NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1993276725|ref|WP_204917253|]
View 

helix-turn-helix domain-containing protein [Microlunatus panaciterrae]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 11448415)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
18-86 4.74e-10

Predicted transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 441383  Cd Length: 113  Bit Score: 54.65  E-value: 4.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993276725  18 DPVRARLLGELA-RPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHGGITERVLQASAASYVV 86
Cdd:COG1777    16 NPTRRRILALLSeEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAFRLEV 85
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
18-86 4.74e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 54.65  E-value: 4.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993276725  18 DPVRARLLGELA-RPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHGGITERVLQASAASYVV 86
Cdd:COG1777    16 NPTRRRILALLSeEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAFRLEV 85
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 17-68 3.80e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 3.80e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1993276725  17 LDPVRARLLGELAR--PASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERR 68
Cdd:pfam12840   8 ADPTRLRILRALVGdePLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-69 3.06e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.44  E-value: 3.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1993276725  18 DPVRARLLGELA-RPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRH 69
Cdd:cd00090     6 DPTRLRILRLLLeGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-70 5.95e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 37.05  E-value: 5.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1993276725  18 DPVRARLLGELAR-PASAAGLAARVGIARQKVNYHLKALEAHGLValsEERRHG 70
Cdd:NF033788   10 DPTRLRILELLAEgELCVCELAEALGLSQSAVSQHLKVLRDAGLV---TSRREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-70 1.71e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1993276725   30 RPASAAGLAARVGIARQKVNYHLKALEAHGLValsEERRHG 70
Cdd:smart00418   9 GELCVCELAEILGLSQSTVSHHLKKLREAGLV---ESRREG 46
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
18-86 4.74e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 54.65  E-value: 4.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993276725  18 DPVRARLLGELA-RPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHGGITERVLQASAASYVV 86
Cdd:COG1777    16 NPTRRRILALLSeEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAFRLEV 85
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 17-68 3.80e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 3.80e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1993276725  17 LDPVRARLLGELAR--PASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERR 68
Cdd:pfam12840   8 ADPTRLRILRALVGdePLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
18-76 1.11e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 44.95  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993276725  18 DPVRARLLGELAR-PASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHGGITERV 76
Cdd:COG4189    18 SETRLRILRLLAEePLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKIC 77
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-69 3.06e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.44  E-value: 3.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1993276725  18 DPVRARLLGELA-RPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRH 69
Cdd:cd00090     6 DPTRLRILRLLLeGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-70 3.63e-06

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 43.72  E-value: 3.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1993276725  18 DPVRARLLGELAR-PASAAGLAARVGIARQKVNYHLKALEAHGLValsEERRHG 70
Cdd:COG0640    19 DPTRLRILRLLAEgELCVGELAEALGLSQSTVSHHLKVLREAGLV---TSRREG 69
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
8-71 3.31e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.99  E-value: 3.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1993276725   8 ESAEAAAAALDPVRARLLGEL--ARPASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHGG 71
Cdd:COG2345     2 TDTPALAALADPTRRRILELLkrAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRG 67
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 17-70 1.32e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 38.34  E-value: 1.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1993276725  17 LDPVRARLLGELAR--PASAAGLAARVGIARQKVNYHLKALEAHGLVALSEERRHG 70
Cdd:pfam12802   3 LTPAQFRVLLALARnpGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-70 5.95e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 37.05  E-value: 5.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1993276725  18 DPVRARLLGELAR-PASAAGLAARVGIARQKVNYHLKALEAHGLValsEERRHG 70
Cdd:NF033788   10 DPTRLRILELLAEgELCVCELAEALGLSQSAVSQHLKVLRDAGLV---TSRREG 60
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 18-61 1.03e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 35.50  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1993276725  18 DPVRARLLGELAR-PASAAGLAARVGIARQKVNYHLKALEAHGLV 61
Cdd:pfam01022   1 DPTRLKILKLLAEgELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-70 1.71e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1993276725   30 RPASAAGLAARVGIARQKVNYHLKALEAHGLValsEERRHG 70
Cdd:smart00418   9 GELCVCELAEILGLSQSTVSHHLKKLREAGLV---ESRREG 46
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
23-61 3.15e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 34.33  E-value: 3.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1993276725  23 RLLGELAR--PASAAGLAARVGIARQKVNYHLKALEAHGLV 61
Cdd:pfam13412   5 KILNLLQEnpRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
23-71 3.22e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.39  E-value: 3.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1993276725  23 RLLGELAR--PASAAGLAARVGIARQKVNYHLKALEAHGLValseERRHGG 71
Cdd:COG3398   101 RILLYLLEnpGATNKELAEELGISRSTVSWHLKRLEEDGLV----ERERDG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH