MULTISPECIES: helix-turn-helix domain-containing protein [Gammaproteobacteria]
Protein Classification
helix-turn-helix domain-containing protein( domain architecture ID 229396)
helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| HTH_36 super family | cl48226 | Helix-turn-helix domain; |
46-93 | 1.51e-05 | ||
Helix-turn-helix domain; The actual alignment was detected with superfamily member pfam13730: Pssm-ID: 463970 [Multi-domain] Cd Length: 55 Bit Score: 40.55 E-value: 1.51e-05
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| Name | Accession | Description | Interval | E-value | ||
| HTH_36 | pfam13730 | Helix-turn-helix domain; |
46-93 | 1.51e-05 | ||
Helix-turn-helix domain; Pssm-ID: 463970 [Multi-domain] Cd Length: 55 Bit Score: 40.55 E-value: 1.51e-05
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| HTH_MARR | smart00347 | helix_turn_helix multiple antibiotic resistance protein; |
69-100 | 5.35e-04 | ||
helix_turn_helix multiple antibiotic resistance protein; Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 37.57 E-value: 5.35e-04
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| GlpR | COG1349 | DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
63-99 | 5.17e-03 | ||
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism]; Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 35.88 E-value: 5.17e-03
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| WHTH_GntR | cd07377 | Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
72-100 | 5.64e-03 | ||
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences. Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 33.96 E-value: 5.64e-03
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| Name | Accession | Description | Interval | E-value | ||
| HTH_36 | pfam13730 | Helix-turn-helix domain; |
46-93 | 1.51e-05 | ||
Helix-turn-helix domain; Pssm-ID: 463970 [Multi-domain] Cd Length: 55 Bit Score: 40.55 E-value: 1.51e-05
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| GntR | pfam00392 | Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
50-100 | 5.34e-04 | ||
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor. Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 36.44 E-value: 5.34e-04
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| HTH_MARR | smart00347 | helix_turn_helix multiple antibiotic resistance protein; |
69-100 | 5.35e-04 | ||
helix_turn_helix multiple antibiotic resistance protein; Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 37.57 E-value: 5.35e-04
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| HTH_11 | pfam08279 | HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
70-97 | 2.88e-03 | ||
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 34.33 E-value: 2.88e-03
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| GlpR | COG1349 | DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
63-99 | 5.17e-03 | ||
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism]; Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 35.88 E-value: 5.17e-03
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| WHTH_GntR | cd07377 | Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
72-100 | 5.64e-03 | ||
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences. Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 33.96 E-value: 5.64e-03
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