Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside ...
8-369
2.42e-83
Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity.
The actual alignment was detected with superfamily member cd11579:
Pssm-ID: 470237 [Multi-domain] Cd Length: 347 Bit Score: 257.47 E-value: 2.42e-83
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this ...
8-369
2.42e-83
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.
Pssm-ID: 211420 [Multi-domain] Cd Length: 347 Bit Score: 257.47 E-value: 2.42e-83
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis ...
12-365
1.78e-47
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.
Pssm-ID: 464132 [Multi-domain] Cd Length: 311 Bit Score: 163.44 E-value: 1.78e-47
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this ...
8-369
2.42e-83
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.
Pssm-ID: 211420 [Multi-domain] Cd Length: 347 Bit Score: 257.47 E-value: 2.42e-83
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis ...
12-365
1.78e-47
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.
Pssm-ID: 464132 [Multi-domain] Cd Length: 311 Bit Score: 163.44 E-value: 1.78e-47
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside ...
38-365
1.77e-11
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.
Pssm-ID: 211419 Cd Length: 313 Bit Score: 64.35 E-value: 1.77e-11
Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside ...
47-358
1.17e-09
Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity.
Pssm-ID: 211414 Cd Length: 284 Bit Score: 58.66 E-value: 1.17e-09
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside ...
54-365
6.65e-04
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.
Pssm-ID: 211416 Cd Length: 376 Bit Score: 41.56 E-value: 6.65e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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