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Conserved domains on  [gi|1957683921|ref|WP_201069906|]
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HAMP domain-containing sensor histidine kinase, partial [Bacillus sp. TH13]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KinB super family cl47425
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 14-180 1.96e-86

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5806:

Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 259.80  E-value: 1.96e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSE-AVIVGNKQHFQQCFLNLIKNSI 92
Cdd:COG5806   245 EELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPgLYIEGDRQKLQQCLINIIKNGI 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  93 EAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGTT 172
Cdd:COG5806   325 EAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTT 404


                  ....*...
gi 1957683921 173 LTITFPKY 180
Cdd:COG5806   405 FTITLPLA 412
 
Name Accession Description Interval E-value
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 14-180 1.96e-86

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 259.80  E-value: 1.96e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSE-AVIVGNKQHFQQCFLNLIKNSI 92
Cdd:COG5806   245 EELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPgLYIEGDRQKLQQCLINIIKNGI 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  93 EAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGTT 172
Cdd:COG5806   325 EAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTT 404


                  ....*...
gi 1957683921 173 LTITFPKY 180
Cdd:COG5806   405 FTITLPLA 412
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
14-178 2.95e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 115.84  E-value: 2.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNLIKNS 91
Cdd:PRK11360  433 REVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINA 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  92 IEAMPNGGTLNIS-SSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKG 170
Cdd:PRK11360  513 VQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592


                  ....*...
gi 1957683921 171 TTLTITFP 178
Cdd:PRK11360  593 TTFTLYLP 600
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 75-179 3.09e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.56  E-value: 3.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   75 GNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK-----TKGTGLGTMV 149
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1957683921  150 AVKIIETMHGSLKIRSIVSKGTTLTITFPK 179
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 75-178 1.15e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 87.42  E-value: 1.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  75 GNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNsKVEIRIEDSGVGMSQEQIHRFGEPYFS---TKTKGTGLGTMVAV 151
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 1957683921 152 KIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 82-178 1.12e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 84.78  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  82 QCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT--KGTGLGTMVAVKIIETMHG 159
Cdd:cd16943     6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGG 85

                          90
                  ....*....|....*....
gi 1957683921 160 SLKIRSIVSKGTTLTITFP 178
Cdd:cd16943    86 TIRVASVPGGGTRFTIILP 104
 
Name Accession Description Interval E-value
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 14-180 1.96e-86

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 259.80  E-value: 1.96e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSE-AVIVGNKQHFQQCFLNLIKNSI 92
Cdd:COG5806   245 EELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPgLYIEGDRQKLQQCLINIIKNGI 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  93 EAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGTT 172
Cdd:COG5806   325 EAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTT 404


                  ....*...
gi 1957683921 173 LTITFPKY 180
Cdd:COG5806   405 FTITLPLA 412
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 14-179 1.32e-47

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 161.82  E-value: 1.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNLIKNS 91
Cdd:COG5805   328 SELDRIESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDpfIYCDENQIKQVFINLIKNA 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  92 IEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGT 171
Cdd:COG5805   408 IEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487


                  ....*...
gi 1957683921 172 TLTITFPK 179
Cdd:COG5805   488 TFTITLPL 495
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 13-185 4.41e-47

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 160.14  E-value: 4.41e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  13 MEELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNLIKN 90
Cdd:COG5809   311 LSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIpdILGDENQLKQVFINLLKN 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  91 SIEAMPNGGTLNIS-SSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSK 169
Cdd:COG5809   391 AIEAMPEGGNITIEtKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGK 470

                         170
                  ....*....|....*.
gi 1957683921 170 GTTLTITFPKYSKNTH 185
Cdd:COG5809   471 GTTFSITLPIKLSEQV 486
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 9-179 1.72e-46

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 157.43  E-value: 1.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   9 IRKQMEELNRaqeIIDDYLTFAK-PAPEKSDqISVKQELNRVINMIFPLCNMNTIHITQDFSEA--VIVGNKQHFQQCFL 85
Cdd:COG5000   248 IIRQVDRLKR---IVDEFLDFARlPEPQLEP-VDLNELLREVLALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLI 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRS 165
Cdd:COG5000   324 NLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELES 403

                         170
                  ....*....|....
gi 1957683921 166 IVSKGTTLTITFPK 179
Cdd:COG5000   404 RPGGGTTFTIRLPL 417
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
14-183 1.07e-43

