NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1960469735|ref|WP_202019183|]
View 

MULTISPECIES: recombinase family protein [Klebsiella]

Protein Classification

recombinase family protein( domain architecture ID 10132949)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0000150|GO:0003677|GO:0006310|GO:0015074
PubMed:  21645851|26104451|11972771|16077726|9348666
SCOP:  3000065

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 6-150 1.06e-71

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


:

Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 214.50  E-value: 1.06e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKEHSYTIAAEFIENESGASLGRPELFNLLKVAQPGDVLLVEQVDRLSRLKDEDWK 85
Cdd:cd03767     1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1960469735  86 TLRQMISSKGIRVVALDLPTSHMLLN-TGDEFTSRMFEALNSMMLDMLAAIARKDYTDRQRRQEEG 150
Cdd:cd03767    81 TLKASIAAKGLRVVSLDLPTSHSALAaEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 6-150 1.06e-71

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 214.50  E-value: 1.06e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKEHSYTIAAEFIENESGASLGRPELFNLLKVAQPGDVLLVEQVDRLSRLKDEDWK 85
Cdd:cd03767     1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1960469735  86 TLRQMISSKGIRVVALDLPTSHMLLN-TGDEFTSRMFEALNSMMLDMLAAIARKDYTDRQRRQEEG 150
Cdd:cd03767    81 TLKASIAAKGLRVVSLDLPTSHSALAaEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 5-202 3.53e-31

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 117.05  E-value: 3.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   5 RVYAYLRASTSEQDAS---RAKEALQEFAKEHSYTIAAEFIENE-SGASLGRPELFNLLKVAQPG--DVLLVEQVDRLSR 78
Cdd:COG1961     3 RAAGYARVSTDDQEGLsleRQREALRAYAEKAGWEIVRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  79 lKDEDWKTLRQMISSKGIRVVALDLPtshmlLNTGDeftsrmfeALNSMMLDMLAAIARKDYTDRQRRQEEGIKKAKEQG 158
Cdd:COG1961    83 -NLADLLELVEELKERGVRLISLTEG-----IDTST--------PMGRLLLTILAAFAEFERELISERTRAGLAAAKARG 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1960469735 159 LYKGRP-----------VNE---KLHKQILALRQAGHSYSQIQELTGAA------RTTISKAIN 202
Cdd:COG1961   149 KYLGRPpygyrdpkklvIDEeeaEVVRRIFELYLEGKSLREIARELNERgiptwsRSTVYRILK 212
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 6-160 3.92e-27

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 100.78  E-value: 3.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735    6 VYAYLRASTSEQDAS---RAKEALQEFAKEHSYTIAAEFIEN-ESGASLGRPELFNLLKVAQPGD--VLLVEQVDRLSRl 79
Cdd:smart00857   1 AAGYARVSTDDQADGsleRQLEALRAYAERNGWEVVRIYEDEgVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGR- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   80 KDEDWKTLRQMISSKGIRVVALDLPTshmlLNTGDeftsrmfeALNSMMLDMLAAIARKDYTDRQRRQEEGIKKAKEQGL 159
Cdd:smart00857  80 SLRDLLALLELLEEKGVRLVSLKEGI----LDTST--------PAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147


                   .
gi 1960469735  160 Y 160
Cdd:smart00857 148 W 148
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 6-160 5.11e-18

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 76.92  E-value: 5.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDAS--RAKEALQEFAKEHSytIAAEFIE-NESGASLGRPELFNLLKVAQP--GDVLLVEQVDRLSRLK 80
Cdd:pfam00239   1 AIGYARVSTEDQDDSleRQLEALRAYAACNG--KIVEFEDkGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  81 dEDWKTLRQMISSKGIRVVALDLPtshmlLNTGDEFtsrmfealNSMMLDMLAAIA---RKDYTDRQRrqeEGIKKAKEQ 157
Cdd:pfam00239  79 -RDLLTLVEELREKGVDLVSLDEG-----IDTSTPM--------GRLLLTILAALAefeRALIRERTR---AGLAAAAAR 141


                  ...
gi 1960469735 158 GLY 160
Cdd:pfam00239 142 GKL 144
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-202 2.79e-09

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 54.72  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKEHSYTIAAEFIENESGA-SLGRPELFNLLKVAQPGDVLLVEQVDRLSRlkdedw 84
Cdd:PRK13413    2 IYAYIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTkSYKDRKLGKLLKKMRKGDILIVSELSRLGR------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  85 kTLRQMIS------SKGIRVvaldlptshmlLNTGDEFtsRMFEALNSMML----DMLAAIARKDYTDRQRrqeEGIKKA 154
Cdd:PRK13413   76 -NLMEIMSilnicmEKEVIV-----------YTIKEGY--ELGDDINSKVLafafGLSAEIERNLISQRTK---EALARK 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1960469735 155 KEQGLYKGRPVNE-----KL---HKQILALRQAGHSYSQIQELTGAARTTISKAIN 202
Cdd:PRK13413  139 KAEGVTLGRPKGStpkkyKLtgkEEKIKKLLDKGTSKSEIARKLGVSRTTLARFLK 194
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 6-150 1.06e-71

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 214.50  E-value: 1.06e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKEHSYTIAAEFIENESGASLGRPELFNLLKVAQPGDVLLVEQVDRLSRLKDEDWK 85
Cdd:cd03767     1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1960469735  86 TLRQMISSKGIRVVALDLPTSHMLLN-TGDEFTSRMFEALNSMMLDMLAAIARKDYTDRQRRQEEG 150
Cdd:cd03767    81 TLKASIAAKGLRVVSLDLPTSHSALAaEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 5-202 3.53e-31

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 117.05  E-value: 3.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   5 RVYAYLRASTSEQDAS---RAKEALQEFAKEHSYTIAAEFIENE-SGASLGRPELFNLLKVAQPG--DVLLVEQVDRLSR 78
Cdd:COG1961     3 RAAGYARVSTDDQEGLsleRQREALRAYAEKAGWEIVRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  79 lKDEDWKTLRQMISSKGIRVVALDLPtshmlLNTGDeftsrmfeALNSMMLDMLAAIARKDYTDRQRRQEEGIKKAKEQG 158
Cdd:COG1961    83 -NLADLLELVEELKERGVRLISLTEG-----IDTST--------PMGRLLLTILAAFAEFERELISERTRAGLAAAKARG 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1960469735 159 LYKGRP-----------VNE---KLHKQILALRQAGHSYSQIQELTGAA------RTTISKAIN 202
Cdd:COG1961   149 KYLGRPpygyrdpkklvIDEeeaEVVRRIFELYLEGKSLREIARELNERgiptwsRSTVYRILK 212
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 6-160 3.92e-27

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 100.78  E-value: 3.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735    6 VYAYLRASTSEQDAS---RAKEALQEFAKEHSYTIAAEFIEN-ESGASLGRPELFNLLKVAQPGD--VLLVEQVDRLSRl 79
Cdd:smart00857   1 AAGYARVSTDDQADGsleRQLEALRAYAERNGWEVVRIYEDEgVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGR- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   80 KDEDWKTLRQMISSKGIRVVALDLPTshmlLNTGDeftsrmfeALNSMMLDMLAAIARKDYTDRQRRQEEGIKKAKEQGL 159
Cdd:smart00857  80 SLRDLLALLELLEEKGVRLVSLKEGI----LDTST--------PAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147


                   .
gi 1960469735  160 Y 160
Cdd:smart00857 148 W 148
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 6-150 2.25e-18

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 77.52  E-value: 2.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKehsytIAAEFIENESGASLGRPELFNLLKVAQPGDVLLVEQVDRLSR-LKD--E 82
Cdd:cd03768     1 VIGYARVSTDDQSLERQLEALKAAGE-----CDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRsTKDllE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1960469735  83 DWKTLRQmissKGIRVVALDLPtshmlLNTGDeftsrmfeALNSMMLDMLAAIARKDYTDRQRRQEEG 150
Cdd:cd03768    76 IVEELRE----KGVSLRSLTEG-----IDTST--------PSGKLMLTILGAFAEFERELIRERTKEG 126
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 6-160 5.11e-18

