRFLERLHYVSGDF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  89 TNIEHYETLKNLAQDLDDRysAQGNRIFYMAMAPKFFGTIAEHINDQHLTSS-GFNRIVVEKPFGRDLATAEELNKQITA 167
Cdd:pfam00479  80 DDPESYEKLKERLEEHEDE--TRGNRLFYLAVPPSLFGPIAENLGRAGLSEEgGWRRVVIEKPFGHDLESARELNDQLAK 157

                         170       180
                  ....*....|....*....|.
gi 1946570871 168 SFAEDDIFRIDHYLGKEMIQN 188
Cdd:pfam00479 158 VFKEEQIYRIDHYLGKETVQN 178
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 8-473 1.86e-81

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 260.81  E-value: 1.86e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   8 MIIFGGSGDLAHRKLYPALFNLFEQGLIH-DNFAVIATARRPWSHEYLRDQVSDAVHETHNEvDENDLAAFASHFYYQSH 86
Cdd:PLN02539   20 IIVLGASGDLAKKKTFPALFNLYRQGFLPpDEVHIFGYARSKITDEELRDRIRGYLKDEKNA-PAEAVSKFLQLIKYVSG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  87 DVTNIEHYETL-KNLAQDLDDRYSAQG--NRIFYMAMAPKFFGTIAEHINDQHLTSSG-FNRIVVEKPFGRDLATAEELN 162
Cdd:PLN02539   99 AYDSEEGFRRLdKEISEHEISKNSAEGssRRLFYLALPPSVYPPVCKMIKKCCMNKSGlWTRIVVEKPFGKDLESAEELS 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 163 KQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHI 242
Cdd:PLN02539  179 SQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 243 FQIITLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIarhfVRGQYLgsdvtfGYRQEPNVAEDSNTETFVAGEVKFK 322
Cdd:PLN02539  259 LQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEV----VLGQYE------GYRDDPTVPDDSNTPTFASVVLRIN 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 323 KGPLADLPIYFRTGKEMREKKNRIDIVLKHM-----------SNQYGMahsnniSIIIDPQMQIFITINGKKINESGIRR 391
Cdd:PLN02539  329 NERWEGVPFILKAGKALDSRKAEIRVQFKDVpgdifkcqkqgRNEFVI------RLQPSEAMYMKLTVKQPGLEMSTVQS 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 392 E-DLSYGFSSDEQKqVPDGYERLLHDVFVNDSTNFTHWSELKNYW-------KFIDNveeawqkeneQGQEPEQYLPYRM 463
Cdd:PLN02539  403 ElDLSYGQRYQDVV-IPEAYERLILDTIRGDQQHFVRRDELKAAWeiftpllHRIDA----------GKVKPIPYKQGSR 471

                         490
                  ....*....|
gi 1946570871 464 GPKSAAKIFE 473
Cdd:PLN02539  472 GPAEADELLE 481
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 10-479 5.51e-80

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 259.56  E-value: 5.51e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  10 IFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAV--HETHNEVDENDLAAFASHFYYQSHD 87
Cdd:PLN02640   93 VVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLtcRIDQRENCGDKMDQFLKRCFYHSGQ 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  88 VTNIEHYETL-KNLAQDLDDRYSaqgNRIFYMAMAPKFFGTIAEHINDQHLTSSGFNRIVVEKPFGRDLATAEELNKQIT 166
Cdd:PLN02640  173 YDSEEDFAELnKKLKEKEAGKLS---NRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRCLK 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 167 ASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNHIFQII 246
Cdd:PLN02640  250 QYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQIL 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 247 TLLAMPEPKDLTSQSIHQAKQELLDSMVIPNEKEIARHFVRGQYLGSDVTFGYRQEPNVAEDSNTETFVAGEVKFKKGPL 326
Cdd:PLN02640  330 ALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAAALFINNARW 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 327 ADLPIYFRTGKEMREKKNRIDIVLKHM-SNQYGMAH-------SNNISIIIDPQMQIFITINgKKINESGIR--REDLSY 396
Cdd:PLN02640  410 DGVPFLMKAGKALHTRRAEIRVQFRHVpGNLYKRNFgtdldkaTNELVLRVQPDEAIYLKIN-NKVPGLGMRldRSDLNL 488

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 397 GFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIdnvEEAWQKENEQGQEPEQYlPY-RMGPKSAAKIFESP 475
Cdd:PLN02640  489 LYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALF---TPLLKELEEKKIIPELY-PYgSRGPVGAHYLAAKY 564


                  ....
gi 1946570871 476 TERW 479
Cdd:PLN02640  565 NVRW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 6-479 5.81e-75

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 247.20  E-value: 5.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871   6 VIMIIFGGSGDLAHRKLYPALFNLFEQGLIHDNFAVIATARRPWSHEYLRDQVSDAVH---ETHNEVDENdLAAFASHFY 82
Cdd:PLN02333  118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTcriDKRENCGEK-MEEFLKRCF 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871  83 YQSHDVTNIEHYETL-KNLAQDLDDRYSaqgNRIFYMAMAPKFFGTIAEHINDQHLTSSGFNRIVVEKPFGRDLATAEEL 161
Cdd:PLN02333  197 YHSGQYDSQEHFAELdKKLKEHEGGRVS---NRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSESSAAL 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 162 NKQITASFAEDDIFRIDHYLGKEMIQNILPMRLTNPLIKNIWNNHNIKNVQVTLAEQLGVEARGGYYETSGALRDMVQNH 241
Cdd:PLN02333  274 TKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNH 353

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 242 IFQIITLLAMPEPKDLTSQSIHQAKQELLDSMViPNEKEiarHFVRGQYLG---SDVTF-GYRQEPNVAEDSNTETFVAG 317
Cdd:PLN02333  354 LLQILALFAMETPVSLDAEDIRNEKVKVLRSMR-PIQLE---DVVIGQYKShtkGGVTYpAYTDDKTVPKGSLTPTFAAA 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 318 EVKFKKGPLADLPIYFRTGKEMREKKNRIDIVLKHM-SNQYGM-------AHSNNISIIIDPQMQIFITINgKKINESGI 389
Cdd:PLN02333  430 ALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVpGNLYNRnfgtdldQATNELVIRVQPDEAIYLKIN-NKVPGLGM 508

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946570871 390 R--REDLSYGFSSDEQKQVPDGYERLLHDVFVNDSTNFTHWSELKNYWKFIDNVeeawQKENEQGQEPEQYLPY-RMGPK 466
Cdd:PLN02333  509 RldRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPL----LKELEEKKIIPEYYPYgSRGPV 584

                         490
                  ....*....|...
gi 1946570871 467 SAAKIFESPTERW 479
Cdd:PLN02333  585 GAHYLAARYKVRW 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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