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 148.46  E-value: 1.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMI---FPlcnmNTIHITQDFSEAV--IVGNKQHFQQCFLNLI 88
Cdd:COG3852   178 EEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLraeAP----KNIRIVRDYDPSLpeVLGDPDQLIQVLLNLV 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  89 KNSIEAMPNGGTLNISSSI----------NNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMH 158
Cdd:COG3852   254 RNAAEAMPEGGTITIRTRVerqvtlgglrPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHG 333

                         170       180
                  ....*....|....*....|....*
gi 1957683921 159 GSLKIRSIVSKGTTLTITFPKYSKN 183
Cdd:COG3852   334 GTIEVESEPGKGTTFRIYLPLEQAE 358
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 5-178 8.20e-43

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 146.10  E-value: 8.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   5 IASNIRKQMEELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQ 82
Cdd:COG4191   180 LREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLppVLGDPGQLEQ 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  83 CFLNLIKNSIEAMPNG--GTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK--TKGTGLGTMVAVKIIETMH 158
Cdd:COG4191   260 VLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKpvGKGTGLGLSISYGIVEKHG 339

                         170       180
                  ....*....|....*....|
gi 1957683921 159 GSLKIRSIVSKGTTLTITFP 178
Cdd:COG4191   340 GRIEVESEPGGGTTFTITLP 359
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
14-179 1.09e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 134.65  E-value: 1.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAK----PAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNL 87
Cdd:COG0642   152 RSADRLLRLINDLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNL 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  88 IKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK----TKGTGLGTMVAVKIIETMHGSLKI 163
Cdd:COG0642   232 LSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsrrGGGTGLGLAIVKRIVELHGGTIEV 311

                         170
                  ....*....|....*.
gi 1957683921 164 RSIVSKGTTLTITFPK 179
Cdd:COG0642   312 ESEPGKGTTFTVTLPL 327
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
14-179 3.70e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 115.39  E-value: 3.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEK----SDQISVKQELNRVINMIFPLCNMNTIHITQDFSE--AVIVGNKQHFQQCFLNL 87
Cdd:COG2205    61 ESAERLLRLIEDLLDLSRLESGKlsleLEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPelPLVYADPELLEQVLANL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  88 IKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF----STKTKGTGLGTMVAVKIIETMHGSLKI 163
Cdd:COG2205   141 LDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWV 220

                         170
                  ....*....|....*.
gi 1957683921 164 RSIVSKGTTLTITFPK 179
Cdd:COG2205   221 ESEPGGGTTFTVTLPL 236
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
14-178 2.95e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 115.84  E-value: 2.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNLIKNS 91
Cdd:PRK11360  433 REVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINA 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  92 IEAMPNGGTLNIS-SSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKG 170
Cdd:PRK11360  513 VQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592


                  ....*...
gi 1957683921 171 TTLTITFP 178
Cdd:PRK11360  593 TTFTLYLP 600
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
14-182 5.59e-30

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 113.11  E-value: 5.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAK----PAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSE--AVIVGNKQHFQQCFLNL 87
Cdd:COG5002   210 EEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  88 IKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGTMVAVKIIETMHGSL 161
Cdd:COG5002   290 LDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRI 369

                         170       180
                  ....*....|....*....|.
gi 1957683921 162 KIRSIVSKGTTLTITFPKYSK 182
Cdd:COG5002   370 WVESEPGKGTTFTITLPLARE 390
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 75-179 3.09e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.56  E-value: 3.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   75 GNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK-----TKGTGLGTMV 149
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1957683921  150 AVKIIETMHGSLKIRSIVSKGTTLTITFPK 179
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
17-182 1.13e-25

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 102.83  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  17 NRAQEIIDDYLTFAKpapeKSDQISVKQELNRVINMIFPLCNMNTI-HITQDFSE----AVIVGNKQHFQQCFLNLIKNS 91
Cdd:PRK13837  497 ARARLIIDQILAFGR----KGERNTKPFDLSELVTEIAPLLRVSLPpGVELDFDQdqepAVVEGNPAELQQVLMNLCSNA 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  92 IEAMPNGGTLNIS-SSINNSK--------------VEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIET 156
Cdd:PRK13837  573 AQAMDGAGRVDISlSRAKLRApkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSA 652

                         170       180
                  ....*....|....*....|....*.
gi 1957683921 157 MHGSLKIRSIVSKGTTLTITFPKYSK 182
Cdd:PRK13837  653 HAGYIDVQSTVGRGTRFDVYLPPSSK 678
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
11-178 4.41e-24

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 97.55  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  11 KQMEELNRaqeIIDDYLTFAKPAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAV--IVGNKQHFQQCFLNLI 88
Cdd:PRK10364  281 KEADRLNR---VVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpeIQADPDRLTQVLLNLY 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  89 KNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVS 168
Cdd:PRK10364  358 LNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEG 437

                         170
                  ....*....|
gi 1957683921 169 KGTTLTITFP 178
Cdd:PRK10364  438 KGATFTLWLP 447
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 75-178 1.15e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 87.42  E-value: 1.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  75 GNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNsKVEIRIEDSGVGMSQEQIHRFGEPYFS---TKTKGTGLGTMVAV 151
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 1957683921 152 KIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 82-178 1.12e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 84.78  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  82 QCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT--KGTGLGTMVAVKIIETMHG 159
Cdd:cd16943     6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGG 85

                          90
                  ....*....|....*....
gi 1957683921 160 SLKIRSIVSKGTTLTITFP 178
Cdd:cd16943    86 TIRVASVPGGGTRFTIILP 104
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-178 4.37e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 80.52  E-value: 4.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAM----PNGGTLNISSSINNSK-VEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIE 155
Cdd:cd16920     2 QQVLINLVRNGIEAMseggCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIE 81

                          90       100
                  ....*....|....*....|...
gi 1957683921 156 TMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16920    82 AHGGRLSVESPAGGGATFQFTLP 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 80-178 1.04e-18

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 77.42  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPNGGTLNISSS---------------INNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT--KG 142
Cdd:cd16919     1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1957683921 143 TGLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16919    81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 17-181 2.07e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 79.06  E-value: 2.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  17 NRAQEIIDDYLTFAK--PAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDfSEAVIVGNKQHFQQCFLNLIKNSIEA 94
Cdd:COG4251   331 ERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKY 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  95 MPNG--GTLNISSSINNSKVEIRIEDSGVGMSQEQIHR-FGepYF-----STKTKGTGLG-TMVAvKIIETMHGSLKIRS 165
Cdd:COG4251   410 SRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKiFE--IFqrlhsRDEYEGTGIGlAIVK-KIVERHGGRIWVES 486

                         170
                  ....*....|....*.
gi 1957683921 166 IVSKGTTLTITFPKYS 181
Cdd:COG4251   487 EPGEGATFYFTLPKAP 502
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 80-178 9.32e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 69.41  E-value: 9.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTK------GTGLGTMVAVKI 153
Cdd:cd16946     5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNI 84

                          90       100
                  ....*....|....*....|....*
gi 1957683921 154 IETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16946    85 ALAHGGTISAEHSPLGGLRLVLTLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 6-181 2.06e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 72.95  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   6 ASNIRkqmEELNRAQEIIDDYLTFAK----PAPEKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAVIVGNKQHFQ 81
Cdd:PRK11100  294 TGNIL---TQSARLQQLIDRLLELARleqrQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLR 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  82 QCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFS-----TKTKGTGLGTMVAVKIIET 156
Cdd:PRK11100  371 QALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVARL 450

                         170       180
                  ....*....|....*....|....*
gi 1957683921 157 MHGSLKIRSIVSKGTTLTITFPKYS 181
Cdd:PRK11100  451 HGGEVTLRNRPEGGVLATLTLPRHF 475
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 80-178 9.59e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 66.75  E-value: 9.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPNGG-TLNIS---SSINNSKVEIRIEDSGVGMSQEQIHRFGEPY------FSTKTKGTGLGTMV 149
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEvTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAI 80

                          90       100
                  ....*....|....*....|....*....
gi 1957683921 150 AVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 82-178 2.95e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 65.64  E-value: 2.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  82 QCFLNLIKN---SIEAMPNG-GTLNISSSIN-NSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIET 156
Cdd:cd16944     7 QVLTNILKNaaeAIEGRPSDvGEVRIRVEADqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEE 86

