|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
92-446 |
2.56e-83 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 261.41 E-value: 2.56e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 92 LLQSFNALQTYVRHSQYDNKRDVGNYQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKLPISENLIIRQFTLSEL 171
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 172 ISQTFNTQSKQQSILNLTINGETRQYDASTLYHQSGAEGEVMIMLYDLTSVLQIERMQADFLANASHEFKTPLTAITGFV 251
Cdd:COG5002 108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 252 ETLQGPAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRL-KHKADGEVSMIKVSEIVNQQIQKINSQ----RVKIH-N 325
Cdd:COG5002 188 ELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLeSGELKLEKEPVDLAELLEEVVEELRPLaeekGIELElD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 326 AVAEKFEVLGVSEDATTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRK 405
Cdd:COG5002 268 LPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRE 347
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1956131982 406 IaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5002 348 T-GGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-446 |
2.71e-68 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 217.47 E-value: 2.71e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 224 QIERMQADFLANASHEFKTPLTAITGFVETLQGPAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRLKH-KADGEVSM 302
Cdd:COG2205 11 ELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESgKLSLELEP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 303 IKVSEIVNQQIQKINSQ----RVKIHNAVAEKFEVLGVSEDA-TTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVR 377
Cdd:COG2205 91 VDLAELLEEAVEELRPLaeekGIRLELDLPPELPLVYADPELlEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVS 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1956131982 378 DSGIGIPLSQQSRIFERFYRGDESRQRKiasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG2205 171 DNGPGIPEEELERIFERFYRGDNSRGEG---GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
208-446 |
4.62e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 212.08 E-value: 4.62e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 208 AEGEVMIMLYDLTSVLQIERMQADFLANASHEFKTPLTAITGFVETLQGpagDDPKTRAQFLSIVANESQRLSDLVNDIL 287
Cdd:COG0642 89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 288 SLSRLKH-KADGEVSMIKVSEIVNQQIQ----KINSQRVKIHNAVAEKFEVLGVSEDA-TTIIQNLLTNAVKYNVENGEV 361
Cdd:COG0642 166 DLSRLEAgKLELEPEPVDLAELLEEVVElfrpLAEEKGIELELDLPDDLPTVRGDPDRlRQVLLNLLSNAIKYTPEGGTV 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 362 WVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTIT 441
Cdd:COG0642 246 TVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG---GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322
|
....*
gi 1956131982 442 LTLPL 446
Cdd:COG0642 323 VTLPL 327
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
91-446 |
1.94e-58 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 197.49 E-value: 1.94e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 91 DLLQSFNALQTYVRHSQYDNKRDVGNYQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKL---PISEnlIIRQFT 167
Cdd:COG5000 66 ELARAFNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELigkPLEE--LLPELD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 168 LSELISQTFntQSKQQSILNLTINGETRQYDASTLYHQSGAegevMIMLYDLTSVLQIERMQA--DFLANASHEFKTPLT 245
Cdd:COG5000 144 LAELLREAL--ERGWQEEIELTRDGRRTLLVRASPLRDDGY----VIVFDDITELLRAERLAAwgELARRIAHEIKNPLT 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 246 AITGFVETLQ----GPAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRLKHKADGEVSMIK-VSEIVNQQIQKINSQR 320
Cdd:COG5000 218 PIQLSAERLRrklaDKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNElLREVLALYEPALKEKD 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 321 VKIHNAVAEkfEVLGVSEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFY- 396
Cdd:COG5000 298 IRLELDLDP--DLPEVLADRDQLEQvliNLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFt 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1956131982 397 -RgdesrqrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5000 376 tK---------PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
117-446 |
8.24e-52 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 178.50 E-value: 8.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 117 YQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKL---PISEnLIIRQFTLSELISQTFNTQS--KQQSILNLTIN 191
Cdd:COG3852 9 LRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELlgrPLAE-LFPEDSPLRELLERALAEGQpvTEREVTLRRKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 192 GETRQYDAS-TLYHQSGAEGEVMIMLYDLTSVLQIERM--QADFLANAS-------HEFKTPLTAITGFVETLQGPAGDD 261
Cdd:COG3852 88 GEERPVDVSvSPLRDAEGEGGVLLVLRDITERKRLERElrRAEKLAAVGelaaglaHEIRNPLTGIRGAAQLLERELPDD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 262 PKTRaqFLSIVANESQRLSDLVNDILSLSRLKhkaDGEVSMIKVSEIVNQQIQKINS---QRVKIHnavaEKF-----EV 333
Cdd:COG3852 168 ELRE--YTQLIIEEADRLNNLVDRLLSFSRPR---PPEREPVNLHEVLERVLELLRAeapKNIRIV----RDYdpslpEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 334 LGvseDATTIIQ---NLLTNAVKYNVENGE----------VWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGde 400
Cdd:COG3852 239 LG---DPDQLIQvllNLVRNAAEAMPEGGTitirtrverqVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTT-- 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1956131982 401 srqrKiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG3852 314 ----K-EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
231-445 |
1.75e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 162.26 E-value: 1.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 231 DFLANASHEFKTPLTAITGFVETLQGPAGD--DPKTRaQFLSIVANESQRLSDLVNDILSLSRLkHKADGEVSMIKVSEI 308
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGR-EYLERIRDAAERMQALIDDLLAYSRV-GRQELEFEPVDLNEL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 309 VNQQIQ----KINSQRVKIHnaVAEKFEVLGVSEDATTIIQNLLTNAVKYN--VENGEVWVTAKKDKSQWTLSVRDSGIG 382
Cdd:COG4251 362 LEEVLEdlepRIEERGAEIE--VGPLPTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVFSVRDNGIG 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1956131982 383 IPLSQQSRIFERFYRGDESRQRkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:COG4251 440 IDPEYAEKIFEIFQRLHSRDEY---EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
208-445 |
1.99e-43 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 157.86 E-value: 1.99e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 208 AEGEVMIMLYDLTSVLQIERMQADFLANASHEFKTPLTAITGFVETLQGPAGDDPkTRAQFLSIVANESQRLSDLVNDIL 287
Cdd:PRK11006 183 TEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 288 SLSRLK----HKADGEVSMIKVSEIVNQQIQKINSQRVKIHNAVAEKFEVLGVSEDATTIIQNLLTNAVKYNVENGEVWV 363
Cdd:PRK11006 262 TLSKIEaaptIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 364 TAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLT 443
Cdd:PRK11006 342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQ-TGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFV 420
|
..
