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Conserved domains on  [gi|1957657632|ref|WP_201045984|]
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XRE family transcriptional regulator [Streptomyces sp. MBT55]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10611723)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator; also contains a DUF2690 domain

CATH:  1.10.260.40
Gene Ontology:  GO:0003677
PubMed:  10473770|8831795|15808743|2644244
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2690 super family cl12482
Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.
 301-382 3.76e-19

Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.


The actual alignment was detected with superfamily member pfam10901:

Pssm-ID: 402475  Cd Length: 86  Bit Score: 81.40  E-value: 3.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957657632 301 CAGQDPEAMGCGGEFARTVATAVVGGSKVEVRYSKVCSAAWARLTEAAIGDTVQIT---GGADPQNGEVMGD-TDAYTPM 376
Cdd:pfam10901   1 CDGEDPDATMCARDGRTVKTTTVVGGSVVELRYSPTCRAAWAKFWLARSGDTYEVTsrgGDGVLVAGYPADDsKSTYTPM 80


                  ....*.
gi 1957657632 377 VAVKKA 382
Cdd:pfam10901  81 VFVLSP 86
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 17-74 1.64e-08

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


:

Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 50.60  E-value: 1.64e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1957657632  17 EFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGR-LLAPRGAVVALAEVTGTPQH 74
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVDGA 59
 
Name Accession Description Interval E-value
DUF2690 pfam10901
Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.
 301-382 3.76e-19

Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.


Pssm-ID: 402475  Cd Length: 86  Bit Score: 81.40  E-value: 3.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957657632 301 CAGQDPEAMGCGGEFARTVATAVVGGSKVEVRYSKVCSAAWARLTEAAIGDTVQIT---GGADPQNGEVMGD-TDAYTPM 376
Cdd:pfam10901   1 CDGEDPDATMCARDGRTVKTTTVVGGSVVELRYSPTCRAAWAKFWLARSGDTYEVTsrgGDGVLVAGYPADDsKSTYTPM 80


                  ....*.
gi 1957657632 377 VAVKKA 382
Cdd:pfam10901  81 VFVLSP 86
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 17-74 1.64e-08

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 50.60  E-value: 1.64e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1957657632  17 EFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGR-LLAPRGAVVALAEVTGTPQH 74
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVDGA 59
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-72 4.40e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 40.96  E-value: 4.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1957657632   22 LRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTP 72
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVS 52
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 19-72 1.25e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.46  E-value: 1.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1957657632  19 ASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTP 72
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVS 54
Spo0J COG1475
Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, ...
 9-115 4.53e-03

Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441084 [Multi-domain]  Cd Length: 241  Bit Score: 38.43  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957657632   9 EELDPqiREFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLngRLLA--------------PRGAVVALAEVTGtPQH 74
Cdd:COG1475   101 EDLNP--LEEARAYQRLLEEFGLTQEEIAERLGKSRSEVSNLL--RLLKlppevqealregklSLGHARALAALSD-PER 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1957657632  75 HLTTMWELAERAWSRAEMRHDMTMEAIRITQARAALGELGT 115
Cdd:COG1475   176 QEELAEKIIEEGLSVRETEELVKALAKDLARLERRLSELGT 216
 
Name Accession Description Interval E-value
DUF2690 pfam10901
Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.
 301-382 3.76e-19

Protein of unknown function (DUF2690); This bacterial family of proteins has no known function.


Pssm-ID: 402475  Cd Length: 86  Bit Score: 81.40  E-value: 3.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957657632 301 CAGQDPEAMGCGGEFARTVATAVVGGSKVEVRYSKVCSAAWARLTEAAIGDTVQIT---GGADPQNGEVMGD-TDAYTPM 376
Cdd:pfam10901   1 CDGEDPDATMCARDGRTVKTTTVVGGSVVELRYSPTCRAAWAKFWLARSGDTYEVTsrgGDGVLVAGYPADDsKSTYTPM 80


                  ....*.
gi 1957657632 377 VAVKKA 382
Cdd:pfam10901  81 VFVLSP 86
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 17-74 1.64e-08

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 50.60  E-value: 1.64e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1957657632  17 EFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGR-LLAPRGAVVALAEVTGTPQH 74
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVDGA 59
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-72 4.40e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 40.96  E-value: 4.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1957657632   22 LRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTP 72
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVS 52
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 19-72 1.25e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.46  E-value: 1.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1957657632  19 ASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTP 72
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVS 54
Spo0J COG1475
Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, ...
 9-115 4.53e-03

Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441084 [Multi-domain]  Cd Length: 241  Bit Score: 38.43  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957657632   9 EELDPqiREFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLngRLLA--------------PRGAVVALAEVTGtPQH 74
Cdd:COG1475   101 EDLNP--LEEARAYQRLLEEFGLTQEEIAERLGKSRSEVSNLL--RLLKlppevqealregklSLGHARALAALSD-PER 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1957657632  75 HLTTMWELAERAWSRAEMRHDMTMEAIRITQARAALGELGT 115
Cdd:COG1475   176 QEELAEKIIEEGLSVRETEELVKALAKDLARLERRLSELGT 216
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
16-72 5.21e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 35.74  E-value: 5.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1957657632  16 REFASQLRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTP 72
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVS 62
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 22-76 5.50e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 35.34  E-value: 5.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1957657632  22 LRRLVDRSGLNINAVADRTGYSKTSWERYLNGRLLAPRGAVVALAEVTGTPQHHL 76
Cdd:pfam12844   4 LRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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