                          90       100
                  ....*....|....*....|..
gi 1957683921 157 MHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16944    87 HGGRISLSNREAGGACIRIILP 108
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 86-179 4.66e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 69.11  E-value: 4.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPNGGTLN----ISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTK-GTGLGTMVAVKIIETMHGS 160
Cdd:COG3290   288 NLLDNAIEAVEKLPEEErrveLSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYGGT 367

                          90
                  ....*....|....*....
gi 1957683921 161 LKIRSIVSKGTTLTITFPK 179
Cdd:COG3290   368 IEVESEEGEGTVFTVRLPK 386
PRK13557 PRK13557
histidine kinase; Provisional
 85-178 3.47e-13

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 66.62  E-value: 3.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  85 LNLIKNSIEAMPNGGTLNISSSinNSKVE-----------------IRIEDSGVGMSQEQIHRFGEPYFSTKT--KGTGL 145
Cdd:PRK13557  283 LNVLINARDAMPEGGRVTIRTR--NVEIEdedlamyhglppgryvsIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGL 360

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1957683921 146 GTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK13557  361 GLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-165 5.43e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 62.09  E-value: 5.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPN--GGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT--KGTGLGTMVAVKIIET 156
Cdd:cd16976     2 QQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVEE 81


                  ....*....
gi 1957683921 157 MHGSLKIRS 165
Cdd:cd16976    82 HGGRLSVAN 90
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 84-178 2.23e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 60.68  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  84 FLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGTMVAVKIIETM 157
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHVMSRH 84

                          90       100
                  ....*....|....*....|.
gi 1957683921 158 HGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16952    85 DARLLIASELGKGSRFTCLFP 105
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 87-178 5.69e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 59.61  E-value: 5.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  87 LIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK-----TKGTGLGTMVAVKIIETMHGSL 161
Cdd:cd16948    13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKI 92

                          90
                  ....*....|....*..
gi 1957683921 162 KIRSIVSKGTTLTITFP 178
Cdd:cd16948    93 DVESEVGEGTTFTITFP 109
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 7-178 1.09e-11

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 62.40  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   7 SNIRKQMEELNRaqeIIDDYLTFAKpapeKSDQISVKQELNRVINMIFPLCNMN------TIHITQDfseAVIVGNKQHF 80
Cdd:COG4192   475 DKIEGLIERMDK---IIKSLRQFSR----KSDTPLQPVDLRQVIEQAWELVESRakpqqiTLHIPDD---LMVQGDQVLL 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMsqEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGS 160
Cdd:COG4192   545 EQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGD 622

                         170
                  ....*....|....*...
gi 1957683921 161 LKIRSIVSKGTTLTITFP 178
Cdd:COG4192   623 LYLASTLERGAMVILEFN 640
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
86-179 2.23e-11

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 61.57  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPyFSTKTKGTGLGTMVAVKIIETMHG---SLK 162
Cdd:COG2972   347 NAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYYGeeyGLE 425

                          90
                  ....*....|....*..
gi 1957683921 163 IRSIVSKGTTLTITFPK 179
Cdd:COG2972   426 IESEPGEGTTVTIRIPL 442
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
76-178 3.01e-11

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 61.29  E-value: 3.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   76 NKQHFQQCFLNLIKNSIEaMPNGGTLNISSSI-----NNSKVEIRIEDSGVGMSQEQIHRFGEPYFST----KTKGTGLG 146
Cdd:PRK09959   825 DPQAFKQVLSNLLSNALK-FTTEGAVKITTSLghiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLG 903

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1957683921  147 TMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK09959   904 LMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
14-179 5.90e-11

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 60.02  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  14 EELNRAQEIIDDYLTFAK----PAPEKSDQISVKQELNRVINMIFPLCNmNTIHITQDFSEAVIV-GNKQHFQQCFLNLI 88
Cdd:PRK11006  248 EQTQRMEGLVKQLLTLSKieaaPTIDLNEKVDVPMMLRVLEREAQTLSQ-GKHTITFEVDNSLKVfGNEDQLRSAISNLV 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  89 KNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGtMVAVKIIETMHGS-L 161
Cdd:PRK11006  327 YNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLG-LAIVKHALSHHDSrL 405

                         170
                  ....*....|....*...
gi 1957683921 162 KIRSIVSKGTTLTITFPK 179
Cdd:PRK11006  406 EIESEVGKGTRFSFVLPE 423
PRK15347 PRK15347
two component system sensor kinase;
11-178 2.00e-10

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 58.89  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  11 KQMEELNRAQ-------EIIDDYLTFAKPapeKSDQISVKQELNRvinmIFPLCN--MNTIH---ITQDFSEAVIVGnkQ 78
Cdd:PRK15347  431 EQMDLADTARqctlsllAIINNLLDFSRI---ESGQMTLSLEETA----LLPLLDqaMLTIQgpaQSKSLTLRTFVG--A 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  79 HF-----------QQCFLNLIKNSIEAMPNGG-TLNISSSinNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT--KGTG 144
Cdd:PRK15347  502 HVplylhldslrlRQILVNLLGNAVKFTETGGiRLRVKRH--EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADThsQGTG 579

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1957683921 145 LGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK15347  580 LGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 80-179 4.17e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 54.25  E-value: 4.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPngGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGTMVAVKI 153
Cdd:cd16949     1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|....*.
gi 1957683921 154 IETMHGSLKIRSIVSKGTTLTITFPK 179
Cdd:cd16949    79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 86-184 1.32e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 56.46  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPN--GGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMVAVKIIETMHGSLKI 163
Cdd:PRK11086  440 NLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAV 519

                          90       100
                  ....*....|....*....|.
gi 1957683921 164 RSIVSKGTTLTITFPKYSKNT 184
Cdd:PRK11086  520 ESEPGVGTQFFVQIPWDGERS 540
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 61-178 4.42e-09

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 54.86  E-value: 4.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  61 TIHITQDFSEAVIvGNKQHFQQCFLNLIKNSIEAMPNGgTLNISS---SINNSKVEIRIE--DSGVGMS---QEQI---- 128
Cdd:PRK11107  391 TLNIDPDVPDNVI-GDPLRLQQIITNLVGNAIKFTESG-NIDILVelrALSNTKVQLEVQirDTGIGISerqQSQLfqaf 468

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1957683921 129 --------HRFGepyfstktkGTGLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK11107  469 rqadasisRRHG---------GTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
62-178 4.44e-09

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 54.64  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  62 IHITQDFSE-AVIVGNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT 140
Cdd:PRK10549  334 LTLQLSLPDsATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEG 413

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1957683921 141 K------GTGLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK10549  414 SrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
PRK09303 PRK09303
histidine kinase;
81-182 1.13e-08

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 53.42  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTlnISSSI---NNSKVEIRIEDSGVGMSQEQIHRFGEPYF----STKTKGTGLGTMVAVKI 153
Cdd:PRK09303  274 RQVLLNLLDNAIKYTPEGGT--ITLSMlhrTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRI 351

                          90       100
                  ....*....|....*....|....*....
gi 1957683921 154 IETMHGSLKIRSIVSKGTTLTITFPKYSK 182
Cdd:PRK09303  352 VRVHYGQIWVDSEPGQGSCFHFTLPVYRG 380
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-166 1.98e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 50.15  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFS-----TKTKGTGLGTMVAVKIIE 155
Cdd:cd16945     6 RQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQ 85

                          90
                  ....*....|.
gi 1957683921 156 TMHGSLKIRSI 166
Cdd:cd16945    86 LHGGRITLRNR 96
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 75-176 1.66e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 47.89  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  75 GNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT------KGTGLGTM 148
Cdd:cd16947    16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLT 95

                          90       100
                  ....*....|....*....|....*...
gi 1957683921 149 VAVKIIETMHGSLKIRSIVSKGTTLTIT 176
Cdd:cd16947    96 ITKRLAESMGGSIYVNSKPYEKTVFTVT 123
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 62-178 1.70e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 50.29  E-value: 1.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  62 IHITQDFSEAV---IVGNKQHFQQCFLNLIKNSIEaMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPY--F 136
Cdd:PRK11466  541 IRLATDIADDLptaLMGDPRRIRQVITNLLSNALR-FTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFvqV 619

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1957683921 137 STKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK11466  620 SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-154 1.89e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 47.40  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMP-NGGTLNISSSINNS----------KVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGTGLGTMV 149
Cdd:cd16918     2 IQVFLNLVRNAAQALAgSGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAI 81


                  ....*
gi 1957683921 150 AVKII 154
Cdd:cd16918    82 AQNIV 86
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
81-181 2.05e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 49.97  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTLnISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKT------KGTGLGTMVAVKII 154
Cdd:PRK10841  564 QQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGLGLAICEKLI 642

                          90       100
                  ....*....|....*....|....*..
gi 1957683921 155 ETMHGSLKIRSIVSKGTTLTITFPKYS 181
Cdd:PRK10841  643 NMMDGDISVDSEPGMGSQFTIRIPLYG 669
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 82-178 3.01e-07

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.55  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  82 QCFLNLIKNSIEAMPNGG-TLNISSSINNsKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTK-------GTGLGTMVAVKI 153
Cdd:PRK11091  401 QILWNLISNAVKFTQQGGvTVRVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRL 479

                          90       100
                  ....*....|....*....|....*
gi 1957683921 154 IETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK11091  480 AQAMGGDITVTSEEGKGSCFTLTIH 504
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 35-178 3.83e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.13  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  35 EKSDQISVKQELNRVINMIFPLCNMNTIHITQDFSEAVIvgNKQHFQQC--FLN-LIKNSIE-AMPNG--GTLNISSSIN 108
Cdd:COG3920   354 EDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVEL--PADAAVPLglILNeLVTNALKhAFLSGegGRIRVSWRRE 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921 109 NSKVEIRIEDSGVGMSQEqihrfgepyfSTKTKGTGLGTMVAVKIIETMHGSLKIRSivSKGTTLTITFP 178
Cdd:COG3920   432 DGRLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFP 489
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
99-178 5.81e-07

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 48.64  E-value: 5.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  99 GTLNISSSINNSKVEIRIEDSGVG-----------------------MSQEQIHRF-GEPYFSTKTK-----GTGLGtMV 149
Cdd:COG0643   309 GTITLSAYHEGGRVVIEVSDDGRGldlekirakaiekglitaeeaaaLSDEELLELiFAPGFSTAEEvtdlsGRGVG-MD 387

                          90       100       110
                  ....*....|....*....|....*....|
gi 1957683921 150 AVK-IIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:COG0643   388 VVKtNIEALGGTIEIESEPGKGTTFTLRLP 417
envZ PRK09467
osmolarity sensor protein; Provisional
 5-178 7.85e-07

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 47.98  E-value: 7.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   5 IASNIRKQMEELNraqEIIDDYLTFAKPAPEKS-----------DQISVKQELNRVINMIFPLC----NMNTIHItqdfs 69
Cdd:PRK09467  261 LAESINKDIEECN---AIIEQFIDYLRTGQEMPmemadlnallgEVIAAESGYEREIETALQPGpievPMNPIAI----- 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  70 eavivgnkqhfQQCFLNLIKNSIEAmpNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYfsTK------TKGT 143
Cdd:PRK09467  333 -----------KRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPF--TRgdsargSSGT 397

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1957683921 144 GLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK09467  398 GLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-177 7.99e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 45.86  E-value: 7.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPNGGTLNISSSiNNSKVEIRIEDSGVGMSQEQIHRFGEPYF---STKTKGTGLGTMVAVKIIETMHGSLK 162
Cdd:cd16940    20 NLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVELHGGQIF 98

                          90
                  ....*....|....*
gi 1957683921 163 IRSIVSKGTTLTITF 177
Cdd:cd16940    99 LGNAQGGGLEAWVRL 113
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-178 1.57e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 44.63  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTLNIS--SSINNSKVEIRIEDSGVGMSQEQIHR----FGEPYFSTKTKGTGLGTMVAVKII 154
Cdd:cd16921     2 GQVLTNLLGNAIKFRRPRRPPRIEvgAEDVGEEWTFYVRDNGIGIDPEYAEKvfgiFQRLHSREEYEGTGVGLAIVRKII 81

                          90       100
                  ....*....|....*....|....
gi 1957683921 155 ETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16921    82 ERHGGRIWLESEPGEGTTFYFTLP 105
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
4-179 1.85e-06

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 47.07  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921   4 VIASNirkqMEELNRAQEIIDDYLTFAKP-----APEKSdQISVKQELNRVINMIFPLCNMNTIHITQDFSEAVIVGNKQ 78
Cdd:PRK09835  300 VLYSN----LEELTRMAKMVSDMLFLAQAdnnqlIPEKK-MLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPL 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  79 HFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFST------KTKGTGLGTMVAVK 152
Cdd:PRK09835  375 MLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKS 454

                         170       180
                  ....*....|....*....|....*..
gi 1957683921 153 IIETMHGSLKIRSIVsKGTTLTITFPK 179
Cdd:PRK09835  455 IVVAHKGTVAVTSDA-RGTRFVISLPR 480
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 84-177 1.99e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 44.76  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  84 FLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTKTKGT-----GLGTMVAVKIIETMH 158
Cdd:cd16975     9 LINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIAKNLVEKHG 88

                          90
                  ....*....|....*....
gi 1957683921 159 GSLKIRSIVSKGTTLTITF 177
Cdd:cd16975    89 GSLIIENSQKGGAEVTVKI 107
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-164 2.47e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 44.36  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAmpNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF----STKTKGTGLGTMVAVKIIETMHGSL 161
Cdd:cd16950     7 NLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISDAHGGSL 84


                  ...
gi 1957683921 162 KIR 164
Cdd:cd16950    85 TLA 87
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-178 3.64e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 43.82  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAM----PNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYFSTK-TKGTGLGTMVAVKIIETMHGS 160
Cdd:cd16915     7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgQGERGIGLALVRQSVERLGGS 86

                          90
                  ....*....|....*...
gi 1957683921 161 LKIRSIVSKGTTLTITFP 178
Cdd:cd16915    87 ITVESEPGGGTTFSIRIP 104
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 99-178 4.57e-06

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 44.88  E-value: 4.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  99 GTLNISSSINNSKVEIRIEDSGVG-----------------------MSQEQIHRF-GEPYFSTKTK-----GTGLGTMV 149
Cdd:cd16916    70 GTITLRAEHQGNQVVIEVSDDGRGidrekirekaierglitadeaatLSDDEVLNLiFAPGFSTAEQvtdvsGRGVGMDV 149

                          90       100
                  ....*....|....*....|....*....
gi 1957683921 150 AVKIIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16916   150 VKRSIESLGGTIEVESEPGQGTTFTIRLP 178
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 80-178 6.77e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 43.25  E-value: 6.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPNGGTLNISSSINN-SKVEIRIEDSGVG----MSQEQIHRF--GEPYFSTKTKGTGLGTMVAVK 152
Cdd:cd16925     5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGippnLREEIFERFrqGDGSSTRAHGGTGLGLSIVKE 84

                          90       100
                  ....*....|....*....|....*.
gi 1957683921 153 IIETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:cd16925    85 FVELHGGTVTVSDAPGGGALFQVELP 110
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
97-178 9.19e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.61  E-value: 9.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  97 NGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRfgepyfstktKGTGLGTMVavKIIETMHGSLKIRSIVSKGTTLTIT 176
Cdd:COG4585   179 GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG----------GGLGLRGMR--ERAEALGGTLTIGSAPGGGTRVRAT 246


                  ..
gi 1957683921 177 FP 178
Cdd:COG4585   247 LP 248
PRK10337 PRK10337
sensor protein QseC; Provisional
 86-159 4.74e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 42.71  E-value: 4.74e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1957683921  86 NLIKNSIEAMPNGGTLNISSSINnskvEIRIEDSGVGMSQEQIHRFGEPYF----STKTkGTGLGTMVaVKIIETMHG 159
Cdd:PRK10337  359 NLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYrppgQEAT-GSGLGLSI-VRRIAKLHG 430
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 98-178 1.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 40.09  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  98 GGTLNISSSINNSKVEIRIEDSGVGMSQEqihrfgepyFSTKTKGTgLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITF 177
Cdd:cd16951    61 GGTITIRSVVDGDYLRITVIDDGVGLPQD---------EDWPNKGS-LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDI 130


                  .
gi 1957683921 178 P 178
Cdd:cd16951   131 P 131
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
61-164 1.55e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 41.11  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  61 TIHITQDFSEAVIVGNKQHFQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPY--FST 138
Cdd:PRK10755  229 TLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFvrMDS 308

                          90       100
                  ....*....|....*....|....*.
gi 1957683921 139 KTKGTGLGTMVAVKIIETMHGSLKIR 164
Cdd:PRK10755  309 RYGGIGLGLSIVSRITQLHHGQFFLQ 334
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-178 2.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 38.60  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAMPNGGTLNISSSI-NNSKVEIRIEDSGVGMSQEQIHRFGEPYFstktKGTGLGTMVAVKIIETMHGS-LKI 163
Cdd:cd16955    12 NAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEM----PGNKIGLLNVHQRLKLGYGEgLHI 87