gi 1956131982 444 LP 445
Cdd:PRK11006 421 LP 422
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
124-446 |
4.78e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 149.74 E-value: 4.78e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 124 LPVGVINVDRHHTIDVFNQKAADLLGVSLPKL---PISEnlIIRQFTLsELISQTFNTQSKQQSILNLTI-----NGETR 195
Cdd:COG5809 150 SPDGIIVTDLDGRIIYANPAACKLLGISIEELigkSILE--LIHSDDQ-ENVAAFISQLLKDGGIAQGEVrfwtkDGRWR 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 196 QYDAS-TLYHQSGAEGEVMIMLYDLTSVLQIERM--QAD-------FLANASHEFKTPLTAITGFVETLQGPAGDDpktR 265
Cdd:COG5809 227 LLEASgAPIKKNGEVDGIVIIFRDITERKKLEELlrKSEklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEE---Q 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 266 AQFLSIVANESQRLSDLVNDILSLSRLKhkaDGEVSMIKVSEIVNQQIQKINSQ----RVKIHNAVAEKF-EVLGVSEDA 340
Cdd:COG5809 304 KTYLDIMLSELDRIESIISEFLVLAKPQ---AIKYEPKDLNTLIEEVIPLLQPQallkNVQIELELEDDIpDILGDENQL 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 341 TTIIQNLLTNAVKYNVENGEVWV-TAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYrgdeSRQRKiasGTGLGLAIVNE 419
Cdd:COG5809 381 KQVFINLLKNAIEAMPEGGNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFY----TTKEK---GTGLGLMVSYK 453
|
330 340
....*....|....*....|....*..
gi 1956131982 420 IVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5809 454 IIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
343-446 |
3.46e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 137.01 E-value: 3.46e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRkiASGTGLGLAIVNEIVT 422
Cdd:smart00387 9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRK--IGGTGLGLSIVKKLVE 86
|
90 100
....*....|....*....|....
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:smart00387 87 LHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
343-444 |
2.25e-38 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 134.27 E-value: 2.25e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiasGTGLGLAIVNEIVT 422
Cdd:cd00075 4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG---GTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTL 444
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
223-446 |
5.81e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 138.78 E-value: 5.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 223 LQIERMQAdfL----ANASHEFKTPLTAITGFVETLQG--PAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRlkhKA 296
Cdd:COG4191 134 VQSEKLAA--LgelaAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSR---RD 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 297 DGEVSMIKVSEIVNQQIQ----KINSQRVKIHNAVAEkfEVLGVSEDATTIIQ---NLLTNAVK--YNVENGEVWVTAKK 367
Cdd:COG4191 209 EEEREPVDLNELIDEALEllrpRLKARGIEVELDLPP--DLPPVLGDPGQLEQvllNLLINAIDamEEGEGGRITISTRR 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1956131982 368 DKSQWTLSVRDSGIGIPLSQQSRIFERFYRgdesrQRKIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG4191 287 EGDYVVISVRDNGPGIPPEVLERIFEPFFT-----TKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
112-446 |
1.19e-36 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 142.03 E-value: 1.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 112 RDVGNY-QTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKL---PISEnLIIRQFTLSELISQTF--NTQSKQQSI 185
Cdd:PRK11360 258 RETRSLnELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELvgkPYSE-LFPPNTPFASPLLDTLehGTEHVDLEI 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 186 LNLTINGETRQYDASTLYHqsGAEGEVM---IMLYDLT-------SVLQIERMQA--DFLANASHEFKTPLTAITGFVET 253
Cdd:PRK11360 337 SFPGRDRTIELSVSTSLLH--NTHGEMIgalVIFSDLTerkrlqrRVARQERLAAlgELVAGVAHEIRNPLTAIRGYVQI 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 254 LQGPAGDDPKTRaqFLSIVANESQRLSDLVNDILSLSRLKHkadgeVSMIKVSeiVNQQIQK--------INSQRVKIHN 325
Cdd:PRK11360 415 WRQQTSDPPSQE--YLSVVLREVDRLNKVIDQLLEFSRPRE-----SQWQPVS--LNALVEEvlqlfqtaGVQARVDFET 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 326 AVAEkfEVLGVSEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKS-QWTLSVRDSGIGIPLSQQSRIFERFYRGDes 401
Cdd:PRK11360 486 ELDN--ELPPIWADPELLKQvllNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELLKKIFDPFFTTK-- 561
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1956131982 402 rqrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK11360 562 -----AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
104-446 |
7.71e-36 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 135.68 E-value: 7.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 104 RHSQYDNKRDVGNYQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSlpklpiSENLIIRQFTLSELISQTFNTQSKQQ 183
Cdd:COG5807 16 NQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLS------QNEYIGKTFVEEKCILKDEQLYNKEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 184 SILNL----TINGETRQYDAStLYHQSGAEGEVMIMLYDLT-------SVLQIERMQA--DFLANASHEFKTPLTAITGF 250
Cdd:COG5807 90 FDRIEisylTKNGEFDEIIYP-IYYKDGVILGLITVYRDITkrkeaedKLLRSEKLSVagELAAGIAHEIRNPLTSIKGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 251 VETLQGPAGDDpkTRAQFLSIVANESQRLSDLVNDILSLSRlKHKADgeVSMIKVSEIVNQQIQKINSQRVKIHNAVAEK 330
Cdd:COG5807 169 LQLLQESREDS--EREEYFNIIISEIDRINTIITELLVLSK-PKKFN--FKKLNLNDVLEDVIALLSTEAILKNISIKYD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 331 F--EVLGVSEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESrqrk 405
Cdd:COG5807 244 LadDEPVINGDKNQLKQvfiNLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEE---- 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1956131982 406 iasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5807 320 ---GTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
238-446 |
4.64e-35 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 135.74 E-value: 4.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 238 HEFKTPLTAITGFVETLQGPAgdDPKTRAQFLSIVANESQRLSDLVNDILSLSRL-KHKADGEVSMIKVSEIVNQQIQKI 316
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLeQRQELEVLEPVALAALLEELVEAR 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 317 NSQRVKIHNAVAEKFEVLGVSEDA---TTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFE 393
Cdd:PRK11100 343 EAQAAAKGITLRLRPDDARVLGDPfllRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1956131982 394 RFY---RGDESRqrkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK11100 423 RFYslpRPANGR-----KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
335-446 |
2.52e-34 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 124.02 E-value: 2.52e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 335 GVSEDATTIIQNLLTNAVKYNVENGEVWVTAKKDkSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiaSGTGLGL 414
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG----GGTGLGL 75
|
90 100 110
....*....|....*....|....*....|..
gi 1956131982 415 AIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
89-446 |
1.09e-31 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 124.96 E-value: 1.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 89 YYDLLQSFNALQTYVRHSQYDNKRDVGNYQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKLPISENLIIRQFTL 168
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 169 SELISQTFNTQSKQQSILNLTINGETRQYDASTLYHQsgaegEVMIMLYDLTSVlqieRMQADFLANASHEFKTPLTAIT 248
Cdd:COG3290 138 ERDEEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRT-----ELERLEEELEGV----KELAEALRAQRHDFRNHLHTIS 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 249 GFVETlqgpaGDDPKTRaQFLSIVANESQRLSDLVndilsLSRLKHKAdgevsmikVSEIVNQQIQKINSQRVKIHNAVA 328
Cdd:COG3290 209 GLLQL-----GEYDEAL-EYIDEISEELQELIDSL-----LSRIGNPV--------LAALLLGKAARARERGIDLTIDID 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 329 EKFEVLGVSE-DATTIIQNLLTNAV----KYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERfyrGDESrq 403
Cdd:COG3290 270 SDLPDLPLSDtDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER---GFST-- 344
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1956131982 404 rKIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG3290 345 -KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
343-446 |
1.70e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 116.44 E-value: 1.70e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNvENGEVWVTAKKDKS-----QWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIV 417
Cdd:cd16922 4 ILLNLLGNAIKFT-EEGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRK-YGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 1956131982 418 NEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
226-446 |
8.81e-31 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 123.59 E-value: 8.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 226 ERMQADFLANASHEFKTPLTAITGFVETLQ-GPAGDDPKTRAQFLSIVANesqrLSDLVNDI--LSLSRLkhkadGEVSM 302
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQdGVRKFTPESVASLQAEVGT----LTKLVDDLhqLSLSDE-----GALAY 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 303 IKVSEIVNQQIQ--------KINSQRVKIHNAVAEKFEVLGVSEDATTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTL 374
Cdd:PRK10549 308 RKTPVDLVPLLEvaggafreRFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRL 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1956131982 375 SVRDSGIGIPLSQQSRIFERFYRGDESRQRkiAS-GTGLGLAIVNEIVTKHNGRLQVK-SQVGvGTTITLTLPL 446
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSRNR--ASgGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELPL 458
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
117-446 |
2.67e-29 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 119.84 E-value: 2.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 117 YQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKLpISENLI-IRQFTLSELISQTFN--TQSKQQSILN---LTI 190
Cdd:COG5805 159 LQTLIENSPDLICVIDTDGRILFINESIERLFGAPREEL-IGKNLLeLLHPCDKEEFKERIEsiTEVWQEFIIEreiITK 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 191 NGETRQYDA--STLYHQSGAEGEVMIMLYDLTSVLQIERM--QADFLANA-------SHEFKTPLTAITGFVETLQGpag 259
Cdd:COG5805 238 DGRIRYFEAviVPLIDTDGSVKGILVILRDITEKKEAEELmaRSEKLSIAgqlaagiAHEIRNPLTSIKGFLQLLQP--- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 260 dDPKTRAQFLSIVANESQRLSDLVNDILSLSrlKHKADGEVsMIKVSEIVNQQIQKINSQrVKIHNAVAEKF---EVLGV 336
Cdd:COG5805 315 -GIEDKEEYFDIMLSELDRIESIISEFLALA--KPQAVNKE-KENINELIQDVVTLLETE-AILHNIQIRLElldEDPFI 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 337 SEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESrqrkiasGTGLG 413
Cdd:COG5805 390 YCDENQIKQvfiNLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK-------GTGLG 462
|
330 340 350
....*....|....*....|....*....|...
gi 1956131982 414 LAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5805 463 LMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
227-445 |
5.68e-29 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 118.26 E-value: 5.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 227 RMQADFLANASHEFKTPLTAITGFVETlqgpAGDDPKTRAQFLSIVAN---ESQRLSDLVNDILSLSRLKHkadGEVSMI 303
Cdd:TIGR01386 239 QRLSQFSADLAHELRTPLTNLLGQTQV----ALSQPRTGEEYREVLESnleELERLSRMVSDMLFLARADN---GQLALE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 304 KVSEIVNQQIQKinsqrvkihnaVAEKFEVLGvsEDATTIIQ-------------------NLLTNAVKYNVENGEVWVT 364
Cdd:TIGR01386 312 RVRLDLAAELAK-----------VAEYFEPLA--EERGVRIRvegeglvrgdpqmfrraisNLLSNALRHTPDGGTITVR 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 365 AKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTKHNGRLQVKSQVGvGTTITLTL 444
Cdd:TIGR01386 379 IERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNS-GEGTGLGLAIVRSIMEAHGGRASAESPDG-KTRFILRF 456
|
.
gi 1956131982 445 P 445
Cdd:TIGR01386 457 P 457
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
222-446 |
1.01e-27 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 113.81 E-value: 1.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 222 VLQIERMQA--DFLANASHEFKTPLTAITGFVETLQGPAGDDPKtRAQFLSIVANESQRLSDLVNDILSLSRlkhKADGE 299
Cdd:COG5806 192 LQRAEKLEVvsELAASIAHEVRNPLTVVRGFIQLLQEPELSDEK-RKQYIRIALEELDRAEAIITDYLTFAK---PQPEK 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 300 VSMIKVSEIVNQQIQKI----NSQRVKIHNAVAEKFEVLGvseDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKSQW 372
Cdd:COG5806 268 LEKIDVSEELEHVIDVLspyaNMNNVEIQTELEPGLYIEG---DRQKLQQcliNIIKNGIEAMPNGGTLTIDVSIDKNKV 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1956131982 373 TLSVRDSGIGIPLSQQSRIFERFYRGDEsrqrkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG5806 345 IISIKDTGVGMTKEQLERLGEPYFSTKE-------KGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
2.49e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 102.02 E-value: 2.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYN--VENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDesrQRKIASGTGLGLAIVNEI 420
Cdd:cd16921 4 VLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1956131982 421 VTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
234-446 |
4.04e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 109.88 E-value: 4.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 234 ANASHEFKTPLTAITGFVETL--QGPAGDDPKTRAQflsIVANESQRLSDLVNDILSLSRLKHKAdgeVSMIKVSEIVNQ 311
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFaeRAPAGGEAHQLAQ---VMAKEADRLNRVVSELLELVKPTHLA---LQAVDLNDLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 312 QIQKI----NSQRVKIHNAVAEKFEVLGVSED-ATTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLS 386
Cdd:PRK10364 316 SLQLVsqdaNSREIQLRFTANDTLPEIQADPDrLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAAD 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 387 QQSRIFERFYRGDesrqrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK10364 396 QLEAIFTPYFTTK-------AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
1.64e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 100.23 E-value: 1.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVT 422
Cdd:cd16946 8 LFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRA-SGGSGLGLAICHNIAL 86
|
90 100
....*....|....*....|....
gi 1956131982 423 KHNGRLQVK-SQVGvGTTITLTLP 445
Cdd:cd16946 87 AHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
222-446 |
1.18e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 105.78 E-value: 1.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 222 VLQIERM---QADFLANASHEFKTPLTAITGFVETLQGPAGDDPKtraqfLSIVANESQRLSDLVNDILSLSRLKHKADG 298
Cdd:PRK09470 233 VTALERMmtsQQRLLSDISHELRTPLTRLQLATALLRRRQGESKE-----LERIETEAQRLDSMINDLLVLSRNQQKNHL 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 299 EVSMIKVSEIVNQQIQ--KINSQRVKIH---NAVAEKFEVLGVSEDATTIIQNLLTNAVKYNveNGEVWVTAKKDKSQWT 373
Cdd:PRK09470 308 ERETFKANSLWSEVLEdaKFEAEQMGKSltvSAPPGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLT 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1956131982 374 LSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTKHNGRLQV-KSQVGvGTTITLTLPL 446
Cdd:PRK09470 386 ITVDDDGPGVPEEEREQIFRPFYRVDEARDRE-SGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLPL 457
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-445 |
3.04e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 96.50 E-value: 3.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTK 423
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRN-TGGTGLGLAIVKHVMSR 83
|
90 100
....*....|....*....|..
gi 1956131982 424 HNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16952 84 HDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-446 |
5.17e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.95 E-value: 5.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 346 NLLTNAVKYNVENGEVWV-TAKKDKSQWtLSVRDSGIGIPLSQQSRIFERFYRgdesrQRKIASGTGLGLAIVNEIVTKH 424
Cdd:cd16943 10 NLLVNAAQAMEGRGRITIrTWAHVDQVL-IEVEDTGSGIDPEILGRIFDPFFT-----TKPVGEGTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|..
gi 1956131982 425 NGRLQVKSQVGVGTTITLTLPL 446
Cdd:cd16943 84 GGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-446 |
1.41e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 94.70 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYNveNGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTK 423
Cdd:cd16949 5 LENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRE-SGGTGLGLAIAERAIEQ 81
|
90 100
....*....|....*....|...
gi 1956131982 424 HNGRLQVKSQVGVGTTITLTLPL 446
Cdd:cd16949 82 HGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
226-446 |
1.46e-21 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 97.83 E-value: 1.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 226 ERMQA--DFLANASHEFKTPLTAITGFVETLQGPAGDDPKTRAQFLSIVaNESQRLSDLVNDILSLSRlkhKADGEVSMI 303
Cdd:PRK13837 445 RRLEAvgTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEII-SAGARARLIIDQILAFGR---KGERNTKPF 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 304 KVSEIVnqqiQKINSQ-RVKIHNAVAEKFE-------VLGVSEDATTIIQNLLTNAVKYNVENGEV-------WVTAKKD 368
Cdd:PRK13837 521 DLSELV----TEIAPLlRVSLPPGVELDFDqdqepavVEGNPAELQQVLMNLCSNAAQAMDGAGRVdislsraKLRAPKV 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 369 KSQWT--------LSVRDSGIGIPLSQQSRIFERFYrgdESRqrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTI 440
Cdd:PRK13837 597 LSHGVlppgryvlLRVSDTGAGIDEAVLPHIFEPFF---TTR----AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRF 669
|
....*.
gi 1956131982 441 TLTLPL 446
Cdd:PRK13837 670 DVYLPP 675
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
224-446 |
3.31e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 96.63 E-value: 3.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 224 QIERMQA---DFLANASHEFKTPLTAITGFVETLQ-GPAgdDPKTRaQFLSIVANESQRLSDLVNDILSLSRLKhkADG- 298
Cdd:PRK15347 390 RAEQANKrksEHLTTISHEIRTPLNGVLGALELLQnTPL--TAEQM-DLADTARQCTLSLLAIINNLLDFSRIE--SGQm 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 299 EVSMIKVS--EIVNQQIQKINSQ--------RVKIHNAVAEKFEVlgvseDATTIIQ---NLLTNAVKYNvENGEVWVTA 365
Cdd:PRK15347 465 TLSLEETAllPLLDQAMLTIQGPaqsksltlRTFVGAHVPLYLHL-----DSLRLRQilvNLLGNAVKFT-ETGGIRLRV 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 366 KKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:PRK15347 539 KRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ-----GTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
.
gi 1956131982 446 L 446
Cdd:PRK15347 614 L 614
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
224-445 |
3.55e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 94.63 E-value: 3.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 224 QIERMQAdflanasHEFKTPLTAITGFVETLQG-----PAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSR-----LK 293
Cdd:PRK09303 153 RVLAMLA-------HDLRTPLTAASLALETLELgqideDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRtrweaLR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 294 HKADgEVSMIKVS-EIVNQQIQKINSQRVKIHNAVAEkfEVLGVSEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDK 369
Cdd:PRK09303 226 FNPQ-KLDLGSLCqEVILELEKRWLAKSLEIQTDIPS--DLPSVYADQERIRQvllNLLDNAIKYTPEGGTITLSMLHRT 302
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1956131982 370 SQWT-LSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:PRK09303 303 TQKVqVSICDTGPGIPEEEQERIFEDRVRLPRDEG---TEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
343-445 |
5.50e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 87.55 E-value: 5.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEV-WVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKIAsGTGLGLAIVNEIV 421
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIrCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHG-GTGLGLSIVKEFV 86
|
90 100
....*....|....*....|....
gi 1956131982 422 TKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16925 87 ELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
218-446 |
1.23e-20 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 95.19 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 218 DLTSVLQIERMQA--------DFLANASHEFKTPLTAITGFVETLQGpAGDDPKTRAQFLSIVANESQRLSDLVNDILSL 289
Cdd:PRK09959 693 DLIHALEVERNKAinatvaksQFLATMSHEIRTPISSIMGFLELLSG-SGLSKEQRVEAISLAYATGQSLLGLIGEILDV 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 290 SRLKH-KADGEVSMIKVSEIVNQQ------IQKINSQRVKIHNAVAEKFEVLGVSEDATTIIQNLLTNAVKYNVEnGEVW 362
Cdd:PRK09959 772 DKIESgNYQLQPQWVDIPTLVQNTchsfgaIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTE-GAVK 850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 363 VTAK-----KDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVG 437
Cdd:PRK09959 851 ITTSlghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQ---TGSGLGLMICKELIKNMQGDLSLESHPGIG 927
|
....*....
gi 1956131982 438 TTITLTLPL 446
Cdd:PRK09959 928 TTFTITIPV 936
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
2.43e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 85.80 E-value: 2.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKIAsgTGLGLAIVNEIVT 422
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQES--TGMGLYLVKKLCD 86
|
90 100
....*....|....*....|...
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16948 87 KLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
223-446 |
4.98e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 93.18 E-value: 4.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 223 LQIERMQA--DFLANASHEFKTPLTAITGFVE--TLQGPAGDDPKT------RAQFLSIvanesqrlSDLVNDILSLSRL 292
Cdd:PRK10490 656 LASEREQLrnALLAALSHDLRTPLTVLFGQAEilTLDLASEGSPHArqaseiRQQVLNT--------TRLVNNLLDMARI 727
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 293 KhkaDGEVSMIK----VSEIVNQQIQKINSQRVKIHNAVAEKFEVLGVSEDATTI---IQNLLTNAVKYNVENGEVWVTA 365
Cdd:PRK10490 728 Q---SGGFNLRKewltLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFervLINLLENAVKYAGAQAEIGIDA 804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 366 KKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGD-ESrqrkIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTL 444
Cdd:PRK10490 805 HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNkES----AIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
|
..
gi 1956131982 445 PL 446
Cdd:PRK10490 881 PL 882
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
229-445 |
8.83e-20 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 91.37 E-value: 8.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 229 QADFLANASHEFKTPLTAITGFVETLQGPAgDDPKTRAQFLSIVANESQRLSDLVNDILSLSrlkhKADgevsmikvsei 308
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIALSQS-RSQKELEDVLYSNLEELTRMAKMVSDMLFLA----QAD----------- 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 309 vNQQI---QKINSQRVKIHNaVAEKFEVLGVSEDAT------------------TIIQNLLTNAVKYNVENGEVWVTAKK 367
Cdd:PRK09835 326 -NNQLipeKKMLDLADEVGK-VFDFFEAWAEERGVElrfvgdpcqvagdplmlrRAISNLLSNALRYTPAGEAITVRCQE 403
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1956131982 368 DKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTKHNGRLQVKSQVgVGTTITLTLP 445
Cdd:PRK09835 404 VDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRK-GEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
232-429 |
1.68e-19 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 90.48 E-value: 1.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 232 FLANASHEFKTPLTAITGFVETLQgPAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRLKHKAD-GEVSMIKVSEIVN 310
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEVAQ-LSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNlQDVAEIPLEDLLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 311 QQIQKI--NSQRVKIH---NAVAEKFEVLGVSEDATTIIQNLLTNAVKYNVENGEVWVTAKKDksqwTLSVRDSGIGIPL 385
Cdd:PRK10337 319 SAVMDIyhTAQQAGIDvrlTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTP 394
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1956131982 386 SQQSRIFERFYR--GDEsrqrkiASGTGLGLAIVNEIVTKHNGRLQ 429
Cdd:PRK10337 395 EALARIGERFYRppGQE------ATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
227-446 |
2.60e-19 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 90.68 E-value: 2.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 227 RMQADFLANASHEFKTPLTAITGFvetlqgpagddpkTRaQFLSIVANESQR------------LSDLVNDILSLSRLK- 293
Cdd:PRK11107 291 RIKSEFLANMSHELRTPLNGVIGF-------------TR-QTLKTPLTPTQRdylqtiersannLLAIINDILDFSKLEa 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 294 ------------HKADGEVSMI-------KVSEIVnqqiqkinsqrVKIHNAVAEkfevlGVSEDAT---TIIQNLLTNA 351
Cdd:PRK11107 357 gklvlenipfslRETLDEVVTLlahsaheKGLELT-----------LNIDPDVPD-----NVIGDPLrlqQIITNLVGNA 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 352 VKYNvENGEVWV-----TAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKIAsGTGLGLAIVNEIVTKHNG 426
Cdd:PRK11107 421 IKFT-ESGNIDIlvelrALSNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHG-GTGLGLVITQKLVNEMGG 498
|
250 260
....*....|....*....|
gi 1956131982 427 RLQVKSQVGVGTTITLTLPL 446
Cdd:PRK11107 499 DISFHSQPNRGSTFWFHLPL 518
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
221-446 |
1.24e-18 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 87.66 E-value: 1.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 221 SVLQIERMQADFLANASHEFKTPLTAITGFVETLqgPAGDDpktraqFL--SIVANesqrlSDLVNDILS--LSRLKHKA 296
Cdd:PRK09467 221 GIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMM--SEEDG------YLaeSINKD-----IEECNAIIEqfIDYLRTGQ 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 297 DGEVSMIKVSEIVNQQIQKINSQRVKIHNAVAE-KFEVLGVSEDATTIIQNLLTNAVKYNveNGEVWVTAKKDKSQWTLS 375
Cdd:PRK09467 288 EMPMEMADLNALLGEVIAAESGYEREIETALQPgPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQ 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1956131982 376 VRDSGIGIPLSQQSRIFERFYRGDESRQrkiASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK09467 366 VEDDGPGIPPEQLKHLFQPFTRGDSARG---SSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
227-446 |
1.65e-18 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 88.46 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 227 RMQADFLANASHEFKTPLTAITGFVETLQgpagDDPKTRAQF--LSIVANESQRLSDLVNDILSLSRLKHKadgevsmiK 304
Cdd:PRK11091 281 RDKTTFISTISHELRTPLNGIVGLSRILL----DTELTAEQRkyLKTIHVSAITLGNIFNDIIDMDKMERR--------K 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 305 VsEIVNQQIQKIN--SQRVKIHNAVAE------KFEVLG-----VSEDAT---TIIQNLLTNAVKYNVEnGEVWVTAKKD 368
Cdd:PRK11091 349 L-QLDNQPIDFTDflADLENLSGLQAEqkglrfDLEPLLplphkVITDGTrlrQILWNLISNAVKFTQQ-GGVTVRVRYE 426
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1956131982 369 KSQ-WTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK11091 427 EGDmLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
4.78e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.03 E-value: 4.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNveNGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiASGTGLGLAIVNEIVT 422
Cdd:cd16950 4 VLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG---TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
226-446 |
7.00e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 7.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 226 ERMQADFLANASHEFKTPLTAITGFVETLqgpaGDDPKTRAQ--FLSIVANESQRLSDLVNDILSLSRLkhKADGevSMI 303
Cdd:PRK11466 441 SQAKSAFLAAMSHEIRTPLYGILGTAQLL----ADNPALNAQrdDLRAITDSGESLLTILNDILDYSAI--EAGG--KNV 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 304 KVSEIVNQQIQKINSQRVKIHNAVAEKFEVLG--VSEDATT-----------IIQNLLTNAVKYnVENGEVWVTAKKDKS 370
Cdd:PRK11466 513 SVSDEPFEPRPLLESTLQLMSGRVKGRPIRLAtdIADDLPTalmgdprrirqVITNLLSNALRF-TDEGSIVLRSRTDGE 591
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1956131982 371 QWTLSVRDSGIGIPLSQQSRIFERFYRGDESRqrkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK11466 592 QWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR-----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-445 |
1.18e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 78.20 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 346 NLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiASGTGLGLAIVNEIVTKHN 425
Cdd:cd16923 7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN---TEGAGLGLSIAKAIIELHG 83
|
90 100
....*....|....*....|
gi 1956131982 426 GRLQVKSQvGVGTTITLTLP 445
Cdd:cd16923 84 GSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-444 |
2.40e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 77.45 E-value: 2.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 346 NLLTNAVKYNVENGEVWVT-AKKDKSQwtLSVRDSGIGIPLSQQSRIFERFYRGDESRqrkiASGTGLGLAIVNEIVTKH 424
Cdd:cd16940 20 NLVDNAVRYSPQGSRVEIKlSADDGAV--IRVEDNGPGIDEEELEALFERFYRSDGQN----YGGSGLGLSIVKRIVELH 93
|
90 100
....*....|....*....|
gi 1956131982 425 NGRLQVKSQVGVGTTITLTL 444
Cdd:cd16940 94 GGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-446 |
5.51e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 76.31 E-value: 5.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYnvENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTK 423
Cdd:cd16939 5 LDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRA-TGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|....
gi 1956131982 424 HNGRLQV-KSQVGvGTTITLTLPL 446
Cdd:cd16939 82 HGGHVECdDSELG-GACFRLTWPR 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-444 |
5.93e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 75.96 E-value: 5.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVK--YNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRgdesrQRKIASGTGLGLAIVNEI 420
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGKGTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 1956131982 421 VTKHNGRLQVKSQVGVGTTITLTL 444
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-442 |
7.34e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 75.96 E-value: 7.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYR--GDESRQRKiasgTGLGLAIVNEIV 421
Cdd:cd16945 9 INNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlpRPHSGQKS----TGLGLAFVQEVA 84
|
90 100
....*....|....*....|..
gi 1956131982 422 TKHNGRLQVKS-QVGVGTTITL 442
Cdd:cd16945 85 QLHGGRITLRNrPDGVLAFLTL 106
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
232-446 |
8.76e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 83.10 E-value: 8.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 232 FLANASHEFKTPLTAITGFVETLQGPAgdDPKTRAQFLSIVANESQRLSDLVNDILSLSrlkhKADGEVSMIKVSEIVNQ 311
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLLQTKE--LPKGVDRLVTAMNNSSSLLLKIISDILDFS----KIESEQLKIEPREFSPR 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 312 Q-IQKINSQRVKIhnaVAEKfeVLG------------VSEDAT---TIIQNLLTNAVKYNvENGEVWVTAKKDKSQWTLS 375
Cdd:PRK10841 524 EvINHITANYLPL---VVKK--RLGlycfiepdvpvaLNGDPMrlqQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFR 597
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1956131982 376 VRDSGIGIPLSQQSRIFERFYRGDESRQRKIaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK10841 598 VRDTGVGIPAKEVVRLFDPFFQVGTGVQRNF-QGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
346-446 |
9.42e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 81.96 E-value: 9.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 346 NLLTNAVKYNveNGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiASGTGLGLAIVNEIVTKHN 425
Cdd:PRK10604 326 NLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRA-TGGCGLGLAIVHSIALAMG 402
|
90 100
....*....|....*....|.
gi 1956131982 426 GRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK10604 403 GSVNCDESELGGARFSFSWPV 423
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-430 |
3.92e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 74.59 E-value: 3.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 332 EVLGvsedattiiqNLLTNAVKYNveNGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiasGTG 411
Cdd:cd16954 40 ELLG----------NLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP-----GQG 102
|
90
....*....|....*....
gi 1956131982 412 LGLAIVNEIVTKHNGRLQV 430
Cdd:cd16954 103 LGLAIAKEIVEQYGGELSL 121
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
226-291 |
7.26e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 71.86 E-value: 7.26e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1956131982 226 ERMQADFLANASHEFKTPLTAITGFVETLQGPAGDDPKTRaQFLSIVANESQRLSDLVNDILSLSR 291
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
228-294 |
1.24e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 71.09 E-value: 1.24e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1956131982 228 MQADFLANASHEFKTPLTAITGFVETLQgpAGDDPKTRAQFLSIVANESQRLSDLVNDILSLSRLKH 294
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLR--DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
228-294 |
1.82e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 70.67 E-value: 1.82e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1956131982 228 MQADFLANASHEFKTPLTAITGFVETLQGPAGDDPKtrAQFLSIVANESQRLSDLVNDILSLSRLKH 294
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
343-446 |
2.76e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 74.28 E-value: 2.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVEN----GEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDEsrqrkiasGTGLGLAIVN 418
Cdd:COG2972 340 ILQPLVENAIEHGIEPkeggGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE--------GRGIGLRNVR 411
|
90 100 110
....*....|....*....|....*....|.
gi 1956131982 419 EIVTKHNG---RLQVKSQVGVGTTITLTLPL 446
Cdd:COG2972 412 ERLKLYYGeeyGLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-442 |
1.04e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 67.10 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 341 TTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKiaSGTGLGLAIVNEI 420
Cdd:cd16975 6 SRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG--GHYGMGLYIAKNL 83
|
90 100
....*....|....*....|..
gi 1956131982 421 VTKHNGRLQVKSQVGVGTTITL 442
Cdd:cd16975 84 VEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-445 |
1.15e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 66.93 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 342 TIIQNLLTNAV----KYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRkiasgtGLGLAIV 417
Cdd:cd16915 3 TIVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER------GIGLALV 76
|
90 100
....*....|....*....|....*...
gi 1956131982 418 NEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16915 77 RQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
2.71e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 65.88 E-value: 2.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVK----YNVENGEVWV-TAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDesrqrkiASGTGLGLAIV 417
Cdd:cd16920 4 VLINLVRNGIEamseGGCERRELTIrTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK-------SEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 1956131982 418 NEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-444 |
3.39e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 66.00 E-value: 3.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRQRKIaSGTGLGLAIVNEIVT 422
Cdd:cd16947 24 ILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAK-QGNGLGLTITKRLAE 102
|
90 100
....*....|....*....|..
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTL 444
Cdd:cd16947 103 SMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
118-445 |
4.03e-13 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 71.10 E-value: 4.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 118 QTLLTSLPVGVINVDRHHTIDVFNQKAADLLGV--SLPKLPISENL--IIRQFTLSELISQTFNTQSKQQSILNLTI--- 190
Cdd:PRK11086 224 QAMLQSIKEGVIAVDDRGEVTLINDEAKRLFNYkkGLEDDPLGTDVesWMPVSRLKEVLRTGTPRRDEEININGRLLltn 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 191 ------NGETrqydastlyhqSGAegevmIMLY-DLTSVLQ-IER-----MQADFLANASHEFKTPLTAITGFVETlqgp 257
Cdd:PRK11086 304 tvpvrvNGEI-----------IGA-----IATFrDKTEVRQlAQRldgmvNYADALRAQSHEFMNKLHVILGLLHL---- 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 258 agddpKTRAQF----LSIVANESQRLSDLVNDILS-------LSRLKHKADGEVSMIkVSEivNQQIQKINSQRVkIHna 326
Cdd:PRK11086 364 -----KSYDQLedyiLKTANNYQEEIGSLLGKIKSpviagflLGKISRARELGITLI-ISE--DSQLPDSGDEDQ-VH-- 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 327 vaekfevlgvseDATTIIQNLLTNAVKY--NVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFY--RGDesr 402
Cdd:PRK11086 433 ------------ELITILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYstKGS--- 497
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1956131982 403 qrkiasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:PRK11086 498 ------NRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
374-445 |
4.39e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 65.48 E-value: 4.39e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1956131982 374 LSVRDSGIGIPLSQQSRIFERFYRGDEsrqrkIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFFTTKE-----VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
279-446 |
1.52e-12 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 69.16 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 279 LSDLVNDILSLSRLkHK---ADGEVSMIKVSEIVNQQIQKI----NSQRVKIHNAVAEkfevLGVSEDATT----IIQNL 347
Cdd:COG3920 333 LEESQNRIQALALV-HEllyQSEDWEGVDLRDYLRELLEPLrdsyGGRGIRIELDGPD----VELPADAAVplglILNEL 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 348 LTNAVKY---NVENGEVWVTAKKDKSQWTLSVRDSGIGIPlsqqsrifERFyrgdesrqrKIASGTGLGLAIVNEIVTKH 424
Cdd:COG3920 408 VTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLP--------EDV---------DPPARKGLGLRLIRALVRQL 470
|
170 180
....*....|....*....|..
