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Conserved domains on  [gi|1957511203|ref|WP_200906448|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Gulbenkiania]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-65 2.16e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.44  E-value: 2.16e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGD 65
Cdd:NF033788   5 FKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLAD 69
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-65 2.16e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.44  E-value: 2.16e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGD 65
Cdd:NF033788   5 FKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLAD 69
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-79 4.14e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.18  E-value: 4.14e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVLKMMREVF 79
Cdd:COG0640   14 FKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-72 1.35e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 74.64  E-value: 1.35e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1957511203  2 KAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVL 72
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAERLLAL 72
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
11-76 1.45e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.85  E-value: 1.45e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1957511203  11 KIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVLKMMR 76
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 6-50 1.19e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 1.19e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1957511203  6 HPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVL 50
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 2-63 8.51e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.27  E-value: 8.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1957511203   2 KAMSHPLRLKIISVLADQ-EVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRV 63
Cdd:PRK10141   11 KILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-65 2.16e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.44  E-value: 2.16e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGD 65
Cdd:NF033788   5 FKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLAD 69
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-79 4.14e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.18  E-value: 4.14e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVLKMMREVF 79
Cdd:COG0640   14 FKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-72 1.35e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 74.64  E-value: 1.35e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1957511203  2 KAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVL 72
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAERLLAL 72
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
11-76 1.45e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.85  E-value: 1.45e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1957511203  11 KIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGDIRTLEVLKMMR 76
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-54 7.33e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 58.05  E-value: 7.33e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1957511203  1 MKAMSHPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRK 54
Cdd:COG4189   13 LKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 6-50 1.19e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 1.19e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1957511203  6 HPLRLKIISVLADQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVL 50
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 2-55 4.41e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.53  E-value: 4.41e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1957511203  2 KAMSHPLRLKIISVLA-DQEVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKD 55
Cdd:pfam12840  5 EALADPTRLRILRALVgDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 2-63 8.51e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.27  E-value: 8.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1957511203   2 KAMSHPLRLKIISVLADQ-EVSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRV 63
Cdd:PRK10141   11 KILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
11-65 1.14e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 43.33  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1957511203  11 KIISVLADQE-VSVQDIVEQVGTSQSNISQHLAIMRDKGVLRTRKDANRVFYRVGD 65
Cdd:COG3398   101 RILLYLLENPgATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
PRK06474 PRK06474
hypothetical protein; Provisional
 1-51 3.47e-03

hypothetical protein; Provisional


Pssm-ID: 235811  Cd Length: 178  Bit Score: 34.34  E-value: 3.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1957511203   1 MKA--MSHPLRLKIISVLAD--QEVSVQDIVEQVG-TSQSNISQHLAIMRDKGVLR 51
Cdd:PRK06474    3 NKAeiLMHPVRMKICQVLMRnkEGLTPLELVKILKdVPQATLYRHLQTMVDSGILH 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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