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 76.92  E-value: 5.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDAS--RAKEALQEFAKEHSytIAAEFIE-NESGASLGRPELFNLLKVAQP--GDVLLVEQVDRLSRLK 80
Cdd:pfam00239   1 AIGYARVSTEDQDDSleRQLEALRAYAACNG--KIVEFEDkGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  81 dEDWKTLRQMISSKGIRVVALDLPtshmlLNTGDEFtsrmfealNSMMLDMLAAIA---RKDYTDRQRrqeEGIKKAKEQ 157
Cdd:pfam00239  79 -RDLLTLVEELREKGVDLVSLDEG-----IDTSTPM--------GRLLLTILAALAefeRALIRERTR---AGLAAAAAR 141


                  ...
gi 1960469735 158 GLY 160
Cdd:pfam00239 142 GKL 144
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 8-150 1.12e-17

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 75.76  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   8 AYLRASTSEQDAS----RAKEALQEFAKEHSYTIAAEFIENESGAS--LGRPELFNLLK--VAQPGDVLLVEQVDRLSRl 79
Cdd:cd00338     1 IYARVSTDKQEQGdsleRQREALREYAARNGLEVVGEYEDAGSSATslVDRPGLQRLLAdvKAGKIDVVLVEKLDRLSR- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1960469735  80 KDEDWKTLRQMISSKGIRVVALDLPtshmlLNTGDEFtsrmfealNSMMLDMLAAIARKDYTDRQRRQEEG 150
Cdd:cd00338    80 NLVDLLELLELLEAHGVRVVTADGE-----IDLDSED--------GRLMLGILAAMAEEESKLISERTKRG 137
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-202 2.79e-09

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 54.72  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDASRAKEALQEFAKEHSYTIAAEFIENESGA-SLGRPELFNLLKVAQPGDVLLVEQVDRLSRlkdedw 84
Cdd:PRK13413    2 IYAYIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTkSYKDRKLGKLLKKMRKGDILIVSELSRLGR------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735  85 kTLRQMIS------SKGIRVvaldlptshmlLNTGDEFtsRMFEALNSMML----DMLAAIARKDYTDRQRrqeEGIKKA 154
Cdd:PRK13413   76 -NLMEIMSilnicmEKEVIV-----------YTIKEGY--ELGDDINSKVLafafGLSAEIERNLISQRTK---EALARK 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1960469735 155 KEQGLYKGRPVNE-----KL---HKQILALRQAGHSYSQIQELTGAARTTISKAIN 202
Cdd:PRK13413  139 KAEGVTLGRPKGStpkkyKLtgkEEKIKKLLDKGTSKSEIARKLGVSRTTLARFLK 194
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 6-102 2.00e-06

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 45.72  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQ--DASRAKEALQEFAKEHsYTIAAEFIENESGASLGRPELFNLLKVAQPGDV--LLVEQVDRLSRLKD 81
Cdd:cd03769     1 TVLYARVSSHDQkdDLERQIERLEAYATAQ-GWIVEVIKDIGSGLNEKRKGLLKLLEDVLAGKVerVVITYKDRLARFGF 79

                          90       100
                  ....*....|....*....|.
gi 1960469735  82 EdwkTLRQMISSKGIRVVALD 102
Cdd:cd03769    80 E---LLEELFKAYGVEIVVIN 97
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 6-101 6.89e-05

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 41.20  E-value: 6.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1960469735   6 VYAYLRASTSEQDA------SRAKEALQEFAKEHSYTIAAEFI-ENESGASLGRPELFNLLKVAQPG--DVLLVEQVDRL 76
Cdd:cd03770     1 TALYCRLSRDDDLDgesnsiENQKAILEEYAKENGLENIRHYIdDGFSGTTFDRPGFNRMIEDIEAGkiDIVIVKDMSRL 80

                          90       100
                  ....*....|....*....|....*
gi 1960469735  77 SRLKDEDWKTLRQMISSKGIRVVAL 101
Cdd:cd03770    81 GRNYLKVGLYMEILFPKKGVRFIAI 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH