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Conserved domains on  [gi|1949187237|ref|WP_198499229|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Brevibacterium]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
16-156 3.14e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.87  E-value: 3.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949187237  16 REERAQWAWRTYFETSQRIRQELDDRLKEqAGLTVSDYNALLLLWEAPdrTLTMGALAKGLVFSPSRLNYRIKVLEDAGL 95
Cdd:COG1846     5 PDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  96 VEKTTCADDRRSHNVRLTEVGARRFLDAARLHRRAIDEvVLSQVSDEELEIIGTVFSRIAA 156
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
16-156 3.14e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.87  E-value: 3.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949187237  16 REERAQWAWRTYFETSQRIRQELDDRLKEqAGLTVSDYNALLLLWEAPdrTLTMGALAKGLVFSPSRLNYRIKVLEDAGL 95
Cdd:COG1846     5 PDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  96 VEKTTCADDRRSHNVRLTEVGARRFLDAARLHRRAIDEvVLSQVSDEELEIIGTVFSRIAA 156
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
47-144 3.43e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.15  E-value: 3.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949187237   47 GLTVSDYNALLLLWEAPdrTLTMGALAKGLVFSPSRLNYRIKVLEDAGLVEKTTCADDRRSHNVRLTEVGaRRFLDAARL 126
Cdd:smart00347   7 GLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEG-RELIEQLLE 83

                           90
                   ....*....|....*...
gi 1949187237  127 HRRAIDEVVLSQVSDEEL 144
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 47-107 1.41e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 1.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  47 GLTVSDYNALLLLWEAPDrtLTMGALAKGLVFSPSRLNYRIKVLEDAGLVEKTTCADDRRS 107
Cdd:pfam12802   2 GLTPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 90-154 5.25e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 40.76  E-value: 5.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949187237  90 LEDAGLVEKTTCADDRRSHNVRLTEvGARRFLdaarlhrRAIDEVV-------LSQVSDEELEIIGTVFSRI 154
Cdd:PRK03573   70 LEEKGLISRQTCASDRRAKRIKLTE-KAEPLI-------SEVEAVInktraeiLHGISAEEIEQLITLIAKL 133
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
16-156 3.14e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.87  E-value: 3.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949187237  16 REERAQWAWRTYFETSQRIRQELDDRLKEqAGLTVSDYNALLLLWEAPdrTLTMGALAKGLVFSPSRLNYRIKVLEDAGL 95
Cdd:COG1846     5 PDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  96 VEKTTCADDRRSHNVRLTEVGARRFLDAARLHRRAIDEvVLSQVSDEELEIIGTVFSRIAA 156
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
47-144 3.43e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.15  E-value: 3.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949187237   47 GLTVSDYNALLLLWEAPdrTLTMGALAKGLVFSPSRLNYRIKVLEDAGLVEKTTCADDRRSHNVRLTEVGaRRFLDAARL 126
Cdd:smart00347   7 GLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEG-RELIEQLLE 83

                           90
                   ....*....|....*...
gi 1949187237  127 HRRAIDEVVLSQVSDEEL 144
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 47-107 1.41e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 1.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  47 GLTVSDYNALLLLWEAPDrtLTMGALAKGLVFSPSRLNYRIKVLEDAGLVEKTTCADDRRS 107
Cdd:pfam12802   2 GLTPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 48-108 1.19e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.61  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949187237  48 LTVSDYNALLLLWEAPDrtLTMGALAKGLVFSPSRLNYRIKVLEDAGLVEKTTCADDRRSH 108
Cdd:pfam01047   1 LTLTQFHILRILYEHGP--LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 90-154 5.25e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 40.76  E-value: 5.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949187237  90 LEDAGLVEKTTCADDRRSHNVRLTEvGARRFLdaarlhrRAIDEVV-------LSQVSDEELEIIGTVFSRI 154
Cdd:PRK03573   70 LEEKGLISRQTCASDRRAKRIKLTE-KAEPLI-------SEVEAVInktraeiLHGISAEEIEQLITLIAKL 133
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
52-96 6.13e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.18  E-value: 6.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1949187237  52 DYNALLLLWEAPDrtLTMGALAKGLVFSPSRLNYRIKVLEDAGLV 96
Cdd:pfam13412   3 DRKILNLLQENPR--ISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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