                          90
                  ....*....|....*
gi 1957683921 164 RSIVSKGTTLTITFP 178
Cdd:cd16955    88 RSRPDPGTLIAFYIP 102
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-178 2.85e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 38.52  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  81 QQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF----STKTKGTGLGTMVAVKIIET 156
Cdd:cd16923     2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIEL 81

                          90       100
                  ....*....|....*....|..
gi 1957683921 157 MHGSLKIRsIVSKGTTLTITFP 178
Cdd:cd16923    82 HGGSASAE-YDDNHDLFKVRLP 102
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 98-176 3.46e-04

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 39.06  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  98 GGTLNISSSINNSKVEIRIEDSGVGMsqEQIHRFGEPYFSTKT--KGTGLGtmvaVKIIETMHGSLKIRSIVSKGTTLTI 175
Cdd:cd16942    60 NGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPelERSGMG----FTIMENFMDEVIVESEVNKGTTVYL 133


                  .
gi 1957683921 176 T 176
Cdd:cd16942   134 K 134
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
10-181 9.31e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.15  E-value: 9.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  10 RKQME--ELNR----AQEI---IDDYLTFAKpapeksdqISVKQELNRVI------------NMIFPLCNMN-TIHITQD 67
Cdd:PRK09470  270 RRQGEskELERieteAQRLdsmINDLLVLSR--------NQQKNHLERETfkanslwsevleDAKFEAEQMGkSLTVSAP 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  68 FSEAVIVGNKQHFQQCFLNLIKNSIEAMPNggTLNISSSINNSKVEIRIEDSGVGMSQ---EQIHRfgePYFST------ 138
Cdd:PRK09470  342 PGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEeerEQIFR---PFYRVdeardr 416

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1957683921 139 KTKGTGLGTMVAVKIIETMHGSLKI-RSIVsKGTTLTITFPKYS 181
Cdd:PRK09470  417 ESGGTGLGLAIVENAIQQHRGWVKAeDSPL-GGLRLTIWLPLYK 459
PRK10490 PRK10490
sensor protein KdpD; Provisional
 80-178 1.05e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 38.86  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  80 FQQCFLNLIKNSIEAMPNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPyFSTKTK-----GTGLGTMVAVKII 154
Cdd:PRK10490  779 FERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK-FARGNKesaipGVGLGLAICRAIV 857

                          90       100
                  ....*....|....*....|....
gi 1957683921 155 ETMHGSLKIRSIVSKGTTLTITFP 178
Cdd:PRK10490  858 EVHGGTIWAENRPEGGACFRVTLP 881
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 55-177 1.85e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 36.84  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  55 PLCNM-NTIH------ITQDFS-EAVIVGNKQHFQQCFLNLIKNS-------IEampnggtlnISSSINNSKVEIRIEDS 119
Cdd:cd16954     5 SLCSAlNKVYqrkgvsISLDISpELRFPGERNDLMELLGNLLDNAckwclefVE---------VTARQTDGGLHLIVDDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921 120 GVGMSQEQIHRFGE--PYFSTKTKGTGLGTMVAVKIIETMHGSLKIRSIVSKGTTLTITF 177
Cdd:cd16954    76 GPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 85-178 7.40e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 34.71  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  85 LNLIKNSIEAMPNggTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGTMVAVKIIETMH 158
Cdd:cd16939     6 DNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVALWHG 83

                          90       100
                  ....*....|....*....|
gi 1957683921 159 GSLKIRSIVSKGTTLTITFP 178
Cdd:cd16939    84 GHVECDDSELGGACFRLTWP 103
PRK10604 PRK10604
sensor protein RstB; Provisional
 86-178 7.63e-03

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 36.12  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957683921  86 NLIKNSIEAmpNGGTLNISSSINNSKVEIRIEDSGVGMSQEQIHRFGEPYF------STKTKGTGLGTMVAVKIIETMHG 159
Cdd:PRK10604  326 NLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGG 403

                          90
                  ....*....|....*....
gi 1957683921 160 SLKIRSIVSKGTTLTITFP 178
Cdd:PRK10604  404 SVNCDESELGGARFSFSWP 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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