gi 1956131982 425 NGRLQVKSqvGVGTTITLTLPL 446
Cdd:COG3920 471 GGTLELDR--PEGTRVRITFPL 490
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
219-431 |
3.67e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 67.30 E-value: 3.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 219 LTSVLQIERMqadFLANASHEFKTPLTAITGFVETL--QGPAGDDPktraqflsIVANESQrLSDLVNDILSLSRLKHK- 295
Cdd:PRK10755 130 LTSTLDQERL---FTADVAHELRTPLAGIRLHLELLekQHHIDVAP--------LIARLDQ-MMHTVEQLLQLARAGQSf 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 296 ADGEVSMIK-VSEIVNQQIQKINS------QRVKIHNAVAEkfevLGVSEDAT---TIIQNLLTNAVKYNVENGEVWVTA 365
Cdd:PRK10755 198 SSGHYQTVKlLEDVILPSQDELSEmleqrqQTLLLPESAAD----ITVQGDATllrLLLRNLVENAHRYSPEGSTITIKL 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1956131982 366 KKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDesrQRkiASGTGLGLAIVNEIVTKHNGRLQVK 431
Cdd:PRK10755 274 SQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SR--YGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
343-446 |
2.73e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 63.48 E-value: 2.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYnVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQqsriferfyrgdesrqrkiASGTGLGLAIVNEIVT 422
Cdd:COG4585 166 IVQEALTNALKH-AGATRVTVTLEVDDGELTLTVRDDGVGFDPEA-------------------APGGGLGLRGMRERAE 225
|
90 100
....*....|....*....|....
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG4585 226 ALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
237-445 |
8.58e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 63.92 E-value: 8.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 237 SHEFKTPLTAITGFVETLQG----PAGDDPKTRAQFLSIvANESQRLSDLVNDILSLSRlKHKADGEV-SMIKVSEIVNQ 311
Cdd:PRK13557 171 AHDFNNLLQVMSGYLDVIQAalshPDADRGRMARSVENI-RAAAERAATLTQQLLAFAR-KQRLEGRVlNLNGLVSGMGE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 312 QIQKINSQRVKIHNAVAEKFEVLGV-SEDATTIIQNLLTNA---------VKYNVENGEVwvtAKKDKSQW--------- 372
Cdd:PRK13557 249 LAERTLGDAVTIETDLAPDLWNCRIdPTQAEVALLNVLINArdampeggrVTIRTRNVEI---EDEDLAMYhglppgryv 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1956131982 373 TLSVRDSGIGIPLSQQSRIFERFYRGDESRQrkiasGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:PRK13557 326 SIAVTDTGSGMPPEILARVMDPFFTTKEEGK-----GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-445 |
1.57e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.18 E-value: 1.57e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1956131982 373 TLSVRDSGIGIPLSQQSRIFERFYRGDESrqrkiasGTGLGLAIVNEIVTKHNGRLQVKSQVGvGTTITLTLP 445
Cdd:cd16918 45 RVSVIDNGPGIPPDLQDTIFYPMVSGREN-------GTGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
334-428 |
1.27e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 60.03 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 334 LGVSEDATTIIQNLLTNAVKYNVENGEVwvTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRGDESRqrkiaSGTGLG 413
Cdd:PRK10815 373 VGEKNDFMEVMGNVLDNACKYCLEFVEI--SARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLR-----PGQGLG 445
|
90
....*....|....*
gi 1956131982 414 LAIVNEIVTKHNGRL 428
Cdd:PRK10815 446 LSVAREITEQYEGKI 460
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-428 |
1.29e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.66 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNV-ENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFERFYRgDESRQRKIASGTGLGLAIVNEIV 421
Cdd:cd16953 4 VLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAFGQHSGLGLSISRQII 82
|
....*..
gi 1956131982 422 TKHNGRL 428
Cdd:cd16953 83 EAHGGIS 89
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-445 |
8.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.92 E-value: 8.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 339 DATTIIQ---NLLTNAVKyNVEN-----GEVWVTAKKDKSQW-TLSVRDSGIGIPLSQQSRIFERfYRGDESRqrkiasG 409
Cdd:cd16944 1 DTTQISQvltNILKNAAE-AIEGrpsdvGEVRIRVEADQDGRiVLIVCDNGKGFPREMRHRATEP-YVTTRPK------G 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 1956131982 410 TGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
323-446 |
1.04e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 53.38 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 323 IHNAVAEKFEVLGVSE----DATTIIQNLLTNAVKY---NVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIFErf 395
Cdd:COG2172 14 ARRAVRALLRELGLDEddadDLVLAVSEAVTNAVRHaygGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-- 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1956131982 396 yrgdesrqrkIASGTGLGLAIVNEIVTkhngRLQVKSQVGvGTTITLTLPL 446
Cdd:COG2172 92 ----------TLAEGGRGLFLIRRLMD----EVEYESDPG-GTTVRLVKRL 127
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-445 |
2.32e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 51.02 E-value: 2.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYNvENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRiferfyrgdesrqrkiasGTGLGLAIVNEIVT 422
Cdd:cd16917 4 IVQEALTNALKHA-GASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG------------------GGGFGLLGMRERAE 64
|
90 100
....*....|....*....|...
gi 1956131982 423 KHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16917 65 LLGGTLTIGSRPGGGTRVTARLP 87
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
408-446 |
6.54e-07 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 51.72 E-value: 6.54e-07
10 20 30
....*....|....*....|....*....|....*....
