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Conserved domains on  [gi|1959076869|ref|WP_201588713|]
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helix-turn-helix domain-containing protein [Psychrobacter pulmonis]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11444466)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator; also contains a DUF4115 domain; similar to cytoskeleton protein RodZ, an inner membrane protein which functions in cell-shape control through regulation of the length of the long axis

CATH:  1.10.10.10|1.10.260.40
Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 15-77 1.80e-21

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 85.24  E-value: 1.80e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1959076869  15 SFGAMLQQARKTKQVSLEEAAAELFILKRHLQALENENFADLPQAAFARGFAINYAKFLGLDP 77
Cdd:COG1426     5 TIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDP 67
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 199-262 2.13e-06

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


:

Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 44.48  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1959076869 199 VKLTDAAVVVITDASGSNLMNGSQTVGD-YKLSGTPPFNVQIDNVKNVSLMLNEEAVALDSYATG 262
Cdd:pfam13464   2 LTFTGDSWVEVRDADGKVLFEGLLKAGEtRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGYARG 66
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 15-77 1.80e-21

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 85.24  E-value: 1.80e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1959076869  15 SFGAMLQQARKTKQVSLEEAAAELFILKRHLQALENENFADLPQAAFARGFAINYAKFLGLDP 77
Cdd:COG1426     5 TIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDP 67
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 19-77 2.41e-20

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 82.16  E-value: 2.41e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1959076869  19 MLQQARKTKQVSLEEAAAELFILKRHLQALENENFADLPQAAFARGFAINYAKFLGLDP 77
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDP 59
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 199-262 2.13e-06

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 44.48  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1959076869 199 VKLTDAAVVVITDASGSNLMNGSQTVGD-YKLSGTPPFNVQIDNVKNVSLMLNEEAVALDSYATG 262
Cdd:pfam13464   2 LTFTGDSWVEVRDADGKVLFEGLLKAGEtRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGYARG 66
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 15-77 1.80e-21

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 85.24  E-value: 1.80e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1959076869  15 SFGAMLQQARKTKQVSLEEAAAELFILKRHLQALENENFADLPQAAFARGFAINYAKFLGLDP 77
Cdd:COG1426     5 TIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDP 67
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 19-77 2.41e-20

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 82.16  E-value: 2.41e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1959076869  19 MLQQARKTKQVSLEEAAAELFILKRHLQALENENFADLPQAAFARGFAINYAKFLGLDP 77
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDP 59
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 199-262 2.13e-06

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 44.48  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1959076869 199 VKLTDAAVVVITDASGSNLMNGSQTVGD-YKLSGTPPFNVQIDNVKNVSLMLNEEAVALDSYATG 262
Cdd:pfam13464   2 LTFTGDSWVEVRDADGKVLFEGLLKAGEtRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGYARG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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