gi 1956131982 408 SGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:COG0643 380 SGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
118-446 |
9.09e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.46 E-value: 9.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 118 QTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKL---PISEnlIIRQFTLS-ELISQTFNT-QSKQQSILNLTING 192
Cdd:PRK11073 10 GQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLfgtPLPE--LLSYFSLNiELMRESLQAgQGFTDNEVTLVIDG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 193 ETR--QYDASTLYHQsgaegevmIMLYDLTSVLQIERMQADFLANA------------SHEFKTPLTAITGFVETLQgPA 258
Cdd:PRK11073 88 RSHilSLTAQRLPEG--------MILLEMAPMDNQRRLSQEQLQHAqqvaardlvrglAHEIKNPLGGLRGAAQLLS-KA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 259 GDDPKTRaQFLSIVANESQRLSDLVNDILSLSRL-KHKADgevSMIKVSEIVNQQIQKINSQRVKIHNAVAEKF-EVLGV 336
Cdd:PRK11073 159 LPDPALT-EYTKVIIEQADRLRNLVDRLLGPQRPgTHVTE---SIHKVAERVVQLVSLELPDNVRLIRDYDPSLpELAHD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 337 SEDATTIIQNLLTNAVKYNVENGEVWVTAKKDKSQWTL-----------SVRDSGIGIPLSQQSRIFERFYRGDESrqrk 405
Cdd:PRK11073 235 PDQIEQVLLNIVRNALQALGPEGGTITLRTRTAFQLTLhgeryrlaariDIEDNGPGIPPHLQDTLFYPMVSGREG---- 310
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1956131982 406 iasGTGLGLAIVNEIVTKHNGRLQVKSQVGvGTTITLTLPL 446
Cdd:PRK11073 311 ---GTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLPI 347
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
232-446 |
1.38e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 50.70 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 232 FLANASHEFKTPLTAITGFVETLQGPagDDPKTRAQFLSIVANESQRLSDLVNDILSLSRLK------HKADGEVSMIkV 305
Cdd:PRK10618 453 FLQNIGDELKQPLQSLAQLAAQLRQT--SDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLEtqdwkpEQELFSLQDL-I 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 306 SEIVNQQIQKINSQRVK--IHNAVAEKFEVLGVSEDATTIIQNLLTNAVKyNVENGEVWVTAKKDKS---QWTLSVRDSG 380
Cdd:PRK10618 530 DEVLPEVLPAIKRKGLQllIHNHLKAEQLRIGDRDALRKILLLLLNYAIT-TTAYGKITLEVDQDESspdRLTIRILDTG 608
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1956131982 381 IGIPLSQQSRIfeRFYRGDESRQRKIASGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLPL 446
Cdd:PRK10618 609 AGVSIKELDNL--HFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-445 |
1.95e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 43.19 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKY----NVENGEVWVTAKKDKSQWTLSVRDSGIGiplsqqsriferfYRGDESRQRKIASGTGLGLAIVNE 419
Cdd:cd16956 6 LQPIVENAVKHglsgLLDGGRVEITARLDGQHLLLEVEDNGGG-------------MDPDTLARILIRSSNGLGLNLVDK 72
|
90 100
....*....|....*....|....*....
gi 1956131982 420 IVTK---HNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16956 73 RLRQafgNDYGLDIECAPGEGTRITIRLP 101
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
339-443 |
2.10e-05 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 44.07 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 339 DATTIIQNLLTNAVKY---NVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRifERFYRGDESRQRkiasgTGLGLA 415
Cdd:cd16942 38 EIKTVVSEAVTNAIIHgynNDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEAR--QPLFTTKPELER-----SGMGFT 110
|
90 100
....*....|....*....|....*...
gi 1956131982 416 IVNEIVTKhngrLQVKSQVGVGTTITLT 443
Cdd:cd16942 111 IMENFMDE----VIVESEVNKGTTVYLK 134
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
408-445 |
4.58e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 43.72 E-value: 4.58e-05
10 20 30
....*....|....*....|....*....|....*...
gi 1956131982 408 SGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16916 141 SGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
237-445 |
8.55e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 45.06 E-value: 8.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 237 SHEFKTPLTAITGFVETLQGPAGDDPKTRAQ-FLSIVANESQRLSDLVNDILSLSRlkhKADGEVSMIKVSEIVNQQIQK 315
Cdd:COG4192 441 AHELNQPLNAMSMYLFSAKKALEQENYAQLPtSLDKIEGLIERMDKIIKSLRQFSR---KSDTPLQPVDLRQVIEQAWEL 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 316 INSqRVKIHNAVAEKFEVLGVSEDATTIIQ---NLLTNAVKYNVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQqsRIF 392
Cdd:COG4192 518 VES-RAKPQQITLHIPDDLMVQGDQVLLEQvlvNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLF 594
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1956131982 393 ERFYRGDEsrqrkiaSGTGLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:COG4192 595 TPFTTTKE-------VGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-445 |
2.09e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.49 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYNV----ENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRIferfyrGDESRQRKiaSGTGLGLAIVNE 419
Cdd:cd16957 6 LQVLVENAIRHAFpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL------GKTTVTSE--KGTGTALENLNR 77
|
90 100
....*....|....*....|....*....
gi 1956131982 420 IVTKHNGR---LQVKSQVGVGTTITLTLP 445
Cdd:cd16957 78 RLIGLFGSeacLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-445 |
2.88e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 40.86 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 337 SEDATTI---IQNLLTNAVKY---NVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSriferfyrgdesrqrkiASGT 410
Cdd:cd16951 34 SEVATAIglvVNELLQNALKHafsDREGGTITIRSVVDGDYLRITVIDDGVGLPQDEDW-----------------PNKG 96
|
90 100 110
....*....|....*....|....*....|....*
gi 1956131982 411 GLGLAIVNEIVTKHNGRLQVKSQVGVGTTITLTLP 445
Cdd:cd16951 97 SLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
117-161 |
6.47e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.91 E-value: 6.47e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1956131982 117 YQTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVSLPKLPISENL 161
Cdd:pfam13188 3 LRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELL 47
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-445 |
1.64e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 37.81 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 344 IQNLLTNAVKYNVE----NGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRiferfyrgdesRQRKIASGTGLGLAIVNE 419
Cdd:cd16924 6 LQPLVENAIQHGLSpltdKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNI-----------LGKKPKEGNGIGLYNVHQ 74
|
90 100
....*....|....*....|....*....
gi 1956131982 420 IVTKHNGR---LQVKSQVGVGTTITLTLP 445
Cdd:cd16924 75 RLILLFGEdygIHIASEPDKGTRITFTIP 103
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
118-217 |
3.14e-03 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 39.79 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 118 QTLLTSLPVGVINVDRHHTIDVFNQKAADLLGVS---LPKLPISEnlIIRQFTLSE-LISQTFNTQSkqqsiLNLTINGE 193
Cdd:COG3283 83 DALLEALPDPVFSIDLKGKIELANPAALSLLGLSeeeLIGQPLSE--LLKGFNFSRwLESNEPRPQS-----ERVVINGQ 155
|
90 100
....*....|....*....|....*...
gi 1956131982 194 TRQYDASTLYHQSGAEGEV----MIMLY 217
Cdd:COG3283 156 DYLADILPIYLPDEEGKSIlagaVVTLK 183
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
343-446 |
5.85e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 38.81 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1956131982 343 IIQNLLTNAVKYnVENGEVWVTAKKDKSQWTLSVRDSGIGIPLSQQSRiferfyrgdesrqrkiasgtGLGLAIVNEIVT 422
Cdd:PRK11644 414 VCQEGLNNIVKH-ADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ--------------------GFGLRGMRERVT 472
|
90 100
....*....|....*....|....
gi 1956131982 423 KHNGRLQVKSQvgVGTTITLTLPL 446
Cdd:PRK11644 473 ALGGTLTISCT--HGTRLSVSLPQ 494
|
|
| |
